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| 1 | Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test显示文摘AIM: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration. RESULTS: Using the UBT as the standard, the sensitivity, specif icity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were signif icantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A450/630) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099). | Masaaki Kodama Kazunari Murakami Tadayoshi Okimoto Yoshihiro Fukuda Tadashi Shimoyama Masumi Okuda Chieko Kato Intetsu Kobayashi Toshio Fujioka | 2012 | World Journal of Gastroenterology2012，18，1： | 7 |
| 2 | Clinical importance of colonoscopy in patients with gastric neoplasm undergoing endoscopic submucosal dissection显示文摘AIM To evaluate the usefulness of total colonoscopy(TCS) for patients undergoing gastric endoscopic submucosal dissection(ESD) and to assess risk factors for colorectal neoplasms.METHODS Of the 263 patients who underwent ESD at our department between May 2010 and December 2013, 172 patients undergoing TCS during a one-year period before and after ESD were targeted. After excluding patients with a history of surgery or endoscopic therapy for colorectal neoplasms, 158 patients were analyzed. Of the 868 asymptomatic patients who underwent TCS during the same period because of positive fecal immunochemical test(FIT) results, 158 patients with no history of either surgery or endoscopic therapy for colorectal neoplasms who were matched for age and sex served as the control group for comparison.RESULTS TCS revealed adenoma less than 10 mm in 53 patients(33.6%), advanced adenoma in 17(10.8%), early colorectal cancer in 5(3.2%), and advanced colorectalcancer in 4(2.5%). When the presence or absence of adenoma less than 10 mm, advanced adenoma, and colorectal cancer and the number of adenomas were compared between patients undergoing ESD and FITpositive patients, there were no statistically significant differences in any of the parameters assessed. The patients undergoing ESD appeared to have the same risk of colorectal neoplasms as the FIT-positive patients. Colorectal neoplasms were clearly more common in men than in women(P = 0.031). Advanced adenoma and cancer were significantly more frequent in patients with at least two of the following conditions: hypertension, dyslipidemia, and diabetes mellitus(P = 0.019).CONCLUSION In patients undergoing gastric ESD, TCS appears to be important for detecting synchronous double neoplasms. Advanced adenoma and cancer were more common in patients with at least two of the following conditions: hypertension, dyslipidemia, and diabetes mellitus. Caution is therefore especially warranted in patients with these risk factors. | Chieko Tsuchida Naoto Yoshitake Hitoshi Kino Yoshihito Kaneko Masakazu Nakano Kohei Tsuchida Keiichi Tominaga Takako Sasai Hironori Masuyama Hidetsugu Yamagishi Yasuo Imai Hideyuki Hiraishi | 2017 | World Journal of Gastroenterology2017，23，23： | 3 |
| 3 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 4 | 烟酰胺和N-乙酰葡萄糖胺改善色斑效果观察显示文摘目的:比较含烟酰胺和N-乙酰葡萄糖胺的护肤品在改善色素沉着方面的效果。方法:双盲、基质对照人体试验。采用REAL3.0系统采集所有图像,用相关软件分析色斑面积百分比、L*a*b值、黑素相关的色斑面积百分比、平均黑素含量(灰度)和黑素相关的皮肤颜色均匀度;Chromameter测量非色斑部位皮肤颜色改变;由皮肤科专家分析使用护肤品前后照片改善情况和受试者自我比较进行主观评价。结果:与基质相比,含烟酰胺和N-乙酰葡萄糖胺的护肤品可以抑制色斑面积的增加,减轻紫外线引起的肤色加深和肤色不均匀。结论:正常人皮肤对含烟酰胺和N-乙酰葡萄糖胺的护肤品有良好的耐受性,与基质相比,该护肤品有一定的减轻色素沉着的效果。 | 吴艳 仲少敏 Joe Kaczvinsky 赵俊郁 乔圆 邓琳 Chieko Soh Cindy Berge Michael Marmor Donald Bissett Larry Robinson 朱学骏 | 2007 | 临床皮肤科杂志2007，36，10： | 2 |
| 5 | Important roles of drought and cold inducible genes for galactinol synthase in stress tolerance in Arabidopis显示文摘 | Teruaki Taji Chieko Ohsumi | 2002 | The Plant Journal2002，29，4： | 1 |
| 6 | Studies on synthesis and physical characterization of biodegradable aliphatic poly(butylene succinate-co-caprolactone)s显示文摘 | Amin Cao Takashi Okamura chieko Ishiguro | 2002 | Polymer2002，43，： | 1 |
| 7 | Coumarin Glycosides of Glehnia littoralis Root and Rhizoma 显示文摘 | Junichi K Chieko O Toru I | 1998 | Chem Pharm Bull1998，46，9： | 1 |
| 8 | Endothelial and Antithrombotic Actions of HDL显示文摘 | Chieko Mineo Hiroshi Deguchi John H. Griffin Philip W. Shaul | 2006 | Circulation Research2006，，11： | 1 |
| 9 | Beneficial effect of atrial natriuretic peptide on pulmo-nary gas exchange in patients with acute lung injury显示文摘 | Chieko Mitaka Yukio Hirata Takashi Nagura | 1998 | Chest1998，114，1： | 1 |
| 10 | High level expression of the synthetic human lysozyme gene in Aspergillus oryzae显示文摘 | Kozo Tsuchiya Setsuzo Tada Katsuya Gomi katsuhiko Kitamoto Chieko Kumagai Yoshifumi Jigami Gakuzo Tamura | 1992 | Applied Microbiology and Biotechnology1992，，1： | 1 |
| 11 | Studies on Synthesis and Physical Characterization of Biodegradable Aliphatic Poly( butylene succinate-co-ε- caprolactone) s显示文摘 | Amin Cao Takashi Okamura Chieko Ishiguro | 2002 | Polymer2002，43，3： | 1 |
| 12 | Comparative study on the strain-specific triterpenoid components of Ganodermalucidum 显示文摘 | Masao Hirotani Chieko Ino Tsutomu Furuya | 1993 | Phytochemistry1993，33，2： | 1 |
| 13 | Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats显示文摘 | Hitoshi Suhara Yoshiki Sawa Norihide Fukushima Koji Kagisaki Chieko Yokoyama Tadashi Tanabe Shigeaki Ohtake Hikaru Matsuda | 2002 | The Journal of Thoracic and Cardiovascular Surgery2002，，5： | 1 |
| 14 | Academic libraries as learning spaces in Japan: Toward the development of learning commons 显示文摘 | Donkai Saori Toshimori Atsushi Mizoue Chieko | 2011 | International Information & Library Review2011，43，4： | 1 |
| 15 | Global view of aerosol vertical distributions from CALIPSO lidar measurements and GOCART simulations: Regional and seasonal variations显示文摘 | Yu Hongbin Chin Mian Winker David M. Omar Ali H. Liu Zhaoyan Kittaka Chieko Diehl Thomas | 2010 | Journal of Geophysical Research Atmospheres2010，，： | 1 |
| 16 | Effects of atrial natriuretic peptide on inter-organ crosstalk among the kidney, lung, and heart in a rat model of renal ischemia-reperfusion injury显示文摘 | Chieko Mitaka May Khin Hnin Si Miniwan Tulafu Qi Yu Tokujiro Uchida Shinya Abe Masanobu Kitagawa Satoshi Ikeda Yoshinobu Eishi Makoto Tomita | 2014 | Intensive Care Medicine Experimental2014，，1： | 1 |
| 17 | Antigenic differences in the H proteins of canine distemper viruses显示文摘 | Kiyoko Iwatsuki Sachio Tokiyoshi Norio Hirayama Kazuya Nakamura Kenjiro Ohashi Chiaki Wakasa Takeshi Mikami Chieko Kai | 2000 | Veterinary Microbiology2000，，3： | 1 |
| 18 | Basic Study on Elderly Tele-nursing Model for Emote Nursing by Smart Device显示文摘 | Hideaki Takayanagi Chieko Kawakatsu Tatsuto Kihara Kazuhide Kawaguchi Hidetoshi Kawaguchi Takaaki Furukawa Yuka Kimura | 2018 | Journal of Civil Engineering and Architecture2018，12，8： | 1 |
| 19 | Ganoderic acid derivatives and ergosta-4,7,22-triene-3,6-dione from Ganoderma lucidum显示文摘 | Chieko Ino Isao Asaka | 1987 | Phytochemistry1987，26，10： | 1 |
| 20 | Liposomal Arg-Gly-Asp analogs effectively inhibit metastic B16 melanoma colonization in murine lungs显示文摘 | Yoshihiro Tokudome Chieko Koike | 1996 | Life Sci1996，58，24： | 1 |
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