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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | 男性C反应蛋白、纤维蛋白原和心肺适应性与高血压发生风险的相关性显示文摘在正常血压和高血压高危人群中,较高的心肺适应性(cardiorespiratory fitness)可预防高血压[1-2]。但高心肺适应性能否降低炎症水平升高的受试者发生高血压的风险,尚不清楚。本研究旨在探讨男性中,独立于肥胖,炎症与高血压发生的相关性;心肺适应性、炎症与高血压发生的联合相关性。研究者假设炎症与高血压发生相关,但高心肺适应性可降低这种相关性。 | Jae SY Kurl S Laukkanen JA Lee CD Choi YH Fernhall B Franklin BA | 2015 | 中华高血压杂志2015，23，9： | 2 |
| 3 | Feasibility of laparoscopic techniques as the surgical approach of choice for primary colorectal cancer: an analysis of 570 consecutive cases 显示文摘 | LimSB Choi HS Jeong SY | 2008 | Surg Endosc2008，22，： | 1 |
| 4 | Excretory-secretory antigen is better than crude antigen for the serodiagnosis of clonorchiasis by ELISA显示文摘 | Choi MH Park IC Li SY | 2003 | Korean J Parasitol2003，41，1： | 1 |
| 5 | Synchronous gastric cancer in primary sporadic colorectal cancer patients in Korea显示文摘 | Lim SB Jeong SY Choi HS | 2008 | Int J Colorectal Dis2008，23，1： | 1 |
| 6 | Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons显示文摘 | Yoon SY Choi JE Choi JM | 2008 | NeurosciLett2008，437，2： | 1 |
| 7 | Assessment of left ventricular rotation and torsion with two-dimensional speckle tracking echocardiography显示文摘 | Kim HK Sohn DW Choi SY | 2007 | J Am Soc Echocardiogr2007，20，1： | 1 |
| 8 | Percutaneous coronary intervention for acute myocardial infarction in elderly patients with renal dysfunction:results from the Korea Acute Myocardial Infarction Registry显示文摘 | Lim SY Bae EH Choi JS | 2013 | J Korean Med Sci2013，28，7： | 1 |
| 9 | Coxsackievirus B4 uses autoph- agy for replication after calpain activation in rat primary neurons 显示文摘 | Yoon SY Ha YE Choi JE | 2008 | J Virol2008，82，11： | 1 |
| 10 | Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5:involvement of ROS-dependent ER-stress显示文摘 | Moon DO Park SY Choi YH | 2011 | Biochem Pharmacol2011，82，11： | 1 |
| 11 | PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model显示文摘 | Choi HS An JJ Kim SY | 2006 | Free Radic Biol Med2006，41，7： | 1 |
| 12 | Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron显示文摘 | Yoon SY Choi HI Choi JE | 2007 | Biochem Biophys Res Commun2007，363，3： | 1 |
| 13 | Evidence that ginsenosides prevent the development of opioid tolerance at the central nervous system显示文摘 | Choi S Jung SY Rhim H | 2000 | Life Sci2000，67，8： | 1 |
| 14 | Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues显示文摘 | Ha TS Jeong SY Cho SW Jeon HK Roh GS Choi WS Park CS | | 0，，： | 1 |
| 15 | Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat显示文摘 | Cho B Choi SY Park OH | 2012 | Mol Cells2012，33，6： | 1 |
| 16 | Percutaneous treatment of renal cysts with OK-432 sclerosis显示文摘 | Choi YD Cho SY Cho KS | 2007 | Yonsel Med J2007，48，2： | 1 |
| 17 | Is it necessary to perform prophylactic cholecystectomy for asymptomatic subjects with gallbladder polyps and gallstones显示文摘 | Choi SY Kim TS Kim HJ | | 0，，： | 1 |
| 18 | Delayed-offset retinal detachment af- ter an intravitreal injection of ranibizumab for zone 1 plus reti- nopathy of prematurity 显示文摘 | Jang SY Choi KS Lee SJ | 2010 | J AAPOS2010，14，5： | 1 |
| 19 | Regulation of ROS-independent ERK signaling rescues replicative cellular senescence in ex vivo expanded human c-kit-positive cardiac progenitor cells 显示文摘 | Choi SH Jung SY Yoo SM | 2013 | Int J Cardiol2013，169，1： | 1 |
| 20 | Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax in children显示文摘 | Choi SY Kim YH Jo KH | 2013 | Pediatric surgery international2013，29，5： | 1 |
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