|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia显示文摘AIM:To evaluate blood concentration of melatonin and urinary excretion of its metabolite,6-sulfatoxymelatonin(6-OHMS),in functional dyspepsia(FD).METHODS:Ninety individuals were enrolled in the study:30 in each study group:patients with postprandial distress syndrome(PDS),epigastric pain syndrome(EPS),and controls.Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed.Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay.RESULTS:Serum melatonin concentration at night and in the morning was significantly(P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL,quartile range(QR):79.8-116.2;at 09.00 h-14.3 pg/mL,QR:7.06-19.0] than in EPS(57.2 pg/mL,QR:42.6-73.1;8.1 pg/mL,QR:4.1-9.3) and control patients(57.7 pg/mL,QR:51.2-62.5;8.1 pg/mL,QR:5.4-10.3).A similar relationship was observed for urinary 6-OHMS excretion.Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes,whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms.CONCLUSION:Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD. | Cezary Chojnacki Tomasz Poplawski Grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J Reiter | 2011 | World Journal of Gastroenterology2011，17，21： | 8 |
| 2 | Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis显示文摘AIM: To study an assessment of the number of enterochromaffin cells and expression of hydroxyindole-Omethyltransferase in colonic mucosa and urine excretion of 6-sulfatoxymelatonin in patients with ulcerative colitis. METHODS: The study included 30 healthy subjects (groupⅠ-C), 30 patients with ulcerative proctitis [group Ⅱ-ulcerative proctitis (UP)] and 30 patients with ulcerative colitis [group Ⅲ-ulcerative colitis (UC)] in acute phases of these diseases. The number of enterochromaffin cells (EC) was estimated in rectal and colonic mucosa. Bioptates were assembled from many different parts of the large intestine. Immunorective cells collected from various parts of the colon were counted according to the Eurovision DAKO (Dako A/S, Copenhagen, Denmark) System in the range of 10 fields in each bioptate at × 200 magnification. The level of mRNA expression of hydroxyindole-O-methyltransferase (HIOMT) in colonic mucosa was estimated with RT-PCR. Urine 6-sulfatoxymelatonin (6-HMS) excretion was determined immunoenzymatically using an IBL (IBL International GmbH, Hamburg, Germany) kit (RE 54031). RESULTS: The number of EC cells in healthy subjects (C) was 132.40 ± 31.26. In patients of group Ⅱ (UP) and group Ⅲ (UC) the number of these cells was higher 225.40 ± 37.35 (P < 0.001) and 225.24 ± 40.50 (P < 0.001) respectively. Similar differences were related to HIOMT expression, which was 1.04 ± 0.36 in group C, 1.56 ± 0.56 (P < 0.01) in group UP and 2.00 ± 0.35 (P < 0.001) in group UC. Twenty-four hour 6-HMS urinary excretion was as follows: C 16.32 ± 4.95 μg/24 h, UP 26.30 ± 7.29 μg/24 h (P < 0.01), UC 42.30 ± 12.56 μg/24h (P < 0.001). A correlation between number of EC cells and 6-HMS excretion was noted in all groups: r = 0.766 in patients with UP, r = 0.703 with UC and r = 0.8551 in the control group; the correlation between the results is statistically significant. CONCLUSION: In the acute phases of both UP and UC, proliferation of EC cells and high expression of HIOMT and urine excretion of 6-HMS is noted. These changes may represent a beneficial response in the anti-inflammatory and defense mechanism. | Cezary Chojnacki Maria Wisniewska-Jarosińska Grazyna Kulig Ireneusz Majsterek Russel J Reiter Jan Chojnacki | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 3 | Bioavailability of heavy metals from polluted soils to plants显示文摘 | K. Chojnacka A. Chojnacki H. Górecka H. Górecki | 2004 | Science of the Total Environment2004，，1： | 3 |
| 4 | Polyprenols from plants structural analogues of mammalian dolichols 显示文摘 | Chojnacki T Swiezewska E And Vogtman T | 1987 | Chemica Scripta1987，27，： | 1 |
| 5 | Immunotherapy of inflammatory bowel disease 显示文摘 | Wiehan P Chojnacki J Wojtufi S | 2004 | Pol Merkur Lekarski2004，17，1： | 1 |
| 6 | Maturation-dependent HIV-1Surface Protein Redistribution Revealed by Fluorescence Nanoscopy显示文摘 | CHOJNACKI J STAUDT T BINGEN P | 2012 | Sci2012，338，6106： | 1 |
| 7 | Production of neurons,astrocytes and oligodendrocytes from mammalian CNS stem cells显示文摘 | Chojnacki A Weiss S | 2008 | Nat Protoc2008，3，6： | 1 |
| 8 | isolation of a novel platelet- derived growth factor-responsive precursor from the embryonic ventral forebrain 显示文摘 | Chojnacki A and Weiss S | 2004 | J Neurosci2004，24，10： | 1 |
| 9 | Melato- nin secretion and metabolism in patients with hepatic en- cephalopathy 显示文摘 | Chojnacki C Wachowska-Kelly P Blasiak J | 2013 | Journal of Gastroenterology and Hepatol- ogy2013，28，2： | 1 |
| 10 | Estimating down deadwood from FIA forest inventory variables in Maine显示文摘 | David C Chojnacky Linda S Heath | 2002 | Environmental Pollution2002，116，： | 1 |
| 11 | Search for polyprenols in leaves of ever green and deciduous Ericaceae plants 显示文摘 | Ranjan R Marczewski A and Chojnacki T | 2001 | Acta Biochimica Polonica2001，48，2： | 1 |
| 12 | Promoting oligodendrogenesis and myelin repair using the muhiple sclerosis medication glatiramer acetate 显示文摘 | Skihar V Silva C Chojnacki A | 2009 | Proc Natl Acad Sci USA2009，106，17： | 1 |
| 13 | Modeling diameter growth for pinyon and juniper trees in dryland forests 显示文摘 | Chojnacky D C | 1997 | For Ecol Manage1997，93，： | 1 |
| 14 | Initiation of a Critical Pathway for Pancreaticoduodenectomy at an Academic Institution—the First Step in Multidisciplinary Team Building显示文摘 | Eugene P. Kennedy Ernest L. Rosato Patricia K. Sauter Laura M. Rosenberg Cataldo Doria Ignazio R. Marino Karen A. Chojnacki Adam C. Berger Charles J. Yeo | 2007 | Journal of the American College of Surgeons2007，，5： | 1 |
| 15 | Bioavailability of heavy metals from polluted soils to plants显示文摘 | Chojnacka K Chojnacki H G6recka H | 2005 | Science of the Total Environment2005，337，13： | 1 |
| 16 | Helicobacter pylori infection and antioxidants can modulate the genotoxic effects of heterocylic amines in gastric mucosa cells 显示文摘 | Poplawski T Chojnacki C Czubatka A | 2013 | Mol Biol Rep2013，40，8： | 1 |
| 17 | Bioavail- ability of Heavy Metals from Polluted Soils to Plants 显示文摘 | Chojnacka K Chojnacki A G6recka H | 2005 | Science of the Total Environment2005，337，： | 1 |
| 18 | Implementation of a Critical Pathway for Distal Pancreatectomy at an Academic Institution显示文摘 | Eugene P. Kennedy Tyler R. Grenda Patricia K. Sauter Ernest L. Rosato Karen A. Chojnacki Francis E. Rosato Jr Bernadette C. Profeta Cataldo Doria Adam C. Berger Charles J. Yeo | 2009 | Journal of Gastrointestinal Surgery2009，，5： | 1 |
| 19 | Revisiting Pentland's Estimator of Light Source Direction显示文摘 | Wojciech Chojnacki | | 0，，01： | 1 |
| 20 | Serum sero- tonin eoneentration and urine 5-hydroxyindole acetic aeid excretion in patients with irritable bowel syndrome显示文摘 | Moskwa A Chojnacki J Wisiewska-Jarosifiska M | 2007 | Pol Merkur Lelarski2007，22，131： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员