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| 1 | 未破裂颅内动脉瘤患者管理指南美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾(1977年1月至2014年6月),参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据,指出现有知识的差距;如果合适,则根据美国心脏协会( American Heart Association, AHA)标准做出推荐。本指南经过了包括卒中委员会领导层以及AHA科学声明监督委员会在内的广泛同行评议,然后由AHA科学咨询和协调委员会审批通过。结果本指南对未破裂颅内动脉瘤患者的医疗诊治提出了循证建议,涉及临床表现、自然史、流行病学、危险因素、筛查、诊断、影像学以及手术和血管内治疗的转归。 | B. Gregory Thompson Robert D. Brown Sepideh Amin-Hanjani Joseph P. Broderick Kevin M. Cockroft E. Sander Connolly Gary R. Duckwiler Catherine C. Harris Virginia J. Howard S. Claiborne (Clay) Johnston Philip M. Meyers Andrew Molyneux Christopher S. Ogilvy Andrew J. Ringer James Torner 肖国栋 徐加平 石际俊 尤寿江 张霞 刘慧慧 曹勇军 | 2015 | 国际脑血管病杂志2015，23，8： | 127 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome显示文摘 | Christophe Ginestier Min Hee Hur Emmanuelle Charafe-Jauffret Florence Monville Julie Dutcher Marty Brown Jocelyne Jacquemier Patrice Viens Celina G. Kleer Suling Liu Anne Schott Dan Hayes Daniel Birnbaum Max S. Wicha Gabriela Dontu | 2007 | Cell Stem Cell2007，，5： | 5 |
| 4 | Disturbance cues in freshwater prey fishes: Does urea function as an 'early warning cue' in juvenile convict cichlids and rainbow trout?显示文摘 | Grant E. BROWN Christopher D. JACKSON Patrick H. MALKA Elisa JACQUES Marc-Andre COUTURIER | 2012 | Current Zoology2012，58，2： | 4 |
| 5 | Paleotemperatures from fluid inclusions in halite: method verification and a 100,000 year paleotemperature record, Death Valley, CA显示文摘 | Tim K. Lowenstein Jianren Li Christopher B. Brown | 1998 | Chemical Geology1998，，3： | 3 |
| 6 | Critical Appraisal of the Diagnosis of the Sessile Serrated Adenoma显示文摘 | Mark Bettington Neal Walker Christophe Rosty Ian Brown Andrew Clouston Leesa Wockner Vicki Whitehall Barbara Leggett | 2014 | The American Journal of Surgical Pathology2014，，2： | 2 |
| 7 | The application of Fourier transform mid-infrared(FTIR) spectroscopy to identify variation in cell wall composition of Setaria italica ecotypes显示文摘Cell wall composition in monocotyledonous grasses has been identified as a key area of research for developing better feedstocks for forage and biofuel production.Setaria viridis and its close domesticated relative Setaria italica have been chosen as suitable monocotyledonous models for plants possessing the C_4 pathway of photosynthesis including sorghum,maize,sugarcane,switchgrass and Miscanthus×giganteus.Accurate partial least squares regression(PLSR)models to predict S.italica stem composition have been generated,based upon Fourier transform mid-infrared(FTIR)spectra and calibrated with wet chemistry determinations of ground S.italica stem material measured using a modified version of the US National Renewable Energy Laboratory(NREL)acid hydrolysis protocol.The models facilitated a high-throughput screening analysis for glucan,xylan,Klason lignin and acid soluble lignin(ASL)in a collection of 183 natural S.italica variants and clustered them into classes,some possessing unique chemotypes.The predictive models provide a highly efficient screening tool for large scale breeding programs aimed at identifying lines or mutants possessing unique cell wall chemotypes.Genes encoding key catalytic enzymes of the lignin biosynthesis pathway exhibit a high level of conservation with matching expression profiles,measured by RT-q PCR,among accessions of S.italica,which closely mirror profiles observed in the different developmental regions of an elongating internode of S.viridis by RNASeq. | Christopher Brown Antony P.Martin Christopher P.L.Grof | 2017 | Journal of Integrative Agriculture2017，16，6： | 2 |
| 8 | Learning multi-label scene classification显示文摘 | Matthew R. Boutell Jiebo Luo Xipeng Shen Christopher M. Brown | 2004 | Pattern Recognition2004，，9： | 2 |
| 9 | Outcomes of Neoadjuvant Transarterial Chemoembolization to Downstage Hepatocellular Carcinoma Before Liver Transplantation显示文摘 | William C. Chapman M B. Majella Doyle Jourdan E. Stuart Neeta Vachharajani Jeffrey S. Crippin Christopher D. Anderson Jeffrey A. Lowell Surendra Shenoy Michael D. Darcy Daniel B. Brown | 2008 | Annals of Surgery2008，，4： | 2 |
| 10 | An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer显示文摘 | Fiona J. Collinson David G. Jayne Alessio Pigazzi Charles Tsang Jennifer M. Barrie Richard Edlin Christopher Garbett Pierre Guillou Ivana Holloway Helen Howard Helen Marshall Christopher McCabe Sue Pavitt Phil Quirke Carly S. Rivers Julia M. B. Brown | 2012 | International Journal of Colorectal Disease2012，，2： | 2 |
| 11 | MRI After Treatment of Locally Advanced Rectal Cancer: How to Report Tumor Response—The MERCURY Experience显示文摘 | Uday B. Patel Lennart K. Blomqvist Fiona Taylor Christopher George Ashley Guthrie Nicola Bees Gina Brown | 2012 | American Journal of Roentgenology2012，，4： | 2 |
| 12 | Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management显示文摘 | Christophe Rosty David G. Hewett Ian S. Brown Barbara A. Leggett Vicki L. J. Whitehall | 2013 | Journal of Gastroenterology2013，，3： | 2 |
| 13 | Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: An international multicenter cohort study显示文摘 | Jorg Petersen Vlad Ratziu Maria Buti Harry L.A. Janssen Ashley Brown Pietro Lampertico Jan Schollmeyer Fabien Zoulim Heiner Wedemeyer Martina Sterneck Thomas Berg Christoph Sarrazin Marc Lutgehetmann Peter Buggisch | 2011 | Journal of Hepatology2011，，3： | 2 |
| 14 | Signal Processing Techniques for Landmine Detection Using Impulse Ground Penetrating Radar显示文摘 | Abdelhak M Zoubir Ian James Chant Christopher L Brown | 2002 | Sensors Journal IEEE2002，2，： | 1 |
| 15 | Elective groin irradiation is not indicated for patients with adenocarcinoma of the rectum extending to the anal canal显示文摘 | Noah Taylor Christopher Crane John Skibber Barry Feig Lee Ellis Jean-Nicholas Vauthey Stanley Hamilton Karen Cleary Ronelle Dubrow Thomas Brown Robert Wolff Paulo Hoff Nicholas Sanfilippo Nora Janjan | 2001 | International Journal of Radiation Oncology Biology Physics2001，，3： | 1 |
| 16 | Adult multilocular cystic nephroma: Report of six cases with clinical, radio-pathologic correlation and review of literature显示文摘 | Christopher Wilkinson Victor Palit Mallikarjun Bardapure Jennifer Thomas Anthony Browning Kanwar Gill Chandra Biyani | 2013 | Urology Annals2013，，1： | 1 |
| 17 | Detecting Trichodesmium blooms in SeaWiFS imagery显示文摘 | AJIT Subramaniam CHRISTOPHER W Brown RALEIGH R Hood | 2002 | Deep-Sea Resereh: II2002，49，： | 1 |
| 18 | The relationship between place attachment and landscape values: Toward mapping place attachment 显示文摘 | Gregory Brown Christopher Raymond | 2007 | Applied Geography2007，，27： | 1 |
| 19 | Photophysical characterization of triazole-substituted coumarin fluorophores显示文摘 | Jessie A. Key Sherni Koh Qadir K. Timerghazin Alex Brown Christopher W. Cairo | 2009 | Dyes and Pigments2009，，2： | 1 |
| 20 | The Novel Marker, DOG1 , Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status显示文摘 | Robert B. West Christopher L. Corless Xin Chen Brian P. Rubin Subbaya Subramanian Kelli Montgomery Shirley Zhu Catherine A. Ball Torsten O. Nielsen Rajiv Patel John R. Goldblum Patrick O. Brown Michael C. Heinrich Matt van de Rijn | 2004 | The American Journal of Pathology2004，，1： | 1 |
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