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| 1 | Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms显示文摘这篇文章在开发,基因疾病和癌症考察分子的结构,表达式模式,生理的函数,病理学的角色和 Twist1 的分子的机制。Twist1 是基本 helix-loop-helix 包含域的抄写因素。以便绑 Nde1 电子盒子元素并且激活或镇压形成 homo-dimers 或 hetero-dimers 它的目标基因。在开发期间, Twist1 为中层说明和区别是必要的。人的 Twist1 基因的异质接合的 loss-of-function 变化包括 Saethre-Chotzen 症候群引起几疾病。Twist1 空的老鼠胚胎与打开的头部的神经试管和有缺点的头间充组织死,体节和手足芽。Twist1 在胸被表示,肝,前列腺,胃并且癌症的另外的类型,和它的表示通常与侵略、变形的癌症显型被联系。在癌症房间, Twist1 是由包括 SRC-1 的多重因素的 upregulated, STAT3, MSX2, HIF-1α,连接 integrin 的 kinase 和 NF-κ B。Twist1 显著地提高上皮间充质的转变(EMT ) 和癌症房间移植和侵略,因此支持癌症转移。Twist1 由直接镇压部分地支持 EMT 由招募的 E-cadherin 表示改变的 nucleosome 和为基因压抑并且由 upregulating Bmi1 的 deacetylase 建筑群, AKT2, YB-1,等等。新兴的证据也建议 Twist1 在扩大和癌症干细胞的化学疗法的抵抗起一个作用。Twist1 由支持 Twist1 功能的调节的人的转移和鉴定的机制的进一步的理解可以为开发新策略禁止 EMT 和癌症转移保持诺言。 | Qian Qin Young Xu Tao He Chunlin Qin Jianming Xu | 2012 | Cell Research2012，22，1： | 66 |
| 2 | Crack location identification of rotating rotor systems using operating deflection shape data显示文摘Crack location identification, as one key destination of structural health monitoring, is still a challenge for operating rotor systems. The operating deflection shape (ODS), which represents a visual description of the structural vibration patterns under operating conditions, has been gaining importance for structure damage detection in recent years. The ODS carries damage information of a structure, however, it is also difficult to detect weak cracks of rotor directly. The approximate waveform capacity dimension (AWCD) method was successfully applied to damage detection of plates and beam-like structures. In this paper,a strategic approach that combines ODS and weighted AWCD is proposed for crack location identification of the rotating rotor.To eliminate the false peaks of AWCD and obtain desirable results, a weight factor and ODS curvature data are introduced to the expression of the weighted AWCD. The effectiveness of the proposed method is validated by numerical simulation and experimental investigation in a cracked rotor system. The results indicate that the proposed approach not only provides good identifying performance for incipient rotor cracks, but also effectively eliminates the fault peaks introduced by the inflexion locations of ODSs. Moreover, the proposed approach proves promising in detecting crack locations of rotating rotor systems. | ZHANG ChunLin LI Bing YANG ZhiBo XIAO WenRong HE ZhengJia | 2013 | Science China(Technological Sciences)2013，56，7： | 6 |
| 3 | A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice,rabbits and NHPs显示文摘The emergence of SARS-CoV-2 variants and potentially other highly pathogenic sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines.Here,we discovered a new STING agonist,CF501,and found that CF501-adjuvanted RBD-FC vaccine(CF501/RBD-FC)elicited significantly stronger neutralizing antibody(nAb)and T cell responses than Alum-and cGAMP-adjuvanted RBD-FC in mice.Vaccination of rabbits and rhesus macaques(nonhuman primates,NHPs)with CF501/RBD-FC elicited exceptionally potent nAb responses against SARS-CoV-2 and its nine variants and 41 S-mutants,SARS-CoV and bat SARSr-CoVs.CF501/RBD-FC-immunized hACE2-transgenic mice were almost completely protected against SARS-CoV-2 challenge,even 6 months after the initial immunization.NHPs immunized with a single dose of CF501/RBD-FC produced high titers of nAbs.The immunized macaques also exhibited durable humoral and cellular immune responses and showed remarkably reduced viral load in the upper and lower airways upon SARS-CoV-2 challenge even at 108 days post the final immunization.Thus,CF501/RBD-Fc can be further developed as a novel pan-sarbecovirus vaccine to combat current and future outbreaks of sarbecovirus diseases. | Zezhong Liu Jie Zhou Wei Xu Wei Deng Yanqun Wang Meiyu Wang Qian Wang Ming Hsieh Jingming Dong Xinling Wang Weijin Huang Lixiao Xing Miaoling He Chunlin Tao Youhua Xie Yilong Zhang Youchun Wang Jincun Zhao Zhenghong Yuan Chuan Qin Shibo Jiang Lu Lu | 2022 | Cell Research2022，32，3： | 5 |
| 4 | Corrosion Behavior and Protection Efficiency of 2024Al and SiC_p/2024Al Metal Matrix Composite显示文摘The corrosion resistance of 2024 Al and SiC particle reinforced 2024 Al metal matrix composite (SiCp/2024Al MMC)in 3.5% NaCl solution was investigated with electrochemical method and immersion test, and the corrosion protection of sulfuric acid anodized coatings on both materials was evaluated by electrochemical impedance spectroscopy. The results showed that the SiCp/2024Al MMC is more susceptible to corrosion than its matrix alloy in 3.5% NaCl.For 2024Al, the anodized coating provides excellent corrosion resistance to 3.5% NaCl. The anodized coating on the SiCp/2024Al provides satisfactory corrosion protection, but it is not as effective as that for 2024Al because the structure of the anodized layer is affected by the SiC particulates. | Chunlin HE, Changsheng LIU, Fengqin LI and Qingkui CAISchool of Materials and Metallurgy, Northeastern University, Shenyang 110004, ChinaZhiming SHI, Liqing CHEN and Jing BIInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2002 | Journal of Materials Science & Technology2002，18，4： | 2 |
| 5 | Synthesis and Characterization of Fluorodinitrobenzenes with Tunable Melting Point:Potential Low Sensitive Energetic Plasticizer and Melt-Cast Carrier显示文摘of main observation and conclusion In order to explore the effects of fluoro substituents on the energy and safety of energetic compounds,a series of fluorodinitrobenzenes including l,3-difluoro-2,4-dinitrobenzene(1),1,5-difluoro-2,4-dinitrobenzene(2),1,2,3-trifluoro-4,6-dinitrobenzne(3)and 1,3,5-trifluoro-2,4-dinitrobenzene(4)were prepared.All the compounds were fully characterized.The structures of 2 and 3 were further confirmed by single crystal X-ray diffraction analysis.The results show that these compounds exhibit comparable detonation properties(D=6703-6978 m s^-1,and p=21.3-23.76Pa)to those of 2,4,6-trinitrotoluene(TNT)due to the significantly increased density of fluorine introduced.Low sensitivity(IS>40 J,and FS>360 N)of these compounds along with different melting points make them potential candidates for different allocation.Among them,1 and 4 with the melting point of 42.5℃and 55.2℃,respectively,show promise for application in the field of energetic plasticizer.Compounds 2 and 3 are potential low sensitive melt-cast carrier due to their similar melting point and superior detonation performance to that of TNT. | Yunlu Li Peng Chen Yan Liu Ping Yin Chunlin He Siping Pang | 2020 | Chinese Journal of Chemistry2020，38，12： | 2 |
| 6 | A general and simple method for evaluating the electrical transport performance of graphene by the van der Pauw–Hall measurement显示文摘Expected for many promising applications in the field of electronics and optoelectronics, a reliable method for the characterization of graphene electrical transport properties is desired to predict its device performance or provide feedback for its synthesis.However, the commonly used methods of extracting carrier mobility from graphene field effect transistor or Hall-bar is time consuming, expensive, and significantly affected by the device fabrication process other than graphene itself.Here we reported a general and simple method to evaluate the electrical transport performance of graphene by the van der Pauw–Hall measurement.By annealing graphene in vacuum to remove the adsorbed dopants and then exposing it in ambient surroundings, carrier mobility as a function of density can be measured with the increase of carrier density due to the dopant re-adsorption from the surroundings.Further, the relationship between the carrier mobility and density can be simply fitted with a power equation to the first level approximation, with which any pair of measured carrier mobility and density can be normalized to an arbitrary carrier density for comparison.We experimentally demonstrated the reliability of the method, which is much simpler than making devices and may promote the standard making for graphene characterization. | Fangzhu Qing Yang Shu Linsen Qing Yuting Niu He Guo Shuyi Zhang Chunlin Liu Changqing Shen Wanli Zhang Samuel S.Mao Wenjuan Zhu Xuesong Li | 2018 | Science Bulletin2018，63，22： | 2 |
| 7 | A Modifed Real GA for the Sparse Linear Array Synthesis with Multiple Constraints显示文摘 | Chen Kesong He Zishu Han Chunlin | 2006 | IEEE Trans on Antennas Propagat2006，54，7： | 1 |
| 8 | Fat deposition deficiency is critical for the high mortality of pre-weanling newborn piglets显示文摘Background: The high mortality of pre-weanling piglets is a dominant challenge which severely restricts the development of pig industry. A number of factors including nutrients imbalance and temperature variation during postnatal period of piglets have been reported to closely associated with the high mortality of postnatal piglets.This study aims to find out the relationship between fat deposition and survival of newborn piglets.Results: There were no differences in organ coefficient and bone density between the surviving and dead piglets(P > 0.05). The body weight and the fat deposition in the dead piglets were lower than the live individuals(P < 0.05).Consistently, the average sizes of white adipocytes in back and abdominal adipose tissues of dead piglets were smaller than the survivals(P < 0.05). The protein expression levels of adipocyte differentiation markers PPARγ and C/EBPα in the back and abdominal adipose tissues were lower in dead piglets compared to live piglets. The mRNA expressions of thermogenic markers PGC1α and PRDM16 in adipose tissues were decreased in the dead piglets(P < 0.05). The microarray of back fat samples from the surviving and dead piglets were conducted; two down-regulated genes namely AAMDC and CASTOR1 were identified from the dead piglets. According to quantitative real-time PCR(RT-PCR) analysis, the mRNA expression of AAMDC decreased, whereas CASTOR1 expression elevated in the dead piglets compared to the surviving piglets(P < 0.05).Conclusions: The fat deposition and adipocyte differentiation in the dead piglets are insufficient compared to the surviving piglets, which may attenuate the thermogenic ability of white adipose tissue(WAT). Our data indicate that fat deposition in newborn piglets is vital to their survival. | Ting He Long He Enen Gao Jinhua Hu Jianjun Zang Chunlin Wang Jinshan Zhao Xi Ma | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 1 |
| 9 | Phylotranscriptomics of Swertiinae(Gentianaceae)reveals that key floral traits are not phylogenetically correlated显示文摘Establishing how lineages with similar traits are phylogenetically related remains critical for understanding the origin of biodiversity on Earth.Floral traits in plants are widely used to explore phylogenetic relationships and to delineate taxonomic groups.The subtribe Swertiinae(Gentianaceae)comprises more than 350 species with high floral diversity ranging from rotate to tubular corollas and possessing diverse nectaries.Here we performed phylogenetic analysis of 60 species from all 15 genera of the subtribe Swertiinae sensu Ho and Liu,representing the range of floral diversity,using data from the nuclear and plastid genomes.Extensive topological conflicts were present between the nuclear and plastome trees.Three of the 15 genera represented by multiple species are polyphyletic in both trees.Key floral traits including corolla type,absence or presence of lobe scales,nectary type,nectary position,and stigma type are randomly distributed in the nuclear and plastome trees without phylogenetic correlation.We also revealed the likely ancient hybrid origin of one large clade comprising 10 genera with diverse floral traits.These results highlight the complex evolutionary history of this subtribe.The phylogenies constructed here provide a basic framework for further exploring the ecological and genetic mechanisms underlying both species diversification and floral diversity. | Chunlin Chen Brad R.Ruhfel Jialiang Li Zefu Wang Lushui Zhang Lei Zhang Xingxing Mao Ji Wang Dashan He Yue Luo Quanjun Hu Yuanwen Duan Xiaoting Xu Zhenxiang Xi Jianquan Liu | 2023 | Journal of Integrative Plant Biology2023，65，6： | 1 |
| 10 | Additive manufacturing of energetic materials:Tailoring energetic performance via printing显示文摘Additive manufacturing(AM),also called three-dimensional(3D)printing,has been developed to obtain energetic materials within the past decade.3D printing represents a family of flexible manufacturing techniques that enable fast and accurate fabrication of structures with complex 3D features and a broad range of sizes,from submicrometer to several meters.Various methods have already been explored,including templating,melting extrusion,inkjet printing and electrospray methods.It was demonstrated that the structure achieved by AM could be used to manipulate the reactivity of energetic or reactive materials by changing the flow of gases and entrained particles via architecture.By employing different AM techniques,energetic materials with controllable nanostructures and uniformly dispersed ingredients can be prepared.It is exciting to tailor the energy release without defaulting to change the formulation of the conventional method.The combustion and mechanical properties of conventional energetic materials can be retained at the same time.In this review,the preparation and characterization of AM energetic materials that have been developed in the last decade are summarized.Various AM techniques used in the fabrication of energetic materials are compared and discussed.In particular,formulations of energetic materials applied in AM,metallic fuels,binders and energetic fillers and their advantages in terms of combustion efficiency and other properties are proposed. | Nihan Chen Chunlin He Siping Pang | 2022 | Journal of Materials Science & Technology2022，，32： | 1 |
| 11 | Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy显示文摘Receptor-interacting protein(RIP)kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis(UC)by regulating necroptosis and inflammation.Our group previously identified TAK-632(5)as an effective necroptosis inhibitor by dual-targeting RIP1 and RIP3.In this study,using ligand-based substituent-anchoring design strategy,we focused on the benzothiazole ring to obtain a series of TAK-632 analogues showing significantly improving on the anti-necroptosis activity and RIP1 selectivity over RIP3.Among them,a conformational constrained fluorine-substituted derivative(25)exhibited 333-fold selectivity for RIP1(K_(d)= 15 nmol/L)than RIP3(K_(d)>5000 nmol/L).This compound showed highly potent activity against cell necroptosis(EC_(50)=8 nmol/L)and systemic inflammatory response syndrome(SIRS)induced by TNF-α in vivo.Especially,it was able to exhibit remarkable anti-inflammatory treatment efficacy in a DSS-induced mouse model of UC.Taken together,the highly potent,selective,orally active anti-necroptosis inhibitor represents promising candidate for clinical treatment of UC. | Jing Zhu Meng Xin Congcong Xu Yuan He Wannian Zhang Zhibin Wang Chunlin Zhuang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 12 | A Case Report of Multiple Aneurysmal Bone Cysts显示文摘Case Report A 30-year old male patient, admitted in our hospital for a fracture of the upper end of the left humerus in February, 2006, received treatment with curettage of the lesion in combination with an au- tologous bone graft from the right ilium plus internal fixation. A post-operative pathological examination indicated that there was a simple bone cyst in the area of the | Nengbin He Yang Dong Kun Bao Zhongmin Shi Chunlin Zhang | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 1 |
| 13 | A Modified Real GA for the Spare Linear Array Synthesis with Multiple Constraints显示文摘 | Chen'Kesong He Zhishu Han Chunlin | 2006 | IEEE Transactions on Antennas and Propagation2006，54，7： | 1 |
| 14 | Co_(1-x)S embedded in porous carbon derived from metal organic framework as a highly efficient electrocatalyst for oxygen evolution reaction显示文摘Developing active, robust, and cost-efficient electrocatalysts is critical for oxygen evolution reaction(OER). Here, a novel composite catalyst of Co_(1-x)S embedded in porous dodecahedron carbon hybrid was synthesized by a two-step conversion protocol of a cobalt-based metal-organic framework(ZIF-67). The porous dodecahedron Co_(1-x)S@C composite catalyst was prepared by direct oxidation of ZIF-67 followed by sulfurization reaction. The Co_(1-x)S@C composite exhibit superior OER performance, including a low overpotential of 260 mV for 10 mA/cm2, a small Tafel slope of ~85 mV/dec, outstanding stability over 80 h and almost 100% Faradaic efficiency. The various material characterizations indicate that the excellent activity and strong stability of Co_(1-x)S@C might be attributed to good conductivity of Co_(1-x)S, mesoporous nanostructure, and synergistic effect of Co_(1-x)S encapsulated within porous carbon. This work provides a novel strategy for designing and synthesizing advanced composite | Denghong He Xiaolin Wu Wei Liu Chaojun Lei Chunlin Yu Guokui Zheng Junjie Pan Lecheng Lei Xingwang Zhang | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 15 | A modified real GA for the sparse linear array synthesis with mul- tiple constraints 显示文摘 | CHEN Kesong HE Zishu HAN Chunlin | 2006 | IEEE Trans Antennas Propag2006，54，7： | 1 |
| 16 | New Methods to Solve Fuzzy Shortest Path Problems 显示文摘 | Chunlin Liu Jianmin He Shi Jianjun | 2001 | Journal of Southeast University2001，17，1： | 1 |
| 17 | Microstructure and performances of graphite scattered Cr3C2 -NiCr composites pre- pared by laser processing显示文摘 | Lou Deyuan He Chunlin Shang Shuo | 2013 | Materials Letters2013，93，： | 1 |
| 18 | Biomass increment and mortality losses in tropical secondary forests of Hainan, China显示文摘Secondary forests, created after heavy logging,are an important part of China's forests. We investigated forest biomass and its accumulation rate in 38 plots in a tropical secondary forest on Hainan Island. These secondary forests are moderate carbon sinks, averaging1.96–2.17 t C ha-1 a-1. Biomass increment is largely by medium-sized(10–35 m) trees. Tree mortality accounts for almost 30% of the biomass and plays a negligible role in biomass accumulation estimates. Mortality rate is highly dependent on tree size. For small trees and seedlings, it is related to competition due to elevated irradiance after logging. Regarding prospective biomass and rates of accumulation, recovery is not as rapid as in secondary forests of cleared land. Therefore, tropical forests are susceptible to logging operations and need careful forest management. | Junfu Zhao Chunsheng He Chunlin Qi Xu Wang Haiyan Deng Chunxin Wang Haiwei Liu Lianyan Yang Zhenghong Tan | 2019 | Journal of Forestry Research2019，30，2： | 1 |
| 19 | A modified real GA for the sparse linear array synthesis with multiple constraints显示文摘 | Kesong Chen Zishu He and Chunlin Han | 2006 | IEEE Trans Antennas Propagat2006，54，7： | 1 |
| 20 | Exosomal long non-coding RNAs:Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology显示文摘Metastasis is a major challenge in the treatment of cancer.Exosomes are a class of small extracellular vesicles(EVs)that play critical roles in several human diseases,especially cancer,by transferring information(e.g.,DNA,RNA,and protein)via cell-to-cell communication.Numerous recent studies have shown that exosomal long non-coding RNAs(lncRNAs)play crucial regulatory roles in cancer metastasis in the tumor microenvironment by altering the expression of several key signaling pathways and molecules.Due to their specificity and sensitivity,exosomal lncRNAs have potential as novel tumor markers and therapeutic targets in the treatment of cancer metastasis.In this review,we aim to summarize the roles of exosomal lncRNAs in cancer metastasis,the mechanisms underlying their roles,and their potential clinical applications. | Hui Nie Zhujun Liao Yutong Wang Jianhua Zhou Xiaoyun He Chunlin Ou | 2021 | Genes & Diseases2021，8，6： | 1 |
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