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| 1 | Phylogenetic and genetic characterization of a 2017 clinical isolate of H7N9 virus in Guangzhou,China during the fifth epidemic wave显示文摘Pathogenic H7N9 influenza viruses continue to pose a public health concern. The H7N9 virus has caused five outbreak waves of human infections in China since 2013. In the present study, a novel H7N9 strain(A/Guangdong/8 H324/2017) was isolated from a female patient with severe respiratory illness during the fifth wave of the 2017 H7N9 epidemic. Phylogenetic analysis showed that the H7N9 viruses collected during the fifth wave belong to two different lineages: the Pearl River Delta lineage and the Yangtze River Delta lineage. The novel isolate is closely related to the Pearl River Delta H7N9 viruses, which were isolated from patients in Guangdong Province. The novel H7N9 isolate has an insertion of three basic amino acids in the cleavage site of hemagglutinin(HA), which may enhance virulence in poultry. The 2017 isolate also possesses an R292 K substitution in the neuraminidase(NA)protein, which confers oseltamivir resistance. This study highlights the pandemic potential of the novel H7N9 virus in mammals;thus, future characterization and surveillance is warranted. | Yongqiang Deng Chunlin Li Jianfeng Han Yingfen Wen Jian Wang Wenxing Hong Xiaofeng Li Zhongyu Liu Qing Ye Jing Li Changshuai Zhou Lei Yu Chengfeng Qin Fuchun Zhang Tao Jiang | 2017 | Science China(Life Sciences)2017，60，12： | 9 |
| 2 | A Modifed Real GA for the Sparse Linear Array Synthesis with Multiple Constraints显示文摘 | Chen Kesong He Zishu Han Chunlin | 2006 | IEEE Trans on Antennas Propagat2006，54，7： | 1 |
| 3 | Genetic and Breeding Progress Analysis on Five Pure Lines of Dahen Broiler显示文摘To timely modify breeding scheme and improve selection efficiency of Dahen broiler,genetic and breeding progress analysis on five pure lines was conducted. The results showed that the selection on breeding goal traits of each line was effective since 14 generations,especially the selection on growth traits did not cause adverse influence on reproductive performance. After the 6 thgeneration,main performances of each line maintained in higher level,but the breeding progress obviously declined. It illustrated that current breeding means was effective for maintaining and consolidating breeding goal traits of Dahen broiler,and it should timely adjust breeding scheme to obtain more genetic progress. | Chaowu YANG Huarui DU Zengrong ZHANG Mohan QIU Chunlin YU Lan LIU Xiaoyu JIANG Bo XIA Chenming HU Xiaoyan SONG Xia XIONG Li YANG Han PENG Qingyun LI Xiaosong JIANG | 2018 | Agricultural Biotechnology2018，7，5： | 1 |
| 4 | Determination of Water-Soluble and Acid-Soluble Zinc in Soils by Flame Atomic Absorption Spectrometry after Cloud Point Extraction显示文摘 | Huayun Han Jie Zhou Yayun Xu Chunlin Jia Hui Xia Yage Wang | 2012 | Communications in Soil Science and Plant Analysis2012，，18： | 1 |
| 5 | WALK-ASSISTING BALANCE SYSTEM OF THE EXOSKELETON ROBOT FOR DISABLED PEOPLE显示文摘A novel methodology for a walk-assisting balance system of the exoskeleton robot for disabled people is presented.The experiment on the walk-assisting balance system is implemented using a mini-type ropewalker robot.The mechanism of the ropewalker robot is designed,its dynamic model is built,and its control system based on PWM is developed.The emulations in Matlab and the results of experiments prove that this methodology is effective. | Yin Yuehong Zhou Chunlin Song Jiaren Chen Shiyi Han Tianpu Zhou Chen Research Institute of Robotics,Shanghai Jiaotong University,Shanghai 200030, China | 2004 | Chinese Journal of Mechanical Engineering2004，17，2： | 1 |
| 6 | A Modified Real GA for the Spare Linear Array Synthesis with Multiple Constraints显示文摘 | Chen'Kesong He Zhishu Han Chunlin | 2006 | IEEE Transactions on Antennas and Propagation2006，54，7： | 1 |
| 7 | A modified real GA for the sparse linear array synthesis with mul- tiple constraints 显示文摘 | CHEN Kesong HE Zishu HAN Chunlin | 2006 | IEEE Trans Antennas Propag2006，54，7： | 1 |
| 8 | A survey on coverage and connectivity issues in wireless sensor networks显示文摘 | Zhu Chuan Zheng Chunlin Shu Lei Han Guangjie | 2012 | Journal of Network and Computer Applications2012，35，2： | 1 |
| 9 | A modified real GA for the sparse linear array synthesis with multiple constraints显示文摘 | Kesong Chen Zishu He and Chunlin Han | 2006 | IEEE Trans Antennas Propagat2006，54，7： | 1 |
| 10 | Low-field inverse magnetocaloric effect in Ni50-xMn39+xSn11 Heusler alloys显示文摘 | HAN Zhida WANG Dunhui ZHANG Chunlin | 2007 | Appl Phys Lett2007，90，4： | 1 |
| 11 | The martensitic transformation and the magnetoealoric effect in Ni50-xMn38+xIn12 alloys显示文摘 | HAN Zhida WANG Dunhui ZHANG Chunlin | 2008 | Solid State Commun2008，146，34： | 1 |
| 12 | The Fabrication and Characterization of Polarization Insensitive Semiconductor Optical Amplifier显示文摘An angled facet strained bulk InGaAs SOA has been designed and fabricated. A device with double-layer antireflection coatings had <2dB polarization sensitivity and <0.5dB gain ripple. | Lijuan Yu Weihua Guo Chunlin Han Yong-Zhen Huang Xiaoyu Ma Manqing Tan | 2003 | 光学学报2003，23，S1： | 1 |
| 13 | A Modified Real GA for the Sparse Linear Array Synthesis with Multiple Constraints 显示文摘 | Kesong Chen Zishu He and Chunlin Han | 2006 | IEEE Transactions on Antennas and Propagation2006，54，7： | 1 |
| 14 | Trilineage Sequencing Reveals Complex TCRβTranscriptomes in Neutrophils and Monocytes Alongside T Cells显示文摘Recent findings indicate the presence of T cell receptor(TCR)-based combinatorial immune receptors beyond T cells in neutrophils and monocytes/macrophages.In this study,using a semiquantitative trilineage immune repertoire sequencing approach as well as under rigorous bioinformatic conditions,we identify highly complex TCRβtranscriptomes in human circulating monocytes and neutrophils that separately encode repertoire diversities one and two orders of magnitude smaller than that of T cells.Intraindividual transcriptomic analyses reveal that neutrophils,monocytes,and T cells express distinct TCRβrepertoires with less than 0.1%overall trilineage repertoire sharing.Interindividual comparison shows that in all three leukocyte lineages,the vast majority of the expressed TCRβvariants are private.We also find that differentiation of monocytes into macrophages induces dramatic individual-specific repertoire shifts,revealing a surprising degree of immune repertoire plasticity in the monocyte lineage.These results uncover the remarkable complexity of the two phagocyte-based flexible immune systems which until now has been hidden in the shadow of T cells. | Tina Fuchs Kerstin Puellmann Chunlin Wang Jian Han Alexander W.Beham Michael Neumaier Wolfgang E.Kaminski | 2021 | Genomics, Proteomics & Bioinformatics2021，19，6： | 0 |
| 15 | Optimized Design of Intelligent Management and Analysis System for Broiler Breeding Information显示文摘For a long time,the management and analysis of broiler breeding information in China remain in the 1.0 era of manual recording,careless processing,non-standard analysis and non-standard filing,and lack of accurate and intelligent information management and analysis system,which limit the development of broiler breeding industry.Based on the actual needs of broiler breeding in China,the project team focused on the collection,management and analysis of broiler breeding information and successfully developed Intelligent Management and Analysis System for Broiler Breeding Information.The system is the most complete management and analysis system of broiler breeding information in China,which is closely combined with practice.It has been successfully applied to broiler breeding by more than 10 breeding institutions in China,some of which are national-level core broiler breeding farms.The successful development and application of the system will effectively improve the efficiency of broiler breeding in China,narrow the gap between China and developed countries,open the 2.0 era of precise,intelligent and modular broiler breeding,and improve the core competitiveness of broiler breeding in China. | Yang Chaowu Yu Chunlin Qiu Mohan Zhang Zenrong Hu Chenming Xiong Xia Yang Li Peng Han Xia Bo Chen Jialei Du Huarui Li Qingyun Jiang Xiaosong | 2020 | Animal Husbandry and Feed Science2020，12，2： | 0 |
| 16 | An Energy Regularization Method for the Backward Diffusion Problem and its Applications to Image Deblurring显示文摘For the backward diffusion equation,a stable discrete energy regularization algorithm is proposed.Existence and uniqueness of the numerical solution are given.Moreover,the error between the solution of the given backward diffusion equation and the numerical solution via the regularization method can be estimated.Some numerical experiments illustrate the efficiency of the method,and its application in image deblurring. | Houde Han Ming Yan Chunlin Wu | 2008 | Communications in Computational Physics2008，4，6： | 0 |
| 17 | Small RNA Sequencing Reveals Differentially Expressed piRNAs Related to Hypoxia in Tibetan Chickens显示文摘The relevance of genetic mechanism to the phenotype of hypoxic adaptation remains elusive.Tibetan chickens typically used to investigate the mechanism for the adaptation of hypoxia and the recognition of hypoxia-related piRNA remains an open issue.The purpose of this study was to illustrate whether the piRNAs were related to hypoxic adaptation.First of all,the differentially expressed piRNAs(DEpiRNAs)were identified through RNA sequencing between the Tibetan chickens and Daheng broilers.Subsequently,the target genes of DEpiRNAs were predicted and annotated by software.The network was constructed by Cytoscape.In our study,a total of 277 DEpiRNAs(33 down-regulated,244 up-regulated)were identified in the Tibetan chickens compared with the Daheng broilers.All of the 277 DEpiRNAs predicted 36658 targeted genes.Gene Ontology(GO)analysis showed that the target genes were significantly enriched in the biological process correlated with proliferation and apoptosis of cells,including cell cycle,mitochondrial outer membrane permeabilization,and positive regulation of stress-activated mitogen-activated protein kinase cascade.Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis implicated that the DEpiRNAs were mainly involved in immune and metabolism,including natural killer cell-mediated cytotoxicity,toll-like receptor signaling pathway and fatty acid metabolism.Furthermore,a predicted network with four piRNAs acted on 11 pathways via interacting with 22 target genes,in which piR-gga-1368839 regulated metabolic pathways by acting on DHCR24.In conclusion,we determined the DEpiRNAs in the Tibetan chickens and found that these piRNAs were associated with metabolism,which may be favorable for researching the biological adaptation to hypoxic stress. | Zengrong ZHANG Xiaosong JIANG Mohan QIU Chunlin YU Huarui DU Qingyun LI Han PENG Xia XIONG Xiaoyan SONG Chenming HU Jialei CHEN Chaowu YANG | 2022 | Agricultural Biotechnology2022，11，4： | 0 |
| 18 | Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors显示文摘Two series of sulfur-containing diarylbenzopyrimidines are designed by the fragment combination of a thioacetamide with our previous disclosed DABP 3 and further oxidation.The best compound 6 e with a sulfonyl scaffold displayed EC(50)values of 0.0356μmol/L against WT and 0.0228μmol/L against HIV K103 N mutant strain.More pronounced,it had a lower cytotoxicity(CC(50)=99.6μmol/L),higher selectivity index(SIWT=2799,SIK103 N=4375)and better calculated logarithm of the octanol-water partition coefficient(cLogP)than the lead compound 3.Molecular docking and dynamics provided the binding modes of these compounds with reve rse transcriptase,explaining their activity.Collectively,the new compounds could be candidates for anti-HIV drug discovery. | Sheng Han Yuan Lei Christophe Pannecouque Erik De Clercq Chunlin Zhuang Fener Chen | 2020 | Chinese Chemical Letters2020，31，3： | 0 |
| 19 | Genetic and Breeding Progress Analysis on S06M Line of Dahen Broiler显示文摘The genetic and breeding progress of Dahen S06M line was analyzed, in order to improve the selection efficiency. The results showed that six generations of selection was effective in selecting main characters of S06M line, especially the selection of growth rate had no adverse effect on reproductive performance. All indicators of reproductive performance were improved in varying degrees during breeding, particularly the egg pro-duction at 68 weeks of age. The breeding progress of main target traits significantly slowed down after the second generation, but they still main-tained at higher levels and the characters of S06M tended to be stable. | Qiu Mohan Yang Chaowu Du Huarui Li Qingyun Xiong Xia Zhang Zengrong Hu Chenming Xia Bo Yu Chunlin Song Xiaoyan Yang Li Peng Han Jiang Xiaosong | 2018 | Animal Husbandry and Feed Science2018，10，4： | 0 |
| 20 | Comparative Analysis of Slaughter Performance and Meat Flavor Traits of Quality Chicken under Cage Rearing and Free-range Farming Conditions显示文摘[Objective]The paper was to compare the slaughter performance and meat flavor of quality chicken under cage rearing and free-range farming conditions.[Method]A total of 4001-day-old cocks,S07 line cultivated by Sichuan Dahen Poultry Breeding Co.,Ltd.(bred for 4 succes-sive generations),were kept in cages until the end of 5 weeks of age,which were then divided into cage rearing and free-range farming groups.All cocks were fed with the same diet,and slaughter tests and meat quality analysis were carried out at the end of 10 and 22 weeks of age,respectively.[Result]The live weight,carcass weight and abdominal fat percentage in cage rearing group were significantly higher than those in free-range farming group(P<0.01),and the percentage of half-eviscerated yield and percentage of eviscerated yield in cage rearing group were significantly higher than those in free-range farming group(P<0.05),but there were no significant differences in dressing percentage,percentage of leg muscle and per-centage of breast muscle.The intramuscular fat(IMF)content and muscle fiber density of chicken in cage rearing group were significantly higher than those in free-range farming group(P<0.01),but there was no significant difference in inosinic acid(IMP)content.The content of IMF and IMF increased with the increase of feeding age,but the deposition rate of intramuscular fat was higher than that of IMF in late feeding period.[Conclusion]The study will provide reliable guidance for production and market consumption of high quality chicken. | Yang Chaowu Yu Chunlin Qiu Mohan Zhang Zengrong Hu Chenming Xiong Xia Xia Bo Peng Han Song Xiaoyan Chen Jialei Zhu Shiliang Liu Siyang Du Huarui Li Qingyun | 2022 | Animal Husbandry and Feed Science2022，14，1： | 0 |
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