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| 1 | Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors显示文摘AIM:To determine the prevalence and characteristics of bile reflux in gastroesophageal reflux disease(GERD) patients with persistent symptoms who are non-responsive to medical therapy.METHODS:Sixty-five patients(40 male,25 female;mean age,50 ± 7.8 years) who continued to report symptoms after 8 wk of high-dose proton pump inhibitor(PPI) therapy,as well as 18 patients with Barrett's esophagus,were studied.All patients filled out symptom questionnaires and underwent endoscopy,manometry and combined pH-metry and bilimetry.RESULTS:There were 4 groups of patients:22(26.5%) without esophagitis,24(28.9%) grade A-B esophagitis,19(22.8%) grade C-D and 18(21.6%) Barrett's esophagus.Heartburn was present in 71 patients(85.5%) and regurgitation in 55(66.2%),with 44(53%) reporting simultaneous heartburn and regurgitation.The prevalence of pathologic acid reflux in the groups without esophagitis and with grades A-B and C-D esophagitis was 45.4%,66.6% and 73.6%,respectively.The prevalence of pathologic bilirubin exposure in these 3 groups was 53.3%,75% and 78.9%,respectively.The overall prevalence of bile reflux in non-responsive patients was 68.7%.Pathologic acid and bile reflux was observed in 22.7% and 58.1% of non-esophagitic patients and esophagitic patients,respectively.CONCLUSION:The high percentage of patients poorly responsive to PPI therapy may result from poor control of duodenogastroesophageal reflux.Many patients without esophagitis have simultaneous acid and bile reflux,which increases with increasing esophagitis grade. | Luigi Monaco Antonio Brillantino Francesco Torelli Michele Schettino Giuseppe Izzo Angelo Cosenza Natale Di Martino | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 2 | Adenocarcinoma of gastric cardia in the elderly: Surgical problems and prognostic factors显示文摘AIM: To analyze retrospectively, our results about patients who underwent surgical treatment for adenocarcinoma of the cardia in relation to age, in order to evaluate surgical problems and prognostic factors.METHODS: From January 1987 to March 2003, 140 patients with adenocarcinoma of the cardia underwent resection in the authors' institution. They were divided into three groups with regard to age. Patients <70 and >60 year old (31) were excluded; we also excluded 18 out of 109 patients with poor general status or systemic metastases. So, we compared 51 elderly (≥ 70 year old)and 58 younger patients (≤ 60 year old). The treatment was esophagectomy for type Ⅰ tumors, and extended gastrectomy and distal esophagectomy for type Ⅱ and Ⅲ lesions.RESULTS: Laparotomy was carried out in 91 patients (83.4%), 38 in the elderly (74.5%) and 53 in younger patients (91.3%, P<0.05). Primary resection was performed in 811 cases (89%) without significant differences between the two groups. Postoperative death was higher in the elderly (12.1%) than the other group (4.1%, P<0.05), while morbidity was similar in both groups. A curative resection (R0) was performed in 59 patients (72.8%), 69.6% in the elderly and 75% in the younger group (P>0.05). The overall 3- and 5-year survival rates were 26.7% and 117.8% respectively for the elderly and 40.7% and 35.1% respectively for younger patients (P = 0.1544). Survival rates were significantly associated with R0 resection,pathological node-positive category and tumor differentiation in both groups.CONCLUSION: As the age of the general population increases, more elderly patients with gastric cardia cancer will be candidates for surgical resection. Age alone should not preclude surgical treatment in elderly patients with gastric cardia cancer and a tumor resection can be carried out safely. Certainly, we should take care in defining the surgical treatment in elderly patients, particularly as regarding the surgical approach; although the surgical approach does not influence the survival rate, the transhiatal way still remains the best one due, to the lower incidence of respiratory morbidity and thoracic pain. | Natale Di Martino Giuseppe Izzo Angelo Cosenza Guido Cerullo Francesco Torelli Antonio Brillantino Alberto del Genio | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 3 | Laparoscopic calibrated total vs partial fundoplication following Heller myotomy for oesophageal achalasia显示文摘AIM:To compare the mid-term outcomes of laparoscopic calibrated Nissen-Rossetti fundoplication with Dor fundoplication performed after Heller myotomy for oesophageal achalasia.METHODS:Fifty-six patients(26 men,30 women;mean age 42.8±14.7 years)presenting for minimally invasive surgery for oesophageal achalasia,were enrolled.All patients underwent laparoscopic Heller myotomy followed by a 180°anterior partial fundoplication in 30 cases(group 1)and calibrated NissenRossetti fundoplication in 26(group 2).Intraoperative endoscopy and manometry were used to calibrate the myotomy and fundoplication.A 6-mo follow-up period with symptomatic evaluation and barium swallow was undertaken.One and two years after surgery,the patients underwent symptom questionnaires,endoscopy,oesophageal manometry and 24 h oesophago-gastric pH monitoring.RESULTS:At the 2-year follow-up,no significant difference in the median symptom score was observed between the 2 groups(P=0.66;Mann-WhitneyU-test).The median percentage time with oesophageal pH< 4 was significantly higher in the Dor group compared to the Nissen-Rossetti group(2;range 0.8-10 vs 0.35;range 0-2)(P<0.0001;Mann-WhitneyU-test).CONCLUSION:Laparoscopic Dor and calibrated Nissen-Rossetti fundoplication achieved similar results in the resolution of dysphagia.Nissen-Rossetti fundoplication seems to be more effective in suppressing oesophageal acid exposure. | Natale Di Martino Antonio Brillantino Luigi Monaco Luigi Marano Michele Schettino Raffaele Porfidia Giuseppe Izzo Angelo Cosenza | 2011 | World Journal of Gastroenterology2011，17，29： | 4 |
| 4 | Non-linear modeling of RC rectangular hollow piers confined with CFRP显示文摘 | G.P. Lignola A. Prota G. Manfredi E. Cosenza | 2008 | Composite Structures2008，，1： | 2 |
| 5 | Total gastrectomy for gastric cancer:can the type of lymphadenectomy condition the long-term results? 显示文摘 | Di Martino N Izzo G Cosenza A | 2005 | Suppl Tumori2005，4，3： | 1 |
| 6 | A 3-year naturalistic study of 53 preschool children with pervasive developmental disorders treated with risperidone显示文摘 | Masi G Cosenza A Mucci M | 2003 | J Clin Psychiatry2003，64，： | 1 |
| 7 | Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents 显示文摘 | Reddy MVR Mallireddigari MR Cosenza SC | 2008 | J Med Chem2008，51，1： | 1 |
| 8 | Analysis of continuous composite beams including partial interaction and bond 显示文摘 | Fabbrocino G Manfredi G Cosenza E | 2000 | Journal of Structural Engineering2000，126，11： | 1 |
| 9 | Damage indices and damage measures显示文摘 | Cosenza E Manfredi G | 2000 | Progress in StructUral Engineering and Materials2000，2，1： | 1 |
| 10 | Clinical and Immunological Impact of Early Postoperative Enteral Immunonutrition After Total Gastrectomy in Gastric Cancer Patients: A Prospective Randomized Study显示文摘 | Luigi Marano Raffaele Porfidia Modestino Pezzella Michele Grassia Marianna Petrillo Giuseppe Esposito Bartolomeo Braccio PierLuigi Gallo Virginia Boccardi Angelo Cosenza Giuseppe Izzo Natale Di Martino | 2013 | Annals of Surgical Oncology2013，，12： | 1 |
| 11 | Segmenting Local Residents by their Attiudes,Interests and Opinions toward Tourism显示文摘 | Davis D J Allen R M Cosenza | 1988 | Journal of Travel Research1988，27，2： | 1 |
| 12 | Use of damage functionals in earthquake ehgineeringl A comparison between different methods 显示文摘 | Cosenza E Manfredi G Ramasco R | 1993 | Earth- quake Engineering & Structural Dynamics1993，22，10： | 1 |
| 13 | Faecal calprotectin as reliable non-invasive marker to assess the severity of mucosal inflammation in children with inflammatory bowel disease显示文摘 | R. Berni Canani G. Terrin L. Rapacciuolo E. Miele M.C. Siani C. Puzone L. Cosenza A. Staiano R. Troncone | 2008 | Digestive and Liver Disease2008，，7： | 1 |
| 14 | Damage indices and damage measures 显示文摘 | Cosenza E Manfredi G | 2000 | Progress in Structural Engineering and Materials2000，2，1： | 1 |
| 15 | Electromagnetic determination of clay water content:role of the microporosity显示文摘 | Cosenza A T | 2004 | Applied Clay Science2004，26，： | 1 |
| 16 | Behavior and modeling of bond of FRP rods to concrete显示文摘 | Cosenza E Manfredi G Realfonzo R | 1997 | ASCE Journal of Composites for Construction1997，1，1： | 1 |
| 17 | Behavior and modeling of bond of FRP rebars to concrete显示文摘 | Cosenza E Manfredi G Realfonzo R | 1997 | Journal of composites for construction1997，1，2： | 1 |
| 18 | Damage indices and damage measures显示文摘 | CosenzaE Manfredi G | 2000 | Progress in Structural Engineering and Materials2000，2，1： | 1 |
| 19 | Hospital Volume, Margin Status, and Long-Term Survival after Pancreaticoduodenectomy for Pancreatic Adenocarcinoma显示文摘 | La Torre Marco Nigri Giuseppe Ferrari Linda Cosenza Giulia Ravaioli Matteo Ramacciato Giovanni | 2012 | EN2012，，2： | 1 |
| 20 | The use of damage funetionals in earthquake engineering: a comparison between different methods 显示文摘 | Cosenza E Manfredi G Ramaseo R | 1993 | Earthquake Engineering & Structural Dynamics1993，22，10： | 1 |
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