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| 1 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 2 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 3 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 4 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 5 | Molecular genetic investigations of the mechanism of tumourgenesis in von Hippel-Lindau disease:analysis of allele loss in VHL tumors 显示文摘 | Foster K Crossey PA Richards FM | 1994 | Hum Mol Genet1994，3，： | 2 |
| 6 | Omega‐3 fatty acids and/or fluvastatin in hepatitis C prior non‐responders to combination antiviral therapy – a pilot randomised clinical trial显示文摘 | David A. Sheridan Simon H. Bridge Mary M. E. Crossey Daniel J. Felmlee Fiona I. Fenwick Howard C. Thomas R. Dermot G. Neely Simon D. Taylor‐Robinson Margaret F. Bassendine | 2014 | Liver Int2014，，5： | 2 |
| 7 | Organic - inorganic interactions and sandstone diagenesis 显示文摘 | Surdam R C Crossey L J Hagen S E | 1989 | AAPG Bulletin1989，73，1： | 1 |
| 8 | Organic-inorganic interactions and sandstone diagenesis显示文摘 | Surdam R C Crossey L J Hagen E S | 1989 | AAPG Bulletin1989，73，： | 1 |
| 9 | Organic - inorganic reactions during pro- gressive burial:key to porosity/permeability enhancement and preser- vation显示文摘 | Surdam R C Crossey L J | 1985 | Philosophical Transactions of the Royal Society of Lon- don1985，315，1531： | 1 |
| 10 | Organic -inorganic interaction and sandstone diagenesis 显示文摘 | Surdam R C Crossey L J Hagen S E | 1989 | AAPG Bulletin1989，73，1： | 1 |
| 11 | Integrated diagenetic modeling: A process-oriented approach for clastie systems 显示文摘 | Surdam R C Crossey L J | 1987 | Annual Review of Earth and Planetary Sciences1987，15，： | 1 |
| 12 | The chemistry of secondary po- rosity显示文摘 | Surdam R C Boese S W Crossey L J | 1984 | AAPG Memoir1984，37，： | 1 |
| 13 | Dysregulation of the insulin/IGF binding protein-1 axis in transgenie mice is associated with hyper- insulinemia and glucose intolerance 显示文摘 | Crossey PA Jones JS Mien JP | 2000 | Diabetes2000，49，： | 1 |
| 14 | Organic-inorganic interactions and sandstone diagensis显示文摘 | SURDAM R C CROSSEY L J HAGEN E S | 1989 | AAPG Bull1989，73，： | 1 |
| 15 | Organic-inorganic interactions and sandstone diagenesis 显示文摘 | Surdam R C Crossey L J | 1989 | AAPG Bulletin1989，73，1： | 1 |
| 16 | Organic Inorganic and Sandstone Diagenesis显示文摘 | Surdam R C Crossey L J Hagen E S | 1989 | AAPG Bulletin1989，73，： | 1 |
| 17 | Organic-inorganic interac- tion and sandstone diagenesis显示文摘 | Surdam R C Crossey L J Hagen E S | 1989 | AAPG Bulletin1989，73，1： | 1 |
| 18 | Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy显示文摘 | Higgins MF Russell NE Crossey PA | | 0，，02： | 1 |
| 19 | Organic-inorganic interaction and sandstone diagenesis显示文摘 | Surdam R C Crossey L J Hagen E S | 1983 | AAPG Bulletin1983，73，： | 1 |
| 20 | Redox reactions involving hydrocarbons and mineral oxidants: A mechanism for significant porosity enhancement in sandstones显示文摘 | SURDAM R C CROSSEY L J GEWAN M | 1993 | AAPG Bulletin1993，77，9： | 1 |
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