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| 1 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
| 2 | Effect of Glycerin on Stucture Transition of PVA/SF Blends显示文摘 | Dai Lixing Jun Li Eisuke Yamada | 2002 | J Appl Polym Sci2002，96，9： | 1 |
| 3 | Safety of Bevacizumab in Treating Metastatic Colorectal Cancer: A Systematic Review and Meta-analysis of All Randomized Clinical Trials显示文摘 | Fei Dai Lixing Shu Yangfang Bian Zhuo Wang Zhangwei Yang Wengong Chu Shen Gao | 2013 | Clinical Drug Investigation2013，，11： | 1 |
| 4 | Isolation and difference in Anti-Staphylococcus aureus bioactivity of curvularin derivates from fungus Eupeni-cilliumsp显示文摘 | Xie LW Ouyang YC Zou K Wang GH Chen MJ Sun HM Dai SK LiX | | 0，，： | 1 |
| 5 | Preparation of porous poly ( vinyl alcohol)-silk fibroin (PVA/SF) blend membranes 显示文摘 | Li Mingzhong Norihiko Minoura Dai Lixing | 2001 | Maeromolecular Materials and Engineering2001，286，9： | 1 |
| 6 | Infrared spectroscopic investigation of hydrogen bonding in EVAL containing PVA fibers显示文摘 | Dai Lixing Ying Lina | 2002 | Macromol Mater Eng2002，287，9： | 1 |
| 7 | Effect of glycerin on structure transition of PVA/SF blends显示文摘 | Dai Lixing Li Jun Yamada E | 2002 | Journal of Applied Polymer Science2002，86，9： | 1 |
| 8 | Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer显示文摘 | LiX Xu H Dai X | 2012 | Int J Nanomedicine2012，7，： | 1 |
| 9 | Infrared spectroscopic investigation of hydrogen bonding in EVAL containing PVA fibers 显示文摘 | Dai Lixing Ying Lina | 2002 | Macromol Mater Eng2002，287，9： | 1 |
| 10 | Safety of Bevacizumab in Treating Metastatic Colorectal Cancer: A Systematic Review and Meta-analysis of All Randomized Clinical Trials显示文摘 | Fei Dai Lixing Shu Yangfang Bian Zhuo Wang Zhangwei Yang Wengong Chu Shen Gao | 2013 | Clinical Drug Investigation2013，，11： | 1 |
| 11 | Infrared Spectroscopic Investigation of Hydrogen Bonding in EVOH Containing PVA Fibers显示文摘 | Lixing Dai Lina Ying | 2002 | Macormol Mater Eng2002，287，8： | 1 |
| 12 | Preparation of Photocatalyst-supported Polyacrylonitrile Micro/Nano Composite Fiber Material and Its Photocatalytic Activity显示文摘A composite photocatalyst,with branch-like BiOI/Bi_(2)WO_(6) heterojunction deposited on the polyacrylonitrile micro/nano composite fiber(PAN MNCF),was prepared via two step hydrothermal method.The products are characterized by X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),photoluminescence(PL)spectra,UV-Vis diffuse reflection spectroscopy(UV-Vis DRS)and time-resolved fluorescence spectra.The PAN/BiOI/Bi_(2)WO_(6) micro/nano composite fiber(PAN/BiOI/Bi_(2)WO_(6) MNCF)showed better visible-light photocatalytic performance than PAN MNCF or BiOI/Bi_(2)WO_(6) powder,probably ascribed to the collective effect between PAN MNCF and BiOI/Bi_(2)WO_(6) heterojunction.Significantly,the PAN/BiOI/Bi_(2)WO_(6) MNCF could be easily recycled through filtration method,thus avoiding the secondary pollution. | GUO Xiaofei QIN Chuanxiang HUANG Sihui ZHU Mingyue WANG Jian-jun SUN Jun DAI Lixing | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
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