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20篇 您的检索式:作者名="DENG ShengHui"
    题名 作者 年代 出处 被引量
1Quantitative Analysis of Paleoatmospheric CO2 Level Based on Stomatal Characters of Fossil Ginkgo from Jurassic to Cretaceous in China显示文摘更好理论的 A 并且在地质的历史期间的在 paleo-CO_2 和气候之间的连接的实际理解是重要的提高现代人的社会的持续发展。自从 1980 年代,在植物生理学的开发导致了石块植物能为 paleoatmosphere 和 paleobiosphere 作为一个代理服务的实现。作为有进化壅滞的寡妇裸子植物,白果树很好适合 paleoenvironmental 重建。这篇论文用植物生理学的解剖数据在中国的北方从综合阶层分析石块白果树种类。用有气孔的参数,为 paleo-C0_2 水平的一个趋势在早中间的侏罗记和早白垩纪期间被获得,它与由 GEOCARB 的估计一致。趋势也类似于在地质的时间的吝啬的全球表面温度的。与三个另外的大气的 CO_2 集中参数相比, paleo-CO_2 水平的趋势基于从三个连续阶层的石块白果树标本的有气孔的参数是更多准确。SUN Bainian XIAO Liang XIE Sanping DENG Shenghui WANG Yongdong JIA Hui Susan Tumer 2007Acta Geologica Sinica(English Edition)2007,81,6:23
2Significant carbon isotope excursions in the Cambrian and their implications for global correlations显示文摘The existing 13C data in the Cambrian from different regions of the world are analyzed here.There are four well-documented carbon isotope excursions with global significance.In ascending order,they are:(1) a large negative excursion,comparable to 'BACE' (BAsal Cambrian Carbon isotope Excursion) event,which occurs near the Precambrian-Cambrian boundary with a magnitude of 4‰-10‰ (PDB);(2) the 'ZHUCE' (ZHUjiaqing Carbon isotope Excursion) event,a distinct positive excursion (over 5‰) that can be recognized at the Fortunian Stage to Stage 2 transition;(3) another strong negative one,so-called 'ROECE' (Redlichiid-Olenellid Extinction Carbon isotope Excursion) event,shifting at the interval between Series 2 and Series 3,peaking at 3‰-5‰ (PDB);(4) the famous Steptoean positive carbon isotope excursion (SPICE),which has been widely identified at the base of Furongian Series,Paibian Stage,with an amplitude about 4‰ (PDB).The four sharp δ 13 C shifts correlate well with coeval paleoceanographic changes and bioevents.Besides,there are some 13 C excursions from a few sections in previous studies,and more data are required to identify whether they are global or regional ones.FAN Ru DENG ShengHui ZHANG XueLei 2011Science China Earth Sciences2011,54,11:16
3Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD.Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao 2018Bone Research2018,6,3:13
4High-precision Dating and Geological Significance of Chang 7 Tuff Zircon of the Triassic Yanchang Formation, Ordos Basin in Central China显示文摘The Ordos Basin, as the second largest petroliferous basin of China, contains abundant oil and gas resources, oil shale, and sandstone-type uranium mineral resources. Chang 7 shale is not only the major source rock of the Mesozoic petroliferous system of the Basin, but is also crucial in determining the space-time distribution relationship of the shale section for the effective exploration and development of the Basin's oil and gas resources. To obtain a highly precise age of the shale development section, we collected tuff samples from the top and bottom profile of the Chang 7 Member, Yishi Village, Yaoqu Town, Tongchuan District, on the southern margin of the Ordos Basin and performed high-precision chemical abrasion(CA)–isotope dilution(ID)–thermal ionization mass spectrometry(TIMS) zircon U-Pb dating on the basis of extensive laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) zircon U-Pb dating data. Our results show the precise ages of the top and bottom zircon in the Chang 7 shale to be 241.06±0.12 Ma and 241.558±0.093 Ma, respectively. We first obtained Chang 7 age data with Grade 0.1-Ma precision and then determined the age of the shale development in the Chang 7 Member to be the early-Middle Triassic Ladinian. This result is supported by paleontological evidence. The deposition duration of the Chang 7 shale is 0.5 Ma with an average deposition rate of the shale section being 5.3 cm/ka. Our research results provide time scale and basic data for further investigation of the basin–mountain coupling relation of the shale section, the sedimentary environment and volcanic ash and organic-matter-rich shale development relation, and the organism break-out and organic-matter enrichment mechanism.ZHU Rukai CUI Jingwei DENG Shenghui LUO Zhong LU Yuanzheng QIU Zhen 2019Acta Geologica Sinica(English Edition)2019,93,6:13
5Carbon isotope composition and correlation across the Cambrian-Ordovician boundary in Kalpin Region of the Tarim Basin, China显示文摘Biostratigraphically constrained sequences at the Wushi Yingshan and Kalpin Cement Plant sections (Kalpin Region; Tarim Basin) were densely sampled for geochemical studies. Carbonates across the Cambrian-Ordovician boundary of both sections mainly record negative carbon isotope values. Stable isotope curves show four negative and four positive excursions appearing alternately at the Wushi Yingshan section and five negative alternating with five positive excursions at the Kalpin Cement Plant section. The carbon isotope logs of these two sections are correlated with the international Cambrian-Ordovician boundary key sections: (1) Dayangcha section in China, (2) Green Point section in Canada, (3) Black mountain section in Australia and (4) Lowson Cove section in USA. These correlations suggest that the Cambrian-Ordovician boundary of the Wushi Yingshan section and the Kalpin Cement Plant section can be placed within a particular horizon that also corresponds to the observed biostratigraphic units.JING XiuChun DENG ShengHui ZHAO ZongJu LU YuanZheng ZHANG ShiBen 2008Science China Earth Sciences2008,51,9:8
6Stratigraphy of the Triassic-Jurassic Boundary Successions of the Southern Margin of the Junggar Basin,Northwestern China显示文摘The Triassic-Jurassic(Tr-J) boundary marks a major extinction event,which(~200 Ma) resulted in global extinctions of fauna and flora both in the marine and terrestrial realms.There prevail great challenges in determining the exact location of the terrestrial Tr-J boundary,because of endemism of taxa and the scarcity of fossils in terrestrial settings leading to difficulties in linking marine and terrestrial sedimentary successions.Investigation based on palynology and bivalves has been carried out over a 1113 m thick section,which is subdivided into 132 beds,along the Haojiagou valley on the southern margin of the Junggar Basin of the northern Xinjiang,northwestern China.The terrestrial Lower Jurassic is conformably resting on the Upper Triassic strata.The Upper Triassic covers the Huangshanjie Formation overlaid by the Haojiagou Formation,while the Lower Jurassic comprises the Badaowan Formation followed by the Sangonghe Formation.Fifty six pollen and spore taxa and one algal taxon were identified from the sediments.Based on the key-species and abundance of spores and pollen,three zones were erected:the Late Triassic(Rhaetian) Aratrisporites-Alisporites Assemblage,the Early Jurassic(Hettangian) Perinopollenites-Pinuspollenites Assemblage,and the Sinemurian Perinopollenites-Cycadopites Assemblage.The Tr-J boundary is placed between bed 44 and 45 coincident with the boundary between the Haojiagou and Badaowan formations.Beds with Ferganoconcha(?),Unio-Ferganoconcha and Waagenoperna-Yananoconcha bivalve assemblages are recognized.The Ferganoconcha(?) bed is limited to the upper Haojiagou Formation, Unio-Ferganoconcha and Waagenoperna-Yananoconcha assemblages are present in the middle and upper members of the Badaowan Formation.The sedimentary succession is interpreted as terrestrial with two mainly lake deposit intervals within Haojiagou and Badaowan formations,yielding fresh water algae and bivalves.However,the presence of brackish water algae Tasmanites and the marine-littoral facies bivalve Waagenoperna from the Badaowan Formation indicate that the Junggar Basin was influenced by sea water caused by transgressions from the northern Tethys,during the Sinemurian.SHA Jingeng Vivi VAJDA PAN Yanhong Linda LARSSON YAO Xiaogang ZHANG Xiaolin WANG Yaqiong CHENG Xiansheng JIANG Baoyu DENG Shenghui CHEN Siwei PENG Bo 2011Acta Geologica Sinica(English Edition)2011,85,2:7
7Discovery of Pseudofrenelopsis gansuensis from the Lower Cretaceous of Wangqing,Jilin Province,and Its Significance in Correlation of Cretaceous Red Beds in China显示文摘从丰富的植物的射击和表皮的分析的新数据被为白垩纪 cheirolepidiaceous 针叶树 Pseudofrenelopsis gansuensis 邓,提供杨 et 陆。材料在 Luozigou 盆从更低的白垩纪阶层的一个新地区被发现, Wangqing,吉林省,东北中国。Pseudofrenelopsis 是在 Yanji 盆的 Dalazi 形成的普通植物从 Wangqing 的大约 150 km,但是在那里存在不同种类, Pseudofrenelopsis dalatzensis 仅仅。两 P。dalatzensis 和 P。gansuensis 从更低的白垩纪被记录了 Jiuquan, Gansu 省,而是他们在不同 stratigraphic 地平线。在 Luozigou 的更低的白垩纪忍受植物的阶层过去常与 Yanji 盆的 Dalazi 形成相关。P 的发现。gansuensis,它比 P 在地平线更低。在 Jiuquan 的 dalatzensis,可以显示他们在在吉林的地平线也是不同的。Cheirolepidiaceous 针叶树在在中国的早白垩纪的红床的很少石块之中。Pseudofrenelopsis gansuensis 的现在的发现在诺思中国的遥远的区域为二分开的盆的早白垩纪非海洋的红存款的地质的年龄的分类,关联和决心提供重要证据。YANG Xiaoju DENG Shenghui 2007Acta Geologica Sinica(English Edition)2007,81,6:3
8New knowledge of the Upper Triassic in Liupanshan Basin,Ningxia,China显示文摘Based upon the new data of spore pollen, plant and bivalve fossils, the coal bearing strata in the Liupanshan Basin, Ningxia Hui Autonomous Region, Northwest China, which were formerly assigned to the Middle Jurassic Yan’an Formation, are divided into two parts in the present study. The major part is assigned to the Upper Triassic and the overlying part remains in the Jurassic. The new division is of significance to the oil gas exploration of the basin and the interpretation of the sedimentary and tectonic history and the geographic environment of Liupanshan area during the early Mesozoic.Daliang Li Shuxin Dong Shenghui Deng 1998Chinese Science Bulletin1998,43,13:3
9Formation and evolution of intraplatform basin from the late Sinian to early Cambrian in Sichuan Basin,China显示文摘Based on the drilling,logging,seismic and outcrop data,the formation and evolution of the late Sinian to early Cambrian intraplatform basin in Sichuan Basin was studied.Through the analysis of the total residual thickness of Member 3+Member 4 of Dengying Formation,the total thickness of Maidiping Formation+Qiongzhusi Formation,and lithofacies characteristics of Maidiping Formation,the distribution of the intraplatform basin was defined and its controlling effect on natural gas distribution of Dengying Formation was revealed.The intraplatform basin was characterized by small total residual thickness of Member 3 and Member 4 of Dengying Formation,the large total thickness of Maidiping Formation and Qiongzhusi Formation,and the deep-water phosphorous-carbonaceous-siliceous mudstone in Maidiping Formation.Horizontally,the intraplatform basin was mainly distributed in Qingchuan-Ziyang-Yibin area,and experienced four evolution periods.During the period of Member 1 and Member 2 of Dengying Formation,the Sichuan Basinwas a rimmed carbonate platform with the well developed mounds and shoals on the platform margin and its interior.The intraplatform basin in western Sichuan Basin was initially formed due to the first episode of Tongwan movement.During the period of Member 3 and Member 4 of Dengying Formation,the depositional center was formed in Moxi,Changning and Zhengxiong area due to extension and rifting of the Upper Yangtze Craton,thereafter,the Sichuan Basin evolved into a rimmed carbonate platform with an intraplatform basin.The second episode of Tongwan movement between Sinian and Cambrian led to the overall uplift and exposure of Sichuan Basin characterized by weathering denudation at high position and downward fluid erosion at low position.During the period of Maidiping Formation,three lithofacies zones were developed horizontally,and the third episode of the Tongwan movement between Maidiping Formation and Qiongzhusi Formation modified the sedimentary geomorphology locally.During the period of Qiongzhusi Formation and Canglangpu Formation,continuous deposition made the Sichuan Basin evolve into a gentle siliciclastic ramp.The evolution of the intraplatform basin not only promoted formation of high-quality platform-margin dolomite reservoirs of Member 4 of Dengying Formation,but also controlled distribution of the high-quality source rocks of Maidiping Formation and Qiongzhusi Formation.The dolomite of Dengying Formation in the surrounding area of the intraplatform basin was the most favorable hydrocarbon exploration area because of its good source-reservoir configuration.Hui Zhou Wei Li Baomin Zhang Jingjiang Liu Shenghui Deng Shiben Zhang Xiuqin Shan Jing Zhang Xiaobo Wang Hua Jiang 2017Petroleum Research2017,2,1:2
10Subdivision and age of the Yanchang Formation and the Middle/Upper Triassic boundary in Ordos Basin, North China显示文摘The Yanchang Formation is extensively developed in the Ordos Basin and its surrounding regions. As one of the best terrestrial Triassic sequences in China and the major oil-gas bearing formations in the Ordos Basin, its age determination and stratigraphic assignment are important in geological survey and oil-gas exploration. It had been attributed to the Late Triassic and regarded as the typical representative of the Upper Triassic in northern China for a long time, although some scholars had already proposed that the lower part of this formation should be of the Middle Triassic age in the mid-late 20 th century. In this paper, we suggest that the lower and middle parts of the Yanchang Formation should be of the Ladinian and the bottom possibly belongs to the late Anisian of the Middle Triassic, mainly based on new fossils found in it and high resolution radiometric dating results. The main source rocks, namely the oil shales and mudstones of the Chang-7, are of the Ladinian Age. The upper part of the Yanchang Formation, namely the Chang-6 and the above parts, belongs to the Late Triassic. The uppermost of the Triassic is missed in most parts of the Ordos Basin. The Middle-Upper Triassic Series boundary lies in the Yanchang Formation, equivalent to the boundary between Chang-7 and Chang-6. The Ladinian is an important palaeoenvironmental turning point in the Ordos Basin. Palaeoenvironmental changes in the basin are coincidence with that of the Sichuan Basin and the main tectonic movement of the Qinling Mountains. It indicates that tectonic activities of the Qinling Mountains are related to the big palaeoenvironmental changes in both the Ordos and Sichuan Basins, which are caused by the same structural dynamic system during the Ladinian.Shenghui DENG Yuanzheng LU Zhong LUO Ru FAN Xin LI Yi ZHAO Xueying MA Rukai ZHU Jingwei CUI 2018Science China Earth Sciences2018,61,10:2
11Ecology of the Early Cretaceous Ferns of Northeast China 显示文摘Deng Shenghui 2002Review of Palaeobotany and Palynology2002,119,:1
12In situ reproductive organs of Early Cretaceous ferns from Northeast China显示文摘FILICOPSIDA is a predominant group of the Early Cretaceous floras of Northeast China, whichapproximates 100 species and accounts for more than one third of the floras. The majority ofthis group are of great importance and significance in stratigraphy. The previous studies ofthese ferns are mainly morphological, with only a few concerning the in situ spores andsporangia. In recent years. the authors have carried out a research project on the in situreproductive organs of the Early Cretaceous ferns from/ basins of Inner Mongolia, Liaoning,Jilin and Heilongjiang of Northeast China. The study focuses on 35 species of 17 genera be-longing to 10 families. The present note briefly introduces the results of this study by listingsome representative species.DENG Shenghui and CHEN Fen1. Research Institute of Petroleum and Development, Beijing 100083 2. China University of Geosciences, Beijing 100083, China 1997Chinese Science Bulletin1997,42,23:1
13Binder-free carbon fiber/TiNb2O7 composite electrode as superior high-rate anode for lithium ions batteries显示文摘Construction of advanced high-rate anodes is critical for the development of high-power lithium ion batteries(LIBs).In this work, we report a binder-free carbon fiber(CF)/titanium niobium oxide(TiNb_2O_7(TNO)) composite electrode via a simple solvothermal method combined with heat treatment.Continuous TNO film consisting of cross-linked TNO nanoparticles of 30-50 nm is strongly anchored on the carbon fiber forming integrated CF/TNO composite electrode. Owing to the intimate threedimensional structure, the as-prepared CF/TNO electrode presents exceptional high-rate performance(245 mAh/g at 1 C, and 138 mAh/g at 80 C) and enhanced cyclability with a capacity of 150 mAh/g at the current density of 10 C after 1000 cycles. Our results demonstrate the CF/TNO electrode as efficient anode for application in high-power lithium ion batteries.Shenghui Shen Shengjue Deng Yu Zhong Jianbo Wu Xiuli Wang Xinhui Xia Jiangping Tu 2017Chinese Chemical Letters2017,28,12:1
14The Phototropism of Jurassic Petrified Wood in North China Plate显示文摘Trees on the side directly exposed to sunlight generally grow faster than on the opposite side,a phenomenon termed plant phototropism.There are in situ vertical trunks of silicified wood in the Xiadelongwan area of Yanqing County,north Beijing,where the first National Geologic Park of Petrified Wood of China has been built since 2002.A few trunks have well-preserved growth rings.One petrified stump from the formation shows a positive phototropism direction of SW23O0.As compared with the modern normal growth stumps in Beijing plain area,which have a positive phototropism direction of SW210 °± 5°,the evidence of wood phototropism supports the conclusion of previous palaeomagnetic studies that the North China Plate has rotated clockwise since the Late Jurassic.The known petrified wood stumps in the Yanshan-Liaoning area are mainly found from the strata of 165-136 Ma,which corresponds to the main stage of the Yanshanian Movement.JIANG Zikun LIU Benper HUANG Min DENG Shenghui LU Yuanzheng LIU Lu LI Mingming DONG Shuxin WANG Yongdong 2014Acta Geologica Sinica(English Edition)2014,88,5:1
15查看详情显示文摘Wei W B Jin S Ye G E Deng M Tan H D Martyn Unsworth Alan G Jones John Booker Shenghui Li 0,,:1
16Why Terrestrial Stable Carbon-isotope Stratigraphy Works: a Review显示文摘Carbon-isotope stratigraphy launched since the early technological development of carbonisotope measurement in 1950 s, however, the emergence and advance of terrestrial carbon-isotope stratigraphy took quite a long way. At early stage the exploration of carbon-isotope stratigraphy based on the marine biological shell carbonates was verified by repeatable carbon-isotope stratigraphic data, laboratory chemical experiments and the later laboratory foraminiferal culture experiments. The breakthrough for testifying the fundamentals of terrestrial carbon-isotope stratigraphy lies on the synchronous fluctuations between the carbon-isotope stratigraphic curves derived from marine biological shell carbonates and those derived from terrestrial C3 plants. The character that carbon-isotope stratigraphic curves can be globally synchronously correlated over the marine and terrestrial/atmospheric reservoir mainly excludes the potential biasing factors, such as diagenetic bias, carbon-isotope variations in intra/inter individual plant in same species or between species, ecological changes, changes in aridity, changes in source input and representative sampling. Therefore, the fundamentals of terrestrial carbon-isotope stratigraphy based on C3 plant successfully established. The terrestrial carbon-isotope stratigraphy can be used for global stratigraphic correlation, reconstructing the evolution of atmospheric CO2 and can further verify the published global carbon-cycle models. The terrestrial carbon-isotope stratigraphy based on the compound specific biomarkers and single-grained pollen may be a promising perspective in future.FANG Linhao LU Yuanzheng DENG Shenghui 2014Acta Geologica Sinica(English Edition)2014,88,5:1
17Assembling Co_9S_8 nanoflakes on Co_3O_4 nanowires as advanced core/shell electrocatalysts for oxygen evolution reaction显示文摘Rational design of advanced cost-effective electrocatalysts is vital for the development of water electrolysis. Herein, we report a novel binder-free efficient Co_9S_8@Co_3O_4 core/shell electrocatalysts for oxygen evolution reaction(OER) via a combined hydrothermal-sulfurization method. The sulfurized net-like Co_9S_8 nanoflakes are strongly anchored on the Co_3O_4 nanowire core forming self-supported binder-free core/shell electrocatalysts. Positive advantages including larger active surface area of Co_9S_8 nanoflakes,and reinforced structural stability are achieved in the Co_9S_8@Co_3O_4 core/shell arrays. The OER performances of the Co_9S_8@Co_3O_4 core/shell arrays are thoroughly tested and enhanced electrocatalytic performance with lower over-potential(260 m V at 20 m A cm^(-2)) and smaller Tafel slopes(56 mV dec-1) as well as long-term durability are demonstrated in alkaline medium. Our proposed core/shell smart design may provide a new way to construct other advanced binder-free electrocatalysts for applications in electrochemical catalysis.Shengjue Deng Shenghui Shen Yu Zhong Kaili Zhang Jianbo Wu Xiuli Wang Xinhui Xia Jiangping Tu 2017Journal of Energy Chemistry2017,26,6:0
18Sequence stratigraphy and lithofacies paleogeography of the Middle–Upper Cambrian Xixiangchi Group in the Sichuan Basin and its adjacent area, SW China显示文摘Based on isotopic, lithologic and electrical data and logging cycle analysis technique, stratigraphic sequences in the Middle-Upper Cambrian Xixiangchi Group in the Sichuan Basin and its adjacent area are divided, and its sedimentary characteristics and evolution are analyzed. The Xixiangchi Group can be divided into 5 third-order sequences(Sql-Sq5), of which sequences Ⅰ to Ⅲ(Sql-Sq3) are relatively complete, sequences Ⅳ and Ⅴ are denuded in the Late Cambrian because of the Dian-Chuan paleo-uplifts.Third-order sequences of the Xixiangchi Group in this area have the characteristics of thin in the west and thick in the east, showing that the Caledonian paleo-uplift is a synsedimentary paleo-uplift and the paleogeomorphology in the platform is a gentle slope. Sequence Ⅰdevelops high stand systems tract and transgressive systems tract. The other third-order sequences are dominated by highstand systems tracts, and the transgressive systems tracts last shortly in time and are limited in area. The basic features of evaporative-restricted platform of gentle slope type developed continuously in the sedimentary period of the Xixiangchi Group, its sedimentary environment of 'high in west and low in east' and the change of micro paleogeomorphology in the platform control the continuous development of sedimentary facies. Open platform is developed only in sequence Ⅰ and sequence Ⅱ, and the inner beach of the platform and the edge beach of the platform are mostly developed in sequence Ⅱ and sequence Ⅲ. It indicates that there are two platform margin zones in the study area,a relatively stable, large-scale platform marginal zone in NE Guizhou-Western Hunan and Hubei, and a moving and small-scale platform marginal zone in North Chongqing-Western Hubei.LI Wei FAN Ru JIA Peng LU Yuanzheng ZHANG Zhijie LI Xin DENG Shenghui 2019Petroleum Exploration and Development2019,46,2:0
19Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis显示文摘Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen 2024Acta Pharmaceutica Sinica B2024,14,2:0
20The Relationship between Phototropism and Plate Motion显示文摘Objective Plant phototropism means that trees on the side directly exposed to sunlight generally grow faster than those on the opposite,and positive phototropism is easy to observe in crown and trunk.In this study,we chose the transverse section of tree trunk to observe.The definitive intensity of plant phototropism ranges regularly from strong toJIANG Zikun HUANG Min LIU Benpei LU Yuanzheng DENG Shenghui WANG Yongdong 2017Acta Geologica Sinica(English Edition)2017,91,1:0
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