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| 1 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 2 | Single-anten- na coherent detection of collided FM0 RFID signals 显示文摘 | BLETSAS A KIMIONIS J DIMITRIOU A G | 2012 | IEEE Transactions on Communications2012，60，3： | 1 |
| 3 | Investigation of the Molecular Weight Increase of Commercial Lignosulfonates by Laccase Catalysis显示文摘 | Dimitri A Jiebing Li Goran G | 2010 | Biomacromolecules2010，11，： | 1 |
| 4 | Comparison of effects of theophylline and caffeine on respiratory function of prematurely born infants 显示文摘 | Laubscher B Greenough A Dimitriou G | 1998 | Early Hum Dev1998，50，2： | 1 |
| 5 | Early prediction of chronic oxygen dependency by lung function test results 显示文摘 | Kavvadia V Greenough A Dimitriou G | 2000 | Pediatr Pulmonol2000，29，1： | 1 |
| 6 | Synchronized mechanical ventilation for respiratory support in newborn infant 显示文摘 | Greenough A Dimitriou G Prendergast M Milner AD | 2001 | Cochrane Database Syst Rev2001，，00： | 1 |
| 7 | Lung vol- ume and the response to high volume strategy, high frequency oscillation 显示文摘 | Dimitriou G Cheeseman P Greenough A | 2004 | Acta Paediatr2004，93，5： | 1 |
| 8 | Synchronized mechanicalventilation for respiratory support in newborn infants显示文摘 | Greenough A Dimitriou G Prenderqast M | 2008 | Cochrane Database Syst Rev2008，23，00： | 1 |
| 9 | Prediction of extubation failure in preterm infants 显示文摘 | Dimitriou G Greenough A Endo A | 2002 | Arch Dis Child Fetal Neonatal Ed2002，86，1： | 1 |
| 10 | Synchronized mechanical ventilation for respiratory support in newborn infants 显示文摘 | Greenough A Dimitriou G Prendergast M | 2008 | Cochrane Database Syst Rev2008，，00： | 1 |
| 11 | Randomised trial of fluid restriction in ventilated very lowbirth weight infants 显示文摘 | Kavvadia V Greenough A Dimitriou G | 2000 | Arch Dis Child Fetal Neonatal Ed2000，83，2： | 1 |
| 12 | Rescue high frequency oscillation and predictors of adverse neurodevelopmental outcome in preferm infants显示文摘 | Dimitriou G Greenough A Broomfiled D | 2002 | Early Hum Dev2002，66，2： | 1 |
| 13 | Absolute reaction rate of chlorine atoms with chloroiodomethane显示文摘 | KYRIAKOS G DIMITRIS Y A | 1999 | J Phys Chem A1999，103，： | 1 |
| 14 | Resue high frequency scillatory and predictors of adverse neurodevelopment outcome in preterm infants显示文摘 | Dimitriou G Greenough A Broomfiled D | 2002 | Early Hum Dev2002，66，10： | 1 |
| 15 | Randomised trial of fluid restriction in ventilated very low birthweight infants显示文摘 | Kavvadia V Greenough A Dimitriou G | 2000 | Arch Dis Child Fetal Neonatal Ed2000，83，2： | 1 |
| 16 | Single-antenna coherent detection of collided FM0 RFID signals显示文摘 | BLETSAS A KIMIONIS J DIMITRIOU A G | 2012 | IEEE Transactions on Communications2012，60，3： | 1 |
| 17 | Rescue high frequency oscillation and predictors of adverse neurodevelopmental outcome in preterm infants 显示文摘 | Greenough A Broomfiled D | 2002 | Early Hum Dev2002，66，10： | 1 |
| 18 | High frequency oscillation,respiratory activity and changes in blood gases 显示文摘 | Greenough A Dimitriou G | 1995 | Early Human Dev1995，40，2： | 1 |
| 19 | Appropriate positive end expiratory pressure level in surfactant- treated preterm infants显示文摘 | Dimitriou G Greenough A Laubscher B | 1999 | Eur J Pediatr1999，158，： | 1 |
| 20 | Randomised trial of fluid restriction in ventilated very low birthweight infants 显示文摘 | Kavvadia V Greenough A Dimitriou G | 2000 | Arch Dis Child Fetal Neonatal Ed2000，83，2： | 1 |
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