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| 1 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 2 | Hybrid nano-scale Au with ITO structure for a high-performance near-infrared silicon-based photodetector with ultralow dark current显示文摘An internal photoemission-based silicon photodetector detects light below the silicon bandgap at room temperature and can exhibit spectrally broad behavior,making it potentially suited to meet the need for a near-infrared pure Si photodetector.In this work,the implementation of a thin Au insertion layer into an ITO/n-Si Schottky photodetector can profoundly affect the barrier height and significantly improve the device performance.By fabricating a nanoscale thin Au layer and an ITO electrode on a silicon substrate,we achieve a well-behaved ITO/Au/n-Si Schottky diode with a record dark current density of 3.7×10^(−7) A/cm^(2) at−1 V and a high rectification ratio of 1.5×10^(8) at±1 V.Furthermore,the responsivity has been obviously improved without sacrificing the dark current performance of the device by decreasing the Au thickness.Such a silicon-based photodetector with an enhanced performance could be a promising strategy for the realization of a monolithic integrated pure silicon photodetector in optical communication. | Xinxin Li Zhen Deng Jun Li Yangfeng Li Linbao Guo Yang Jiang Ziguang Ma Lu Wang Chunhua Du Ying Wang Qingbo Meng Haiqiang Jia Wenxin Wang Wuming Liu Hong Chen | 2020 | Photonics Research2020，8，11： | 4 |
| 3 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
| 4 | Weighted Correlation Network Analysis(WGCNA) of Japanese Flounder(Paralichthys olivaceus) Embryo Transcriptome Provides Crucial Gene Sets for Understanding Haploid Syndrome and Rescue by Diploidization显示文摘Artificial gynogenesis is of great research value in fish genetics and breeding technology. However, existing studies did not explain the mechanism of some interesting phenomena. Severe developmental defects in gynogenetic haploids can lead to death during hatching. After diploidization of chromosomes, gynogenetic diploids may dispense from the remarkable malformation and restore the viability, although the development time is longer and the survival rate is lower compared with normal diploids. The aim of this study was to reveal key mechanism in haploid syndrome of Japanese flounder, a commercially important marine teleost in East Asia. We measured genome-scale gene expression of flounder haploid, gynogenetic diploid and normal diploid embryos using RNA-Seq, constructed a module-centric co-expression network based on weighted correlation network analysis(WGCNA) and analyzed the biological functions of correlated modules. Module gene content analysis revealed that the formation of gynogenetic haploids was closely related to the abnormality of plasma proteins, and the up-regulation of p53 signaling pathway might rescue gynogenetic embryos from haploid syndrome via regulating cell cycle arrest, apoptosis and DNA repair. Moreover, normal diploid has more robust nervous system. This work provides novel insights into molecular mechanisms in haploid syndrome and the rescue process by gynogenetic diploidization. | ZHAO Haitao DU Xinxin ZHANG Kai LIU Yuezhong WANG Yujue LIU Jinxiang HE Yan WANG Xubo ZHANG Quanqi | 2018 | Journal of Ocean University of China2018，17，6： | 3 |
| 5 | Health Risk Assessment of Heavy Metals in Road Dusts in Urban Parks of Beijing, China显示文摘 | Yiran Du Bo Gao Huaidong Zhou Xinxin Ju Hong Hao Shuhua Yin | 2013 | Procedia Environmental Sciences2013，，： | 2 |
| 6 | Thermal conductivities study on silica aerogel and its composite insulation materials显示文摘 | Gaosheng Wei Yusong Liu Xinxin Zhang Fan Yu Xiaoze Du | 2011 | International Journal of Heat and Mass Transfer2011，，11： | 2 |
| 7 | Simulation of the potting effect on the high-G MEMS accelerometer显示文摘 | Yuqi Jiang Maohua Du Le Luo Xinxin Li | 2004 | Journal of Electronic Materials2004，，8： | 1 |
| 8 | Integrated photonic RF self-interference cancellation on a silicon platform for full-duplex communication显示文摘In-band full-duplex(IBFD) technology can double the spectrum utilization efficiency for wireless communications,and increase the data transmission rate of B5G and 6G networks and satellite communications. RF self-interference is the major challenge for the application of IBFD technology, which must be resolved. Compared with the conventional electronic method, the photonic self-interference cancellation(PSIC) technique has the advantages of wide bandwidth, high amplitude and time delay tuning precision, and immunity to electromagnetic interference.Integrating the PSIC system on chip can effectively reduce the size, weight, and power consumption and meet the application requirement, especially for mobile terminals and small satellite payloads. In this paper, the silicon integrated PSIC chip is presented first and demonstrated for IBFD communication. The integrated PSIC chip comprises function units including phase modulation, time delay and amplitude tuning, sideband filtering, and photodetection, which complete the matching conditions for RF self-interference cancellation. Over the wide frequency range of C, X, Ku, and K bands, from 5 GHz to 25 GHz, a cancellation depth of more than 20 dB is achieved with the narrowest bandwidth of 140 MHz. A maximum bandwidth of 630 MHz is obtained at a center frequency of10 GHz. The full-duplex communication experiment at Ku-band by using the PSIC chip is carried out. Cancellation depths of 24.9 dB and 26.6 dB are measured for a bandwidth of 100 MHz at central frequencies of 12.4 GHz and14.2 GHz, respectively, and the signal of interest(SOI) with 16-quadrature amplitude modulation is recovered successfully. The factors affecting the cancellation depth and maximum interference to the SOI ratio are investigated in detail. The performances of the integrated PSIC system including link gain, noise figure, receiving sensitivity, and spurious free dynamic range are characterized. | XIUYOU HAN XINXIN SU MENG CHAO XINDI YANG WEIHENG WANG SHUANGLING FU YICHENG DU ZHENLIN WU MINGSHAN ZHAO | 2023 | Photonics Research2023，11，10： | 1 |
| 9 | Identification and expression analysis of Tubulin gene family in upland cotton显示文摘Background:Cott on fibers are single-celled exte nsions of the seed epidermis,a model tissue for studying cytoskeleton.Tubulin genes play a critical role in synthesizing the microtubules(MT)as a core element of the cytoskeleton.However,there is a lack of studies concerning the systematic characterization of the tubulin gene family in cotton.Therefore,the identification and portrayal of G.hirsutum tubulin genes can provide key targets for molecular manipulation in cotton breeding.Result:In this study,we investigated all tubulin genes from different plant species and identified 98 tubulin genes in G.hirsutum.Phylogenetic an a lysis showed that tubulin family genes were classified into three subfamilies.The protein motifs and gene structure ofβ-tubulin genes are more conserved compared withγ-tubulin genes.Most tubulin genes are located at the proximate ends of the chromosomes.Spatiotemporal expression pattern by transcriptome and qRT-PCR analysis revealed that 12α-tubulin andβ-tubulin genes are specifically expressed during different fiber development stages.However,Gh.A03G027200,Gh.D03G 169300,and Gh.A1lG258900 had differential expression patterns at distinct stages of fiber development in varieties JO2508 and ZRI015.Conclusion:In this study,the evol ut io nary an alysis showed that the tubulin genes were divided into three clades.The genetic structures and molecular functions were highly con served in different plants.Three candidate genes,Gh.A03G027200f Gh.D03G169300,and Gh.A11G258900 may play a key role during fiber development complementing fiber length and strength. | CHEN Baojun ZHAO Junjie FU Guoyong PEI Xinxin PAN Zhao'e LI Hongge AHMED Haris HE Shoupu DU Xiongming | 2021 | Journal of Cotton Research2021，4，3： | 1 |
| 10 | Thermal conductivities study on silica aerogel and its composite insulation materials 显示文摘 | Gaosheng Wei Yusong Liu Xinxin Zhang Fan Yu Xi- aoze Du | 2011 | International Journal of Heat and Mass Transfer2011，54，1112： | 1 |
| 11 | The clinical outcomes of late preterm infants: a multi-center survey of Zhejiang, China显示文摘 | Xiaolu Ma Chunxiang Huang Shouzeng Lou Qin Lv Weidong Su Jiarong Tan Youcheng Wang Xinxin Wang Mingyuan Wu Ting Xu Manli Zhuang Lizhong Du the Provincial Collaborative Study Group for Late-preterm Infants | 2009 | Journal of Perinatal Medicine2009，，6： | 1 |
| 12 | Comparison of LecT-Hepa and FibroScan for assessment of liver fibrosis in hepatitis B virus infected patients with different ALT levels显示文摘 | Dongning Du Xuejuan Zhu Atsushi Kuno Atsushi Matsuda Chikayuki Tsuruno Demin Yu Yan Zhang Yuzuru Ikehara Yasuhito Tanaka Xinxin Zhang Hisashi Narimatsu | 2012 | Clinica Chimica Acta . 2012 (21-2)2012，，21： | 1 |
| 13 | Current progress and prospects of enzyme technologies in future foods显示文摘Enzyme technologies are widely used in the food industry due to their advantages of high efficiency,specificity,and safety.Recently,“future foods”is emerging as a new research hotspot with healthier foods that are more nutritious,delicious,and sustainable;however,these foods still have problems with texture,nutrition,and flavor.Advances in enzyme technology have enabled the development of new tools and approaches to better manipulate food textures and nutritional aspects.In this review,we summarize enzyme technology applications in future food production,focusing on food texture,safety,and flavors.Furthermore,we discuss the prospects of enzyme-based technologies for future food production,including the modification of enzyme activities,the development of suitable food-grade hosts for enzyme production,and the optimiza-tion synergistic multi-enzyme systems. | Cuiping Pang Xinxin Yin Guoqiang Zhang Song Liu Jingwen Zhou Jianghua Li Guocheng Du | 2021 | Systems Microbiology and Biomanufacturing2021，1，1： | 1 |
| 14 | Perforated nitrogen-rich graphene-like carbon nanolayers supported Cu-In catalyst for boosting CO_(2) electroreduction to CO显示文摘The combination of a powerful CO_(2)-enriching carrier and robust active component provides a new idea for the construction of efficient catalysts for electrocatalytic CO_(2)reduction.Herein,novel perforated nitrogen-rich graphene-like carbon nanolayers(PNGC)are prepared from biomass derivatives,which promotes the oriented deposition of In-doped Cu_(2)(OH)_(3)(NO_(3))nanosheet patches.A robust Cu-In/PNGC composite catalyst is then obtained via simple in-situ electrochemical reduction.Unsurprisingly,CuIn/PNGC exhibits a CO Faradaic efficiency(FECO)of 91.3%and a remarkable CO partial current density(jCO)of 136.4 m A cm^(-2)at a moderate overpotential of 0.59 V for electrocatalytic CO_(2)reduction reaction(CO_(2)RR).DFT calculations and experimental studies indicate that the strong carrier effect of PNGC makes PNGC carried Cu-In nanosheets improved the adsorption capacity of CO_(2)gas,reconfigured electronic structure,and reduced free energy of key intermediate formation,thereby the CO_(2)activation and conversion are promoted. | Xinxin Zhang Yuxiao Zhu Ziyong Liu Fuli Li Wei Zhou Zichao Dong Jingxin Fan Licheng Liu Chunhua Du | 2022 | Journal of Energy Chemistry2022，，12： | 1 |
| 15 | Zinc-catecholete frameworks biomimetically grown on marine polysaccharide microfibers for soft electronic platform显示文摘Integrating functional nanomaterials on nonplanar organisms has emerged as a rising technology,while significant mismatch would cause interface failure and poor durability.Herein,we demonstrate a facile strategy to assemble crystalline catecholate frameworks with honeycomb lattice on seaweed-derived polysaccharide microfibers,which is expected to form biomimetic connections and maintain durable stability.By physiological coagulation,well-aligned ZnO nanoarrays are tightly attached on alginate fibers,which is fractionally adopted as sacrifice for heteroepitaxial growth of zinc-catecholate frameworks(Zn3(HHTP)2).Benefiting from amplification effect of in-situ formed heterojunctions,promoted interfacial charge transfer is achieved,which allows for fabricating broadband photodetectors.Combined with high porosity for gas adsorption,the heteroepitaxial catecholate framework further enables its use as highly selective ppb-level triethylamine sensors.This work provides a promising strategy for heteroepitaxial growth of catecholate frameworks on organo-substrates and opens new applications in wearable sensor platform based on comfortable biofibers. | Kai Liu Mingxin Zhang Xinxin Du Anqin Zhou Bin Hui Yanzhi Xia Kewei Zhang | 2023 | Nano Research2023，16，1： | 1 |
| 16 | Shape preserving topology optimization for structural radar cross section control显示文摘The purpose of this paper is to present a shape preserving topology optimization method to prevent the adverse effects of the mechanical deformation on the Radar Cross Section(RCS).The optimization will suppress the variation of RCS on the perfect conductor surface by structural design.On the one hand,the physical optics method is utilized to calculate the structural RCS,which is based on the surface displacement field obtained from the finite element analysis of the structure.The corresponding design sensitivities of topology optimization are derived analytically and solved by the adjoint method.On the other hand,the RCS variation and mechanical performance are taken into account simultaneously by extending a standard compliance-based topology optimization model.Two optimization formulations are discussed in an illustrative example,where the influences of upper limits of the compliance and the RCS variation are considered.Two more examples are further tested to show the ability and validity of the proposed optimization method. | Fei CHEN Jihong ZHU Xinxin DU Ruitong ZHANG Weihong ZHANG | 2022 | Chinese Journal of Aeronautics2022，35，6： | 1 |
| 17 | Simulation of the potting effect on the high-G MEMS accelerometer显示文摘 | Yuqi Jiang Maohua Du Le Luo Xinxin Li | 2004 | Journal of Electronic Materials2004，，8： | 1 |
| 18 | The- oretical Study on Transient Hot-Strip Method by Numerical Analysis 显示文摘 | WEI Gaosheng DU Xiaoze ZHANG Xinxin | 2010 | Journal of Heat Transfer2010，132，9： | 1 |
| 19 | Tumor necrosis factor-alpha(TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages显示文摘As an aquatic fish,the spotted halibut Verasper variegatus is highly susceptible to bacterial and virus infections.Tumor necrosis factor-alpha(TNF-α)as a cytokine could control the inflammatory responses.The functions of TNF-αin many species have been widely studied,particularly in mammals.However,little is known about the TNF-αfunctions in V.variegatus.We first cloned and sequenced the TNF-αgene in V.variegatus(VvTNF-α).The two conserved cysteine residues,transmembrane sequence,Thr-Leu motif,and TNF family signature,as well as the TA-rich motifs of its proteins related to inflammatory responses had high similarity to those of the other teleost and mammalian TNF-α.The phylogenetic analysis showed that VvTNF-αwas consistent with TNF-αgenes of other vertebrates.The VvTNF-αtranscripts were extensively distributed in the peripheral blood leukocytes(PBLs),spleen,and gill,indicating that the VvTNF-αhad a role in immune function.Furthermore,treatment with pathogen-associated molecular patterns(PAMPs)could induce a rapid and significant increase of VvTNF-αin the PBLs,which reveals that VvTNF-αdoes participate in the host immune responses against bacterial and viral pathogens.We found that VvTNF-αhad an interesting expression pattern during metamorphosis,showing that the flatfish TNF-αmay have some novel functions during specific developmental stages.In addition,the 3 D structure prediction of VvTNF-αprovided an indication of how it is likely to interact with other proteins.Therefore,VvTNF-αhas multiple functions,and provides valuable information to explore novel functions of TNF-α. | LI Zan LIU Xiumei DU Xinxin ZHANG Kai CHEN Yan WANG Xubo WANG Zhigang YU Haiyang ZHANG Quanqi | 2020 | Journal of Oceanology and Limnology2020，38，2： | 1 |
| 20 | The introduction of cobalt element into nickel-organic framework for enhanced supercapacitive performance显示文摘Metal-organic frameworks(MOFs) as promising electrodes for supercapacitors are attracting increasing research interest. Herein, we report an effective strategy to improve the electrochemical performance of Ni-MOF for supercapacitor by introducing a secondary Co ion. The Co substitution of Ni in Ni-MOF can improve the intrinsic reactivity and stability. As a result, the bimetallic Co/Ni-MOF-1:15 with an optimal Co/Ni ratio delivers high specific capacitance(359 F/g at 0.5 A/g), good rate performance(81.5% retention at 5 A/g) and cycling stability(81% retention after 5000 cycles). These results demonstrate that the bimetallic synergistic strategy is an effective way to improve the pseudocapacitive performance of MOFs. | Xinxin Hang Rui Yang Yadan Xue Shasha Zheng Yuying Shan Meng Du Jiawei Zhao Huan Pang | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
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