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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Interpretive style and in- tolerance of uncertainty in individuals with anxiety disorders : a focus on generalized anxiety disorder 显示文摘 | Anderson KG Dugas M J Koemer N | 2012 | J Anxiety Disord2012，26，8： | 1 |
| 3 | Understand-ing adolescent worry:the application of a cognitive model显示文摘 | LAUGESEN N DUGAS MJ BUKOWSKI WM | | 0，，01： | 1 |
| 4 | FcepsilonRII/CD23 is expressed in Parkinson's disease and induces,in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells 显示文摘 | Hunot S Dugas N Faucheux B | 1999 | J Neurosci1999，19，9： | 1 |
| 5 | Understanding adolescent worry:The application of a cognitive mode显示文摘 | Laugesen N Dugas M J Bukowski W M | 2003 | Journal of Abnormal Child Psychology2003，31，1： | 1 |
| 6 | FcepsilonRII/CD23 is expressed in Parkinson' s disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial ceils 显示文摘 | Hunot S Dugas N Faucheux B | 1999 | J Neurosci1999，19，9： | 1 |
| 7 | Feepsilon RⅡ/CD23 Is Expressed in Parkinson's Disease and Induces, in Vitro, Production of Nitric Oxide and Tumor Necrosis Factor-alpha in Glial Cells显示文摘 | HUNOT S DUGAS N FAUCHEUX B | 1999 | J Neurosei(SO 270- 6474)1999，19，： | 1 |
| 8 | Role of nitric oxide in the anti-tumoral effect of reinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells显示文摘 | Dugas N Mossalayi M D Calenda A | 1996 | Blood1996，88，9： | 1 |
| 9 | Interpretive style and intolerance of uncertainty in individuals with anxiety disorders:a focus on generalized anxiety disorder显示文摘 | Anderson KG Dugas MJ Koerner N | 2012 | J Anxiety Disord2012，26，8： | 1 |
| 10 | Fcepsilon R Ⅱ/CD123 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factar-alpha in glial cells显示文摘 | Hunot S Dugas N Faucheux B | 1999 | J Neuriscu1999，19，： | 1 |
| 11 | Identifying barriers and facilitators towards implementing guidelines to reduce caesarean section rates in Quebec显示文摘 | Chaillet N DubéE Dugas M | 2007 | Bull World Health Organ2007，85，10： | 1 |
| 12 | Role of nitric oxide in the promoting effect of HIV type 1 infection and of gp120 envelope glycoprotein on interleukin 4-induced lgE production by normal human mononuclear cells显示文摘 | Dereuddre Bosquset N Goujard C | 2000 | AIDS Res Hum Retroviruses2000，16，3： | 1 |
| 13 | Leukotriene hances IL-4-induce IgE Production from Normal Lymphocytes显示文摘 | Yamoka KA Dugas B Paul Eugene N | 1994 | Cell lmmunol1994，156，： | 1 |
| 14 | Limitations of the Hamilton Anxiety Rating Seale as a primary outcome measure in random- ized, controlled trials of treatments for generalized anxiety disorder 显示文摘 | Koerner N Antony MM Dugas MJ | 2010 | Am J Psychiatry2010，167，： | 1 |
| 15 | FcepsilonR Ⅱ/CD23 is expressed in Parkinson's disease and induces ,in vitro, production of nitric oxide and tumor necrosis factor-alpha in glia cells 显示文摘 | Hunot S Dugas N Faucheux B | 1999 | J Neurosci1999，19，9： | 1 |
| 16 | Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells显示文摘 | Mossalayi MD Calenda A | 1996 | Blood1996，88，9： | 1 |
| 17 | FcepsilonRII/CD23 is ex- pressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells显示文摘 | Hunot S Dugas N Faucheux B | 1999 | J Neurosci1999，19，9： | 1 |
| 18 | Stressful life events and relationships are associated with mental health symptoms and sub- stance use in young adolescents 显示文摘 | LOW N C DUGAS E RODRIGUEZ D | 2011 | Comprehen Psychi2011，52，6： | 1 |
| 19 | B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity显示文摘 | Zhao HX Dugas N Mathiot C | 1998 | Blood1998，92，3： | 1 |
| 20 | Interpretive style and intolerance of uncertainty in individuals with anxiety disorders: a focus on generalized anxiety disorder 显示文摘 | Anderson KG Dugas M J Koerner N | 2012 | J Anxiety Disord2012，26，8： | 1 |
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