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| 1 | Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities显示文摘Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins,and has also been used for the treatment of severe acute respiratory syndrome(SARS). In vitro, the crude H. cordata polysaccharides(CHCP) exhibited potent anti-complementary activity through both the classical and alternative pathways by acting on components C3 and C4 of the complement system without interfering with the coagulation system. This study was to investigate the preventive effects of CHCP on acute lung injury(ALI) induced by hemorrhagic shock plus lipopolysaccharide(LPS) instillation(two-hit)and LPS-induced fever in rats. CHCP significantly attenuated pulmonary injury in the 'two-hit' ALI model by reducing pulmonary edema and protein exudation in bronchoalveolar lavage fluid(BALF). In addition, it reduced the deposit of complement activation products in the lung and improved oxidantantioxidant imbalance. Moreover, CHCP administration inhibited fever in rats, reduced the number of leukocytes and restored serum complement levels. The inhibition on the inappropriate activation of complement system by CHCP may play an important role in its beneficial effects on inflammatory diseases. The anti-complementary polysaccharides are likely to be among the key substances for the heatclearing function of H. cordata. | Yan Lu Yun Jiang Lijun Ling Yunyi Zhang Hong Li Daofeng Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 18 |
| 2 | The deep-lake deposit in the Upper Triassic Yanchang Formation in Ordos Basin, China and its significance for oil-gas accumulation显示文摘The deep-lake facies of the Yanchang Formation represents a large outflowing lake basin in the Ordos area. Its deposition can be divided into four stages: lake genetic and expanding stage, peak stage, inversion stage and dying stage. All the stages are obviously consistent with the evolution of depositional environment and the paleoclimate in the region. The study indicates that the lake basin has evolution fluctuations from highstand to lowstand for four times in its evolution history, and the deposition center of the lake has not obviously moved, staying along the Huachi-Yijun belt. The deep lake sedimentary system mainly consists of deep water deltas and turbidite fans during the entire evolution course of the lake basin in the Late Triassic. The former mainly developed on the slope of steep shore of the delta in the early period of the deep-water expansion and gradually experienced a big shift from deep-water deltas to shallow-water platform delta. And the latter appeared almost in all the above stages and had two types of turbidite fans, slope-moving turbidite fans and slump turbidite fans. The slope-moving turbidite fans have relatively complete facies belts overlapping one another vertically and consist of the slope channel of inter fans, the turbidite channel, inter turbidite channel and turbidite channel front of middle fans and outer fans (or lakebottom plain). However, the slide-moving turbidity fans are formed in the deep lake with their microfacies difficult to be distinguished, and only the center microfacies and edge microfacies can be determined. The two types of the turbidity fans are similarly distributing in the near-root-slope and far-root-slope regions. The deep-lake deposition governs the distribution of the hydrocarbon and reservoir, while the slope-moving turbidite fans are excellent reservoirs for oil-gas exploration due to their great thickness, widespread distribution and accumulation properties. | CHEN QuanHong LI WenHou GAO YongXiang GUO YanQin FENG JuanPing ZHANG DaoFeng CAO HongXia LIANG JiWei | 2007 | Science China Earth Sciences2007，50，z2： | 12 |
| 3 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 4 | Simultaneous determination of six steroidal saponins and one ecdysone in Asparagus filicinus using high performance liquid chromatography coupled with evaporative light scattering detection显示文摘A high-performance liquid chromatography coupled with an evaporative light scattering detector(HPLC-ELSD)has been developed to evaluate the quality of Asparagus filicinus through a simultaneous determination of six steroidal saponins and one ecdysone,including aspafiliosides A,B,C,E,G,filiasparoside A and 20-hydroxyecdysone.With a C_(18) analytical column,the seven analytes were separated efficiently using acetonitrile-water as the mobile phase in a gradient program.The method limits of detection ranged 0.1250.225μg,and the method limits of quantitation ranged 0.408-0.720μg,respectively.The intra-and inter-day precisions of the method were evaluated and were all less than 3%.All the recoveries for the spiked analytes ranged 95.16%-100.61%.The proposed method was succesfully applied to quantify the seven components in thirteen samples from different localities in China. | Libo Zhou Zhihong Cheng Daofeng Chen | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 2 |
| 5 | Paleogeomorphy evolution of the Ordovician weathering crust and its implication for reservoir development,eastern Ordos Basin显示文摘Gas reservoir development of the Ordovician weathering crust in the Ordos Basin is closely controlled by the pre-Carboniferous paleogeomorphy.Previous studies show that the paleogeomorphy is high in the west and low in the east,and the karst highland,karst slope and karst basin are developed from west to east.With further exploration in recent years,many karst breccia that represent strong karstification,are found in the east area which previously is considered to be the Ordovician karst basin.Thus,it is necessary to revaluate controlling factors of karst paleogeomorphy development from a viewpoint of the dynamic paleogeomorphy evolution,to investigate the paleogeomorphy evolution of the Ordovician weathering crust in geological history and guide further research and prediction of development law of reservoir spaces.In order to reconstruct the paleogeomorphy of the weathering crust in the top of Ordovician in the east Ordos Basin,paleogeography,thickness of residual strata and paleokarst characteristics are well studied.The result shows that a wide range of paleokarst highland occurred in the central to east part of Ordos Basin in the early period,and the karst reservoir spaces were formed;but in the late period,the east part of the basin gradually evolved into the paleokarst basin,the current pre-Carboniferous paleogeomorphy was thus formed,and the dissolution reservoir spaces formed in the early period were mostly filled,accordingly the reservoirs were tight.However fracture networks formed by cave collapse connect intercrystalline pores of dolomite,therefore,the reservoirs can still be well preserved locally and are worthy targets for hydrocarbon exploration. | Xinshan Wei Junfeng Ren Junxing Zhao Daofeng Zhang Shunshe Luo Liubin Wei Juanping Chen | 2018 | Petroleum Research2018，3，1： | 2 |
| 6 | Two New Triterpene Lactones from the Stems of Kadsura polysperma 显示文摘 | Jia Zhengwei Lu Yan Liao Zhixino and Chen Daofeng | 2007 | Helvetica Chimica Acta2007，，90： | 1 |
| 7 | Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides显示文摘Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall function of the complement system. The main objective of our study was to develop a specific enzyme-linked immunosorbent assay(ELISA) as an alternative method to assess the anti-complement activity, particularly against the lectin pathway. By using respective coating substrates against different activation pathways, followed by capturing the stable C3c fragments, our ELISA method can be used to screen complement inhibitors against the classical pathway and the lectin pathway. The inhibitory effect of suramin on the classical pathway, as measured by our hemolytic assay is consistent with previous reports. Further assessment of suramin and Bupleurum polysaccharides against the lectin pathway showed a good reproducibility of the method. Comparison of the lectin pathway IC50 between Bupleurum smithii var. parvifolium polysaccharides(1.055 mg/mL) and Bupleurum chinense polysaccharides(0.98 mg/mL) showed that, similar to the classical and alterative pathway, these two Bupleurum polysaccharides had comparable anti-complementary properties against the lectin pathway. The results demonstrate that the described ELISA assay can compensate for the shortcomings of the hemolytic assay in lectin pathway. | Mulu Wu Hong Li Yunyi Zhang Daofeng Chen | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 1 |
| 8 | Analysis of Schisandra chinensis and Schisandra sphrnanthera显示文摘 | LIU Yan CHEN Daofeng | 2009 | Journal of Chromatography A2009，1216，11： | 1 |
| 9 | Marsdenosides A–H, polyoxypregnane glycosides from Marsdenia tenacissima显示文摘 | Jun Deng Zhixin Liao Daofeng Chen | 2005 | Phytochemistry2005，，9： | 1 |
| 10 | Anti-AIDS Agents-X X VI,structure-activiy correlations of gomisin-G relates anti HIV lignans from Kadsura interior and of relates synthetic analogs显示文摘 | ZHANG SHUNXING XIE LAN | 1997 | Bioorg Med Chem1997，5，8： | 1 |
| 11 | Determination of quinolizidine alkaloids in Sophora medicinal plants by capillary electrophoresis显示文摘 | YU YUNQIU DING PEILAN CHEN DAOFENG | 2004 | Anal Chim Acta2004，，1： | 1 |
| 12 | Two new dibenzocyclooctene lignans from the water ex- tract of Kadsura spp 显示文摘 | JIA Zhengwei LIAO Zhixin CHEN Daofeng | 2005 | Helvetica Chimica Acta2005，88，8： | 1 |
| 13 | Involvement of rose aquaporin RhPIP1;1 in ethylene-regulated petal expansion through interaction with RhPIP2;1显示文摘 | Wen Chen Xia Yin Lei Wang Ji Tian Ruoyun Yang Daofeng Liu Zhenhao Yu Nan Ma Junping Gao | 2013 | Plant Molecular Biology2013，，3： | 1 |
| 14 | Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis显示文摘Houttuynia cordata is traditionally used as phytoantibiotics for treating lung disease in China.Houttuynia cordata polysaccharides(HCPs)have been reported to alleviate influenza virus-induced intestinal and lung immune injury by regulating the gutlung axis.The present study aims to investigate the effects and mechanisms of HCPs on ulcerative colitis(UC).Male C57BL/6 mice were induced by dextran sodium sulfate(DSS)to establish the UC animal model.Our results showed that HCPs significantly reduced the weight loss and the shortening of colon length in colitis mice,and relieved the pathological damage of colon mucosa and inhibited the expression of pro-inflammatory cytokines such as TNF-α,IL-1β,IL-6,etc.It was suggested that HCPs could significantly improve DSS-induced colitis in mice.HCPs directly protected intestinal epithelial cells,ameliorated epithelial barrier dysfunction and cell apoptosis,which was also proved in H2O2 stimulated cell apoptosis model.HCPs inhibited inflammation in the colon,which was related to suppressing the infiltration of macrophages,inhibiting the expression of pro-inflammatory cytokines and proteins(TLR4,NF-κB),and restoring the dysfunction of Th17 and Treg cells.HCPs also restored the alteration of intestinal flora induced by DSS,increased the abundance of Firmicutes and Bacteroides,and reduced the abundance of Proteobacteria.This study confirmed the protective effect of Houttuynia cordata polysaccharide extracted from traditional Chinese medicine on ulcerative colitis,of which the mechanism was closely related to the maintenance of intestinal homeostasis(intestinal barrier,immune cells,and intestinal bacteria). | CEN Lifeng YI Tong HAO Yuanzhen SHI Chenchen SHI Xunlong LU Yan CHEN Daofeng ZHU Haiyan | 2022 | Chinese Journal of Natural Medicines2022，20，12： | 1 |
| 15 | Determination of quinolizidine alkaloids in Sophora medicinal plants by capillary electrophoresis显示文摘 | Yunqiu Yu Peilan Ding Daofeng Chen | 2004 | Analytica Chimica Acta2004，523，1： | 1 |
| 16 | Determination of quinolizidine alkaloids in Sophora medicinal plants by capillary electrophoresis显示文摘 | Yu Yunqiu Ding Peilan Chen Daofeng | 2004 | Analytiea Chimica Acta2004，523，1： | 1 |
| 17 | Dibenzoey-elooctadiene Lignans fromK, heteroelita显示文摘 | Chen Daofeng Xu Guojun Yong Xiuwei | 1992 | Phytoehemistry1992，31，2： | 1 |
| 18 | Anti-AIDS Age nts-X X VI,structure-activiy correlat ions of gomisin-Grelates anti HIV lig naris from Kadsura interior and of re lates syntheticanaiogs显示文摘 | CHEN DAOFENG ZHANG SHUNXI NG XIE LAN | 1997 | Bioorg Med C hem1997，5，8： | 1 |
| 19 | Quantitation of sevenpolyoxypregnane glycosides in Marsdenia tenacissima using reversed-phase high-performance liquid chromatography- evaporative light-scattering detection 显示文摘 | Deng Jun Shen Fan Chen Daofeng | 2006 | J Chromatogr A2006，1116，12： | 1 |
| 20 | Anticomplementary principles of aChinese multiherb remedy for the treatment and prevention ofSARS显示文摘 | Ting Zhang Daofeng Chen | | Journal of E0，，： | 1 |
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