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| 1 | IDH突变的弥漫性和间变性星形细胞瘤具有相同的发病年龄和极小的生存期差异:一个WHO分级的问题显示文摘WHO(2007)中枢神经系统肿瘤分类中列出WHOⅡ级的弥漫性星形细胞瘤(A Ⅱ WHO 2007)和WHOⅢ级的间变性星形细胞瘤( AA Ⅲ WHO 2007)之间的区别。 A Ⅱ WHO (2007)的患者与AA Ⅲ WHO (2007)的患者相比显著年轻、生存期明显较长。迄今为主,分级和分类仅仅依靠形态学而未考虑IDH这一预后相关分子标记的状态。作者发现,对于IDH突变的星形细胞瘤而言,WHO(2007)的分级系统对预后的提示意义较差。检测来自3个独立的病例系列共1360例成人弥漫性星形细胞肿瘤的年龄分布和生存时间,其中包括683例Ⅱ级IDH突变型星形细胞瘤( A Ⅱ IDHmut)、562例IDH突变型的间变性星形细胞瘤( AA Ⅲ IDHmut)和115例IDH 突变的胶质母细胞瘤( GBM IDHmut )。 A ⅡIDHmut和 AA Ⅲ IDHmut的患者显示具有相同的发病年龄(36~37岁),而两级别之间的生存时间差异小于 WHO (2007)的报道(A Ⅱ IDHmut 中位生存时间为10.9年,AAⅢIDHmut为9.3年)。作者分析提示AⅡWHO2007与AAⅢ WHO2007年龄分布和生存时间的差异主要取决于 IDH非突变型肿瘤所占的比例。这些数据结果对目前实行的星形细胞瘤分级和危险分层提出了重大挑战,并可能对 IDH突变型星形细胞瘤的治疗管理产生深远的影响。 | David E Yasin M Daniel S 李晓玲 王行富 | 2015 | 临床与实验病理学杂志2015，31，7： | 17 |
| 2 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 3 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 4 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 5 | Plants, selenium and human health显示文摘 | Danielle R Ellis David E Salt | 2003 | Current Opinion in Plant Biology2003，，3： | 2 |
| 6 | Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα显示文摘 | Daniel J Peet Stephen D Turley Wenzhen Ma Bethany A Janowski Jean-Marc A Lobaccaro Robert E Hammer David J Mangelsdorf | 1998 | Cell1998，，： | 2 |
| 7 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 8 | Evidence for two independent domestications of cattle显示文摘 | Ronan T Lottus David E Machugh Daniel G | 1994 | J Proc Natl Acad Sci USA1994，91，： | 1 |
| 9 | Plants,selenium and human helath显示文摘 | Danielle R E David E S | 2003 | Curr Opin Plant Biol2003，6，3： | 1 |
| 10 | Plants, selenium and hu- man health显示文摘 | Danielle R Ellis David E Salt | 2003 | Current Opinion in Plant Biology2003，6，3： | 1 |
| 11 | Identification of a nuclear receptor that is activated by farnesol metabolites显示文摘 | Barry M Forman Elizabeth Goode Jasmine Chen Anthony E Oro David J Bradley Thomas Perlmann Daniel J Noonan Leo T Burka Trevor McMorris William W Lamph Ronald M Evans Cary Weinberger | 1995 | Cell1995，，5： | 1 |
| 12 | The Si cycle in the Pacific sector of the Southern Ocean: seasonal diatom production in the surface layer and export to the deep sea显示文摘 | Daniel E Sigmon David M Nelson Mark A Brzezinski | 2002 | Deep-Sea Research Part II2002，，9： | 1 |
| 13 | Molecular Evidence for the Early Colonization of Land by Fungi and Plants显示文摘 | David M G Brooke R E Geiser | 2001 | Science2001，293，： | 1 |
| 14 | Plants,selenium and human health显示文摘 | David E S | 2003 | Current Opinion in Plant Biology2003，6，： | 1 |
| 15 | Lessons learned from the first application of the DeBakey VAD child:an intracoporeal ventricular assist device for children显示文摘 | David LS Morales Daniel J DiBardino E Dcan McKenzie | 2005 | The journal of heart and lung transplantation2005，24，3： | 1 |
| 16 | Mitochondrial H^sub 2^O^sub 2^ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans显示文摘 | Anderson Ethan J Lustig Mary E Boyle Kristen E Woodlief Tracey L Kane Daniel A Lin Chien-Te Rice Jesse W Kang Li Rabinovitch Peter S Szeto Hazel H Houmard Joseph A Cortright Ronald N Wasserman David H Neufer P Darrell | 2009 | Journal of Clinical Investigation2009，，3： | 1 |
| 17 | Plants, selenium and human health 显示文摘 | Danielle R E David E S | | Current opinion in plant biology0，200，6： | 1 |
| 18 | Pediatric cardiomyopathies: causes, epidemiology, clinical course, preventive strategies and therapies显示文摘 | Steven E Lipshultz Thomas R Cochran David A Briston Stefanie R Brown Peter J Sambatakos Tracie L Miller Adriana A Carrillo Liat Corcia Janine E Sanchez Melissa B Diamond Michael Freundlich Danielle Harake Tamara Gayle William G Harmon Paolo G Rusconi Sati | 2013 | Future Cardiol2013，，6： | 1 |
| 19 | Phosphoinositide 3-kinase mediates protein kinase C βII mRNA destabilization in rat A10 smooth muscle cell cultures exposed to high glucose显示文摘 | Niketa A Patel Mayumi Yamamoto Philip Illingworth Daniel Mancu Konrad Mebert David S Chappell James E Watson Denise R Cooper | 2002 | Archives of Biochemistry and Biophysics2002，，1： | 1 |
| 20 | Compensatory value of urban trees in the United States显示文摘 | Daniel E Crane John F Dwyer | 2002 | Journal of Arboriculture2002，28，4： | 1 |
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