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| 1 | Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells(strem-1) in peptic ulcer disease显示文摘AIM: To investigate the role of gastric mucosa at the secretion of sTREM-1 in peptic ulcer. METHODS: Seventy two patients were enrolled; 35 with duodenal, 21 with gastric ulcer and 16 with chronic gastritis. Patients were endoscoped and gastric juice was aspirated. Patients with duodenal and gastric ulcer underwent a second endoscopy post-treatment. Biopsies were incubated in the absence/presence of endotoxins or gastric juice. Supernatants were collected and sTREM-1 and TNFα were measured by enzyme immunoabsorbent assays. Scoring of gastritis was performed before and after treatment according to updated Sydney score. RESULTS: Patients with duodenal and gastric ulcer and those with chronic gastritis had similar scores of gastritis. sTREM-1 was higher in supernatants of tissue samples of H pylori-positive than of H pylori-negative patients with gastric ulcer. Median (± SE) sTREM-1 was found increased in supernatants of patients with gastric ulcer before treatment (203.21 ± 88.91 pg/1000 cells) compared to supernatants either from the same patients post-treatment (8.23 ± 5.79 pg/1000 cells) or from patients with chronic gastritis (6.21 ± 0.71 pg/1000 cells) (P < 0.001 and < 0.001, respectively). Similar differences for sTREM-1 were recorded among LPS-stimulated tissue samples of patients (P = 0.001). Similar differences were not found for TNFα. Positive correlations were found between sTREM-1 of supernatants from patients withboth duodenal and gastric ulcer before treatment and the degree of infiltration of neutrophils and monocytes. CONCLUSION: sTREM-1 secreted by the gastric mucosa is an independent mechanism connected to the pathogenesis of peptic ulcer. sTREM-1 was released at the presence of H pylori from the inflamed gastric mucosa in the field of gastric ulcer. | Vassilios Koussoulas Spyridon Vassiliou Ekaterini Spyridaki Maria Demonakou Ilia Vaki Charalambos Barbatzas Helen Giamarellou Evangelos J Giamarellos-Bourboulis | 2007 | World Journal of Gastroenterology2007，13，34： | 11 |
| 2 | Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity显示文摘AIM: Acute hepatitis may seldom have a fulminant course.In the treatment of this medical emergency, potential liver support measure must provide immediate and sufficient assistance to the hepatic function. The goal of our study was to study the adequacy of hepatocyte transplantation (HCTx) in two different anatomical sites, splenic parenchyma and peritoneal cavity, in a rat model of reversible acute hepatitis induced by carbon tetrachloride (CCl4).METHODS: After CCl4 intoxication, 84 male Wistar rats used as recipients were divided in to four experimental groups accordingly to their treatment: Group A (n=24): intrasplenic transplantation of 10±10^6 isolated hepatoo/tes, Group B (n=24):intrapedtoneal transplantation of 20×10^6 isolated hepatocytes attached on plastic microcarriers, Group C (n= 18): intrasplenic injection of 1 mL normal saline (sham-operated controls),Group D (n=18): intraperitoneal injection of 2.5 mL normal saline (sham-operated controls). Survival, liver function tests (LIT) and histology were studied in all four groups, on d 2,5 and 10 post-HCTx.RESULTS: The ten-day survival (and mean survival) in the 4 groups was 72.2% (8.1±3.1), 33.3% (5.4±3.4), 0%(3.1±1.3) and 33.3% (5.4±3.6) in groups A, B, C, D,respectively (PAB<0.05, PAc<0.05, P80=NS). In the final survivors, LIT (except alkaline phosphatase) and hepatic histology retumed to normal, independently of their previous therapy. Viable hepatocytes were identified within splenic parenchyma (in group A on d 2) and both in the native liver and the fatty tissue of abdominal wall (in group B on d 5).CONCLUSION: A significantly better survival of the intrasplenically transplanted animals has been demonstrated,Intraperitoneal hepatocytes failed to promptly engraft. A different timing between liver injury and intraperitoneal HCTx may give better results and merits further investigation. | Charalampos Pilichos Despina Perrea Maria Demonakou Athena Preza Ismini Donta | 2004 | World Journal of Gastroenterology2004，10，14： | 2 |
| 3 | Soluble triggering receptor expressed on myeloid cells (sTREM-1):a new mediator involved in the pathogenesis of pepticulcer disease显示文摘 | Koussoulas V Vassiliou S Demonakou M | 2006 | Eur J Gastroenterol Hepatol2006，18，4： | 1 |
| 4 | Soluble triggering receptor expressed on myeloid cells(sTREM-1):a new mediator involved in the pathogenesis of peptic ulcer disease显示文摘 | Koussoulas V Vassiliou S Demonakou M | 2006 | Gastroenterol Hepatol2006，18，4： | 1 |
| 5 | Soluble triggering receptor exposed on myeloid cells(sTREM-1):a new mediator involved in the pathogenesis of peptic ulcer disease显示文摘 | KOUSSOULAS V VASSILIOU S DEMONAKOU M | 2006 | Eur J Gastroenterol Hepatol2006，18，4： | 1 |
| 6 | Piognostic predictors of gastro in testinal stromal tumors: a multi-institutional analysis of 102 patients with definition of a prognostic index显示文摘 | Kontogianni K Demonakou M Kavantzas N | 2003 | Eur J Surg Oncol2003，29，2： | 1 |
| 7 | Prognostic predictors of gastrointestinal stromal tumors: a multi-institutional analysis of 102 patients with definition of a prognostic index 显示文摘 | Kontogianni K Demonakou M Kavantzas N | 2003 | Eur J Surg 0ncol2003，29，6： | 1 |
| 8 | Can Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM-1) Be Considered an Anti-Inflammatory Mediator in the Pathogenesis of Peptic Ulcer Disease?显示文摘 | Vassilios Koussoulas Michalis Tzivras Evangelos J. Giamarellos-Bourboulis Maria Demonakou Spyridon Vassilliou Aimilia Pelekanou Antonios Papadopoulos Helen Giamarellou Charalambos Barbatzas | 2007 | Digestive Diseases and Sciences2007，，9： | 1 |
| 9 | The hepatoutective effect of putrescine against cadmium-induced acute liver injury 显示文摘 | TZIROGIANNIS K N PANOUTSOPOULOS G I DEMONAKOU M D | 2004 | Arch Toxieol2004，78，6： | 1 |
| 10 | Prognostic predictors of gastrointestinal stromal tumors:a Multi-institutional analysis of 102 patients with definition of a prognostic index显示文摘 | Kontogianni K Demonakou M Kavantzas N | 2003 | Eur J surg Oncol2003，29，6： | 1 |
| 11 | Prognostic predictors of gastrointestinal stromal tumors: a multi-institutional analysis of 102 patients with definition of a prognostic index显示文摘 | Kontogianni K Demonakou M Kavantzas N | 2003 | Eur J Sur Oncol2003，29，5： | 1 |
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