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| 1 | Review of the diagnosis,classification and management of autoimmune pancreatitis显示文摘Autoimmune pancreatitis(AIP)is a rare form of chronic pancreatitis,with as yet undetermined incidence and prevalence in the general population.Our understanding of it continues to evolve.In the last few years,2separate subtypes have been identified:type 1 AIP has been recognised as the pancreatic manifestation of a multiorgan disease,named immunoglobulin G4(IgG4)-related disease while type 2 AIP is a pancreas specific disorder not associated with IgG4.International criteria for the diagnosis of AIP have been defined:the HISORt criteria from the Mayo clinic,the Japan consensus criteria and,most recently,the international association of pancreatology'International Consensus Diagnostic Criteria'.Despite this,in clinical practice it can still be very difficult to confirm the diagnosis and differenti-ate AIP from a pancreatic cancer.There are no large studies into the long-term prognosis and management of relapses of AIP,and there is even less information at present regarding the Type 2 AIP subtype.Further studies are necessary to clarify the pathogenesis,treatment and long-term outcomes of this disease.Critically for clinicians,making the correct diagnosis and differentiating the disease from pancreatic cancer is of the utmost importance and the greatest challenge. | Derek A O'Reilly Deep J Malde Trish Duncan Madhu Rao Rafik Filobbos | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 14 |
| 2 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 3 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 4 | Antimicrobial peptides and the gut microbiome in inflammatory bowel disease显示文摘Antimicrobial peptides(AMP)are highly diverse and dynamic molecules that are expressed by specific intestinal epithelial cells,Paneth cells,as well as immune cells in the gastrointestinal(GI)tract.They play critical roles in maintaining tolerance to gut microbiota and protecting against enteric infections.Given that disruptions in tolerance to commensal microbiota and loss of barrier function play major roles in the pathogenesis of inflammatory bowel disease(IBD)and converge on the function of AMP,the significance of AMP as potential biomarkers and novel therapeutic targets in IBD have been increasingly recognized in recent years.In this frontier article,we discuss the function and mechanisms of AMP in the GI tract,examine the interaction of AMP with the gut microbiome,explore the role of AMP in the pathogenesis of IBD,and review translational applications of AMP in patients with IBD. | John Gubatan Derek R Holman Christopher J Puntasecca Danielle Polevoi Samuel JS Rubin Stephan Rogalla | 2021 | World Journal of Gastroenterology2021，27，43： | 3 |
| 5 | A method of optimization : principal merican Journal of 1995, 11(33) :14 - industrial organization -agent tree 显示文摘 | Derek J | 1995 | A- Agricultural Economics1995，19，： | 1 |
| 6 | The study of aluminium anodes for high powerdensity Al/air batteries with brine electrolytes 显示文摘 | Mafia Nestoridi Derek Pletcher Robert J K Wood etal | 2008 | Joural of Power Sources2008，178，1： | 1 |
| 7 | The neural control of mie- turition显示文摘 | Clare J Fowler Derek Griffiths | 2008 | Nature Reviews Neuroscienee2008，9，： | 1 |
| 8 | Seed Germination and Dormancy显示文摘 | Derek B J | 1997 | The Plant Cell1997，9，： | 1 |
| 9 | New insights into magnetic derivatives for structural mapping 显示文摘 | Verduzco Bruno Fairhead J Derek Green Chris M | 2004 | The Leading Edge2004，23，： | 1 |
| 10 | Biological activity of cryopreserved bovine spermatogonial stem cells during in vitro culture显示文摘 | Jon M O Jerry J R Derek J M | 2004 | Biology of Reproduction2004，71，： | 1 |
| 11 | The syntheses of sulfides bydeoxygenation of sulfoxides using Woollins? reagent 显示文摘 | Hua G-X Derek Woollins J | 2007 | Tetrahedron Lett2007，48，21： | 1 |
| 12 | Cost-Effectiveness of Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease and Abnormal Fractional Flow Reserve显示文摘 | William F. Fearon David Shilane Nico H.J. Pijls Derek B. Boothroyd Pim A.L. Tonino Emanuele Barbato Peter Jüni Bernard De Bruyne Mark A. Hlatky | 2013 | Circulation2013，，12： | 1 |
| 13 | Direct electrochemical reduction of titanium dioxide to titanium in molten calcium chloride显示文摘 | George Z Chen Derek J Fray Tom W Farthing | 2000 | Nature2000，407，21： | 1 |
| 14 | Self-folding of three-dimensional hydrogel microstructures显示文摘 | Jingjiao Guan Hongyan He Derek J Hansford | 2005 | J Phys Chem B2005，109，23： | 1 |
| 15 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 16 | Approximate conditional mean particle filtering for linear/nonlinear dynamic state space models显示文摘 | Derek Yee Reilly Kirubarajan J P Punithakumar T K | 2008 | Signal Processing2008，56，12： | 1 |
| 17 | New insights into magnetic derivatives for structural mapping显示文摘 | Derek J Airhead F Chris G M | 2004 | The Leading Edge2004，23，2： | 1 |
| 18 | Alcoholic fermentation of carbon sources in biomasshydrolysates by Saccharomyces cerevisiae:current status显示文摘 | Maris Antonius J A van Abbott Derek A Bellissimi Eleonora | 2006 | Anton Leeuw Int J G2006，90，4： | 1 |
| 19 | Improving health care through re- design显示文摘 | Derek B Nieki M Mike J | 2006 | BMJ2006，332，： | 1 |
| 20 | Development of progres- sive landslide failure in cohesive materials显示文摘 | David N P Toru H Derek J P | 2005 | Geology2005，33，3： | 1 |
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