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| 1 | 复合二氧化氯发生器对饮用水消毒的适用性研究显示文摘对采用氯酸钠/盐酸法的复合二氧化氯发生器进行了测评和调查,并对其消毒液的成分及消毒后的副产物进行了定量分析。结果表明,复合二氧化氯发生器在实际运行中的转化率仅为30%左右,而在试验模拟条件下的最高转化率也仅为41%左右;在其产生的消毒液中,Cl2量约占Cl2和ClO2总量的30%-48%;由于消毒液中存在大量氯气和残留的氯酸盐,生成的消毒副产物已经给饮用水安全带来了新的威胁。 | 吴明松 黄君礼 鲍立峰 王丽 张玉玲 田禹 Dominic Wang | 2009 | 中国给水排水2009，25，17： | 16 |
| 2 | Boceprevir,GC-376,and calpain inhibitors Ⅱ,Ⅻ inhibit SARS-CoV-2 viral replication by targeting the viral main protease显示文摘A new coronavirus SARS-CoV-2,also called novel coronavirus 2019(2019-nCoV),started to circulate among humans around December 2019,and it is now widespread as a global pandemic.The disease caused by SARS-CoV-2 virus is called COVID-19,which is highly contagious and has an overall mortality rate of 6.35%as of May 26,2020.There is no vaccine or antiviral available for SARS-CoV-2.In this study,we report our discovery of inhibitors targeting the SARS-CoV-2 main protease(Mpro).Using the FRET-based enzymatic assay,several inhibitors including boceprevir,GC-376,and calpain inhibitorsⅡ,andⅫwere identified to have potent activity with single-digit to submicromolar ICs0 values in the enzymatic assay.The mechanism of action of the hits was further characterized using enzyme kinetic studies,thermal shift binding assays,and native mass spectrometry.Significantly,four compounds(boceprevir,GC-376,calpain inhibitorsⅡandⅫ)inhibit SARS-CoV-2 viral replication in cell culture with EC50 values ranging from 0.49 to 3.37μM.Notably,boceprevir,calpain inhibitorsⅡandⅫrepresent novel chemotypes that are distinct from known substrate-based peptidomimetic Mpro inhibitors.A complex crystal structure of SARS-CoV-2 Mpro with GC-376,determined at 2.15(A)resolution with three protomers per asymmetric unit,revealed two unique binding configurations,shedding light on the molecular interactions and protein conformational flexibility underlying substrate and inhibitor binding by Mpro.Overall,the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics. | Chunlong Ma Michael Dominic Sacco Brett Hurst Julia Alma Townsend Yanmei Hu Tommy Szeto Xiujun Zhang Bart Tarbet Michael Thomas Marty Yu Chen Jun Wang | 2020 | Cell Research2020，30，8： | 13 |
| 3 | A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis)显示文摘Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moderate symptoms, there exists challenges in exploring and addressing the underlying cause of the depression. This fact highlights the need for relevant animal models. In the present study, postpartum adult female cynomolgus monkeys(Macaca fascicularis) living in breeding groups were observed for typical depressive behavior. The huddle posture behavior was utilized as an indicator of behavioral depression postpartum(BDP) as it has been established as the core depressive-like behavior in primates. Monkeys were divided into two groups: A BDP group(n=6), which were found to spend more time huddling over the first two weeks postpartum than other individuals that formed a non-depression control group(n=4). The two groups were then further analyzed for locomotive activity, stressful events, hair cortisol levels and for maternal interactive behaviors. No differences were found between the BDP and control groups in locomotive activity, in the frequencies of stressful events experienced and in hair cortisol levels. These findings suggested that the postpartum depression witnessed in the monkeys was not related to external factors other than puerperium period. Interestingly, the BDP monkeys displayed an abnormal maternal relationship consisting of increased infant grooming. Taken together, these findings suggest that the adult female cynomolgus monkeys provide a natural model of behavioral postpartum depression that holds a number of advantages over commonly used rodent systems in PPD modeling. The cynomolgus monkeys have a highly-organized social hierarchy and reproductive characteristics without seasonal restriction—similar to humans—as well as much greater homology to humans than rodents. As such, this model may provide a greater translational efficiency and research platform for systematically investigating the etiology, treatment, prevention of PPD. | Xun-Xun CHU Joshua Dominic Rizak Shang-Chuan YANG Jian-Hong WANG Yuan-Ye MA Xin-Tian HU | 2014 | Zoological Research2014，35，3： | 4 |
| 4 | The P132H mutation in the main protease of Omicron SARSCoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition显示文摘Dear Editor,The ongoing SARS-CoV-2 pandemic continues to be a significant threat to global health.First reported in November 2021,the Omicron variant(B.1.1.529)is more transmissible and can evade immunity better than previous SARS-CoV-2 variants,fueling an unprecedented surge in cases.To produce functional proteins from its polyprotein,SARS-CoV-2 relies on the cysteine proteases Nsp3/papain-like protease(PLpro)and Nsp5/main protease(Mpro)/3C-like protease to cleave at three and more than 11 sites,respectively.1 Therefore,Mpro and PLpro inhibitors are considered to be one of the most promising SARS-CoV-2 antivirals.On December 22,2021,the Food and Drug Administration(FDA)issued an Emergency Use Authorization(EUA)for PAXLOVID,a ritonavir-boosted formulation of nirmatrelvir.Nirmatrelvir is a first-in-class orally bioavailable SARSCoV-2 Mpro inhibitor.2 Thus,the scientific community must vigilantly monitor potential mechanisms of drug resistance,especially because SARS-CoV-2 is naïve to Mpro inhibitors.Mutations have been well identified in variants to this point.3 Notably,Omicron Mpro(OMpro)harbors a single mutation—P132H.In this study,we characterized the enzymatic activity,drug inhibition,and structure of OMpro while evaluating the past and future implications of Mpro mutations. | Michael Dominic Sacco Yanmei Hu Maura Verenice Gongora Flora Meilleur Michael Trent Kemp Xiujun Zhang Jun Wang Yu Chen | 2022 | Cell Research2022，32，5： | 3 |
| 5 | Does social capital enhance health and well-being? Evidence from rural China显示文摘 | Winnie Yip S.V. Subramanian Andrew D. Mitchell Dominic T.S. Lee Jian Wang Ichiro Kawachi | 2006 | Social Science & Medicine2006，，1： | 1 |
| 6 | IAP family protein surviving inhibit caspase activity and apotosis induced by Fas(CD45),Bax,Caspase,and anti-cancer drugs显示文摘 | Ingo Tamm Yang wang Dominic A | 1998 | Cancer Res1998，58，： | 1 |
| 7 | Development of a model-based clinical sepsis biomarker for critically ill patients显示文摘 | Jessica Lin Jacquelyn D. Parente J. Geoffrey Chase Geoffrey M. Shaw Amy J. Blakemore Aaron J. LeCompte Christopher Pretty Normy N. Razak Dominic S. Lee Christopher E. Hann Sheng-Hui Wang | 2010 | Computer Methods and Programs in Biomedicine2010，，2： | 1 |
| 8 | MiRNA target predictions across seven drosophila species and comparison to mammalian targets显示文摘 | Dominic Grun Wang Yi-Lu David Langenberger | 2005 | PLoS Computational Biology2005，1，1： | 1 |
| 9 | RUNX3 Attenuates β-Catenin/T Cell Factors in Intestinal Tumorigenesis显示文摘 | Kosei Ito Anthony Chee-Beng Lim Manuel Salto-Tellez Lena Motoda Motomi Osato Linda Shyue Huey Chuang Cecilia Wei Lin Lee Dominic Chih-Cheng Voon Jason Kin Wai Koo Huajing Wang Hiroshi Fukamachi Yoshiaki Ito | 2009 | Cancer Cell2009，，： | 1 |
| 10 | Simultaneous penile prosthesis and male sling/artificia urinary sphincter显示文摘可勃起的机能障碍(编辑) 和应力从尿道的 sphincteric 缺乏的尿不能自制(穗) 不是一个不平常的问题。最普通的病原学为肌肉是为局部性的前列腺癌症或激进的 cystoprostatectomy 的干预侵略膀胱癌症。尽管有在有机器的帮助 laparoscopic 前列腺切除术和神经 sparing 技术的外科的技术的进展,编辑和穗的率仍然保持相对未改变。他们两个都极大地影响生活领域的质量并且与差的表演结果被联系了。人工的尿括约肌和阴茎修复术分别地是有为结束阶段穗和编辑的证明功效,满足和耐久性的标准答案治疗。为并发的条件的同时的修复术培植很好被描述了,主要在小回顾的系列。联合外科的举起对外科的技术要求并且到程度部分地慢到期,在潜在的复杂并发症上的提高的焦虑。这篇论文试图为有这的各种各样的外科的技术的出版结果接近的疾病实体和水流讨论并发的外科的技术方面。 | Dominic Lee Claudio Romero Frances Alba O Lenaine Westney Run Wang | 2013 | Asian Journal of Andrology2013，15，1： | 0 |
| 11 | Precipitation of High Mg-Calcite and Protodolomite Using Dead Biomass of Aerobic Halophilic Bacteria显示文摘The microbial dolomite model has been used to interpret the origin of sedimentary dolomite.In this model,the formation of low-temperature protodolomite,an important precursor to sedimentary dolomite,can be facilitated either by actively metabolizing cells of anaerobic microbes and aerobic halophilic archaea or by their inactive biomass.Aerobic halophilic bacteria are widely distributed in(proto-)dolomite-depositing evaporitic environments and their biomass might serve as a template for the crystallization of protodolomite.To test this hypothesis,carbonation experiments were conducted using dead biomass of an aerobic halophilic bacterium(Exiguobacterium sp.strain JBHLT-3).Our results show that dead biomass of JBHLT-3 can accelerate Mg2+uptake in carbonate mineral precipitates.In addition,the amount of Mg incorporated into Ca-Mg carbonates is proportional to the concentration of biomass.High Mg-calcite is produced with 0.25 or 0.5 g/L biomass,whereas protodolomite forms with 1 g/L biomass.This is confirmed by the main Raman peak of Ca-Mg carbonates,which shifts towards higher wavenumbers with increased Mg substitution.Microbial cells and their imprints are preserved on the surface of high Mg-calcite and protodolomite.Hence,this study furthers our understanding of the dolomitization within buried and dead microbial mats,which provides useful insights into the origin of ancient dolomite. | Qigao Fan Deng Liu Dominic Papineau Xuan Qiu Hongmei Wang Zhenbing She Linduo Zhao | 2023 | Journal of Earth Science2023，34，2： | 0 |
| 12 | A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling显示文摘Conventional synthetic vascular grafts are associated with significant failure rates due to their mismatched mechanical properties with the native vessel and poor regenerative potential.Though different tissue engineering approaches have been used to improve the biocompatibility of synthetic vascular grafts,it is still crucial to develop a new generation of synthetic grafts that can match the dynamics of native vessel and direct the host response to achieve robust vascular regeneration.The size of pores within implanted biomaterials has shown significant effects on macrophage polarization,which has been further confirmed as necessary for efficient vascular formation and remodeling.Here,we developed biodegradable,autoclavable synthetic vascular grafts from a new polyurethane elastomer and tailored the grafts’interconnected pore sizes to promote macrophage populations with a pro-regenerative phenotype and improve vascular regeneration and patency rate.The synthetic vascular grafts showed similar mechanical properties to native blood vessels,encouraged macrophage populations with varying M2 to M1 phenotypic expression,and maintained patency and vascular regeneration in a one-month rat carotid interposition model and in a four-month rat aortic interposition model.This innovative bioactive synthetic vascular graft holds promise to treat clinical vascular diseases. | Alexander Stahl Dake Hao Janos Barrera Dominic Henn Sien Lin Seyedsina Moeinzadeh Sungwoo Kim William Maloney Geoffrey Gurtner Aijun Wang Yunzhi Peter Yang | 2023 | Bioactive Materials2023，，1： | 0 |
| 13 | Damps’role in inflammatory bowel disease:a paradoxical player of mtDNA-STING signaling pathway in gut homeostasis显示文摘The inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis,are chronic,relapsing immune mediated disorders of the gastrointestinal homeostasis and intestinal inflammation[1].Failure to resolve mucosal inflammation and maintain gut barrier are notable shared clinical challenges in IBD,in particular when they activate immune cells within the gut lamia propria.Clinical trials and animal model studies aiming towards DAMPs have demonstrated that they can be effective therapeutic targets in mucosal inflammation of IBD. | Qiongyuan Hu Yanhan Ren Dominic ASlade Quan Zhou Xiuwen Wu Jinjian Huang Guosheng Gu Gefei Wang Jianan Ren Jieshou Li | 2019 | Science Bulletin2019，64，19： | 0 |
| 14 | Preparation of elastomeric nanocomposites using nanocellulose and recycled alum sludge for flexible dielectric materials显示文摘Flexible dielectric materials with environmental-friendly,low-cost and high-energy density characteristics are in increasing demand as the world steps into the new Industrial 4.0 era.In this work,an elastomeric nanocomposite was developed by incorporating two components:cellulose nanofibrils(CNFs)and recycled alum sludge,as the reinforcement phase and to improve the dielectric properties,in a bio-elastomer matrix.CNF and alum sludge were produced by processing waste materials that would otherwise be disposed to landfills.A biodegradable elastomer polydimethylsiloxane was used as the matrix and the nanocomposites were processed by casting the materials in Petri dishes.Nanocellulose extraction and heat treatment of alum sludge were conducted and characterized using various techniques including scanning electron microscopy(SEM),thermogravimetric analysis/derivative thermogravimetric(TGA/DTG)and X-ray diffraction(XRD)analysis.When preparing the nanocomposite samples,various amount of alum sludge was added to examine their impact on the mechanical,thermal and electrical properties.Results have shown that it could be a sustainable practice of reusing such wastes in preparing flexible,lightweight and miniature dielectric materials that can be used for energy storage applications. | Dongyang Sun Bernard L.H.Saw Amaka J.Onyianta Bowen Wang Callum Wilson Dominic O’Rourke Chan H.See Carmen-Mihaela Popescu Mark Dorris Islam Shyha Zhilun Lu | 2023 | Journal of Advanced Dielectrics2023，13，1： | 0 |
| 15 | Microbially-mediated formation of Ca-Fe carbonates during dissimilatory ferrihydrite reduction:Implications for the origin of sedimentary ankerite显示文摘The origin of sedimentary dolomite has become a long-standing problem in the Earth Sciences.Some carbonate minerals like ankerite have the same crystal structure as dolomite,hence their genesis may provide clues to help solving the dolomite problem.The purpose of this study was to probe whether microbial activity can be involved in the formation of ankerite.Bio-carbonation experiments associated with microbial iron reduction were performed in batch systems with various concentrations of Ca^(2+)(0–20 mmol/L),with a marine iron-reducing bacterium Shewanella piezotolerans WP3 as the reaction mediator,and with lactate and ferrihydrite as the respective electron donor and acceptor.Our biomineralization data showed that Ca-amendments expedited microbially-mediated ferrihydrite reduction by enhancing the adhesion between WP3 cells and ferrihydrite particles.After bioreduction,siderite occurred as the principal secondary mineral in the Ca-free systems.Instead,Ca-Fe carbonates were formed when Ca^(2+)ions were present.The CaCO_(3) content of microbially-induced Ca-Fe carbonates was positively correlated with the initial Ca2+concentration.The Ca-Fe carbonate phase produced in the 20 mmol/L Ca-amended biosystems had a chemical formula of Ca_(0.8)Fe_(1.2)(CO_(3))_(2),which is close to the theoretical composition of ankerite.This ankeritelike phase was nanometric in size and spherical,Ca-Fe disordered,and structurally defective.Our simulated diagenesis experiments further demonstrated that the resulting ankerite-like phase could be converted into ordered ankerite under hydrothermal conditions.We introduced the term“proto-ankerite”to define the Ca-Fe phases that possess near-ankerite stoichiometry but disordered cation arrangement.On the basis of the present study,we proposed herein that microbial activity is an important contributor to the genesis of sedimentary ankerite by providing the metastable Ca-Fe carbonate precursors. | Deng LIU Jinpeng CAO Shanshan YANG Yating YIN Pengcong WANG Dominic PAPINEAU Hongmei WANG Xuan QIU Genming LUO Zongmin ZHU Fengping WANG | 2024 | Science China Earth Sciences2024，67，1： | 0 |
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