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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Sucrose induction of Arobidopsis miR398 represses two Cu/Zn superoxide dismutases显示文摘 | Dugas D V Bartel B | 2008 | Plant Mol Biol2008，67，： | 1 |
| 3 | Impact of LDL carotenoid and α-tocopherol content on LDL oxidation by endothelial cells in culture显示文摘 | Dugas T R Morel D W Harrison E H | 1998 | J Lipid Res1998，39，5： | 1 |
| 4 | Dietary supplementation with β-carotene, but not with lycopene,inhibits endothelial cell-mediated oxidation of low-density lipoprotein显示文摘 | Dugas T R Morel D W Harrison E H | 1999 | Free Radic Biol Med1999，26，910： | 1 |
| 5 | Synthesis of 7-dehydro-choles- terol through a palladium catalyzed selective homoan- nular conjugated diene formation 显示文摘 | Dugas D Brunel J M | 2006 | J Mol Catal A Chem2006，253，： | 1 |
| 6 | Long-term cycling behavior of asymmetric activated carbon/MnO 2 aqueous electrochemical supercapacitor显示文摘 | Thierry Brousse Pierre-Louis Taberna Olivier Crosnier Romain Dugas Philippe Guillemet Yves Scudeller Yingke Zhou Frédéric Favier Daniel Bélanger Patrice Simon | 2007 | Journal of Power Sources2007，，1： | 1 |
| 7 | MicroRNA regulation of NAC-domain targets is required for proper formation and separation of adjacent embryonic,vegetative,and floral organs显示文摘 | MALLORY A C DUGAS D V BARTEL D P BARTEL B | 2004 | Current Biology2004，14，12： | 1 |
| 8 | Tillage-induced soil carbon dioxide loss from different cropping systems 显示文摘 | Reicosky D C Dugas W A Torbert H A | 1997 | Soil and Tillage Research1997，41，： | 1 |
| 9 | MicroRNA regulation of gene expression in plants显示文摘 | Dugas D V Bartel B | 2004 | Current Opinion in Plant Biology2004，7，： | 1 |
| 10 | Carbon dioxide capture with concentrated, aqueous piperazine显示文摘 | Freeman S A Dugas R Wagener D H V | 2010 | International JournalofGreenhouse Gas Control2010，4，2： | 1 |
| 11 | Car- bon Dioxide Capture with Concentrated,Aqueous Piperazine 显示文摘 | FREEMAN S A DUGAS R VAN WAGENER D | 2009 | Energy Procedia2009，1，1： | 1 |
| 12 | Tillage-induced soil carbon dioxide loss from different cropping systems显示文摘 | Reicosky D C Dugas W A Torbert H A | 1997 | Soil and Tillage Research1997，41，12： | 1 |
| 13 | Long-term cycling behavior of asymmetric activated carbon/MnO 2 aqueous electrochemical supercapacitor显示文摘 | Thierry Brousse Pierre-Louis Taberna Olivier Crosnier Romain Dugas Philippe Guillemet Yves Scudeller Yingke Zhou Frédéric Favier Daniel Bélanger Patrice Simon | 2007 | Journal of Power Sources2007，，1： | 1 |
| 14 | Assessment of orchard sprayers using laboratory experiments and computational fluid dynamics modeling显示文摘 | Dekeyser D Duga A T Verboven P | 2013 | Biosystems Engineering2013，114，2： | 1 |
| 15 | microRNA regulation of NAC-domain targets is required for proper formation and separation of adjacent embryonic,vegetative,and floral organs显示文摘 | Mallory A C Dugas D V Bartel D P Bartel B | 2004 | Curr Biol2004，14，12： | 1 |
| 16 | Patholosy related to altitude显示文摘 | Dugas L Riviere D | 1997 | Med Trop (Mars)1997，57，4： | 1 |
| 17 | Sucrose induction of Arabidopsis miR398 repressestwo Cu/2n superoxide dismutases显示文摘 | Dugas D V Bartel B | 2008 | Plant Molecular Hol<^y2008，67，4： | 1 |
| 18 | MicroRNA regulation of gene expression in plants 显示文摘 | Dugas D V Bartd B | 2004 | Curr Opin Plant Biol2004，7，5： | 1 |
| 19 | Tillage-inducedsoil carbon dioxide loss from different cropping systems 显示文摘 | Reicosky D G Dugas W A Torbert H A | 1997 | Soil and Tillage Research1997，41，： | 1 |
| 20 | MicreRNA regulation of NAC - domain targets is required for proper formation and separation of adjacent embryonic, vegetative, and floral organs 显示文摘 | Mallory A C Dugas D V Barrel D P | 2004 | Curr Biol2004，14，12： | 1 |
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