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| 1 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 2 | Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma ceil line: implications for autocrine receptor activation 显示文摘 | Betsholtz C Westermark B Ek B | 1984 | Cell1984，39，32： | 1 |
| 3 | Bone marrow-derived mesenchymal stems cells and cardiac repair显示文摘 | Chugh AR Zuba-Surma EK Dawn B | 2009 | Minerva Car dioangiol2009，57，2： | 1 |
| 4 | Isoelectric focusing immobilized pH gradients : priciples, methodology, and some applications显示文摘 | Bjellqvist B Ek K Righetti PG | 1982 | J Biochem Biophys Meth1982，6，4： | 1 |
| 5 | Upregula-tion of PD-1 expression on HIV-specific CD8 T cells leads to reversible immune dysfunction 显示文摘 | Trautmann L Janbazian L Chomont N Said EA Gimmig S Bessette B Boulassel MR Delwart E Sepulveda H Balderas RS Routy JP Haddad EK Sekaly RP | 2006 | Nat Med2006，12，10： | 1 |
| 6 | Placental expression of glycophosphatidylinositol (GPI)anchored proteins in paroxysmal nocturnal haemoglobinuria显示文摘 | Haram KO Edvardsen B | 2006 | Scand J Immunol2006，64，2： | 1 |
| 7 | Sequence analysis and regu-lation of a gene encoding a cuticle-degrading serine protease from the nematophagous fungus Arthrobotrys oligospora显示文摘 | AHMAN J EK B RASK L | 1996 | Microbiology1996，142，7： | 1 |
| 8 | Crohn disease:perirectal and perianal findings at CT显示文摘 | YOUSEM DM FISHMAN EK JONES B | 1988 | Radiology1988，167，2： | 1 |
| 9 | CTGF directs fibroblast dif- ferentiation from human mesenchymal stenCstromal ceils and defines connective tissue healing in a rodent injury model 显示文摘 | Lee CH Shah B Moioli EK and Mao JJ | 2010 | J Clin Invest2010，120，9： | 1 |
| 10 | Immunoglobulin G4-related disease presenting as an ethmoid and maxillary mass 显示文摘 | Hu EK Parrish C Wrobel B | 2013 | Ann Allergy Asthma Immuno12013，11，1： | 1 |
| 11 | Isoelectric focusing in immobilized pH gradients: principle, methodology and some applications 显示文摘 | Bjellqvist B Ek K Righetti P G | 1982 | Journal of Biochemical and Biophysical Methods1982，6，4： | 1 |
| 12 | Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction 显示文摘 | Zuba-Surma EK Kucia M Dawn B | 2008 | J Mol Cell Cardiol2008，44，： | 1 |
| 13 | Neurophysiological characterization of postherniotomy pain显示文摘 | Aasvang EK Brandsborg B Christensen B | | 0，，01： | 1 |
| 14 | Expression of drug metabolizing enzymes in hepatocyte-like ceils derived from human embryonic stem cells显示文摘 | Ek M Soderdahl T Kuppers-Munther B | 2007 | Biochem Pharmaeol2007，74，3： | 1 |
| 15 | Pretreatment by tubulin agents decreases C-MYC induction in human colon carcinoma cell line HT29-D4显示文摘 | Said EK Veronique B Yves B | 1997 | Biochemical and Biophysical Research Communications1997，231，3： | 1 |
| 16 | Human cord blood-derived cells attain neuronal and glial features in vitro显示文摘 | Buzanska L Machaj EK Zablocka B | 2002 | J cell Sci2002，115，10： | 1 |
| 17 | Antibiotic-mediated selection of quorum-sensing-negative Staphy-lococcus aureus显示文摘 | PAULANDER W NISSEN VARMING A B/EK KT | 2013 | Mbio2013，3，00： | 1 |
| 18 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision显示文摘 | Bro ek J L Bousquet J Baena-Cagnani C E Bonini S Canonica G W Casale T B | 2010 | J Allergy Clin Immunol2010，126，： | 1 |
| 19 | A phenotypic-genetic study of a group of Polish patients with spinal and bulbar muscular atrophy 显示文摘 | Tomik B Partyka D Su?ek A | 2006 | Amyotroph Lateral Scler2006，7，： | 1 |
| 20 | Synthesis of keto- earotenoids in the seed of Arabidopsis thaliana 显示文摘 | Stalberg K Lindgren O Ek B | 2003 | Plant J2003，36，： | 1 |
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