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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Sonic band gaps in finite elastic media:surface states and localiza tion phenomena in linear and point defects显示文摘 | F R Mentero ele Espinosa Garcia-Pablos D | 1999 | Phys Rev Lett1999，82，15： | 1 |
| 3 | Ultrasonic band gap in a periodic two-dimensional composite 显示文摘 | Montero de Espinosa F R | 1998 | Phys Rev Lett1998，80，： | 1 |
| 4 | Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus显示文摘 | Silvarifio R Sant F Espinosa G | 2011 | Lupus2011，20，7： | 1 |
| 5 | The effect of pruning and thinning on above ground aerial biomass of Eucalyptus nitens ( Deane & Maiden ) Maiden 显示文摘 | Munoz F Rnbilar R Espinosa M | 2008 | Forest Ecology and Management2008，255，： | 1 |
| 6 | Monitoring of heavy metals in topsoils, atmospheric particles and plant leaves to identify possible contamination sources 显示文摘 | Oliva S R Espinosa A J F | 2007 | Microehemical Journal2007，86，： | 1 |
| 7 | Infectivity and genome persistence of rotavirus and astrovirus in groundwater and surface water显示文摘 | Espinosa A C Mazari-Hiriart M Espinosa R MaruriAvidal L Méndez E Arias C F | 2008 | Water Res2008，42，1011： | 1 |
| 8 | Monitoring of heavy metals intopsoils,atmospheric particles and plant leaves to identifypossible contamination sources 显示文摘 | Oliva S R Espinosa A J F | 2007 | Microchemical Journal2007，86，1： | 1 |
| 9 | The effect of pruning and thinning on above ground aerial biomass of Eucalyptus nltens (Deane & Maiden) Maiden显示文摘 | Munoz F Rubilar R Espinosa M | 2008 | Forest Ecology and Management2008，255，34： | 1 |
| 10 | Ultrasonic band gap in a periodic two-dimensional composite显示文摘 | MONTERO DE ESPINOSA F R JIMENEZ E TORRES M | 1998 | Phys Rev Lett1998，80，6： | 1 |
| 11 | The effect of pruning and thinning on above ground aerial biomass of Eucalyptus nitens (Deane & Maiden) Maiden显示文摘 | Mufioz F Rubilar R Espinosa M | 2008 | Forest Ecology and Management2008，255，34： | 1 |
| 12 | Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus显示文摘 | Silvarifio R Sant F Espinosa G | 2011 | Lupus2011，20，7： | 1 |
| 13 | Multifrequency piezoelectric composites:one-dimensional modeling显示文摘 | SANCHEZ S ESPINOSA F R M LAMBERTI N | 1999 | Ultrasonics1999，37，： | 1 |
| 14 | The effect of pruning and thinning on above ground aerial biomass of Eucalyptus nitens ( Deane & Maiden ) Maiden 显示文摘 | Munoz F Ruhilar R Espinosa M | 2008 | Forest Ecology and Management2008，255，： | 1 |
| 15 | Ultrasonic band gap in a periodic two-dimensional composite显示文摘 | MONTERO D E ESPINOSA F R JIMENEZ E | 1998 | Physical Review Letters1998，80，6： | 1 |
| 16 | New technique for pulmonary artery reconstruction 显示文摘 | CEREZO F CANO J R ESPINOSA D | 2009 | Eur J Cardiothorac Surg2009，36，2： | 1 |
| 17 | Advanced and in- telligent control techniques applied to the drive control and path tracking systems on a robotic wheelchair 显示文摘 | Espinosa F Guillen E L Mateos R | 2001 | Autono- mous Robots2001，11，2： | 1 |
| 18 | The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes 显示文摘 | Liu S Liu Y Yang X Tong C Edwards D Parkin I A P Zhao M Ma J Yu J Huang S Wang X Wang J Lu K Fang Z Bancroft I Yang T J Hu Q Wang X Yue Z Li H Yang L Wu J Zhou Q Wang W King G J Chris Pires J Lu C Wu Z Sampath P Wang Z Guo H Pan S Yang L Min J Zhang D Jin D Li W Belcram H Tu J Guan M Qi C Du D Li J Jiang L Batley J Sharpe A G Park B S Ruperao P Cheng F Espinosa Waminal N Huang Y Dong C Wang L Li J Hu Z Zhuang M Huang Y Huang J Shi J Mei D Liu J Lee T Wang J Jin H Li Z Li X Zhang J Xiao L Zhou Y Liu Z Liu X Qin R Tang X Liu W Wang Y Zhang Y Lee J Kim H H Denoeud F Xu X Liang X Hua W Wang X Wang J Chalhoub B Paterson A H | 2014 | Nature Communications2014，5，： | 1 |
| 19 | Theory and experiments on elastic band gaps显示文摘 | Carcia-Pablos D Sigalas M Montero de Espinosa F R | 2000 | Physical Review Letters2000，84，19： | 1 |
| 20 | A life cycle analysis of polymer solar cell modules prepared using roll-to-roll methods under ambient conditions 显示文摘 | ESPINOSA N GARCIA-VALVERDE R KREBS F C | 2011 | Sol Energy Mater Sol Ceils2011，95，5： | 1 |
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