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| 1 | 城市规划应对气候变化的适应发展战略——英国等国的经验显示文摘通过分析当今国际上以英国等国为例的城市规划应对气候变化的适应发展方法与策略,论述城市规划作为发展战略的重要专业工具,需要在规划的政策管理体系、规划编制的内容与方法、场地规划的基础设施适应设计三个方面进一步深化研究适应发展战略,以提高城市系统的恢复能力。 | 姜允芳 Eckart Lange 石铁矛 李莉 | 2012 | 现代城市研究2012，27，1： | 17 |
| 2 | 冷冻球囊消融与冷盐水灌注射频消融治疗阵发性心房颤动的长期随访效果比较显示文摘目的探讨阵发性心房颤动(PAF)患者首次采用冷冻球囊消融(CBA)与冷盐水灌注导管射频消融(RFCA)治疗长期随访效果的差异。方法回顾性分析2011年1月至2013年6月首次接受导管消融治疗的PAF患者的住院病历资料、手术记录和门诊随访资料。根据消融方法不同分为CBA组和RFCA组。术后3个月后如有快速型房性心律失常复发的心电学证据判定为消融治疗失败。结果 158例PAF患者纳入研究,其中CBA组103例,RFCA组55例。CBA组与RFCA组术中即刻PVI成功率(98.3%vs 98.1%)和主要并发症发生率(2.9%vs 3.6%)均无明显差异。CBA组X线曝光时间短[20(14,32)min vs 28(16,43)min,P<0.000 1]、X线曝光剂量少[39783(24 528,2 455 559)mGy/cm2vs 63 306(26 478,138 753)mGy/cm2,P=0.000 7]、手术时间短[115(80,151)min vs 159(120,218)min,P<0.000 1]、消融时间短[35(24,55)min vs 49(17,71)min,P=0.000 4]。在(18±8)个月随访期内119例(75.3%)完成随访,消融治疗成功率66.9%(81/121)。消融术后3、6、9、12、24、30个月随访结果显示CBA组成功率依次为95.8%、85.9%、76.1%、69.0%、60.6%、60.6%,RFCA组成功率依次为90.0%、78.0%、78.0%、78.0%、72.0%和72.0%,两组患者消融术后成功率无明显差异。结论 CBA与RFCA治疗PAF手术安全性相似,长期随访效果无差别。 | 刘俊 唐闽 Kaufmann Jan Kriatselis Charalampos Fleck Eckart 李劲宏 方丕华 张澍 | 2014 | 中国心脏起搏与心电生理杂志2014，28，5： | 12 |
| 3 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 4 | 新一代冷冻球囊能提高冷冻消融治疗心房颤动的远期疗效显示文摘目的探讨新一代冷冻球囊能否提高冷冻消融治疗心房颤动(简称房颤)的远期疗效。方法回顾性分析2012年1月至2013年6月序贯接受冷冻球囊消融治疗的房颤患者的介入治疗与术后门诊随访资料。根据术中使用球囊类型不同将患者分为第一代(G1)组和第二代(G2)组。术后3个月后的规律门诊随访中如有房颤或心房扑动或房性心动过速复发的心电学证据则判定为冷冻消融治疗失败。术前经胸超声测量左房前后径。结果共105例患者纳入研究,其中G1组57例,G2组48例。G2组术中即刻肺静脉隔离成功率高于G1组[98.7%(150/152)vs 94.6%(174/184),P=0.042 9]。G2组不同肺静脉最低冷冻温度均明显低于G1组(P<0.01),冷冻消融时间[30(16,44)min vs 35(25,55)min,P<0.000 1]、手术时间[105(75,145)min vs 120(80,190)min,P=0.0056]、X线曝光时间[17(13,28)min vs 20(13,32)min,P=0.047 0]均明显低于G1组。G1组1例发生心包积液,G2组4例(8.3%)发生手术相关主要并发症(2例膈神经麻痹,2例短暂性脑缺血发作)。在平均13(5,20)个月随访期内73例完成随访,46例维持窦性心律。G2组冷冻消融术后成功率明显高于G1组[89.3%(25/28)vs 46.7%(21/45),P=0.0002]。生存分析亦证实G2组成功率高于G1组(Log-Rank=5.023 8,P=0.025 0)。复发患者左房内径较大[(48±7)mm vs(44±6)mm,P=0.007 9]。Logistic回归分析显示采用新球囊[RR=9.524(2.511,36.121),P=0.000 9]与冷冻消融成功率提高独立相关。结论采用新一代冷冻球囊冷冻消融治疗房颤不仅能够缩短术中冷冻标测和消融时间,提高即刻肺静脉隔离成功率,还能提高远期随访成功率,但是在早期应用中主要并发症发生率稍高。 | 刘俊 Jan Kaufmann Charalampos Kriatselis Eckart Fleck 张澍 李劲宏 方丕华 | 2014 | 中国心脏起搏与心电生理杂志2014，28，6： | 8 |
| 5 | 单次冷冻球囊消融治疗心房颤动长期随访效果显示文摘目的分析冷冻球囊消融(CBA)治疗心房颤动(房颤)患者的单中心长期随访效果,探讨影响其疗效的相关临床因素。方法回顾性分析2009年1月至2013年4月接受CBA治疗的房颤患者的住院病历资料、手术记录和门诊随访资料。术前经胸超声测量左心房内径(LAD)。术后3个月后出现的房颤、心房扑动(房扑)、房性心动过速(房速)发作判定为CBA治疗失败。结果 199例房颤接受CBA治疗,术中并发膈神经麻痹3例(1.5%),术后发生心包积液1例(0.5%)、短暂性脑缺血发作1例(0.5%),均自行缓解。在平均(23±14)个月随访中152例患者完成随访,其中65例(42.8%)治疗成功,失败患者中75例(86.2%)为术后12个月内复发。失败患者年龄较大[(62±7)比(52±10),P=0.0379]、LAD较大[(47±7)mm比(43±6)mm,P<0.0001],持续性房颤患者治疗成功率(29.5%)明显低于阵发性房颤患者(48.1%)。Logistic回归分析显示年龄[OR=1.037(1.000,1.076),P=0.0488]和LAD[OR=0.896(0.842,0.953),P=0.005]能独立预测初次CBA治疗效果。结论 CBA治疗房颤安全有效,长期随访效果较好。房性心律失常复发主要发生在术后12个月内。年龄和LAD是预测术后复发的独立危险因素。 | 刘俊 唐闽 Jan Kaufmann Charalampos Kriatselis Eckart Fleck 李劲宏 方丕华 张澍 | 2014 | 中国介入心脏病学杂志2014，22，5： | 7 |
| 6 | 体视学和三维显微术:可选的还是相互竞争的显微组织定量分析技术?显示文摘随着现代三维图像显示技术的发展,使用体视学方法从二维截面估计三维几何似乎越来越显得多余了。本文将讨论这两种途径的局限性并概述两者在实际应用中的优点。对场和特征物参量及数据简约问题进行了讨论。结论是,在大量的应用中,体视学方法是表征不规则三维几何的最有效途径。当需要表征比较复杂的参数如形状、排列或尺寸分布时,应当优先采用三维直接测量手段。从二维截面分析获得的参数,对于比较研究、经验相关性分析和“指纹”识别式描述则是非常有用的。 | HANS ECKART EXNER 黄启今 孙亚 | 2003 | 中国体视学与图像分析2003，8，4： | 3 |
| 7 | KuaFu Mission显示文摘The KuaFu mission-Space Storms, Aurora and Space Weather Explorer-is an 'L1+Polar' triple satellite project composed of three spacecraft: KuaFu-A will be located at L1 and have instruments to observe solar EUV and FUV emissions, and white-light Coronal Mass Ejections (CMEs), and to measure radio waves, the local plasma and magnetic field,and high-energy particles. KuaFuB1 and KuaFu- B2 will bein polar orbits chosen to facilitate continuous 24 hours a day observation of the north polar Aurora Oval. The KuaFu mission is designed to observe the complete chain of disturbances from the solar atmosphere to geospace, including solar flares, CMEs, interplanetary clouds, shock waves, and their geo-effects, such as magnetospheric sub-storms and magnetic storms, and auroral activities. The mission may start at the next solar maximum (launch in about 2012), and with an initial mission lifetime of two to three years. KuaFu data will be used for the scientific study of space weather phenomena, and will be used for space weather monitoring and forecast purposes. The overall mission design, instrument complement, and incorporation of recent technologies will target new fundamental science, advance our understanding of the physical processes underlying space weather, and raise the standard of end-to-end monitoring of the Sun-Earth system. | XIA Lidong TU Chuanyi Schwenn Rainer Donovan Eric Marsch Eckart WANG Jingsong ZHANG Yongwei XIAO Zuo | 2006 | 空间科学学报2006，26，z1： | 3 |
| 8 | SJWD15012600002640显示文摘 | Jens Ricke Karsten Bulla Frank Kolligs Markus Peck‐Radosavljevic Peter Reimer Bruno Sangro Eckart Schott Kerstin Schütte Chris Verslype Jerzy Walecki Peter Malfertheiner | 2015 | Liver Int2015，，2： | 3 |
| 9 | Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection显示文摘 | Eckart Schott Heiko Witt Holger Hinrichsen Konrad Neumann Viola Weich Alexandra Bergk Juliane Halangk Tobias Müller Sebastian Tinjala Gero Puhl Peter Neuhaus Bertram Wiedenmann Thomas Berg | 2006 | Journal of Hepatology2006，，3： | 2 |
| 10 | 难加工材料的超声波磨削显示文摘对由陶瓷、玻璃、硬质合金、金属陶瓷、人造聚晶金刚石或纤维强化复合材料制成的工件进行切削加工,尤其是要形成复杂轮廓外形的工件时,已经证实这种加工任务是特别困难的。超声波辅助磨削加工是一种创新的工艺方法,采用这种方法可以快速和精密地加工这些难加工材料。 | Eckart Uhlmann Sven-Erik Holl | 1999 | 机电信息(北京)1999，，2： | 2 |
| 11 | 不同体位髋臼假体植入参照平面的测定及其临床意义显示文摘目的 分析卧位和站立位时骨盆倾斜度的变化情况 ,观察骨盆前平面作为髋臼假体植入的参照平面时的稳定性。方法 将 90位患者按照其髋关节的情况分为髋关节正常组、髋关节炎组和全髋关节置换术后组 ,每组中男女各 15名。用三维数字化仪系统分别测量患者仰卧位和站立位时的骨盆前平面倾斜度 ,比较各组的测量结果。结果 正常组、关节炎组和术后组卧位时骨盆前平面的倾斜度分别为 5 .91°± 3 .81°、6.12°± 3 .5 1°和 4.3 7°± 2 .2 1° ;站立位时则各为 7.5 1°± 3 .41°、6.73°± 3 .47°和 6.2 5°± 3 .3 1°。患者处于卧位和站立位时各组间骨盆前平面倾斜度的差异没有显著性 (P >0 .0 5 ) ,而且卧位到站立位 ,骨盆前平面倾斜角平均值的变化 <2°。结论 骨盆前平面作为临床手术中髋臼假体植入的参照平面是稳定、可靠的。 | 曾晖 Eckart Mayr Michael Nogler Martin Krismer | 2004 | 中华实验外科杂志2004，21，10： | 2 |
| 12 | Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure显示文摘 | Britta Vogel Andreas Keller Karen S. Frese Petra Leidinger Farbod Sedaghat-Hamedani Elham Kayvanpour Wanda Kloos Christina Backe Ann Thanaraj Thomas Brefort Markus Beier Stefan Hardt Eckart Meese Hugo A. Katus Benjamin Meder | 2013 | European Heart Journal2013，，： | 2 |
| 13 | Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs显示文摘Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic tests.Often,high-throughput approaches are applied to discover biomarker signatures.These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches.Previously,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and Germany.Here,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by RT-qPCR.We computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from controls.Further,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and B-cells.Our study represents the next important step in translational research for a miRNA-based AD test. | Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 2 |
| 14 | The propagation of gravity waves from deep to shallow water显示文摘 | Eckart C | 1952 | National Bureau of Standards Circular1952，20，： | 1 |
| 15 | Application of magnetic fluids in tribotechnical systems显示文摘 | ECKART U GUNTER S NAYIM B | 2002 | Journal of Magnetism and Magnetic Materials2002，，252： | 1 |
| 16 | Age-dependent time course of cerebral brain-derived neurotrophic factor,nerve growth factor,and neurotrophin-3 in APP23 transgenic mice显示文摘 | Schuhe-Herbrüggen O Eckart S Deicke U | 2008 | J Neurosci Res2008，86，12： | 1 |
| 17 | A prototype high-resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals显示文摘 | Sibylle I. Ziegler Bernd J. Pichler Guido Boening Magdalena Rafecas Wendelin Pimpl Eckart Lorenz Norbert Schmitz Markus Schwaiger | 2001 | European Journal of Nuclear Medicine and Molecular Imaging2001，，2： | 1 |
| 18 | The impact of crop growth sub-model choice on simulated water and nitrogen balances 显示文摘 | Eckart Priesack Sebastian Gayler Hans P Hartmann | 2006 | Nutrient Cycling in Agroecosystems2006，75，7： | 1 |
| 19 | Modelling the abrasive flow machining process on advanced ceramic materi- als显示文摘 | Eckart Uhlmann Vanja Mihotovic Andre Coenen | 2009 | Journal of Materials Processing Technology2009，，209： | 1 |
| 20 | Extraction of building polygons from SAR images: Grouping and decision-level in the GESTALT system显示文摘 | Eckart Michaelsen Uwe Stilla Uwe Soergel Leo Doktorski | 2009 | Pattern Recognition Letters2009，，10： | 1 |
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