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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?显示文摘AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality. | Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey Eli García-Ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria José María Remes-Troche | 2015 | World Journal of Hepatology2015，7，17： | 2 |
| 4 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 5 | The Influence of Owner- ship and Control Structures on Firms' Performance: Evidence from Brazil显示文摘 | Dante Mendes Aldrighi Aquiles Elie Guimaraes Kalatzis Ales- sandro Vin i cius Marques de Oliveira | 2009 | Working paper2009，，： | 1 |
| 6 | Halitosis measurement by an industrial sulphide monitor显示文摘 | Rosenberg M Septon I Eli I | 1991 | J Periodontol1991，62，： | 1 |
| 7 | Chronic kidney disease in lithium-trealed older adults: a review of epidemiology, mecha- nisms, and implications for the treatment of late-life mood dis- orders显示文摘 | REJ S ELIE D MUCSI I | 2015 | Drugs Aging2015，32，1： | 1 |
| 8 | Halitosis measurements by an industrial sulphide monitor显示文摘 | Rosenberg M Septon I Eli I | 1991 | J Periodontol1991，62，5： | 1 |
| 9 | Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western C?te d’Ivoire显示文摘 | Giovanna Raso Eliézer K N'Goran Abale Toty Anne Luginbühl Cynthia A Adjoua Norbert T Tian-Bi Isaac I Bogoch Penelope Vounatsou Marcel Tanner Jürg Utzinger | 2003 | Transactions of the Royal Society of Tropical Medicine and Hygiene2003，，1： | 1 |
| 10 | Antecedents of dental anxiety :learnedresponses versus personality traits 显示文摘 | Eli I Uziel N Baht R | 1997 | Cammunity Dent Oral Epidemiol1997，25，3： | 1 |
| 11 | Effectiveness of computerized delivery of intrasulcular anesthetic in primary molars 显示文摘 | ASHKENAZI M BLUMER S ELI I | 2005 | J Am Dent Assoc2005，136，10： | 1 |
| 12 | Antecedents of dental anxiety:learned responses versus personality traits显示文摘 | Uziel N Baht R | 1997 | Commnity Dent Oral Epidemiol1997，25，： | 1 |
| 13 | Halitosis measurement by an industrial sulphide monitor显示文摘 | Rosenberg M Septon I Eli I | 1991 | J Periodontol1991，62，8： | 1 |
| 14 | Expression and biological effects of bone morphogenetic protein-15 in the hen ovary 显示文摘 | Elis S Dupont J Couty I | 2007 | J Endocrinol2007，194，： | 1 |
| 15 | Anministration of abciximab to patients receiving tirofiban or eptifibatide: effect on platelet function 显示文摘 | Julio I O | 2001 | J Am Coll Cardiol2001，，37： | 1 |
| 16 | Stand microclimate and physiological activity of tree leaves in an oak-hornbeam forest显示文摘 | Marek M Masarovi(c)ová E Kratochvilová I Eliá(s) P Janou(s) D | | 0，，： | 1 |
| 17 | Antibiotic TA-a new adherent agent for the treatment of periodontal disease显示文摘 | Eli I Judes H Varon M | 1988 | Refuat Hashinayim1988，6，2： | 1 |
| 18 | Effect of adhesive antibiotic TA on plaque and gingivitis in man显示文摘 | Manor A Eli I Varon M | 1989 | J Clin Periodontol1989，16，10： | 1 |
| 19 | Treatment of As- pirin-Resistant Patients With Omega-3 Fatty Acids Ver-sus Aspirin Dose Escalation 显示文摘 | Eli I L Alejandro S Naama H | 2010 | Journal of the American College of Cardiology2010，55，2： | 1 |
| 20 | Halitosis measurement by an industrial sulphide monitor显示文摘 | Rosenberg M Septon I Eli I | 1991 | J Periodnntol1991，62，8： | 1 |
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