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| 1 | Recent advances and applications of deep learning methods in materials science显示文摘Deep learning(DL)is one of the fastest-growing topics in materials data science,with rapidly emerging applications spanning atomistic,image-based,spectral,and textual data modalities.DL allows analysis of unstructured data and automated identification of features.The recent development of large materials databases has fueled the application of DL methods in atomistic prediction in particular.In contrast,advances in image and spectral data have largely leveraged synthetic data enabled by high-quality forward models as well as by generative unsupervised DL methods.In this article,we present a high-level overview of deep learning methods followed by a detailed discussion of recent developments of deep learning in atomistic simulation,materials imaging,spectral analysis,and natural language processing.For each modality we discuss applications involving both theoretical and experimental data,typical modeling approaches with their strengths and limitations,and relevant publicly available software and datasets.We conclude the review with a discussion of recent cross-cutting work related to uncertainty quantification in this field and a brief perspective on limitations,challenges,and potential growth areas for DL methods in materials science. | Kamal Choudhary Brian DeCost Chi Chen Anubhav Jain Francesca Tavazza Ryan Cohn Cheol Woo Park Alok Choudhary Ankit Agrawal Simon J.L.Billinge Elizabeth Holm Shyue Ping Ong Chris Wolverton | 2022 | npj Computational Materials2022，，1： | 9 |
| 2 | On computer simulation methods to model Zener pinning 显示文摘 | Azmir Harun Elizabeth A Holm Mike P Clode | | Aeta Mater0，，： | 1 |
| 3 | Quantification and Phenotypic Characterization of Circulating Tumor Cells for Monitoring Response to a Preventive HER2/neu Vaccine-Based Immunotherapy for Breast Cancer: A Pilot Study显示文摘 | Alexander Stojadinovic MD Elizabeth A. Mittendorf MD Jarrod P. Holmes MD Asna Amin MD Matthew T. Hueman MD Sathibalan Ponniah PhD George E. Peoples MD | 2007 | Annals of Surgical Oncology2007，，12： | 1 |
| 4 | Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota显示文摘 | Purna C. Kashyap Angela Marcobal Luke K. Ursell Samuel A. Smits Erica D. Sonnenburg Elizabeth K. Costello Steven K. Higginbottom Steven E. Domino Susan P. Holmes David A. Relman Rob Knight Jeffrey I. Gordon Justin L. Sonnenburg | 2013 | Proceedings of the National Academy of Sciences2013，，42： | 1 |
| 5 | Survey of computed grain boundary properties in face-centered cubic metals: I. Grain boundary energy显示文摘 | David L. Olmsted Stephen M. Foiles Elizabeth A. Holm | 2009 | Acta Materialia2009，，13： | 1 |
| 6 | Comparison of Quality-of-Life Instruments in Adults with Strabismus显示文摘 | Sarah R. Hatt David A. Leske Elizabeth A. Bradley Stephen R. Cole Jonathan M. Holmes | 2009 | American Journal of Ophthalmology2009，，4： | 1 |
| 7 | Microvolt T-Wave Alternans Distinguishes Between Patients Likely and Patients Not Likely to Benefit From Implanted Cardiac Defibrillator Therapy: A Solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II Conundrum显示文摘 | Daniel M. Bloomfield Richard C. Steinman Pearila B. Namerow Michael Parides Jorge Davidenko Elizabeth S. Kaufman Timothy Shinn Anne Curtis John Fontaine Douglas Holmes Andrea Russo Chuen Tang J Thomas Bigger | 2004 | Circulation2004，，14： | 1 |
| 8 | Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer显示文摘 | Atnit MAlgotar M Suzanne Stmtton Frederick R Ahmann James Ranger- Moore iqaytltond B Nagle Patrieia A Thompson Elizabeth Slate Chiu i4 Hsu Be L Dalkin Puneet Sindhwani Michael A Holmes John A Tuckey lt/td L Graham Howard L Parnes Lawrence C Clark Steven P Stratton | 2013 | The Prostate2013，73，3： | 1 |
| 9 | President’s Page: Having Light, Pass It On ? ? Motto of Dr. Dove’s alma mater, Wittenberg University, Springfield, Ohio.显示文摘 | James T. Dove David R. Holmes Marcia J. Jackson Elizabeth Klodas Rick A. Nishimura Patrick T. O’Gara | 2007 | Journal of the American College of Cardiology2007，，1： | 1 |
| 10 | Variation in Incidence of Pediatric Crohn?s Disease in Relation to Latitude and Ambient Ultraviolet Radiation: A Systematic Review and Analysis显示文摘 | Elizabeth A. Holmes Fan Xiang Robyn M. Lucas | 2015 | Inflammatory Bowel Diseases2015，，4： | 1 |
| 11 | Relationship between health locus of control, health value, and social support and compliance of persons with diabetes mellitus显示文摘 | Elizabeth A Schlenk R Holm C | 1984 | Prahetes Care1984，7，6： | 1 |
| 12 | The computer simulation of microstructural evolution 显示文摘 | Elizabeth A Holm Corbett C Battaile | 2001 | JOM2001，53，9： | 1 |
| 13 | 购买精品或成时尚趋势显示文摘2014年9月20日The Wall Streets Journal几十个设计师和品牌在纽约时装周展示其2015春装系列。在时装周的嘈杂与纷繁之下,一些专家表示,一场"少买点买精品"的运动正在发酵。 | Elizabeth Holmes | 2014 | 中国制衣2014，0，11： | 0 |
| 14 | Investigational growth factors utilized in animal models of spinal fusion: Systematic review显示文摘BACKGROUND Over 400000 Americans annually undergo spinal fusion surgeries, yet up to 40%of these procedures result in pseudoarthrosis even with iliac crest autograft, the current 'gold standard' treatment. Tissue engineering has the potential to solve this problem via the creation of bone grafts involving bone-promoting growth factors(e.g., bone morphogenetic protein 2). A broad assessment of experimental growth factors is important to inform future work and clinical potential in this area. To date, however, no study has systematically reviewed the investigational growth factors utilized in preclinical animal models of spinal fusion.AIM To review all published studies assessing investigational growth factors for spinal fusion in animal models and identify promising agents for translation.METHODS We conducted a systematic review of the literature using PubMed, Embase,Cochrane Library, and Web of Science databases with searches run on May 29 th,2018. The search query was designed to include all non-human, preclinical animal models of spinal fusion reported in the literature without a timespan limit. Extracted data for each model included surgical approach, level of fusion,animal species and breed, animal age and sex, and any other relevant characteristics. The dosages/sizes of all implant materials, spinal fusion rates,and follow-up time points were recorded. The data were analyzed and the results reported in tables and text. PRISMA guidelines were followed for this systematic review.RESULTS Twenty-six articles were included in this study, comprising 14 experimental growth factors: AB204(n = 1); angiopoietin 1(n = 1); calcitonin(n = 3);erythropoietin(n = 1); basic fibroblast growth factor(n = 1); growth differentiation factor 5(n = 4), combined insulin-like growth factor 1 +transforming growth factor beta(n = 4); insulin(n = 1); NELL-1(n = 5); noggin(n= 1); P-15(n = 1); peptide B2 A(n = 2); and secreted phosphoprotein 24(n = 1).The fusion rates of the current gold standard treatment(autologous iliac crest bone graft, ICBG) and the leading clinically used growth factor(BMP-2) ranged widely in the included studies, from 0-100% for ICBG and from 13%-100% for BMP-2. Among the identified growth factors, calcitonin, GDF-5, NELL-1, and P-15 resulted in fusion rates of 100% in some cases. In addition, six growth factors-AB204, angiopoietin 1, GDF-5, insulin, NELL-1, and peptide B2 A-resulted in significantly enhanced fusion rates compared to ICBG, BMP-2, or other internal control in some studies. Large heterogeneity in animal species, fusion method,and experimental groups and time points was observed across the included studies, limiting the direct comparison of the growth factors identified herein.CONCLUSION Several promising investigational growth factors for spinal fusion have been identified herein; directly comparing the fusion efficacy and safety of these agents may inform clinical translation. | Ethan Cottrill A Karim Ahmed Noah Lessing Zachary Pennington Wataru Ishida Alexander Perdomo-Pantoja Sheng-fu Lo Elizabeth Howell Christina Holmes C Rory Goodwin Nicholas Theodore Daniel M Sciubba Timothy F Witham | 2019 | World Journal of Orthopedics2019，10，4： | 0 |
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