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| 1 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 2 | Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma显示文摘 | Lei Zheng Jing Xue Elizabeth M. Jaffee Aida Habtezion | 2013 | Gastroenterology2013，，6： | 4 |
| 3 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 4 | PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors显示文摘 | Kevin C. Soares Agnieszka A. Rucki Annie A. Wu Kelly Olino Qian Xiao Yi Chai Anthony Wamwea Elaine Bigelow Eric Lutz Linda Liu Sheng Yao Robert A. Anders Daniel Laheru Christopher L. Wolfgang Barish H. Edil Richard D. Schulick Elizabeth M. Jaffee Lei Zhen | 2015 | Journal of Immunotherapy2015，，1： | 2 |
| 5 | Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy显示文摘 | Eric R Lutz Heather Kinkead Elizabeth M Jaffee Lei Zheng | 2014 | OncoImmunology2014，，： | 1 |
| 6 | Vaccine Impedes the Development of Reflux-Induced Esophageal Cancer in a Surgical Rat Model: Efficacy of the Vaccine in a Pre-Barrett’s Esophagus Setting显示文摘 | Tomoharu Miyashita Furhawn A. Shah Guy Marti Jiaai Wang Todd Armstrong Pramod Bonde Michael K. Gibson Kiyoshi Yoshimura Elizabeth A. Montgomery Mark D. Duncan Elizabeth M. Jaffee John W. Harmon | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 1 |
| 7 | Mechanisms of Immune Evasion by Tumors显示文摘 | Charles G. Drake Elizabeth Jaffee Drew M. Pardoll | 2006 | Advances in Immunology2006，，： | 1 |
| 8 | Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival显示文摘 | Alessandra De Remigis Tanja D. de Gruijl Jennifer N. Uram Schey‐Cherng Tzou Shintaro Iwama Monica V. Talor Todd D. Armstrong Saskia J.A.M. Santegoets Susan F. Slovin Lei Zheng Daniel A. Laheru Elizabeth M. Jaffee Winald R. Gerritsen Alfons J.M. van den Ee | 2015 | Int. J. Cancer2015，，1： | 1 |
| 9 | The Impact of Macular Edema on Visual Function in Intermediate, Posterior, and Panuveitis显示文摘 | Simon R. J. Taylor Susan L. Lightman Elizabeth A. Sugar Glen J. Jaffe William R. Freeman Michael M. Altaweel Igor Kozak Janet T. Holbrook Douglas A. Jabs John H. Kempen | 2012 | Ocular Immunology and Inflammation2012，，3： | 1 |
| 10 | Harnessing Immune Responses in the Tumor Microenvironment: All Signals Needed显示文摘 | Dung T. Le Elizabeth M. Jaffee | 2013 | Clinical Cancer Research2013，，： | 1 |
| 11 | 肿瘤反应性T细胞作为癌症治疗方法的应用显示文摘理论上讲。相对于其他类型的癌症治疗方法,激活肿瘤特异性T细胞应答有以下优势:首先,不论肿瘤位于身体何处——即使在深部组织床,T细胞都能归巢到抗原表达肿瘤区;其次,T细胞可在癌细胞表达的具有免疫原性的蛋白刺激下持续增殖直至所有肿瘤细胞被清除;最后,可以产生免疫记忆,如果肿瘤复发可以借此清除表达抗原的肿瘤。本文将重点阐述两种刺激肿瘤特异性T细胞免疫的方法:通过接种癌症疫苗进行主动免疫和通过T细胞过继免疫输注免疫活性T细胞。临床前研究及临床研究均显示,调节肿瘤微环境来促进免疫应答的意义和重要性与激活最适当的效应T细胞相当。未来激活T细胞免疫来治疗癌症的方法需要将分别针对肿瘤和T细胞的疗法结合起来。 | Mary L Disis Helga Bernhard Elizabeth M Jaffee | 2009 | 世界临床医学2009，，8： | 0 |
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