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| 1 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 2 | Long-term clinical outcome of the surgically resected intraductal papillary neoplasm of the bile duct显示文摘 | Geunyoung Jung Kwang-Min Park Seung Soo Lee Eunsil Yu Seung-Mo Hong Jihun Kim | 2012 | Journal of Hepatology2012，，4： | 4 |
| 3 | Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells显示文摘 | Miran Kim Han Chu Lee Orkhontuya Tsedensodnom Rochelle Hartley Young-Suk Lim Eunsil Yu Philippe Merle Jack R. Wands | 2008 | Journal of Hepatology2008，，5： | 2 |
| 4 | Clinical Characteristics and VPS33B Mutations in Patients With ARC Syndrome显示文摘 | Joo Young Jang Kyung Mo Kim Gu-Hwan Kim Eunsil Yu Jin-Joo Lee Young Seo Park Han-Wook Yoo | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，3： | 2 |
| 5 | Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists显示文摘The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion.Although the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions.Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine.Japan is geographically close to Korea,and academic exchanges are active.Additionally,Korean doctors are familiar with Western style medical terminology.As a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea.To solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss of nuclear polarity,thick and irregular nuclear membrane,and nucleoli. | Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | 2011 | World Journal of Gastroenterology2011，17，21： | 2 |
| 6 | Loss of E-cadherin and cytoplasmic-nuclear expression of β -catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas显示文摘 | Mi-Jung Kim Se-Jin Jang Eunsil Yu | 2008 | Human Pathology2008，，2： | 2 |
| 7 | Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma显示文摘 | Sun Och Yoon Sung-Min Chun Eun Hee Han Jene Choi Se Jin Jang Seung A Koh Shin Hwang Eunsil Yu | 2011 | Human Pathology2011，，10： | 1 |
| 8 | Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma显示文摘 | Sang-wook Lee Kyung-Ja Cho Jin-hong Park Sang Yoon Kim Soon Yuhl Nam Bong-Jae Lee Sung-Bae Kim Seung-Ho Choi Jong Hoon Kim Seung Do Ahn Seong Soo Shin Eun Kyung Choi Eunsil Yu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 9 | p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance显示文摘 | Seung-Mo Hong HyungJun Cho Christopher A. Moskaluk Eunsil Yu Alexander I. Zaika | 2007 | Journal of Molecular Histology2007，，3： | 1 |
| 10 | Neuroendocrine differentiation in extrahepatic bile duct carcinomas and its prognostic significance显示文摘 | Seung-Mo Hong Mi-Jung Kim David Y. Pi Daniel Jo Eunsil Yu Jae Y. Ro | 2005 | Human Pathology2005，，7： | 1 |
| 11 | Prevalence and risk factors of non-alcoholic fatty liver disease in potential living liver donors in Korea: A review of 589 consecutive liver biopsies in a single center显示文摘 | Ji Young Lee Kang Mo Kim Sung Gyu Lee Eunsil Yu Young-Suk Lim Han Chu Lee Young-Hwa Chung Yung Sang Lee Dong-Jin Suh | 2007 | Journal of Hepatology2007，，2： | 1 |
| 12 | Overexpression of promyelocytic leukemia protein and alteration of PML nuclear bodies in early stage of hepatocarcinogenesis 显示文摘 | Ghil-Suk Yoon Eunsil Yu | 2001 | J Korean Med Sci2001，16，： | 1 |
| 13 | Expression of metallothionein‐1 and metallothionein‐2 as a prognostic marker in hepatocellular carcinoma显示文摘 | Yangsoon Park Eunsil Yu | 2013 | J Gastroenterol Hepatol2013，，9： | 1 |
| 14 | Diagnosis of hepatic steatosis and fibrosis by transient elastography in asymptomatic healthy individuals: a prospective study of living related potential liver donors显示文摘 | Kang Mo Kim Won-Beom Choi Seong Ho Park Eunsil Yu Sung Gyu Lee Young-Suk Lim Han Chu Lee Young-Hwa Chung Yung Sang Lee Dong-Jin Suh | 2007 | Journal of Gastroenterology2007，，5： | 1 |
| 15 | Factors Predisposing Metastatic Tumor Antigen 1 Overexpression in Hepatitis B Virus Associated Hepatocellular Carcinoma显示文摘 | Young-Joo Jin Young-Hwa Chung Jeong A. Kim Won Hyung Park Danbi Lee Dong Dae Seo Soo Hyung Ryu Myoung Kuk Jang Eunsil Yu Young Joo Lee | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 16 | Factors Predisposing Metastatic Tumor Antigen 1 Overexpression in Hepatitis B Virus Associated Hepatocellular Carcinoma显示文摘 | Young-Joo Jin Young-Hwa Chung Jeong A. Kim Won Hyung Park Danbi Lee Dong Dae Seo Soo Hyung Ryu Myoung Kuk Jang Eunsil Yu Young Joo Lee | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 17 | The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma显示文摘 | Luca Di Tommaso Annarita Destro Jae Yeon Seok Emanuela Balladore Luigi Terracciano Angelo Sangiovanni Massimo Iavarone Massimo Colombo Ja June Jang Eunsil Yu So Young Jin Emanuela Morenghi Young Nyun Park Massimo Roncalli | 2009 | Journal of Hepatology2009，，4： | 1 |
| 18 | Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1‐positive hepatocellular carcinoma显示文摘 | Danbi Lee Young‐Hwa Chung Jeong A. Kim Won Hyung Park Young‐Joo Jin Ju Hyun Shim Soo Hyung Ryu Myoung Kuk Jang Eunsil Yu Young Joo Lee | 2013 | Cancer2013，，12： | 1 |
| 19 | Acute Inflammation of the Proliferative Zone of Gastric Mucosa in Helicobacter pylori Gastritis显示文摘 | Eunsil Yu Hun Kyung Lee Hae Ryun Kim Moo-Song Lee Inchul Lee | 1999 | Pathology - Research and Practice1999，，10： | 1 |
| 20 | Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases显示文摘 | Hee-Kyung Chang Eunsil Yu Jihun Kim Young Kyung Bae Kee-Taek Jang Eun Sun Jung Ghil Suk Yoon Joon Mee Kim Young-Ha Oh Han-Ik Bae Gwang Il Kim Soo Jin Jung Mi Jin Gu Jung Yeon Kim Kyu Yun Jang Sun-Young Jun Dae Woon Eom Kye Won Kwon Gyeong Hoon Kang Jae Bo | 2010 | Human Pathology2010，，8： | 1 |
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