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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey显示文摘Background:The seasonal influenza vaccine coverage rate in China is only 1.9%.There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level,even though this kind of information is important for informing national-level immunization policy decision-making.Methods:A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal perspective.Study participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in 2013.Patient-reported costs from the survey were validated by a review of hospital accounts for a small sample of the inpatients.Results:The study enrolled 529 outpatients(median age:eight years;interquartile range[IQR]:five to 20 years)and 254 inpatients(median age:four years;IQR:two to seven years).Among the outpatients,22.1%(117/529)had underlying diseases and among the inpatients,52.8%(134/254)had underlying diseases.The average total costs related to influenza-associated outpatient visits and inpatient visits were US$155(standard deviation,SD US$122)and US$1,511(SD US$1,465),respectively.Direct medical costs accounted for 45 and 69%of the total costs related to influenza-associated outpatient and inpatient visits,respectively.For influenza outpatients,the mean cost per episode in children aged below five years(US$196)was higher than that in other age groups(US$129–153).For influenza inpatients,the mean cost per episode in adults aged over 60 years(US$2,735)was much higher than that in those aged below 60 years(US$1,417–1,621).Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions(outpatients:US$186 vs.US$146;inpatients:US$1,800 vs.US$1,189).In the baseline analysis,inpatients reported costs were 18%higher than those found in the accounts review(n=38).Conclusion:The economic burden of influenza-associated outpatient and inpatient visits in China is substantial,particularly for young children,the elderly,and patients with underlying medical conditions.More widespread influenza vaccination would likely alleviate the economic burden of patients.The actual impact and cost-effectiveness analysis of the influenza immunization program in China merits further investigation. | Juan Yang Mark Jit Kathy S.Leung Ya-ming Zheng Lu-zhao Feng Li-ping Wang Eric H.Y.Lau Joseph T.Wu Hong-jie Yu | 2015 | Infectious Diseases of Poverty2015，4，1： | 44 |
| 3 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 4 | EZH2: biology, disease, and structure-based drug Jiscovery显示文摘 | Jin-zhi TAN Yan YAN Xiao-xi WANG Yi JIANG H Eric XU | 2014 | Acta Pharmacologica Sinica2014，35，2： | 21 |
| 5 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 6 | An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants显示文摘Abscisic 酸(骆驼毛的织物) 是最重要的荷尔蒙让植物抵抗干旱和另外的不能生活的压力。骆驼毛的织物直接绑在骆驼毛的织物受体的 PYR/PYL 家庭,导致类型 2C 磷酸酶(PP2C ) 和下游的骆驼毛的织物发信号的激活的抑制。骆驼毛的织物由小分子发信号的干预能帮助植物克服象干旱,寒冷和土壤咸度那样的不能生活的压力,这被想象。然而,由植物酶的化学不稳定性和快速的分解代谢限制骆驼毛的织物本身的实际申请。这里,我们报导一件小分子骆驼毛的织物的鉴定模仿(AM1 ) 那充当骆驼毛的织物受体的家庭的多重成员的有势力使活跃之物。在 Arabidopsis, AM1 激活高度类似于由骆驼毛的织物导致了那的一个基因网络。有 AM1 的处理禁止种子萌芽,阻止叶水损失,并且支持干旱抵抗。我们与 PYL2 骆驼毛的织物受体和 HAB1 PP2C 在建筑群解决了 AM1 的水晶结构,它表明 AM1 调停交往的 gate-latch-lock 网络,在骆驼毛的织物界限 receptor/PP2C 建筑群被保存的一个结构的特征。一起,这些结果证明一件单个小分子骆驼毛的织物模仿能激活多重骆驼毛的织物受体并且保护植物免受水损失和干旱应力的伤害。而且, AM1 复杂水晶结构为设计 ABA-mimicking 小分子的下一代提供一个结构的基础。 | Minjie Cao Xue Liu Yan Zhang Xiaoqian Xue X EdwardZhou Karsten Melcher Pan Gao Fuxing Wang Liang Zeng Yang Zhao Pan Deng Dafang Zhong Jian-Kang Zhu H Eric Xu Yong Xu | 2013 | Cell Research2013，23，8： | 17 |
| 7 | Site effects on earthquake ground motion based on microtremor measurements for metropolitan Beijing显示文摘A campaign of microtremor measurements was conducted in summer 2007 for assessing local site effects of seismic strong ground motion in metropolitan Beijing. Using the measurements from over 600 sites with approximately 1―2 km spacing covering the entire area inside Beijing’s 5th Beltway, we present the analysis results in the form of contours of the predominant resonant frequency, the thick- ness of the uppermost soft sediments, and the ground motion amplification factor. The microtremor- derived soft sediment thickness is generally in agreement with previous results based on much sparser borehole data, with the revealing of more short-wavelength undulations, which coincide with major geomorphological and neotectonic expressions in metropolitan Beijing. This study provides additional valuable information to the earthquake-resistant design of civil infrastructures and seismic hazard response in metropolitan Beijing. It also provides a feasible geophysical approaching to explore the 3-D structure beneath metropolitan cities. | CHEN QiFu LIU LanBo WANG WeiJun ROHRBACH Eric | 2009 | Chinese Science Bulletin2009，54，2： | 15 |
| 8 | Drug resistance mechanisms and novel drug targets for tuberculosis therapy显示文摘Drug-resistant tuberculosis(TB) poses a significant challenge to the successful treatment and control of TB worldwide.Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era.New insights into the resistant mechanisms of anti-TB drugs have been provided.Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drugresistant TB.There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis.This review summarizes the anti-TB drug resistance mechanisms,furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs.Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M.tuberculosis.However,further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance. | Md Mahmudul Islam H.M. Adnan Hameed Julius Mugweru Chiranjibi Chhotaray Changwei Wang Yaoju Tan Jianxiong Liu Xinjie Li Shouyong Tan Iwao Ojima Wing Wai Yew Eric Nuermberger Gyanu Lamichhane Tianyu Zhang | 2017 | Journal of Genetics and Genomics2017，44，1： | 15 |
| 9 | Reflective chiral meta-holography: multiplexing holograms for circularly polarized waves显示文摘By allowing almost arbitrary distributions of amplitude and phase of electromagnetic waves to be generated by a layer of sub-wavelength-size unit cells,metasurfaces have given rise to the field of meta-holography.However,holography with circularly polarized waves remains complicated as the achiral building blocks of existing meta-holograms inevitably contribute to holographic images generated by both left-handed and right-handed waves.Here we demonstrate how planar chirality enables the fully independent realization of high-efficiency meta-holograms for one circular polarization or the other.Such circular-polarization-selective meta-holograms are based on chiral building blocks that reflect either left-handed or right-handed circularly polarized waves with an orientation-dependent phase.Using terahertz waves,we experimentally demonstrate that this allows the straightforward design of reflective phase meta-holograms,where the use of alternating structures of opposite handedness yields independent holographic images for circularly polarized waves of opposite handedness with negligible polarization cross-talk. | Qiu Wang Eric Plum Quanlong Yang Xueqian Zhang Quan Xu Yuehong Xu Jiaguang Han Weili Zhang | 2018 | Light(Science & Applications)2018，7，1： | 15 |
| 10 | Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome显示文摘BackgroundObstructive 睡觉呼吸暂停(OSA ) 是在有急性冠的症候群(交流) 的病人的普通疾病并且与致命、非致命的心血管的事件的增加的风险联系。然而,在以前的学习的大多数病人与赤裸的金属 stents 被对待,样品尺寸是相对低的。学习是在病人的严厉和预后上评估 OSA 的影响的这的目标为 ACS.MethodsIn 承认了这未来的队研究,我们与交流注册了病人为冠的 angiogram/percutaneous 被就医冠的干预和经历的 polysomnography。我们把病人划分了成二个组:对严重 OSA 组中等[呼吸暂停呼吸过慢过浅索引(AHI )> 15 events/h ] 并且控制组(AHI 15 events/h ) 。他们被跟随在上面为在 32 个月上面。然后,我们在病人把 ACS 严厉和长期的主要不利心血管的事件(向) 与 OSA.ResultsFive 的不同严厉作比较百和 29 个病人总之被包括,与他们中的 76% 个一起是人和一般水准 59 | Shuo JIA Yu-Jie ZHOU Yi YU Si-Jing WU Yan SUN Zhi-Jian WANG Xiao-Li LIU Bright Eric King Ying-Xin ZHAO Dong-Mei SHI Yu-Yang LIU Zhi-Ming ZHOU | 2018 | Journal of Geriatric Cardiology2018，15，2： | 13 |
| 11 | Neural EGF-like protein 1(NELL-1):Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine显示文摘Bone tissue regeneration holds the potential to solve both osteoporosis and large skeletal defects,two problems associated with significant morbidity.The differentiation of mesenchymal stem cells into the osteogenic lineage requires a specific microenvironment and certain osteogenic growth factors.Neural EGF Like-Like molecule 1(NELL-1)is a secreted glycoprotein that has proven,both in vitro and in vivo,to be a potent osteo-inductive factor.Furthermore,it has been shown to repress adipogenic differentiation and inflammation.NELL-1 can work synergistically with other osteogenic factors such as Bone Morphogenic Protein(BMP)2 and9,and has shown promise for use in tissue engineering and as a systemically administered drug for the treatment of osteoporosis.Here we provide a comprehensive up-to-date review on the molecular signaling cascade of NELL-1 in mesenchymal stem cells and potential applications in bone regenerative engineering. | Mikhail Pakvasa Alex Alverdy Sami Mostafa Eric Wang Lucy Fu Alexander Li Leonardo Oliveira Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Tong-Chuan He Guillermo A.Ameer Russell R.Reid | 2017 | Genes & Diseases2017，4，3： | 13 |
| 12 | Modeling Soil Organic Carbon Storage and Its Dynamics in Croplands of China显示文摘Soil organic carbon (SOC) is one of the centre issues related to not only soil fertility but also environmental safety. Assessing SOC dynamics in croplands has been a challenge in China for long due to the lack of appropriate methodologies and data sources. As an alternative approach for studying SOC dynamics, process-based models are adopted to meet the needs. In this paper, a process-based model, DeNitrification-DeComposition (DNDC), was applied to quantify the SOC storage and the spatial distribution in croplands of China in 2003, with the support of a newly compiled county-level soil/ climate/land use database. The simulated results showed that the total SOC storage in the top layer (0-30 cm) of the 1.18 × 108 ha croplands of China is 4.7-5.2 Pg C in 2003 with an average value of 4.95 Pg C. The SOC storage in the northeastern provinces (1.3 Pg C) accounts for about 1/4 of the whole national totals due to their dominantly fertile soils with high organic matter content. SOC density ranges from 3.9 to 4.4 kg C m-2, with an average of 4.2 kg C m-2, a level is much lower than the world average level. The model results also indicated that high rates of SOC losses occurred in the croplands with the most common cropping patterns in China as like single soybean > maize > paddy > cotton > winter wheat and corn rotation. The results reported in this paper showed that there was still a great potential for improving SOC status in most croplands of China by adopting proper farming practices and land-use pattern. Therefore, long-term policy to protect SOC is urgently needed. | TANG Hua-jun QIU Jian-jun WANG Li-gang LI Hu LI Chang-sheng Eric van Ranst | 2010 | Agricultural Sciences in China2010，9，5： | 13 |
| 13 | Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis显示文摘Irisin,a myokine,is cleaved from the extracellular portion of fibronectin domain-containing 5 protein in skeletal muscle and myocardium and secreted into circulation as a hormone during exercise.Irisin has been found to exert protective effects against lung and heart injuries.However,whether irisin influences myocardial infarction(Ml)remains unclear.In this study we investigated the therapeutic effects of irisin in an acute Ml model and its underlying mechanisms.Adult C57BL76 mice were subjected to ligation of the left anterior descending coronary artery and treated with irisin for 2 weeks after Ml.Cardiac function was assessed using echocardiography.We found that irisin administration significantly alleviated Ml-induced cardiac dysfunction and ventricular dilation at 4 weeks post-MI.Irisin significantly reduced infarct size and fibrosis in post-MI hearts.Irisin administration significantly increased angiogenesis in the infarct border zone and decreased cardiomyocyte apoptosis,but did not influence cardiomyocyte proliferation.In human umbilical vein endothelial cells(HUVEC),irisin significantly increased the phosphorylation of ERK,and promoted the migration of HUVEC detected in wound-healing and transwell chamber migration assay.The effects of irisin were blocked by the ERK inhibitor U0126.In conclusion,irisin improves cardiac function and reduces infarct size in post-MI mouse heart.The therapeutic effect is associated with its pro-angiogenic function through activating ERK signaling pathway. | Qiao Liao Shuang Qu Lu-xun Tang Liang-peng Duo-fen He Chun-yu Zeng Wei Eric Wang | 2019 | Acta Pharmacologica Sinica2019，40，10： | 13 |
| 14 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 15 | 面向学生的远程教育模式研究--以加拿大阿萨巴斯卡大学为例显示文摘在广播电视大学向现代开放大学战略转型之际,进一步加强远程教育模式研究对我们具有重要的意义。本文对阿萨巴斯卡大学基本情况进行简要介绍,主要分析阿萨巴斯卡大学面向学生的远程教育模式之成功要素(如学分制、学分转换机制、个性化学习指导、考试制度),并提出对中国远程教育模式的几点思考。 | 杨冬梅 Eric Zengxiang Wang | 2013 | 中国远程教育2013，，1： | 11 |
| 16 | Enhancement of energy efficiency for mechanical production of fine and ultra-fine particles in comminution显示文摘This paper presents the energy requirements for mechanical production of fine and ultra-fine particles in comminution. Recent approaches for effective size reduction and energy saving in comminution are described, viz., (a) development and application of new mills/classifiers, (b) adjustment of the bead characterization in stirred bead mills, (c) hybrid comminution systems with roller-press and media mill, (d) assisted methods, and (e) simulation. | Yanmin Wang Eric Forssberg | 2007 | China Particuology2007，5，3： | 11 |
| 17 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 18 | Receiver function analysis for seismic structure of the crust and uppermost mantle in the Liupanshan area, China显示文摘A portable broadband seismic array was deployed from the northeast Tibetan Plateau to the southwest Ordos block, China. The seismic structure of the crust and uppermost mantle of the Liupanshan area is obtained using receiver function analysis of teleseismic body waves. The crustal thickness and Poisson's ratios are estimated by stacking the weighted amplitudes of receiver functions. Our results reveal complex seismic phases in the Liupanshan area, implying intense deformation at the boundary between the Tibetan Plateau and the Ordos block. The average crustal thickness is 51.5 km in the northeast Tibetan Plateau, 53.5 km in the Liupan Mountain and 50 km in the southwest Ordos block, resulting in a concave Moho beneath the Liupan Mountain. The Poisson's ratio of the Liupanshan area varies between 0.27-0.29, higher than the value of 0.25-0.26 to the east and west of the Liupan Mountain, suggesting partial melting in the lower crust. The variance in Poisson's ratio across the Liupan Mountain indicates notable changes in the crustal composition and mechanical properties, which may be formed by the northeastward flow of the Tibetan lower crust during the India-Eurasia collision. | TONG WeiWei WANG LiangShu MI Ning XU MingJie LI Hua YU DaYong LI Cheng LIU ShaoWen LIU Mian Eric SanDvol | 2007 | Science China Earth Sciences2007，50，z2： | 9 |
| 19 | 人在摔倒时股骨上端承载能力的有限元分析——(I)有限元分析模型及股骨失效准则的建立显示文摘摔跤后,骨折已成为老年人最严重的损伤之一。有限元分析被证实在股骨的结构分析中是一项非常有用的工具。我们建立了股骨上端的有限元模型,并基于有关文献中关于股骨密质骨和松质骨的强度实验数据建立了Hoffm an失效准则。有限元模型和失效准则用前人的实验结果进行了验证。结果表明:预测的松质骨失效载荷仅比实验值低0.5%,而密质骨失效载荷仅比实验值高4.2%。这说明我们建立的有限元模型结合Hoffm an失效准则将很好地预测人摔倒时股骨的承载能力。 | 樊黎霞 Eric Wang | 2006 | 生物医学工程学杂志2006，23，5： | 9 |
| 20 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
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