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| 1 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 2 | Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis显示文摘1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR ) 是涉及 2-C-methyl-D-erythritol-4-phosphate (MEP ) 的重要的酶为 isoprenoid 生合成提供基本五碳的单位的小径。在植物开发和新陈代谢调查 MEP 小径的角色,我们在 dxr 异种(GK_215C01 ) 和二根 DXR 转基因的合作抑制线上执行了详细分析, OX-DXR-L2 和 OX-DXR-L7。我们发现 dxr 异种是白化体和矮子。它从来没跑,显著地减少了毛状体的数字,大多数 stomata 不能在叶子通常关门。二根合作抑制线没有毛状体生产了更黄的开花期和白化体萼片。涉及毛状体开始的基因的抄写层次被发现强烈被假装,包括 GLABRA1,透明种皮光洁 1, TRIPTYCHON 并且细长纤弱,哪个被 gibberellic 酸(气体) 调整的表示。而 abscisic 酸(骆驼毛的织物) 的外长的申请能救 stomata 闭合缺点, GA3 的外长的申请能部分救矮子显型和 dxr 的毛状体开始,建议 GA 和骆驼毛的织物的底层贡献在 dxr 异种的显型。我们进一步发现涉及 GA 和骆驼毛的织物的 biosynthetic 小径的基因并列地被调整。这些结果显示 plastidial MEP 小径的那混乱导致光合的颜料,气体和骆驼毛的织物的 biosynthetic 缺乏,并且这样发展畸形,并且从细胞质的 mevalonate 小径的流动不是足够的救缺乏,这由 plastidial MEP 小径的阻塞引起了。这些结果在控制 isoprenoids 的生合成为 MEP biosynthetic 小径揭示一个关键角色。 | Shufan Xing Jin Miao Shuang Li Genji Qin Si Tang Haoni Li Hongya Gu Li-Jia Qu | 2010 | Cell Research2010，20，6： | 17 |
| 3 | Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis显示文摘Irisin,a myokine,is cleaved from the extracellular portion of fibronectin domain-containing 5 protein in skeletal muscle and myocardium and secreted into circulation as a hormone during exercise.Irisin has been found to exert protective effects against lung and heart injuries.However,whether irisin influences myocardial infarction(Ml)remains unclear.In this study we investigated the therapeutic effects of irisin in an acute Ml model and its underlying mechanisms.Adult C57BL76 mice were subjected to ligation of the left anterior descending coronary artery and treated with irisin for 2 weeks after Ml.Cardiac function was assessed using echocardiography.We found that irisin administration significantly alleviated Ml-induced cardiac dysfunction and ventricular dilation at 4 weeks post-MI.Irisin significantly reduced infarct size and fibrosis in post-MI hearts.Irisin administration significantly increased angiogenesis in the infarct border zone and decreased cardiomyocyte apoptosis,but did not influence cardiomyocyte proliferation.In human umbilical vein endothelial cells(HUVEC),irisin significantly increased the phosphorylation of ERK,and promoted the migration of HUVEC detected in wound-healing and transwell chamber migration assay.The effects of irisin were blocked by the ERK inhibitor U0126.In conclusion,irisin improves cardiac function and reduces infarct size in post-MI mouse heart.The therapeutic effect is associated with its pro-angiogenic function through activating ERK signaling pathway. | Qiao Liao Shuang Qu Lu-xun Tang Liang-peng Duo-fen He Chun-yu Zeng Wei Eric Wang | 2019 | Acta Pharmacologica Sinica2019，40，10： | 13 |
| 4 | Recyclable adsorbent of BiFeO_3/Carbon for purifying industrial dye wastewater via photocatalytic reproducible显示文摘It is essential to prepare highly-efficiency reproducible adsorbent for purifying industrial dye wastewater. In this work, biscuit with a layered porous structure as a template is applied to prepare a photocatalytic recyclable adsorbent of BiFeO3/Carbon nanocomposites for purifying simulative industrial dye wastewater. It is found that the structure of the prepared BiFeO3/Carbon nanocomposite is related to the natural structure of the biscuit, annealing temperatures and immersing times, demonstrated by XRD, TEM, UV-Vis and adsorptive activities. Kinetics data shows that the adsorption rate of the adsorbent to the dye is rapid and fitted well with the pseudo-second-order model, that more than 80% of dyes can be removed in the beginning 30 min. The adsorption isotherm can be perfectly described by the Langmuir model as well. It can be seen from the adsorption data that the adsorption performance can reach over 90% at pH ? 2–12, which can imply its universal utilization. The prepared BiFeO_3/Carbon nanocomposites have also displayed excellent capacities(over 90% within 30 min) for adsorption of seven different dyes and their mixed one. According to the five times photocatalytic reproducible experiments, it is proved that BiFeO_3/Carbon nanocomposites show the excellent stability and reproduction for purifying simulative industrial dyes, even the sample have been placed for one year. These research results indicate that the adsorbent BiFeO_3/Carbon can be a suitable material used in treating industrial dye wastewater potentially. | Shuang Jiao Yiming Zhao Chensha Li Binsong Wang Yang Qu | 2019 | Green Energy & Environment2019，4，1： | 8 |
| 5 | Methylation of phytohormones by the SABATH methyltransferases显示文摘In plants,one of the most common modifications of secondary metabolites is methylation catalyzed by various methyltransferases. Recently,a new class of methyltransferases,the SABATH family of methyltransferases,was found to modify phytohormones and other small molecules.The SABATH methyltransferases share little sequence similarity with other well characterized methyltransferases.Arabidopsis has 24 members of the SABATH methyltransferase genes,and a subset of them has been shown to catalyze the formation of methyl esters with phytohormones and other small molecules.Physiological and genetic analyses show that methylation of phytohormones plays important roles in regulating various biological processes in plants,including stress responses,leaf development,and seed maturation/germination.In this review,we focus on phytohormone methylation by the SABATH family methyltransferases and the implication of these modifications in plant development. | QU LiJia LI Shuang XING ShuFan | 2010 | Chinese Science Bulletin2010，55，21： | 6 |
| 6 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 7 | A new isocoumarin from metabolites of the endophytic fungus Alternaria tenuissima(Nees & T.Nees:Fr.) Wiltshire显示文摘新 isocoumarin, tenuissimasatin (1 ) ,从 endophytic 真菌 Alternaria tenuissima 的代谢物被孤立(Nees 与 T。Nees:Fr ) 和 11 已知的混合物(212 ) 的 Wiltshire,从 Erythrophleum fordii 奥利弗的 bark 被孤立,。结构和 1 的绝对配置借助于 NMR 和 CD 分析被决定。化合物 3 在人的结肠癌房间 HCT-8 上显示出选择细胞毒素的活动(IC50 = 1.78 mol/L ) 由 vitro 的 MTT 测试。另外的混合物不显示出如此的活动(IC50 > 10 mol/L ) 。 | Zhen Feng Fang Shi Shan Yu Wan Qi Zhou Xiao Guang Chen Shuang Gang Ma Yong Li Jing Qu | 2012 | Chinese Chemical Letters2012，23，3： | 5 |
| 8 | The adsorption properties of NaY zeolite for separation of ethylene glycol and 1,2-butanediol: Experiment and molecular modelling显示文摘The separation of ethylene glycol(EG)and 1,2-butanediol(1,2-BDO)azeotrope in the synthesis process of EG via coal and biomass is becoming of increasing commercial and environmental importance.Selective adsorption is deemed as the most promising methods because of energy saving and environment favorable.In this paper,NaY zeolite was used to separate 1,2-BDO from EG,and its adsorption properties was then investigated.The isotherms of EG and 1,2-BDO in vapor and liquid phases from 298 to 328 K indicated that they fitted Langmuir model quite well,and the NaY zeolite absorbent favored EG more than 1,2-BDO.The Grand Canonical Monte Carlo(GCMC)and molecular dynamics(MD)simulation techniques were conducted to investigate the competition adsorption and diffusion characteristics in different adsorption regions.It was observed that EG and 1,2-BDO molecules all have the most probable locations of the center of the 12-membered ring near the Na cations.The diffusivities of EG are lower than those of 1,2-BDO at the same adsorption concentration.At last,the breakthrough curves of the binary mixture regressed from the empirical Dose–Response model in fixed-bed column showed that the adsorption selectivity of EG could reach to as high as 2.43,verified that the NaY zeolite could effectively separate EG from 1,2-BDO.This work is also helpful for further separation of other dihydric alcohol mixtures from coal and biomass fermentation. | Pei Xiong Peng He Yixin Qu Liguo Wang Yan Cao Shuang Xu Jiaqiang Chen Muhammad Ammar Huiquan Li | 2021 | Green Energy & Environment2021，6，1： | 3 |
| 9 | Temperature-controlled Hydrothermal Synthesis of Copper(Ⅰ or Ⅱ) Coordination Polymers via a Variety of Copper Coordination Modes显示文摘Two 1D coordination polymers Cu2I(C6N3H4)2(1) and CuⅡ(C6N3H4)2·H2O(2) based on benzotriazole(Bta) were hydrothermally synthesized by controlling the crystallization temperature.Single-crystal X-ray diffraction(XRD) analyses reveal that compound 1 is a 1D tubular structure constructed from two types of 1D chains {―Cu―N=N―N―} n,where the Cu(I) ions adopt linear,triangular,and tetrahedral coordination modes to connect two types of Bta ligands via π-π interaction inside the tubular-like chain.For compound 2,the Cu(Ⅱ) ions assume a quadrilateral coordination mode linking to the Bta ligands to give 1D straight chains,which stacks through π-π interactions to construct a 2D layer structure.Further characterizations including elemental analyses,infrared IR spectra,thermogravimetric(TG) analyses and luminescence properties have been done. | QU Xue-jian WANG Shuang ZHANG Dao-jun JING Xue-min ZHANG Li-rong LI Guang-hua HUO Qi-sheng LIU Yun-ling | 2012 | Chemical Research in Chinese Universities2012，28，4： | 3 |
| 10 | Biological porous carbon encapsulated polyethylene glycol-based phase change composites for integrated electromagnetic interference shielding and thermal management capabilities显示文摘The development of functional composites with excellent thermal management capabilities and electro-magnetic interference(EMI)shielding has become extremely urgent for keeping up with the continuous improvement of the operating speed and efficiency for electronic equipment.In this study,the biolog-ical wood-derived porous carbon(WPC)was determined as the supporting material to encapsulating polyethylene glycol(PEG),and a series of WPC/PEG/Fe_(3)O_(4) phase change composites(PCCs)with excel-lent shape stability,EMI shielding and thermal management capabilities were prepared via a simple vac-uum impregnation method.The Fe_(3)O_(4) magnetic particles modified PCCs have greatly improved the EMI shielding effectiveness(SE).The EMI SE of WP-4(7.5 wt.% Fe_(3)O_(4) in PEG)can be up to 55.08 dB between 8.2−12.4 GHz,however,the WP-0 without Fe_(3)O_(4) addition is only 40.08 dB.Meanwhile,the absorption ratio of electromagnetic waves(EMW)has also increased from 75.02%(WP-0)to 85.56%(WP-4),which effectively prevents secondary pollution.In addition,after wrapping a thin layer of polydimethylsiloxane resin(PDMS),the obtained WP-4 can maintain a high heat storage capacity(109.52 J/g)and good wa-ter stability.In short,the prepared WPC/PEG/Fe_(3)O_(4) PCCs have great potential application value in the thermal management and electromagnetic shielding requirements for electronic devices. | Shuang Liu Mengjie Sheng Hao Wu Xuetao Shi Xiang Lu Jinping Qu | 2022 | Journal of Materials Science & Technology2022，，18： | 3 |
| 11 | Direct benzylation reactions from benzyl halides enabled by transition-metal-free photocatalysis显示文摘An SN2-based photochemical strategy using dithiocarbamate anion as catalyst was developed for the activation of benzyl halides,which are extremely challenging to be applied as radical precursors in visible light photocatalysis.With this transition-metal-free and oxidant-free protocol,the benzylation(or cyanomethylation)of various heterocycles including quinoxalin-2(1H)-ones,coumarin,2-phenyl-2H-indazole,1-methyl-5-phenylpyrazin-2(1H)-one,1-(fluoromethyl)cinnolin-4(1H)-one,and 2,4-dibenzyl-1,2,4-triazine-3,5(2H,4H)-dione could be realized(46 examples,up to 98%yield).Importantly,some biologically relevant 3-benzylquinoxalin-2(1H)-ones were also be synthesized under mild conditions. | Panjie Xiang Kai Sun Shuang Wang Xiaolan Chen Lingbo Qu Bing Yu | 2022 | Chinese Chemical Letters2022，33，12： | 2 |
| 12 | Comparative Study of the Genetic Diversity, Antimicrobial Resistance, and Pathogenicity of Aeromonas Isolates from Clinical Patients and Healthy Individuals显示文摘Objective This study was performed to compare the genetic diversity,virulence,and antimicrobial resistance of Aeromonas strains isolated from patients and healthy individuals.Methods A total of 38 clinical strains and 19 strains from healthy individuals were isolated from the samples collected in Ma’anshan City,Anhui Province.Their taxonomy was investigated using concatenated gyrB-cpn60 sequences,and their resistance to 12 antibiotics was evaluated.The pathogenicity of these strains was examined through beta-hemolysis,protease activity,and virulence gene assays.Results The 57 Aeromonas strains were divided into 55 sequence types.Of these types,21 were novel,suggesting that their genetic diversity was high.These Aeromonas isolates could be divided into 7 species,and the positive rates of beta-hemolysis and protease activity were 49.1%and 73.7%,respectively.The detection rate of clinical patients in terms of beta-hemolysis and protease activity was higher than that of healthy individuals.Among the four most common Aeromonas strains,A.dhakensis had the highest detection rate of virulence genes.The multidrug resistance rate of the clinical isolates was much higher than that of the strains isolated from healthy individuals.Conclusions The taxonomy,virulence properties,and antibiotic resistance of Aeromonas isolates from patients differ from those of the isolates from healthy individuals. | MENG Shuang DU Xiao Li WANG Yong Lu QU Feng Tian XIE Gui Lin ZHOU Hai Jian HU Jin Rui QIN Zheng WANG Yue KAN Biao CUI Zhi Gang | 2021 | Biomedical and Environmental Sciences2021，34，6： | 2 |
| 13 | KCNQ1 and type 2 diabetes : study in Hubei Han Chinese and meta- analysis in East Asi- an populations 显示文摘 | Zhang Shuang Qu Ke -yi Huang Han -tao | 2010 | Genes & Genomics2010，32，： | 1 |
| 14 | Noninvasive identificational diagnosis of diabetic nephropathy and non-diabetic renal disease based on clinical characteristics of Traditional Chinese Medicine symptom pattern and conventional medicine显示文摘OBJECTIVE:To study the clinical characteristics relating to differential diagnosis of diabetic nephropathy(DN) and non-diabetic renal disease(NDRD).METHODS:The subjects were patients with type 2 diabetes mellitus(T2DM) complicated with chronic kidney disease(CKD).Western medical history data and Traditional Chinese Medicine(TCM) symptom pattern were collected,and logistic regression was used to analyze.RESULTS:Blood deficiency pattern [odds ratio(OR) = 2.269,P = 0.017] and Qi stagnation pattern(OR = 1.999,P = 0.041) are independently related to DN.CONCLUSIONS:TCM factors blood deficiency pattern and Qi stagnation pattern are relating to differential diagnosis of DN and NDRD. | QU Yilun CHENG Haimei WANG Qian LI Shuang DUAN Shuwei FENG Zhe LI Weizhen JIANG Shuangshuang YANG Hongtao MAO Yonghui GENG Yanqiu LI Jijun LIU Yuning TIAN Jinzhou LIU Hongfang DONG Zheyi CHEN Xiangmei | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 1 |
| 15 | Independent oncogenic and therapeutic significance of phosphatase PRL‐3 in FLT3‐ITD–negative acute myeloid leukemia显示文摘 | Shuang Qu Bin Liu Xiaoling Guo Hongshun Shi Meifeng Zhou Li Li Shulan Yang Xiuzhen Tong Haihe Wang | 2014 | Cancer2014，，14： | 1 |
| 16 | Inhibition of the α-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells显示文摘Protein N-glycosylation plays very important roles in immunity and α-mannosidase is one of the key enzymes in N-glycosylation.This paper reports that inhibition of α-mannosidase Man2cl gene expression enhances adhesion of JurkatT cells.In comparison to the controls with normal expression of the enzyme,Jurkat cells with the inhibition of Man2clgene expression(AS cell)formed larger aggregates in culture,indicating an enhancement of adhesion between the cells.mRNA differential display analysis discovered up-regulation of several adhesion molecule genes in the AS cell.Becauseof the pivotal role played by CD54-LFA-1 interaction in immune cell interaction,this study focused on the contributionof enhanced expression of CD54 and LFA-1 to the enhanced adhesion of AS Jurkat cells.These facts,including increasedbinding of AS cells to ICAM-1-Fc,Mg^(2+)activation of the binding of AS cells to ICAM-1-Fc and enhanced aggregationof AS cells,together with the inhibiting effect of a blocking CD 11a mAb on the binding to ICAM-1-Fc and aggregationof the cells demonstrate an important contribution of enhanced CD54-LFA-1 interaction to increased adhesion betweenAS cells.The enhanced CD54-LFA-1 interaction also resulted in increased adhesion between AS Jurkat T cells and RajiB cells.In addition,AS cells showed cytoskeletal rearrangement.The data imply a biological significance of MAN2C1in T-cell functioning. | Li Qu Ji Yu Ju Shuang Ling Chen Yah Shi Zhi Guang Xiang Yi Qun Zhou Yun Tian Yin Liu Li Ping Zhu | 2006 | Cell Research2006，16，7： | 1 |
| 17 | Use of a high thoracic epidural analgesia for treatment of end-stage congestive heart failure secondary to coronary artery disease显示文摘 | Wu Shuang Fu Shiying Liu Fengqi Qu Renhai Wang Lanfeng Li Zhuqin Wang Xu | 2007 | International Journal of Cardiology2007，，2： | 1 |
| 18 | Bi-specific T1 positive-contrast-enhanced magnetic resonance imaging molecular probe for hepatocellular carcinoma in an orthotopic mouse model显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related mortality.HCC-targeted magnetic resonance imaging(MRI)is an effective noninvasive diagnostic method that involves targeting clinically-related HCC biomarkers,such as alpha-fetoprotein(AFP)or glypican-3(GPC3),with iron oxide nanoparticles.However,in vivo studies of HCC-targeted MRI utilize single-target iron oxide nanoprobes as negative(T2)contrast agents,which might weaken their future clinical applications due to tumor heterogeneity and negative MRI contrast.Ultra-small superparamagnetic iron oxide(USPIO)nanoparticles(approximately 5 nm)are potential optimal positive(T1)contrast agents.We previously verified the efficiency of AFP/GPC3-double-antibody-labeled iron oxide MR molecular probe in vitro.AIM To validate the effectiveness of a bi-specific probe in vivo for enhancing T1-weighted positive contrast to diagnose the early-stage HCC.METHODS The single-and double-antibody-conjugated 5-nm USPIO probes,including antiAFP-USPIO(UA),anti-GPC3-USPIO(UG),and anti-AFP-USPIO-anti-GPC3(UAG),were synthesized.T1-and T2-weighted MRI were performed on day 10 after establishment of the orthotopic HCC mouse model.Following intravenous injection of U,UA,UG,and UAG probes,T1-and T2-weighted images were obtained at 12,12,and 32 h post-injection.At the end of scanning,mice were euthanized,and a histologic analysis was performed on tumor samples.RESULTS T1-and T2-weighted MRI showed that absolute tumor-to-background ratios in UAG-treated HCC mice peaked at 24 h post-injection,with the T1-and T2-weighted signals increasing by 46.7%and decreasing by 11.1%,respectively,relative to pre-injection levels.Additionally,T1-weighted contrast in the UAG-treated group at 24 h post-injection was enhanced 1.52-,2.64-,and 4.38-fold compared to those observed for single-targeted anti-GPC3-USPIO,anti-AFP-USPIO,and nontargeted USPIO probes,respectively.Comparison of U-,UA-,UG-,and UAG-treated tumor sections revealed that UAG-treated mice exhibited increased stained regions compared to those observed in UG-or UA-treated mice.CONCLUSION The bi-specific T1-positive contrast-enhanced MRI probe(UAG)for HCC demonstrated increased specificity and sensitivity to diagnose early-stage HCC irrespective of tumor size and/or heterogeneity. | Xiao-Hong Ma Kun Chen Shuang Wang Si-Yun Liu Deng-Feng Li Yong-Tao Mi Zhi-Yuan Wu Chun-Feng Qu Xin-Ming Zhao | 2022 | World Journal of Gastrointestinal Oncology2022，14，4： | 1 |
| 19 | Itraconazole therapy for infant hemangioma:Two case reports显示文摘BACKGROUND Infantile hemangiomas(IHs)are the most common childhood benign tumors,showing distinctive progression characteristics and outcomes.Due to the high demand for aesthetics among parents of IH babies,early intervention is critical in some cases.β-Adrenergic blockers and corticosteroids are first-line medications for IHs,while itraconazole,an antifungal medicine,has shown positive results in recent years.CASE SUMMARY In the present study,itraconazole was applied to treat two IH cases.The therapeutic course lasted 80-90 d,during which the visible lesion faded by more than 90%.Moreover,no obvious side effects were reported,and the compliance of the baby and parents was desirable.CONCLUSION Although these outcomes further support itraconazole as an effective therapeutic choice for IHs,large-scale clinical and basic studies are still warranted to improve further treatment. | Zhe Liu Sha Lv Shuang Wang Sheng-Ming Qu Gui-Yun Zhang Yi-Tong Lin Lei Yang Fu-Qiu Li | 2021 | World Journal of Clinical Cases2021，9，28： | 1 |
| 20 | Portable quantitative phase microscope for material metrology and biological imaging显示文摘Quantitative phase microscopy(QPM)has emerged as an important tool for material metrology and biological imaging.For broader adoption in those applications,we have proposed and demonstrated a new portable off-axis QPM method,which works in both transmission and reflection modes to meet different sample measurement requirements.The temporal and spatial sensitivities of our system,as quantified by optical path-length difference values,are 0.65 nm and 1.04 nm,respectively.To demonstrate its applicability for a wide range of applications,we deployed our system for profiling transistor gold electrode samples,observing red blood cell membrane fluctuations,imaging living cells flowing in a microfluidic chip,etc.Our portable QPM system has a low-cost design and involves a simple and robust phase-retrieval algorithm that we envision will allow for broader deployment at different environmental settings,including in resource-limited sites and integration with other metrology or imaging modalities. | Mengxuan Niu Gang Luo Xin Shu Fuyang Qu Shuang Zhou Yi-Ping Ho Ni Zhao Renjie Zhou | 2020 | Photonics Research2020，8，7： | 1 |
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