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| 1 | Human embryonic stem cell-derived mesenchymal stem cells improved premature ovarian failure显示文摘BACKGROUND Premature ovarian failure(POF)affects many adult women less than 40 years of age and leads to infertility.According to previous reports,various tissue-specific stem cells can restore ovarian function and folliculogenesis in mice with chemotherapy-induced POF.Human embryonic stem cells(ES)provide an alternative source for mesenchymal stem cells(MSCs)because of their similarities in phenotype and immunomodulatory and anti-inflammatory characteristics.Embryonic stem cell-derived mesenchymal stem cells(ES-MSCs)are attractive candidates for regenerative medicine because of their high proliferation and lack of barriers for harvesting tissue-specific MSCs.However,possible therapeutic effects and underlying mechanisms of transplanted ES-MSCs on cyclophosphamide and busulfan-induced mouse ovarian damage have not been evaluated.AIM To evaluate ES-MSCs vs bone marrow-derived mesenchymal stem cells(BMMSCs)in restoring ovarian function in a mouse model of chemotherapy-induced premature ovarian failure.METHODS Female mice received intraperitoneal injections of different doses of cyclophosphamide and busulfan to induce POF.Either human ES-MSCs or BMMSCs were transplanted into these mice.Ten days after the mice were injected with cyclophosphamide and busulfan and 4 wk after transplantation of the ESMSCs and/or BM-MSCs,we evaluated body weight,estrous cyclicity,folliclestimulating hormone and estradiol hormone concentrations and follicle count were used to evaluate the POF model and cell transplantation.Moreover,terminal deoxynucleotidyl transferase mediated 2-deoxyuridine 5-triphosphate nick end labeling,real-time PCR,Western blot analysis and immunohistochemistry and mating was used to evaluate cell transplantation.Enzyme-linked immunosorbent assay was used to analyze vascular endothelial growth factor,insulin-like growth factor 2 and hepatocyte growth factor levels in ES-MSC condition medium in order to investigate the mechanisms that underlie their function.RESULTS The human ES-MSCs significantly restored hormone secretion,survival rate and reproductive function in POF mice,which was similar to the results obtained with BM-MSCs.Gene expression analysis and the terminal deoxynucleotidyl transferase mediated 2-deoxyuridine 5-triphosphate nick end labeling assay results indicated that the ES-MSCs and/or BM-MSCs reduced apoptosis in the follicles.Notably,the transplanted mice generated new offspring.The results of different analyses showed increases in antiapoptotic and trophic proteins and genes.CONCLUSION These results suggested that transplantation of human ES-MSCs were similar to BM-MSCs in that they could restore the structure of the injured ovarian tissue and its function in chemotherapy-induced damaged POF mice and rescue fertility.The possible mechanisms of human ES-MSC were related to promotion of follicular development,ovarian secretion,fertility via a paracrine effect and ovarian cell survival. | Khadijeh Bahrehbar Mojtaba Rezazadeh Valojerdi Fereshteh Esfandiari Rouhollah Fathi Seyedeh-NafisehHassani Hossein Baharvand | 2020 | World Journal of Stem Cells2020，12，8： | 12 |
| 2 | Loss of offsite power (LOOP) accident analysis by integration of deterministic and probabilistic approaches in Bushehr-1 VVER-1000/V446 nuclear power plant显示文摘The results of an accident analysis for the loss of offsite power(LOOP)scenario in a reference Bushehr-1 VVER-1000/V446 nuclear power plant(NPP)are presented in this paper.This study attempted to provide a better analysis of LOOP accident management by integrating deterministic and probabilistic approaches.The RELAP5 code was used to investigate the occurrence of specific thermal–hydraulic phenomena.The probabilistic safety assessment of the LOOP accident is presented using the SAPHIRE software.LOOP accident data were extracted from the Bushehr NPP final safety analysis reports and probabilistic safety analysis reports.A deterministic approach was used to reduce the core damage frequency in the probabilistic analysis of LOOP accidents.The probabilistic approach was used to better observe the philosophy of defense in depth and safety margins in the deterministic analysis of the LOOP accident.The results show that the integration of the two approaches in LOOP accident investigations improved accident control. | Mohsen Esfandiari Gholamreza Jahanfarnia Kamran Sepanloo Ehsan Zarifi | 2022 | Nuclear Science and Techniques2022，33，5： | 2 |
| 3 | A proinflamma- tory role of IL-18 in the development of spontaneous auto- immune disease 显示文摘 | Esfandiari E McInnes IB Lindop G | 2001 | I mmunol2001，167，9： | 1 |
| 4 | A proinflammatoryrole of IL-18in the development of spontaneous autoin-mune disease显示文摘 | Esfandiari E Mclnnes IB Lindop G | 2001 | J Immunol2001，167，9： | 1 |
| 5 | Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro显示文摘 | Esfandiari N Falcone T Golderg J M | 2005 | Reprod Biomed Online2005，11，5： | 1 |
| 6 | Output feedback stabilization of fully linearizable systems显示文摘 | ESFANDIARI F KHALIL H K | 1992 | Int J Contr1992，56，： | 1 |
| 7 | Utility of the nitroblue tetrazoli-um reduction test for assessment of free radical production by seminal leukocytes and spermatozoa显示文摘 | Esfandiari N | | 0，，： | 1 |
| 8 | Courses of malignant pheo- chromocytoma: implications for therapy 显示文摘 | Sisson JC Shulkin BL Esfandiari NH | 2006 | Ann N Y Acad Sci2006，1073，： | 1 |
| 9 | Addition of low dose hCG to rFSh benefits older women during ovarian stimulation for IVF 显示文摘 | Gomaa H Casper RF Esfandiari N | 2012 | Re- prod Biol Endocrino12012，10，： | 1 |
| 10 | Heat-shock proteins modulate the incidence of apoptosis and oxidative stress in reimplantation mouse embryos 显示文摘 | Esfandiari N Falcone T Goldberg JM | 2007 | Fertil Steril2007，87，5： | 1 |
| 11 | Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro显示文摘 | ESFANDIARI N FALCONE T GOLDBERG J M | 2005 | Reprod Biomed Online2005，11，5： | 1 |
| 12 | Application of the optimization method for estimating in filtration Characteristics in furrow irrigation and its comparison with other methods显示文摘 | Esfandiari M Maheshwari B L | 1997 | Agricultural Water Management1997，34，2： | 1 |
| 13 | The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients 显示文摘 | Bentov Y Esfandiari N Burstein E | 2010 | Fertil steril2010，93，1： | 1 |
| 14 | Field values of the shape factor for estimating surface storage in furrows on clay soil显示文摘 | Esfandiari M Maheshwari B L | 1997 | Irrigation Science1997，17，4： | 1 |
| 15 | Protein supplementation and the incidence of apoptosis and oxidative stress in mouse embryos显示文摘 | ESFANDIARI N FALCONE T AGARWAL A | 2005 | Obstet Gynecol2005，105，3： | 1 |
| 16 | Application of the optimization method for estimating infiltration characteristics in furrow irrigation and its comparison with other methods显示文摘 | Esfandiari M Maheshwari B L | 1997 | Agric Water Manage1997，，34： | 1 |
| 17 | Remifentanil Added to Propofol for Induction of Anesthesia Can Reduce Reorientation Time After Electroconvulsive Therapy in Patients With Severe Mania显示文摘 | Farzin Rezaei Karim Nasseri Gholam Reza Esfandiari Sayed Mohammad Hossein Sadeghi Mohammad Fathie Fardin Gharibi | 2012 | The Journal of Electroconvulsive Therapy2012，，2： | 1 |
| 18 | Combined effects of IL-12 and IL-18 on the induction of collagen- induced arthritis显示文摘 | Leung B P Mcinnes I B Esfandiari E | 2000 | J Immunol2000，164，12： | 1 |
| 19 | Complete failed fertilization after intracytoplasmic sperm injection--analy- sis of 10 years' data显示文摘 | Esfandiari N Javed MH Gotlieb L | 2005 | Int J Fertil Womens Med2005，50，4： | 1 |
| 20 | Complete failed fertilization after intracytoplasmic sperm injection-analysis of 10 years' data显示文摘 | Esfandiari N Javed MH Gotlieb L | 2005 | Int J Fertil Womens Med2005，50，： | 1 |
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