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| 1 | Retrospective cohort study Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘AIM:To identify the most effective endoscopic biliary drainage technique for patients with hilar cholangiocarcinoma.METHODS:In total,118 patients with hilar cholangiocarcinoma underwent endoscopic management[endoscopic nasobiliary drainage(ENBD)or endoscopic biliary stenting]as a temporary drainage in our institution between 2009 and 2014.We retrospectively evaluated all complications from initial endoscopic drainage to surgery or palliative treatment.The risk factors for biliary reintervention,post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis,and percutaneous transhepatic biliary drainage(PTBD)were also analyzed using patient-and procedure-related characteristics.The risk factors for bilateral drainage were examined in a subgroup analysis of patients who underwent initial unilateral drainage.RESULTS:In total,137 complications were observed in92(78%)patients.Biliary reintervention was required in 83(70%)patients.ENBD was significantly associated with a low risk of biliary reintervention[odds ratio(OR)=0.26,95%CI:0.08-0.76,P=0.012].Post-ERCP pancreatitis was observed in 19(16%)patients.An absence of endoscopic sphincterotomy was significantly associated with post-ERCP pancreatitis(OR=3.46,95%CI:1.19-10.87,P=0.023).PTBD was required in 16(14%)patients,and Bismuth type III or IV cholangiocarcinoma was a significant risk factor(OR=7.88,95%CI:1.33-155.0,P=0.010).Of 102 patients with initial unilateral drainage,49(48%)required bilateral drainage.Endoscopic sphincterotomy(OR=3.24,95%CI:1.27-8.78,P=0.004)and Bismuth II,III,or IV cholangiocarcinoma(OR=34.69,95%CI:4.88-736.7,P<0.001)were significant risk factors for bilateral drainage.CONCLUSION:The endoscopic management of hilar cholangiocarcinoma is challenging.ENBD should be selected as a temporary drainage method because of its low risk of complications. | Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Taiki Kudo Yoko A Taya Shuhei Kawahata Yoshimasa Kubota Kimitoshi Kubo Kazunori Eto Nobuyuki Ehira Hiroaki Yamato Manabu Onodera Naoya Sakamoto | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，9： | 26 |
| 2 | Cholangiopancreatography troubleshooting:the usefulness of endoscopic retrieval of migrated biliary and pancreatic stents显示文摘BACKGROUND:Stent migration in the hepatopancreatic duct might arise as one of the rare complications associated with biliary or pancreatic stenting.Although there are some procedures to retrieve the migrated stent,including surgical,percutaneous,and endoscopic approaches,endoscopy should be attempted first because it is least invasive.This study set out to evaluate the usefulness of endoscopic retrieval of migrated biliary and pancreatic stents.METHODS:Plastic stents that migrated in the bile duct(35 patients)or pancreatic duct(2)were retrieved with endoscopic retrograde cholangiopancreatography.Devices used were snare forceps,a basket catheter,grasping forceps,biopsy forceps,a balloon catheter,and the Soehendra stent retriever.RESULTS:Endoscopic retrieval of migrated stents was performed successfully in 36(97.0%)of the 37 patients.The devices utilized for successful treatment were basket catheter(13 patients),grasping forceps(10),snare forceps(8),balloon catheter(3),biopsy forceps(1),and the Soehendra stent retriever(1).The unsuccessfully treated patient with chronic pancreatitis underwent surgery since the guide wire did not move forward due to bile duct stenosis,and there was also duodenal stenosis.One patient developed mild pancreatitis after withdrawal of the stent;the pancreatitis was relieved with conservative treatment.CONCLUSIONS:Endoscopic retrieval of migrated biliary and pancreatic stents appears to be useful because of its safety and low invasiveness.However,various forceps should be prepared for the retrieval of a migrated stent. | Yuji Sakai Toshio Tsuyuguchi Takeshi Ishihara Harutoshi Sugiyama Reiko Eto Tatsuya Fujimoto Shin Yasui Ryo Tamura Seiko Togo Motohisa Tada Osamu Yokosuka | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 3 | Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA显示文摘Schwannomas are peripheral nerve tumors that are typically solitary and benign.Their diagnosis is largely based on surgically resected specimens.Recently,a number of case reports have indicated that retroperitoneal schwannomas could be diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).We report the diagnosis of three cases of schwannoma using EUS-FNA.Subjects were two males and one female,ages 22,40,and 46 years,respectively,all of whom were symptom-free.Imaging findings showed well-circumscribed round tumors.However,as the tumors could not be diagnosed using these findings alone,EUS-FNA was performed.Hematoxylin-eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear palisading.There was no disparity in nuclear sizes.Immunostaining revealed S-100 protein positivity and all cases were diagnosed as schwannomas.Ki-67 indexes were 3%-15%,2%-3%,and 3%,respectively.No case showed any signs of malignancy.As most schwannomas are benign tumors and seldom become malignant,we observed these patients without therapy.All tumors demonstrated no enlargement and no change in characteristics.Schwannomas are almost always benign and can be observed following diagnosis by EUS-FNA. | Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Nobuyuki Ehira Hiroaki Yamato Kazunori Eto Kanako Kubota Masahiro Asaka | 2011 | World Journal of Gastroenterology2011，17，29： | 8 |
| 4 | Fetal stem cell transplantation: Past, present, and future显示文摘Since 1928, human fetal tissues and stem cells have been used worldwide to treat various conditions. Although the transplantation of the fetal midbrain substantia nigra and dopaminergic neurons in patients suffering from Parkinson's disease is particularly noteworthy, the history of other types of grafts, such as those of the fetal liver, thymus, and pancreas, should be addressed as there are many lessons to be learnt for future stem cell transplantation. This report describes previous practices and complications that led to current clinical trials of isolated fetal stem cells and embryonic stem(ES) cells. Moreover, strategies for transplantation are considered, with a particular focus on donor cells, cell processing, and the therapeutic cell niche, in addition to ethical issues associated with fetal origin. With the advent of autologous induced pluripotent stem cells and ES cells, clinical dependence on fetal transplantation is expected to gradually decline due to lasting ethical controversies, despite landmark achievements. | Tetsuya Ishii Koji Eto | 2014 | World Journal of Stem Cells2014，6，4： | 4 |
| 5 | New aspect of development of high strength aluminum alloys for aerospace applications显示文摘 | Manabu Nakai Takehiko Eto | 2000 | Materials Science & Engineering A2000，，1： | 3 |
| 6 | Influence of the safety and diagnostic accuracy of preoperative endoscopic ultrasound-guided fine-needle aspiration for resectable pancreatic cancer on clinical performance显示文摘AIM:To evaluate the safety and diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)in a cohort of pancreatic cancer patients.METHODS:Of 213 patients with pancreatic cancer evaluated between April 2007 and August 2011,82were thought to have resectable pancreatic cancer on the basis of cross-sectional imaging findings.Of these,54 underwent EUS-FNA before surgery(FNA+group)and 28 underwent surgery without preoperative EUSFNA(FNA-group).RESULTS:All 54 lesions were visible on EUS,and all54 attempts at FNA were technically successful.The diagnostic accuracy according to cytology and histology findings was 98.1%(53/54)and 77.8%(42/54),respectively,and the total accuracy was 98.1%(53/54).One patient developed mild pancreatitis after EUS-FNA but was successfully treated by conservative therapy.No severe complications occurred after EUS-FNA.In the FNA+and FNA-groups,the median relapse-free survival(RFS)was 742 and 265 d,respectively(P=0.0099),and the median overall survival(OS)was1042 and 557 d,respectively(P=0.0071).RFS and OS were therefore not inferior in the FNA+group.These data indicate that the use of EUS-FNA did not influence RFS or OS,nor did it increase the risk of peritoneal recurrence.CONCLUSION:In patients with resectable pancreatic cancer,preoperative EUS-FNA is a safe and accurate diagnostic method. | Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Kazunori Eto Shuhei Kawahata Yoko Abe Manabu Onodera Nobuyuki Ehira Hiroaki Yamato Shin Haba Kazumichi Kawakubo Naoya Sakamoto | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 7 | New aspect of development of high strength aluminum alloys for aerospace applications显示文摘 | Manabu Nakai Takehiko Eto | 2000 | Materials Science & Engineering A2000，，1： | 2 |
| 8 | 美国电力公司DSM的过去、现在和未来(续)显示文摘 | Joseph Eto 王之伟 | 2000 | 电力需求侧管理2000，2，1： | 2 |
| 9 | Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission显示文摘 | Tetsuya Eto Ken Takase Toshihiro Miyamoto Yuju Ohno Tomohiko Kamimura Koji Nagafuji Yasushi Takamatsu Takanori Teshima Hisashi Gondo Shuichi Taniguchi Koichi Akashi Mine Harada | 2013 | International Journal of Hematology2013，，2： | 2 |
| 10 | The MicroRNA-21/PTEN Pathway Regulates the Sensitivity of HER2-Positive Gastric Cancer Cells to Trastuzumab显示文摘 | Kojiro Eto Masaaki Iwatsuki Masayuki Watanabe Satoshi Ida Takatsugu Ishimoto Shiro Iwagami Yoshifumi Baba Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Hideo Baba | 2014 | Annals of Surgical Oncology2014，，1： | 2 |
| 11 | Over expression of CD44V8-10 in urinary exfoliated cells as an independent prognostic predictor in patients with urothelial cancer显示文摘 | Miyake H Eto H Arakawa S | 2002 | J Urol2002，167，3： | 1 |
| 12 | Quantitation of the global right ventricular function in children with normal heart and congenital heart disease: a right ventricular myocardial performance index显示文摘 | Ishii M Eto G Tei C | 2000 | Pediatr Cardiol2000，21，5： | 1 |
| 13 | Hydrogensulfide is produced in response to neuronal excitation显示文摘 | Eto K Ogasawara M Umemura K Nagai Y Kimura H | 2002 | Neuro-science2002，22，： | 1 |
| 14 | Platelet aggregability undeshear is enhanced in patients with unstable angina pectoris who developed acute myocardial infarction显示文摘 | Eto K Ochiai M Isshiki T | 2001 | Jpn Circ J2001，65，4： | 1 |
| 15 | High glucose causes up regu- lation of cyclooxygenase 2 and alters prostanoid profile in human en- dorthelial cells role of protein kinase C and reactive oxygen species 显示文摘 | Cosentino F Eto M Depaolis P | 2003 | Circulation2003，107，7： | 1 |
| 16 | SIRT1/eNOS axis as a poten- tial target against vascular senescence, dysfunction and ath- eroselemsis显示文摘 | Ota H Eto M Ogawa S | 2010 | J Atheroscler Thmmb2010，17，5： | 1 |
| 17 | Reduced endothelial vasomotor function and enhanced neointimal formation after vascular injury in a rat model of blood pressure lability显示文摘 | ETO M TOBA K AKISHITA M | 2003 | Hypertens Res2003，26，12： | 1 |
| 18 | CERTS microgrid laboratory test bed显示文摘 | Lasseter R H Eto J H Schenkman B | 2011 | IEEE Transactions on Power Delivery2011，26，1： | 1 |
| 19 | Signaling pathway of nitric oxide pro- Juction induced by ginsenoside Rbl in human aortic endothelial cells: possible involvement of androgen receptor显示文摘 | J Yu M Eto M Akishita | 2007 | Biochem Biophys Res Commun2007，353，3： | 1 |
| 20 | Low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor for elderly patients with previously untreated acute myeloid leukemia显示文摘 | Hitoshi Suzushima Naoko Wada Hiroshi Yamasaki Kenichiro Eto Taizo Shimomura Michiko H. Kugimiya Kentaro Horikawa Shintaro Nishimura Hiroyuki Tsuda Hiroaki Mitsuya Norio Asou | 2009 | Leukemia Research2009，，5： | 1 |
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