| 3 | Globodera pallida,a non-transgenic invertebrate as a new model for investigating Alzheimer’s disease(and other proteinopathies)?显示文摘Biological models of Alzheimer’s disease(AD):Non-human models have contributed tremendously to the understanding of AD and its underlying pathological processes.These models have aided the investigation of the genetic and environmental risk factors.They also have enabled the progression of candidate therapies into human clinical trials.Because of similarities with human brain anatomy and genetics,rodent models have been used extensively to recapitulate some aspects of AD pathology,measure AD-associated behavioral parameters and related nervous system dysfunctions(Eriksen and Janus,2007).For instance,transgenic mice overexpressing human amyloid precursor protein have furthered the development of the amyloid cascade hypothesis as a central pillar of familial AD. | Norah A.Althobaiti Farid Menaa Johnathan J.Dalzell Brian D.Green | 2023 | Neural Regeneration Research2023，18，1： | 0 |
| 4 | Gutmicrobiome modulation:Ancillary effects of inorganic nanoparticles on gut microflora显示文摘The association of gut microflora and human health is being increasingly recognized,and the impact of gut microflora on the host is well characterized,including the body’s energy metabolism and immune system maintenance.Several human diseases,including metabolic,autoimmune,obesity,hypothyroidism,and intestinal disorders,are closely associated with gut dysbiosis.Inorganic nanoparticles(NPs)are extensively utilized in numerous fields due to their distinctive,attractive physicochemical properties.Estimation of the potential impacts of NPs,with a high number of microorganisms inside the human body(microbiota)and its genomes(microbiome),represents one of the most important aspects of nano-toxicology.This review article aims to provide information on the association of gut microflora alterations to diseases and describe the impacts of various inorganic NPs,including silver,zinc,selenium,titania,silicon,and copper,on gut microflora.Research on the effect of inorganic NPs on gut microflora of animal models and the poultry industry is reviewed.The response of pathogenic Enterobacter species to inorganic NPs has been expounded in detail.This review also highlights the need to focus on the ancillary effects of various inorganic NPs on gut microflora to expedite the suitable advancement of these particles for future use.Finally,the key opportunistic areas for the application of nanotechnology are underlined to manipulate the microbiome of gut dysbiosis,provide an overview,and address potential challenges and our perspective on this evolving field. | SEHRISH ABBAS BUSHRA UZAIR MAISRA AZHAR BUTT FARID MENAA BARKAT A.KHAN | 2023 | BIOCELL2023，47，2： | 0 |
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