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| 1 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 2 | Design and simulation of self-powered radio frequency identification (RFID) tags for mobile temperature monitoring显示文摘This paper presents a design for a self-powered radio frequency identification (RFID) tag with a thin film bulk acoustic reso- nating piezoelectric power supply (PPS), which can be used for portable remote temperature monitoring. We call this system a PPS-RFID for short. The RFID systems have been found to have many applications in the internet of things (IOT) in the past decade. But semi-active RFID tags require an onboard battery which limits their applications in many fields. For these reasons, our research focuses on power sources for the RFID tags. This paper emphasizes the circuit design and simulation of PPS. In our tests, 0.283 mW was generated by PPS at 1 Hz vibration by a 650 N impact force. The results showed that the integrated PPS could supply sufficient power for the designed PPS-RFID tag. The PPS-RFID tag can be widely used for temperature monitoring during mobile transport of perishable items such as medicines or food. | CHU HeQun WU GuangMin CHEN JianMing FEI Fei MAI John D LI Wen J | 2013 | Science China(Technological Sciences)2013，56，1： | 6 |
| 3 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 4 | Lipopolysaccharide inhibits or accelerates biomedical titanium corrosion depending on environmental acidity显示文摘Titanium and its alloys are routinely used as biomedical implants and are usually considered to be corrosion resistant under physiological conditions. However, during inflammation, chemical modifications of the peri-implant environment including acidification occur. In addition certain biomolecules including lipopolysaccharide(LPS), a component of Gram-negative bacterial cell walls and driver of inflammation have been shown to interact strongly with Ti and modify its corrosion resistance. Gram-negative microbes are abundant in biofilms which form on dental implants. The objective was to investigate the influence of LPS on the corrosion properties of relevant biomedical Ti substrates as a function of environmental acidity. Inductively coupled plasma mass spectrometry was used to quantify Ti dissolution following immersion testing in physiological saline for three common biomedical grades of Ti(ASTM Grade 2, Grade 4 and Grade 5). Complementary electrochemical tests including anodic and cathodic polarisation experiments and potentiostatic measurements were also conducted. All three Ti alloys were observed to behave similarly and ion release was sensitive to p H of the immersion solution. However, LPS significantly inhibited Ti release under the most acidic conditions(p H 2), which may develop in localized corrosion sites, but promoted dissolution at p H 4–7, which would be more commonly encountered physiologically.The observed pattern of sensitivity to environmental acidity of the effect of LPS on Ti corrosion has not previously been reported. LPS is found extensively on the surfaces of skin and mucosal penetrating Ti implants and the findings are therefore relevant when considering the chemical stability of Ti implant surfaces in vivo. | Fei Yu Owen Addison Stephen J Baker Alison J Davenport | 2015 | International Journal of Oral Science2015，7，3： | 5 |
| 5 | Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells显示文摘尽管发信号的 Activin/Nodal 调整人的胚胎的茎(ES ) 的 pluripotency 细胞,这个发信号怎么在老鼠 ES 细胞行动,仍然保持大部分不清楚。调查这,我们证实了房间拥有活跃调停 Smad2 的 Activin/Nodal 发信号的那老鼠 ES 并且发现调停 Smad2 的 Activin/Nodal 发信号为自强维护是非必需的,但是向 mesendoderm 系为合适的区别被要求。到进内在的机制的获得卓见,联系 Smad2 的基因被染色体宽的染色质 immunoprecipitation 薄片分析识别。结果证明在 Smad2 绑定和 Activin/Nodal 发信号调整之间有 transcriptional 关联,并且发展相关的基因在 Smad2 固定的目标之中被充实。我们进一步在 Activin/Nodal-Smad2 小径下游地行动的老鼠 ES 房间的 mesendoderm 区别作为一个关键播放器识别了 Tapbp。一起拿,我们的调查结果建议发信号的调停 Smad2 的 Activin/Nodal 通过相应发展管理者表示的直接调整安排鼠标 ES 房间的 mesendoderm 系承诺。 | Teng Fei Shanshan Zhu Kai Xia Jianping Zhang Zhongwei Li Jing-Dong J Han Ye-Guang Chen | 2010 | Cell Research2010，20，12： | 4 |
| 6 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 7 | Structural insights into Ca^2+-activated long-range allosteric channel gating of RyR1显示文摘Ryanodine 受体(RyRs ) 是有分子的质量的巨大的离子隧道的一个班超过 2.2 大 -- 道尔顿。这些隧道调停钙在许多房间发信号。因为超过 80% RyR 蛋白质被合拢进细胞质的集会,留下的残余形成 transmembrane 领域, RyR 隧道的激活和规定发生通过,这被假设了一迄今为止 uncharacterized 远程的 allosteric 机制。这里,我们报导 Ca 2+-activated 的描述由 cryo 电子的开状态的 RyR1 结构显微镜学。结构有 4.9 Å 的一个全面决定;并且 4.2 Å 的一个决定;为核心区域。与以前坚定的 apo/closed-state 结构比较,我们在 Ca 2+ 激活之上观察了隧道的远程的 allosteric gating。深入的结构的分析阐明了新奇隧道门机制和 RyR1 的新奇离子选择机制。我们的工作不仅提供结构的卓见进隧道 gating 和 RyRs 的规定的分子的机制,而且为 six-transmembrane-helix 阳离子隧道家庭为隧道门和离子选择机制使结构的基础清楚些。 | Risheng Wei Xue Wang Yan Zhang Saptarshi Mukherjee Lei Zhang Qiang Chen Xinrui Huang Shan Jing Congcong Liu Shuang Li Guangyu Wang Yaofang Xu Sujie Zhu Alan J Williams Fei Sun Chang-Cheng Yin | 2016 | Cell Research2016，26，9： | 3 |
| 8 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 9 | Enhancement and Optimization of ATO Nano-crystalline Films Properties by the Addition of Acetylacetone as Modifier in the Sol-gel Process显示文摘Sb-doped Sn O2(ATO) thin films have been prepared using the spin coating method by selecting the proper amount of acetylacetone as solution modifier. All ATO powders and films exhibited the cassiterite rutile-like structure in a crystal size below 10 nm under all the experimental conditions and a nonpreviously reported crystal structure was observed at high acetylacetone loads. The acetylacetone molar ratio influenced notably the optical and electrical properties of ATO films. When prepared at an acetylacetone molar ratio of 4, ATO films exhibited optical transparencies above 90% in the visible region and above 40% in the UV region for thicknesses of 100 and 300 nm. Films in a thickness of 100 nm and at an annealing temperature of 650 ℃ accounted for a high transparency of 97% in the visible wavelength. Films prepared at an acetylacetone molar ratio of 4 exhibited an electric resistivity of 1.33×10-3 Ω·cm at an annealing temperature of 650 ℃. The optimal Sb content for ATO films was found to be 8 at%. The relationships among the properties of starting solutions, the experimental parameters, and properties of ATO films are discussed. | Galaviz-pérez J A CHEN Fei SHEN Qiang Vargas-garcía J R 张联盟 | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，5： | 2 |
| 10 | The fabrication of color-tunable organic light-emitting diode displays via solution processing显示文摘Electroluminescent devices based on organic semiconductors have attracted significant attention owing to their promising applications in flat-panel displays.The conventional display pixel consisting of side-by-side arrayed red,green and blue subpixels represents the mature technology but bears an intrinsic deficiency of a low pixel density.Constructing an individual color-tunable pixel that comprises vertically stacked subpixels is considered an advanced technology.Although color-tunable organic light-emitting diodes(OLEDs)have been fabricated using the vacuum deposition of small molecules,the solution processing of conjugated polymers would enable a much simpler and inexpensive manufacturing process.Here we present the all-solution processing of color-tunable OLEDs comprising two vertically stacked polymer emitters.A thin layer of highly conducting and transparent silver nanowires is introduced as the intermediate charge injection contact,which allows the emission spectrum and intensity of the tandem devices to be seamlessly manipulated.To demonstrate a viable application of this technology,a 4-by-4 pixelated matrix color-tunable display was fabricated. | Fei Guo Andre Karl Qi-Fan Xue Kai Cheong Tam Karen Forberich Christoph J Brabec | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 11 | Recent progress in thick-film organic photovoltaic devices:Materials,devices,and processing显示文摘A successful transfer of organic photovoltaic technologies from lab to fab has to overcome a range of critical challenges such as developing high-mobility light-harvesting materials,minimizing the upscaling losses,designing advanced solar modules,controlling film quality,decreasing overall cost,and extending long-operation lifetime.To realize large-area devices toward practical applications,much effort has been devoted to understanding the fundamental mechanism of how molecular structures,device architectures,interfacial engineering,and light management and carrier dynamics affect photovoltaic performance.Such studies addressed various fundamental issues of charge carrier behavior in organic heterojunctions primarily in terms of exciton generation dependence upon light incidence,charge transportation dependence on built-in electric field,and charge extraction versus recombination.In consideration of high-throughput roll-to-roll process for large-scale fabrication of organic photovoltaic devices,it is highly appreciable to realize high power conversion efficiencies that are highly tolerable to the film thickness.Herein we summarize the recent progress in developing thick-film organic photovoltaic devices from the perspective of efficiency-loss mechanisms,material design,and device optimization strategies,proposing guidelines for designing high-efficiency thickness-insensitive devices toward mass production. | Difei Zhang Baobing Fan Lei Ying Ning Li Christoph J Brabec Fei Huang Yong Cao | 2021 | SusMat2021，1，1： | 2 |
| 12 | A fundamental theorem for the aggregation problem of Input-output analysis显示文摘 | | 1955 | Econometrica1955，24，： | 1 |
| 13 | Effect of green tea polyphenols on dopamine uptake and on MPP ^+ -induced dopamine neuron injury显示文摘 | Pan T H Fei J Zhou X B | 2003 | Life Sci2003，72，： | 1 |
| 14 | A Theory of Economic Development 显示文摘 | Ranis G Fei J H | 1961 | American Economic Review1961，，9： | 1 |
| 15 | Sumoylation is critical for DJ-1 to repress p53 transcriptional activity显示文摘 | Fan J Ren H Fei E | 2008 | FEBS Lett2008，582，： | 1 |
| 16 | Fetal growth indicators and perfluorinated chemicals: a study in the Danish National Birth Cohort 显示文摘 | Fei C McLaughlin J K Tarone R E | 2008 | American journal of epidemiology2008，168，1： | 1 |
| 17 | Structure,function and immunolocalization of a proton coupled amino acid trans porter (hPAT1) in the human intestinal cell line Caco-2显示文摘 | Chen Z Fei Y J Anderson C M H | 2003 | The Journal of Physiology2003，546，2： | 1 |
| 18 | MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration显示文摘 | Ma J Wang Q Fei T | 2007 | Blood2007，109，3： | 1 |
| 19 | Cloning of the sodium-dependent,broad-scope,neutral amino acid transporter Bo from a human placental choriocarcinoma cell line显示文摘 | Kekuda R Prasad P D Fei Y J | 1996 | Biol Chem1996，271，18： | 1 |
| 20 | Physiological properties of fresh-cut watermelon (Citrullus lanatus) in response to 1- methylcyclopropene and post-processing calcium application显示文摘 | MAO Linchun LEONG J W QUE Fei | 2006 | Journal of the Science of Food and Agriculture2006，86，1： | 1 |
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