|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Parishin C's prevention of Aβ_(1–42)-induced inhibition of long-term potentiation is related to NMDA receptors显示文摘The rhizome of Gastrodia elata(GE), a herb medicine, has been used for treatment of neuronal disorders in Eastern Asia for hundreds of years. Parishin C is a major ingredient of GE. In this study, the i.c.v. injection of soluble Aβ1–42oligomers model of LTP injury was used. We investigated the effects of parishin C on the improvement of LTP in soluble Aβ1–42oligomer–injected rats and the underlying electrophysiological mechanisms. Parishin C(i.p. or i.c.v.) significantly ameliorated LTP impairment induced by i.c.v. injection of soluble Aβ1–42oligomers. In cultured hippocampal neurons,soluble Aβ1–42oligomers significantly inhibited NMDAR currents while not affecting AMPAR currents and voltage-dependent currents. Pretreatment with parishin C protected NMDA receptor currents from the damage induced by Aβ. In summary, parishin C improved LTP deficits induced by soluble Aβ1–42oligomers. The protection by parishin C against Aβ-induced LTP damage might be related to NMDA receptors. | Zhihui Liu Weiping Wang Nan Feng Ling Wang Jiangong Shi Xiaoliang Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 25 |
| 2 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 3 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 4 | Universal Delayed Kalman Filter with Measurement Weighted Summation for the Linear Time Invariant System显示文摘 | GE Quanbo XU Tingliang FENG Xiaoliang WEN Chenglin | 2011 | Chinese Journal of Electronics2011，20，1： | 8 |
| 5 | Diverse Effects of L-arginine on Cardiac Function of Rats Subjected to Myocardial Ischemia and Reperfusion in vivo显示文摘在在不同时间的 L 精氨酸的管理在心肌的局部缺血和灌注(MI/R ) 的功课期间削尖的 vivo 被显示出到差别 regulatepostischemic apoptosis。心脏的功能是过去常判定心肌的损害的度的最重要的索引之一。现在的学习试图决定在 vivo,在 MI/R 的不同阶段的 L 精氨酸的管理是否在 ischemicreperfused 心的心脏的功能上有多样的影响并且那么,调查包含的机制。雄的成年老鼠受到心肌的局部缺血由 5 h 灌注跟随了的 30 min。一丸静脉内的 L 精氨酸大丸药被给任何一个 10 min 在前和在灌注(早处理) 或 3 h 和 4 h afterreperfusion (迟了的处理) 以后的 50 min。有 L 精氨酸的早处理显著地增加了左室的收缩压力(LVSP ) 和 dP/dt_( 最大) ,并且减少心肌的 nitrotyrosinecontent。在严格的对比,有 L 精氨酸的迟了的处理在灌注,和由 nitrotyrosine 测量了的有毒的 peroxynitriteformation 的增加以后从 4 h 导致了重要减少 inLVSP 和 dP/dt_( 最大) 到 5 h。这些结果建议不同时间在 MI/R 的功课期间削尖的 L-arginineat 的管理在心脏的机能障碍上导致多样的效果。早补充减少了 nitrative 压力和改进左室的功能。然而,有 L 精氨酸的迟了的处理增加了 peroxynitrite 的形成并且加重了心脏的功能的损害。 | Xiaoliang WANG Feng LIANG Xiangying JIAO Lei LIU Xiaojie BAI Meixia LI Jianmin ZHI Huirong LIU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 7 |
| 6 | Mesoporous silica SBA-15 functionalized with phosphonate and amino groups for uranium uptake显示文摘Mesoporous silicas have a very attractive ability of sorption and enrichment of metal ions due to their huge surface area and facile functionalization by organic ligands.In this work,phosphonate-amino bifunctionalized mesoporous silica SBA-15(PA-SBA-15) as U(VI) sorbent was fabricated through post-grafting method.The obtained mesoporous silica was characterized by SEM,XRD,NMR and nitrogen sorption/desorption experiments,which revealed the existence of ordered mesoporous structure with uniform pore diameter and large surface area.The adsorptivity of PA-SBA-15 for U(VI) from aqueous solution was investigated using batch sorption technique under different experimental conditions.The preliminary results show that the U(VI) sorption by PA-SBA-15 is very quick with equilibrium time of less than 1 h,and the U(VI) uptake is as large as 373 mg/g at pH 5.5 under 95 ℃.The sorption isotherm has been successfully modeled by the Langmuir isotherm,suggesting a monolayer homogeneous sorption of U(VI) in PA-SBA-15.The sorption is pH-dependent due to the pH-dependent charge of sorbent in the aqueous solution.The thermodynamics research shows that the sorption is a feasible and endothermic process.Based on these results,PA-SBA-15 could be a promising solid phase sorbent for highly-efficient removal of U(VI) ions from waste water and enrichment of U(VI) from a solution at a very low level. | WANG XiaoLiang YUANLiYong WANG YanFei LI ZiJie LIU YaLan FENG YiXiao ZHAO YuLiang CHAI ZhiFang SHI WeiQun | 2012 | Science China Chemistry2012，55，9： | 6 |
| 7 | Risk factors of hyperprolactinemia induced by risperidone and olanzapine and their correlations with plasma glucose and lipids显示文摘Background Hyperprolactinemia is a common adverse reaction in patients with schizophrenia who take antipsychotic drugs;it often leads to treatment noncompliance in patients and has an adverse effect on their prognosis.Aims This study aimed to explore the risk factors of elevated prolactin(PRL)caused by risperidone(RIS)and olanzapine(OLZ)and the relationship between PRL and fasting plasma glucose and lipids.Methods Patients with schizophrenia were divided into two groups:264 patients who were taking RIS and 175 patients who were taking OLZ.These two groups were further divided according to serum PRL levels:an elevated PRL group(>30ng/mL)and a normal PRL group(PRL<30ng/mL).The demographics,medication dosage,fasting plasma glucose,total cholesterol and triglycerides were compared in the two groups.Logistic regression analysis was performed to explore the risk factors of elevated PRL levels.Results Compared with the OLZ group,the RIS group had a greater number of patients with elevated PRL(155/264 vs 58/175).Either the RIS or the OLZ group,the proportion of elevated PRL was greater in female patients(RIS:x^2=6.76,p=0.009;OLZ:x^2=12.98,p<0.001)and with higher doses of the related drugs(RIS:U=-3.73,p<0.001;OLZ:U=-2.31,p=0.021).In patients taking RIS,the elevated PRL subgroup took the drug for a longer period(U=-2.76,p=0.006)and had lower triglyceride levels(U=2.76,p=0.006).In patients taking OLZ,the elevated PRL subgroup had lower fasting plasma glucose levels(U=2.29,p=0.022).Logistic regression analysis showed that gender,dose and fasting glucose levels were significantly associated with elevated PRL levels(RIS:p=0.001,OLZ:p<0.001;RIS:p<0.001;OLZ:p=0.003;RIS:p=0.020,OLZ:p=0.001,respectively).Conclusion Compared with OLZ,RIS had a greater effect on PRL in patients with schizophrenia,and in patients with schizophrenia taking RIS or OLZ,gender and dose were significantly correlated with the PRL value.Moreover,the plasma glucose level of the group with elevated PRL was lower than that of the group with normal PRL.The results also showed that high serum PRL may be associated with a favourable glucose metabolic profile in patients with schizophrenia taking RIS or OLZ.Further studies are warranted to confirm this association. | Sidi He Wen Juan Yu Xiaoliang Wang Lei Zhang Nan Zhao Guanjun Li Yi Feng Shen Huafang Li | 2020 | General Psychiatry2020，33，4： | 5 |
| 8 | HYBRID FILTER WITH PREDICT-ESTIMATOR AND COMPENSATOR FOR THE LINEAR TIME INVARIANT DELAYED SYSTEM显示文摘This paper investigates the problem of real-time estimation for one kind of linear time invariant systems which subject to limited communication capacity. The communication limitations include signal transmission delay, the out-of-sequence measurements and data packet dropout, which appear typically in a network environment. The kernel of filter design is equally to formularize the traditional Kalman filter as one linear weighted summation which is composed of the initial state estimate and all sequential sampled measurements. For it can adapt aforementioned information limitations, the linear weighted summation is then decomposed into two stages. One is a predict-estimator composed by all reached measurements, another is one compensator constructed by those time-delayed data. In the network environment, there are obvious differences between the new hybrid filter and those existing delayed Kalman filters. For example, the novel filter can be optimal in the sense of linear minimum mean square error as soon as all measurements available and has the lowest running time than these existing delayed filters. One simulation, including two cases, is utilized to illustrate the design procedures proposed in this paper. | Wen Chenglin Ge Quanbo Feng Xiaoliang | 2009 | Journal of Electronics(China)2009，26，5： | 5 |
| 9 | Effects of Al^(3+)doping on the structure and properties of goethite and its adsorption behavior towards phosphate显示文摘Al substitution in goethite is common in soils, and has strong influence on the structure and physicochemical properties of goethite. In this research, a series of Al-doped goethites were synthesized, and characterized by powder X-ray diffraction(XRD), transmission electron microscopy(TEM), X-ray photoelectron spectroscopy(XPS), Fourier transform infrared spectroscopy(FT-IR) and extended X-ray absorption fine structure(EXAFS)spectroscopy. The adsorption behavior of these samples towards PO43-was also investigated. Characterization results demonstrated that increasing Al content in goethite led to a reduction in crystallinity, increase in specific surface area(SSA), and morphology change from needle-like to granular. Rietveld structure refinement revealed that the lattice parameter a remained almost constant and b slightly decreased, but c was significantly reduced, and the calculated crystal density increased. EXAFS analysis demonstrated that the Fe(Al)–O distance in the structure of the doped goethites was almost the same, but the Fe–Fe(Al) distance decreased with increasing Al content. Surface analysis showed that, with increasing Al content, the content of OH groups on the mineral surface increased. The adsorption of phosphate per unit mass of Al-doped goethite increased, while adsorption per unit area decreased owing to the decrease of the relative proportion of(110) facets in the total surface area of the minerals. The results of this research facilitate better understanding of the effect of Al substitution on the structure and properties of goethite and the cycling of phosphate in the environment. | Wei Li Longjun Wang Fan Liu Xiaoliang Liang Xionghan Feng Wenfeng Tan Lirong Zheng Hui Yin | 2016 | Journal of Environmental Sciences2016，28，7： | 4 |
| 10 | Circadian locomotor output cycles kaput accelerates atherosclerotic plaque formation by upregulating plasminogen activator inhibitor-1 expression显示文摘 | Qixia Jiang Hua Liu Shengyun Wang Jiamei Wang Yehua Tang Zhiqing He Feng Wu Zhigang Huang Xiaoliang Cong Ru Ding Chun Liang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 11 | Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing显示文摘Most commonly used wound dressings have severe problems,such as an inability to adapt to wound shape or a lack of antibacterial capacity,affecting their ability to meet the requirements of clinical applications.Here,a nanocomposite hydrogel(XKP)is developed by introducing polydopamine nanoparticles(PDA NPs)into a food gum matrix(XK,consisting of xanthan gum and konjac glucomannan,both FDA-approved food thickening agents)for skin wound healing.In this system,the embedded PDA NPs not only interact with the food gum matrix to form a hydrogel with excellent mechanical strength,but also act as photothermal transduction agents to convert near-infrared laser radiation to heat,thereby triggering bacterial death.Moreover,the XKP hydrogel has high elasticity and tunable water content,enabling it to adapt to the shape of the wound and insulate it,providing a moist environment suitable for healing.In-vivo skin wound healing results clearly demonstrate that XKP can significantly accelerate the healing of wounds by reducing the inflammatory response and promoting vascular reconstruction.In summary,this strategy provides a simple and practical method to overcome the drawbacks of traditional wound dressings,and provides further options when choosing suitable wound healing materials for clinical applications. | Qiankun Zeng Yuna Qian Yijing Huang Feng Ding Xiaoliang Qi Jianliang Shen | 2021 | Bioactive Materials2021，6，9： | 3 |
| 12 | Whole-Genome Sequences Analysis Displays Relationship of SARS-CoV-2 Delta Variant Between Four Local Cases and Passengers of a Flight from South Africa—Shenzhen City,Guangdong Province,China,June 2021显示文摘On June 14,2021,a customs officer(Case A)went to the infirmary at Baoan International Airport in Shenzhen due to a runny nose and fever.He was admitted to the Central Hospital of Baoan immediately.This patient preliminarily tested positive for coronavirus disease 2019(COVID-19)infection,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),using a quantitative realtime reverse transcription polymerase chain reaction(qRT-PCR)method in this hospital.Then,a mixed specimen of nasopharyngeal swab. | Yaqing He Renli Zhang Qiuying Lyu Bo Peng Shujiang Mei Ying Sun Dongfeng Kong Chaoqiong Peng Ziquan Lyu Xinyi Wei Can Zhu Xiaoliang Xiao Shimin Li Qingju Lu Jiancheng Chen Hang Zhang Xuan Zou Tiejian Feng Long Chen | 2021 | China CDC weekly2021，3，50： | 3 |
| 13 | Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel:An Open-Label,Blank-Controlled Study—Hohhot City,Inner Mongolia Autonomous Region,China,2022显示文摘Summary What is already known about this topic?The active ingredient of the SA58 Nasal Spray is a broad-spectrum neutralizing antibody with a high neutralizing capacity against different Omicron subvariants in vitro studies.What is added by this report?This study demonstrated the safety and effectiveness of SA58 Nasal Spray against coronavirus disease 2019(COVID-19)infection in medical personnel for the first time.What are the implications for public health practice?This study provides an effective approach for the public to reduce their risk of COVID-19 infection.The findings of this research have the potential to significantly reduce the risk of infection and limit human-to-human transmission in the event of a COVID-19 outbreak. | Shujie Si Canrui Jin Jianping Li Yunlong Cao Biao Kan Feng Xue Xiaoliang Sunney Xie Liang Fang Gang Zeng Shuo Zhang Yaling Hu Xiaoping Dong | 2023 | China CDC weekly2023，5，10： | 1 |
| 14 | Preparation of CH_3NH_3PbI_3 thin films for solar cells via Vapor Transfer Method显示文摘Organometal halide perovskite based solar cells have emerged as one of the most promising candidates for low-cost and high-efficiency solar cell technologies.Here a Vapor Transfer Method(VTM)is used to fabricate high quality perovskite thin films in a balanced vacuum capsule.By adjusting the reaction temperature,CH_3NH_3I saturated vapor which then reacts with PbI_2films can be controlled and the formation process of CH_3NH_3PbI_3perovskite films can be further influenced.Prepared perovskite films which exhibit pure phase,smooth surface and high crystallinity are assembled into planar heterojunction inverted solar cells.The whole fabrication process of solar cell devices is organic solution free.Finally,the champion cell achieved power conversion efficiency(PCE)of 13.08%with negligible current–voltage hysteresis under fully open-air conditions.The photovoltaic performance could be further enhanced by optimizing perovskite composition and the device structure. | Kejie Feng Yitong Liu Yuancheng Zhang Yujie Liu Xiaoliang Mo | 2018 | Journal of Energy Chemistry2018，27，5： | 1 |
| 15 | Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy显示文摘 | Longze Sha Xiaofeng Wu Yuan Yao Bo Wen Jing Feng Zhiqiang Sha Xueqin Wang Xiaoliang Xing Wanchen Dou Liri Jin Wenting Li Naili Wang Yan Shen Jinhui Wang Liwen Wu Qi Xu | 2014 | Molecular Neurobiology2014，，2： | 1 |
| 16 | Microwave assisted solid reaction: reduction of esters to borohydridelithium chloride 显示文摘 | Liu Bin Dai Li Yang Xiaoliang TU Shujiang | 2001 | Synthetic Communications2001，31，2： | 1 |
| 17 | Finite horizon H∞ filtering for networked measurement system 显示文摘 | FENG Xiaoliang WEN Chenglin XU Lizhong | 2013 | International Journal of Control Automation and Systems2013，11，1： | 1 |
| 18 | An antcolony optimization approach for the multidimensional knapsackproblem显示文摘 | Ke Liangjun Feng Zuren Ren Zhigang Wei Xiaoliang | 2010 | Heuristics2010，16，1： | 1 |
| 19 | Finite horizon H∞filtering for networked measurement system显示文摘 | Feng Xiaoliang Xu Lizhong Wen Chenglin | 2013 | International Journal of Control Automation and Systems2013，11，1： | 1 |
| 20 | Antiplatelet and Antithrombotic Activity of L-3-n-butylphthalide in Rats显示文摘 | Ying Peng Xianke Zeng Yipu Feng Xiaoliang Wang | 2004 | Journal of Cardiovascular Pharmacology2004，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员