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| 1 | Internet of Things to network smart devices for ecosystem monitoring显示文摘Smart, real-time, low-cost, and distributed ecosystem monitoring is essential for understanding and managing rapidly changing ecosystems. However, new techniques in the big data era have rarely been introduced into operational ecosystem monitoring, particularly for fragile ecosystems in remote areas.We introduce the Internet of Things(IoT) techniques to establish a prototype ecosystem monitoring system by developing innovative smart devices and using IoT technologies for ecosystem monitoring in isolated environments. The developed smart devices include four categories: large-scale and nonintrusive instruments to measure evapotranspiration and soil moisture, in situ observing systems for CO2 and d13 C associated with soil respiration, portable and distributed devices for monitoring vegetation variables, and Bi-CMOS cameras and pressure trigger sensors for terrestrial vertebrate monitoring. These new devices outperform conventional devices and are connected to each other via wireless communication networks. The breakthroughs in the ecosystem monitoring IoT include new data loggers and longdistance wireless sensor network technology that supports the rapid transmission of data from devices to wireless networks. The applicability of this ecosystem monitoring IoT is verified in three fragile ecosystems, including a karst rocky desertification area, the National Park for Amur Tigers, and the oasis-desert ecotone in China. By integrating these devices and technologies with an ecosystem monitoring information system, a seamless data acquisition, transmission, processing, and application IoT is created. The establishment of this ecosystem monitoring IoT will serve as a new paradigm for ecosystem monitoring and therefore provide a platform for ecosystem management and decision making in the era of big data. | Xin Li Ning Zhao Rui Jin Shaomin Liu Xiaomin Sun Xuefa Wen Dongxiu Wu Yan Zhou Jianwen Guo Shiping Chen Ziwei Xu Mingguo Ma Tianming Wang Yonghua Qu Xinwei Wang Fangming Wu Yuke Zhou | 2019 | Science Bulletin2019，64，17： | 10 |
| 2 | Free cholesterol-induced macrophage apoptosis is mediated by inositol-requiring enzyme 1 alpha-regulated activation of Jun N-terminal kinase显示文摘在先进动脉粥样硬化患者损害的巨噬细胞死亡导致 lesional 坏死,可能的匾破裂,和尖锐脉管的吸藏。巨噬细胞死亡的一个可能的原因是导致 endoplasmic 蜂窝胃的激活的免费胆固醇(FC ) 的累积(嗯) 导致压力的 apoptosis。1 alpha (IRE1 ) 是的要求肌醇的酶 ERthat 的不可分的膜蛋白质是在在巨噬细胞的导致胆固醇的 apoptosis 的关键发信号步,在 ER 由应力激活。然而,在规定的 IRE1 的角色嗯为这个过程的导致压力的巨噬细胞死亡和机制大部分是不清楚的。在这研究,一个房间文化模型被用来探索涉及导致 FC 的巨噬细胞死亡的 ER 压力小径的机制。结果此处证明巨噬细胞装载的 FC 导致部分依赖于由 IRE1 的激活的开始的 apoptotic 回答。一起拿,这些结果证明 IRE1-apoptosis-signaling kinase 1-c-Jun NH2 终端 kinase 串联小径在这个过程被要求。而且,数据在先进动脉粥样硬化患者损害为导致胆固醇的巨噬细胞死亡建议了新奇细胞的机制。这发信号的串联的批评功能被预防显示嗯在 IRE1 的抑制以后的导致压力的 apoptosis,或 c6 月 NH2 终端 kinase。 | Fangming Li Yi Guo Shenggang Sun Xin Jiang Bingshan Tang Qizhang Wang Ling Wang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 7 |
| 3 | Thick Miocene eolian deposits on the Huajialing Mountains:The geomorphic evolution of the western Loess Plateau显示文摘The geomorphic evolution of northwestern China during the Cenozoic has been a subject of much geological interest because of its link with the uplift of the Himalayan-Tibetan complex.Much information about these changes is recoverable from the sedimentary sequences of the region.We report here on the thick eolian deposits mantling the Huajialing Mountains,a relatively flat mountain range in the western Loess Plateau.Correlation of magnetic susceptibility stratigraphy with the QA-I Miocene eolian sequence dates a 134.7 m section(NL-VII) for the interval from 18.7 to 11.8 Ma,as confirmed by micro-mammalian fossils.These eolian deposits demonstrate a much wider distribution of the Miocene eolian deposits,and also indicate that the topography contrasts in the western Loess Plateau,including the uplifts of the Huajialing Mountains and the bedrock highlands in the Qinan region,were formed by the early Miocene.The near-continuous Miocene eolian sequence from 18.7 to 11.8 Ma indicates that the substratum of Huajialing had not experienced any intense tectonic changes during this time interval,which suggests further,the relative tectonic stability of the nearby Tibetan Plateau. | ZHAN Tao GUO ZhengTang WU HaiBin GE JunYi ZHOU Xin WU ChunLin ZENG FangMing | 2011 | Science China Earth Sciences2011，54，2： | 7 |
| 4 | Dynamic changes in fibrinogen levels of patients with acute cerebral infarction after taking defibrase显示文摘BACKGROUND: At present, as a therapeutic drug mainly for reducing fibrinogen (FIB) levels, the dynamic influence of defibrase on the FIB levels of patients with acute cerebral infarction has not been clearly ascertained. OBJECTIVE: To observe the dynamic changes in FIB levels of patients with acute cerebral infarction at different time points after taking defibrase. DESIGN, TIME AND SETTING: Randomized controlled clinical trial. The study was conducted in the Department of Neurology, the Second Affiliated Hospital of Jinan University, from June to November 2006. PARTICIPANTS: Sixty patients with acute cerebral infarction, who had been treated by the Neurological Department of the Second Affiliated Hospital of Jinan University from June to November 2006, were selected, including 37 males and 23 females, aged 35–75 years. All cases met the diagnostic criteria formulated by the Fourth National Cerebrovascular Disease Conference within 12 hours of onset. All the patients were confirmed with definite hemiparesis and cerebral infarction without coma, and were randomly divided into two groups: a treatment group (n =40) and a control group (n =20). Patients’ families had the right to be informed and agree with the treatment, which had permission from the Hospital Ethics Committee. METHODS: Patients in the control group were given routine treatment with 30 mL fleabane and 0.75 g cytidine diphosphate added to 500 mL saline solution once a day for 14 consecutive days. Patients in the treatment group were given routine treatment and Haiwang defibrase injection (purchased from Changchu Guoao Bio-Pharmaceutical Co. Ltd., Approval document number H10983237) within 12 hours of infarction. Defibrase doses of 15, 12.5 and 10 U were given over 2 hours according to the patients’ pre-treatment plasma FIB levels of ≥ 4.50 g/L, 3.50-4.49 g/L and 1.00-3.49 g/L, respectively. Plasma FIB levels in the treatment group were measured before, and once every six hours for 48 hours after administration of defibrase. Later, measurements were taken once every 12 hours and FIB levels were kept in a range of 0.5–1.3 g/L for one week. When the FIB level increased to over 1.3 g/L, a 5 U dose of defibrase was given again over two hours. FIB levels of the control group were measured once before treatment and once after one week of treatment MAIN OUTCOME MEASURES: (1) Dynamic changes of FIB levels in the defibrase treatment group. (2) Comparison of dynamic changes of FIB levels in the treatment group and control group before and after treatment for one week. RESULTS: All 60 patients were included in the final analysis. The treatment group’s FIB levels quickly decreased to 0.5–1.3 g/L within 12 hours of taking the first dose of defibrase and reached a minimum in 24 hours. Later, they began to rise slowly into the therapeutic range (0.5–1.3 g/L) in 48 hours. The FIB levels of the treatment group increased slowly to over 1.3 g/L in 60 hours after the first dose of defibrase and then quickly decreased to the therapeutic range after the second dose of 5 U defibrase with a minimum level higher than after the first dose, and higher again after the third dose. After treatment, patients’ FIB levels could be kept in the therapeutic range for about one week. The FIB levels in patients in the treatment group were significantly lower after taking defibrase for one week in comparison with the levels before treatment (P < 0.01). There was no difference in the control group between the levels pre-treatment and one week after treatment (P > 0.05). CONCLUSIONS: FIB levels in patients with acute cerebral infarction quickly decrease after taking the first dose of defibrase and reach a minimum in 24 hours. Later, they begin to rise slowly into the therapeutic range (0.5–1.3 g/L) in 48 hours. The FIB levels increase slowly to over 1.3 g/L in 60 hours. The effect of defibrase is weaker when the same dose of defibrase is used in patients repeatedly. | Yi Guo Ling Wang Bingshan Tang Fangming Li Qizhang Wang | 2008 | Neural Regeneration Research2008，3，5： | 3 |
| 5 | Risk factors of acute myocardial infarction following primary percutaneous coronary intervention among elderly patients显示文摘背景和客观大使随机化的控制试用证明了然而,有平淡的使用 ofdrug-eluting stents 的经皮的冠的干预(一种总线标准)安全、有效比经历一种总线标准的 75 年老的病人在为主要不利心脏的事件的增加的风险,以便病人通常从这试用被排除。现在的学习的目的是与尖锐的圣举起在老病人估计早临床的结果和风险因素心肌的梗塞(STEMI ) 追随者主要一种总线标准。我们与尖锐 STEMI 在我们的冠的照顾单位在比 60 年老的 136 个病人在 stenting 以后分析了结果的方法,和病人进一步在 2 个年龄组被分类:patients75 年并且 < 75 年。尽管更老的组比那些有不利基线特征和更低的最后的 TIMI 流动的更高的流行,结果更年轻,程序的成功没有二个组之间的差别。为老组的主要不利临床的事件(向) 有点更高与正在作比较在起来的 12 月的列在后面更年轻。结论我们的学习与心肌的梗塞有的尖锐的圣举起在老病人建议那 drug-eluting stent 培植尽管有有更多的严重基线的高起始的程序的成功率冒险特征,并且弄短时间形式症状发作到 PC1 并且改进最后的 TIMI 流动策略可以减少在跟随一种总线标准的老病人之中的向。 | Fangming Guo Xiaohuan Wang Guangping Li Xin Chen Yuguang Jin | 2009 | Journal of Geriatric Cardiology2009，6，2： | 2 |
| 6 | Primary percutaneous coronary intervention on older patients with acute ST-segment elevation myocardial infarction: analysis of its risk factors显示文摘Objective: The aim of the present study was to assess the early clinical outcome and risk factors in old patients with acute ST elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI). Methods: A total of 136 patients older than 60 years with STEMI who received successful PCI were included in this study. The patients were classified in 2 age groups: patients ≥75 years and <75 years of age. The extent of coronary artery lesions was measured by quantitative coronary artery angiography (QCA). Subjects were tracked for subsequent cardiovascular events: cardiac death, myocardial infarction, heart failure, percutaneous coronary intervention, coronary artery bypass and stroke. Results: Though the older group had a higher prevalence of adverse baseline characteristics and lower final TIMI flow than patients<75y (P<0.05), the procedural success did not make difference between the two groups. In 12 months follow-up of 136 study participants, there occurred 39 CV events : cardiac death (five patients), heart failure (nineteen patients), and stroke (six patients). Three patients received coronary bypass grafts and six patients underwent PCI. Heart failure and overall cardiovascular event rates were higher in older patients compared with those in patients<75y. The main adverse clinical events (MACE) for the old group were a little higher comparing with the younger in 12-month follow-up (P=0.029 6 and P=0.043 4). Multivariate cox analysis identified that a diagnosis of diabetes (HR 2.495, 95%CI 1.224 to 5.083, P= 0.011 8) and time from symptom(HR 1.450, 95%CI 1.143 to 1.841, P= 0.008 2) to PCI as independent predictors of CV events after adjustment of all entered baseline variables. Conclusion: Our study suggests that drug-eluting stent implantation in older patients with acute ST elevation myocardial infarction has high initial procedural success rates despite having more severe baseline risk characteristics, and to shorten the time from symptom onset to PCI may decrease cardiovascular events in old patients following PCI. | Guo Fangming Wang Xiaohuan Li Guangping Chen Xin Fan Juexin | 2010 | Journal of Medical Colleges of PLA(China)2010，25，1： | 1 |
| 7 | Mediator tail module subunits MED16 and MED25 differentially regulate abscisic acid signaling in Arabidopsis显示文摘MED25 has been implicated as a negative regulator of the abscisic acid(ABA)signaling pathway.However,it is unclear whether other Mediator subunits could associate with MED25 to participate in the ABA response.Here,we used affinity purification followed by mass spectrometry to uncover Mediator subunits that associate with MED25 in transgenic plants.We found that at least26 Mediator subunits,belonging to the head,middle,tail,and CDK8 kinase modules,were copurified with MED25 in vivo.Interestingly,the tail module subunit MED16 was identified to associate with MED25 under both mock and ABA treatments.We further showed that the disruption of MED16 led to reduced ABA sensitivity compared to the wild type.Transcriptomic analysis revealedthattheexpressionofseveral ABA-responsive genes was significantly lower in med16 than those in wild type.Furthermore,we discovered that MED16 may possibly compete with MED25 to interact with the key transcription factor ABA INSENSITIVE 5(ABI5)to positively regulate ABA signaling.Consistently,med16 and med25 mutants displayed opposite phenotypes in ABA response,cuticle permeability,and differential ABI5-mediated EM1 and EM6 expression.Together,our data indicate that MED16 and MED25 differentially regulate ABA signaling byantagonisticallyaffectingABI5-mediated transcription in Arabidopsis. | Pengcheng Guo Leelyn Chong Fangming Wu Chuan-Chih Hsu Chuanyou Li Jian-Kang Zhu Yingfang Zhu | 2021 | Journal of Integrative Plant Biology2021，63，4： | 1 |
| 8 | Challenges and opportunities in remote sensing-based crop monitoring:a review显示文摘Building a more resilient food system for sustainable development and reducing uncertainty in global food markets both require concurrent and near-real-time and reliable crop information for decision making.Satellite-driven crop monitoring has become a main method to derive crop information at local,regional,and global scales by revealing the spatial and temporal dimensions of crop growth status and production.However,there is a lack of quantitative,objective,and robust methods to ensure the reliability of crop information,which reduces the applicability of crop monitoring and leads to uncertain and undesirable consequences.In this paper,we review recent progress in crop monitoring and identify the challenges and opportunities in future efforts.We find that satellite-derived metrics do not fully capture determinants of crop production and do not quantitatively interpret crop growth status;the later can be advanced by integrating effective satellite-derived metrics and new onboard sensors.We have identified that ground data accessibility and the negative effects of knowledge-based analyses are two essential issues in crop monitoring that reduce the applicability of crop monitoring for decisions on food security.Crowdsourcing is one solution to overcome the restrictions of ground-truth data accessibility.We argue that user participation in the complete process of crop monitoring could improve the reliability of crop information.Encouraging users to obtain crop information from multiple sources could prevent unconscious biases.Finally,there is a need to avoid conflicts of interest in publishing publicly available crop information. | Bingfang Wu Miao Zhang Hongwei Zeng Fuyou Tian Andries B Potgieter Xingli Qin Nana Yan Sheng Chang Yan Zhao Qinghan Dong Vijendra Boken Dmitry Plotnikov Huadong Guo Fangming Wu Hang Zhao Bart Deronde Laurent Tits Evgeny Loupian | 2023 | National Science Review2023，10，4： | 1 |
| 9 | Size-controlled synthesis of monodispersed mesoporous silica nano-spheres under a neutral condition显示文摘 | Qianjun He Xiangzhi Cui Fangming Cui Limin Guo Jianlin Shi | 2008 | Microporous and Mesoporous Materials2008，，3： | 1 |
| 10 | A novel flow-resistor network model for characterizing enhanced geothermal system heat reservoir显示文摘The fracture characteristics of a heat reservoir are of critical importance to enhanced geothennal systems,which can be investigated by theoretical modeling.This paper presents the development of a novel flow.Fesistor network model to describe the hydraulic processes in heat reservoirs.The fractures in the reservoir are simplified by using flow resistors and the typically complicated fracture network of the heat reservoir is converted into a flowresistor network with a reasonably simple pattern.For heat reservoirs with various fracture configurations,the corresponding flow-resistor networks are identical in terms of framework though the networks may have difftrent section numbers and the flow resistors may have different values.In this paper,numerous cases of different section numbers and resistor values are calculated and the results indicate that the total number of flow resistances between the injection and production wells is primarily determined by the number of fractures in the reservoir.It is also observed that a linear dependence of the total flow resistance on the number of fractures and the relation is obtained by the best fit of the calculation results.Besides,it perfbmis a case study dealing with the Soultz enhanced geothermal system(EGS).In addition,the fracture numbers underneath specific well systems are derived.The results provide in sight on the tortuosity of the flow path betwee n different wells. | Jian GUO Wenjiong CAO Yiwei WANG Fangming JIANG | 2019 | Frontiers in Energy2019，13，1： | 1 |
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