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| 1 | Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma:Case report with molecular analysis显示文摘Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma. | Marta Barisella Andrea Lampis Federica Perrone Antonino Carbone | 2008 | World Journal of Gastroenterology2008，14，42： | 3 |
| 2 | Experience with peritoneal mesothelioma at the Milan National Cancer Institute显示文摘Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and rapidly fatal tumor.Therapeutic options have traditionally been limited and ineffective.The biologic and molecular events correlated with poor responsiveness to therapy are still poorly understood.In recent years,an innovative treatment approach involving aggressive cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy has reportedly resulted in improved outcome,as compared to historical controls.Since 1995,at the National Cancer Institute (NCI) of Milan (Italy),patients with DMPM have been treated with CRS and hyperthermic intraperitoneal chemotherapy (HIPEC).In the present paper,clinical experiences and basic science investigations on DMPM at Milan NCI are reviewed.Perioperative and long-term outcome results with CRS and HIPEC are presented.Clinico-pathological prognostic factors were investigated by multivariate analysis.The pathologic features and immunohistochemical markers related to DMPM biologic behavior were assessed in a large case-series uniformly treated at our institution.The prevalence and prognostic role of telomere maintenance mechanisms,which account for the limitless cell replicative potential of many malignancies,were studied.The dysregulation of the apoptotic pathways may play a role in the relative chemo-resistance of DMPM and a better understanding of apoptosis-related mechanisms could result in novel targeted therapeutic strategies.On this basis,the expression of survivin and other IAP family members (IAP-1,IAP-2,and X-IAP),the pro-apoptotic protein Smac/DIABLO,and antigens associated with cell proliferation (Ki-67) and apoptosis (caspase-cleaved cytokeratin-18) were analyzed.Finally,analyses of EGFR,PDGFRA and PDGFRB were performed to ascertain if deregulation of RTK could offer useful alternative therapeutic targets. | Marcello Deraco Dario Baratti Antonello Domenico Cabras Nadia Zaffaroni Federica Perrone Raffaella Villa Jenny Jocollè Maria Rosaria Balestra Shigeki Kusamura Barbara Laterza Silvana Pilotti | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 3 |
| 3 | Local α-Tocopherol for Acute and Short-Term Vaginal Toxicity Prevention in Patients Treated With Radiotherapy for Gynecologic Tumors显示文摘 | Andrea Galuppi Anna Myriam Perrone Mariangela La Macchia Donatella Santini Serena Medoro Lucia Ricci Maccarini Isabella Strada Federica Pozzati Martina Rossi Pierandrea De Iaco | 2011 | International Journal of Gynecological Cancer2011，，9： | 1 |
| 4 | Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene显示文摘 | Giuseppe Pelosi Patrizia Gasparini Alberto Cavazza Giulio Rossi Paolo Graziano Mattia Barbareschi Federica Perrone Massimo Barberis Masayuki Takagi Toshiaki Kunimura Tetsuya Yamada Yukio Nakatani Ugo Pastorino Paolo Scanagatta Gabriella Sozzi Marina Garas | 2012 | Lung Cancer2012，，3： | 1 |
| 5 | Gynecological malignancies and hormonal therapies: Clinical management and recommendations显示文摘Every year in the world a large number of women receive a diagnosis of gynecological cancer and undergo a therapy such as surgery, chemotherapy and radiotherapy to the pelvic region. A large portion of these patients are already in menopause, but for younger patients therapies are responsible of early menopause. The physical and psychological symptoms due to iatrogenic menopause significantly reduce the quality of life; however hormone replacement therapy(HRT) has a high efficacy in reducing menopausal symptoms. The prescription of HRT in patients with story of gynecological cancer is debated because its safety has not been completely proven. The main criticism is based on the theory that the hormone replacement could stimulate growth of residual cancer cells increasing the risk of recurrence. | Anna Myriam Perrone Federica Pozzati Donatella Santini Martina Rossi Martina Procaccini Lucia Casalini Erica Santi Marco Tesei Claudio Zamagni Pierandrea De Iaco | 2014 | World Journal of Obstetrics and Gynecology2014，3，4： | 0 |
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