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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Prostatic arterialembo- lization : post - procedural follow - up显示文摘 | Fernandes L Rio Tinto H Pereira J | 2012 | Teeh Vasc Interv Ra- dio12012，15，： | 1 |
| 3 | Optimisation of the biological treatment of hypersaline wastewater from Dunaliella salina carotenogenesis 显示文摘 | Santos C A Vieira A M Fernandes H L | 2001 | J Chem Technol Biotechnol2001，76，11： | 1 |
| 4 | Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism显示文摘 | Santos S H Fernandes L R Mario E G | 2008 | Diabetes2008，57，： | 1 |
| 5 | Microporous hollow fibres for carbon dioxide absorption:Mass transfer model fitting and the supplying of carbon dioxide to microalgal cultures显示文摘 | Ferreira B S Fernandes H L Reis A | 1998 | Journal of Chemical Technology and Biotechnology1998，71，1： | 1 |
| 6 | Soccer-Related Ocular Injuries显示文摘 | Capao Filipe J A Fernandes V L Barros H | 2003 | Arch Ophthahnol2003，121，1： | 1 |
| 7 | Simultaneous determination of methanol and ethanol in gasoline using NIR spectroscopy : Effect of gasoline composition 显示文摘 | Fernandes H L Raimundo Jr Ivo M Pasquini C | 2008 | Talanta2008，75，： | 1 |
| 8 | Effect of nutrient sources on yield, fruit quality and nutritional status of cucumber plants, cultivated in hydroponics 显示文摘 | Fernandes A A Martinez -H E P Oliveira -L R de et el | 2002 | Horticultura Brasileira2002，204，： | 1 |
| 9 | Energy and protein requirements for maintenance and growth of Boer crossbred kids 显示文摘 | FERNANDES M H M R RESENDE K T TEDES- CHI L O | 2007 | J Anim Sci2007，85，4： | 1 |
| 10 | Design model for socket base connections adjusted from experimental results显示文摘 | R M Fernandes Canha A L H de Cresce El Debs M K EI Debs | 2007 | Structural Concrete2007，8，1： | 1 |
| 11 | Effects of polyunsaturated fatty acids (PUFAs) in the treat- ment of experimental chronic renal failure 显示文摘 | FERNANDES M B CALDAS H C MARTINS L R | 2012 | Int Urol Nephrol2012，44，5： | 1 |
| 12 | Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington' s disease显示文摘 | Fernandes H B Baimbridge K G Church J Hayden M R Raymond L A | 2007 | J Neurosci2007，27，13： | 1 |
| 13 | Elevation of serum phaseⅡ enzymes by anticarcinogenic enzyme inducers:markers for a chemoprotected state?显示文摘 | Prochaska H J Fernandes C L | 1993 | Carcinogenesis1993，14，12： | 1 |
| 14 | Kaposiform Hemangioendothelioma: A Study of 33 Cases Emphasizing Its Pathologic, Immunophenotypic, and Biologic Uniqueness From Juvenile Hemangioma显示文摘 | Lisa L Lyons Paula E North Fernand Mac-Moune Lai Mark H Stoler Andrew L Folpe Sharon W Weiss | 2004 | The American Journal of Surgical Pathology2004，，5： | 1 |
| 15 | Isolation of IgGT from hyperimmune horse anti-snake venom serum:its protective ability显示文摘 | Fernandes L Takehara H A Mota I | 1991 | Toxicon1991，29，11： | 1 |
| 16 | Influence of nitrogen source and photoperiod on exopolysaccharide synthesis by the microalga Botryococcus braunii显示文摘 | LUPI F M FERNANDES H M L TOMME M M | 1994 | Enzyme Microb Technol1994，16，： | 1 |
| 17 | Straining and advection contributions to the mixing process of the Patos Lagoon coastal plume,Brazil显示文摘 | Marques W C Fernandes E H L Moller O O | 2010 | Journal of Geophysical Research2010，115，6： | 1 |
| 18 | Oral Angiotensin-(1-7) prevented obesity and hepaticinflammation by inhibition of resistin/ TLR4/MAPK/NF-κB in rats fed with high-fat diet 显示文摘 | SANTOS S H ANDRADE J M FERNANDES L R | 2013 | Peptides2013，46，： | 1 |
| 19 | Cold-induced repres- sion of the rice anther-specific cell wall invertase gene OSINV4 is correlated with sucrose accumulation and pollen sterility 显示文摘 | Oliver S N Van Dongen J T Alfred S C Mamun E Zhao X Saini H S Fernandes S F Blanchard C L Sutton B Gelgenberger P Dennis E Dolferus R | 2005 | Plant Cell &Environment2005，28，： | 1 |
| 20 | Energy and protein requirements for maintenance and growth of Boer crossbred kids 显示文摘 | FERNANDES M H M R RESENDE K T TEDESCHI L O | 2007 | Journal of Animal Science2007，85，： | 1 |
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