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| 1 | EMT and Dissemination Precede Pancreatic Tumor Formation显示文摘 | Andrew D. Rhim Emily T. Mirek Nicole M. Aiello Anirban Maitra Jennifer M. Bailey Florencia McAllister Maximilian Reichert Gregory L. Beatty Anil K. Rustgi Robert H. Vonderheide Steven D. Leach Ben Z. Stanger | 2012 | Cell2012，，1： | 13 |
| 2 | Pregnancies established through intracytoplasmic sperm injection (ICSI) using spermatozoa with dysplasia of fibrous sheath显示文摘Aim: Dysplasia of the fibrous sheath (DFS) is an anomaly found in asthenozoospermic patients with extremely low or absent motility. In order to determine the efficacy of ICSI in these patients, a retrospective analysis of ICSI results in DFS patients has been done. Methods: Ten ICSI attempts were performed in 6 patients with diagnosis of Dysplasia of the Fibrous Sheath studied by transmission and scanning electron microscopy. Results: In the cases studied, sperm concentration was (29.62 _+ 18.05) x 106/mL, total motility was 1.14 _+ 1.31%. Progressive motility was 0% except for one case with 0.1%. One hundred and three preovulatory oocytes were obtained and 94 metaphase 11 oocytes were injected. Sixty-nine of them showed two pronuclei (fertilization rate: 73.4% ). Forty-nine embryos were obtained and 34 were transferred (mean: 3.4 embryos per transfer). Five pregnancies were diagnosed by β-hCG plasma level determinations that resulted to be one preclinical abortion, one clinical abortion and three deliveries. Another pregnancy (ongoing) was achieved from a cryopreserved embryo transfer. Conclusion: These results showed that ICSI provides a suitable solution for patients suffering from irreversible sperm defects such as DFS. Nevertheless, it is mandatory to inform couples of possible transmission risks to offspring, which are unknown at present. Only when the etiology of this problem is disclosed, it will be possible to assess the real genetic risk. | Santiago Brugo Olmedo Vanesa Y.Rawe Florencia N.Nodar German D.Galavema Anibal A.Acosta Hector E.Chemes | 2000 | Asian Journal of Andrology2000，2，2： | 7 |
| 3 | Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa显示文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P< 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women. | Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo Djeneba Ouermi Florencia W Djigma Salvatore Pignatelli Joseph D Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 4 |
| 4 | Allelic Analyses of the Arabidopsis YUC1 Locus Reveal Residues and Domains Essential for the Functions of YUC Family of Flavin Monooxygenases显示文摘Flavin monooxygenases(FMOs) play critical roles in plant growth and development by synthesizing auxin and other signaling molecules.However,the structure and function relationship within plant FMOs is not understood.Here we defined the important residues and domains of the Arabidopsis YUC1 FMO,a key enzyme in auxin biosynthesis.We previously showed that simultaneous inactivation of YUC1 and its homologue YUC4 caused severe defects in vascular and floral development.We mutagenized the yuc4 mutant and screened for mutants with phenotypes similar to those of yuc1 yuc4 double mutants.Among the isolated mutants,five of them contained mutations in the YUC1 gene.Interestingly,the mutations identified in the new yuc1 alleles were concentrated in the two GXGXXG motifs that are highly conserved among the plant FMOs.One such motif presumably binds to flavin adenine dinucleotide(FAD) cofactor and the other binds to nicotinamide adenine dinucleotide phosphate(NADPH).We also identified the Ser139 to Phe conversion in yuc1,a mutation that is located between the two nucleotide-binding sites.By analyzing a series of yuc1 mutants,we identified key residues and motifs essential for the functions of YUC1 FMO. | Xianhui Hou Sainan Liu Florencia Pierri Xinhua Dai Li-Jia Qu Yunde Zhao | 2011 | Journal of Integrative Plant Biology2011，53，1： | 4 |
| 5 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 6 | Metastatic Nonfunctioning Pancreatic Neuroendocrine Carcinoma to Liver: Surgical Treatment and Outcomes显示文摘 | Daniel Cusati Lizhi Zhang William S. Harmsen Amy Hu Michael B. Farnell David M. Nagorney John H. Donohue Florencia G. Que Kaye M. Reid-Lombardo Michael L. Kendrick | 2012 | Journal of the American College of Surgeons2012，，1： | 3 |
| 7 | Fabrication of titanium based biphasic scaffold using selective laser melting and collagen immersion显示文摘Tissue engineering approaches have been adopted to address challenges in osteochondral tissue regeneration.Single phase scaffolds,which consist of only one single material throughout the whole structure,have been used extensively in these tissue engineering approaches.However,a single phase scaffold is insufficient in providing all the properties required for regeneration and repair of osteochondral defects.Biphasic scaffolds with two distinct phases of titanium/type 1 collagen and titanium-tantalum/type 1 collagen were developed for the first time using selective laser melting and collagen infiltration.Observation of the biphasic scaffolds demonstrated continuous interface between the two phases and mechanical characterization of the metallic scaffolds support the feasibility of the newly developed scaffolds for tissue engineering in osteochondral defects. | Swee Leong Sing Shuai Wang Shweta Agarwala Florencia Edith Wiria Thi Mai Hoa Ha Wai Yee Yeong | 2017 | International Journal of Bioprinting2017，3，1： | 3 |
| 8 | Antimicrobial resistance of abnormal vaginal discharges microorganisms in Ouagadougou,Burkina Faso显示文摘Objective:To assess the prevalence of bacterial strains and fungal strains infecting the vaginal tract and test their sensitivity to antibiotics in women attending Saint Camille Medical Centre in Ouagadougou.Methods:From January 2008 to December 2009,a total of 2000 vaginal swabs were cultivated for bacterial and fungal identification and isolation.Furthermore,bacterial strains were tested for their susceptibility to several antibiotics used in routine in the centre. Results:The results revealed that microbial isolation and identification was attempted for 1536/2000 sample,a positivity rate of 76.80%.Candida albicans(48.76%),followed by Escherichia coli(16.67%),Streptococcus agalactiae(8-14%) and Staphylococcus aureus(7.55%) were the major agents of genital tract infections in patients.Mycoplasma hominis and Ureaplasma urealyticum combined accounted for less than 7%.Trichomonas vaginalis was identified in 1.04%coses.The antimicrobial tests revealed that the microorganisms developed resistance to several antibiotics including beta lactams.However,antibiotics such as cefamenzol,ciprofloxacin and norfloxacin were still active on these bacteria.Conclusions:The results reveal that many sexually active women are infected by one or more microbial pathogens,probably because of the lock of hygiene or the adoption of some risky behaviors,such as not using condoms or having multiple sexual partners.Efforts should be made to address these points in the country. | Simplice D Karou Florencia Djigma Tani Sagna Christelle Nadembega Moctar Zeba Aboudoulaye Kabre Kokou Anani Djeneba Ouermi Charlemagne Gnoula Virginio Pietra Salvatore Pignatelli Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 2 |
| 9 | Hepatic resection of hepatocellular carcinoma in patients with cirrhosis: Model of end-stage liver disease (MELD) score predicts perioperative mortality显示文摘 | Swee H. Teh John Christein John Donohue Florencia Que Michael Kendrick Michael Farnell Stephen Cha Patrick Kamath Raymond Kim David M. Nagorney | 2005 | Journal of Gastrointestinal Surgery2005，，9： | 2 |
| 10 | Integrated preclinical and clinical development of S- trans, trans -farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer显示文摘 | Daniel Laheru Preeti Shah N. V. Rajeshkumar Florencia McAllister Gretchen Taylor Howard Goldsweig Dung T. Le Ross Donehower Antonio Jimeno Sheila Linden Ming Zhao Dongweon Song Michelle A. Rudek Manuel Hidalgo | 2012 | Investigational New Drugs2012，，6： | 2 |
| 11 | Hepatic resection of hepatocellular carcinoma in patients with cirrhosis: Model of end-stage liver disease (MELD) score predicts perioperative mortality显示文摘 | Swee H. Teh M.D. John Christein M.D. John Donohue M.D. Florencia Que M.D. Michael Kendrick M.D. Michael Farnell M.D. Stephen Cha Patrick Kamath M.D. Raymond Kim M.D. David M. Nagorney M.D | 2005 | Journal of Gastrointestinal Surgery2005，，9： | 2 |
| 12 | Is There a Role for Endoscopic Therapy as a Definitive Treatment for Post-Laparoscopic Bile Duct Injuries?显示文摘 | Javairiah Fatima Joshua G. Barton Travis E. Grotz Zhimin Geng William S. Harmsen Marianne Huebner Todd H. Baron Michael L. Kendrick John H. Donohue Florencia G. Que David M. Nagorney Michael B. Farnell | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 13 | Adenosquamous Carcinoma of the Pancreas: A Single-Institution Experience Comparing Resection and Palliative Care显示文摘 | Rory L. Smoot Lizhi Zhang Thomas J. Sebo Florencia G. Que | 2008 | Journal of the American College of Surgeons2008，，3： | 2 |
| 14 | 管理森林休闲地:提高“刀耕火种”农业的经济效益显示文摘对休闲地进行改良已被推荐为热带轮垦农业的管理方法之一。具有经济和生物效益的改良休闲地在美洲分布十分广泛,然而,真正实现上述两种效益的休闲地却很少。在本文中,我们对通过种植用材树来管理休闲地以培肥土壤和生产具有经济价值的木材这一做法的经济可行性进行了评估。在实际利润率为5%时,从事自给自足农业生产的每公顷培肥休闲地产出价值5000~12000美元。该结果表明,以这一方式经营森林休闲地可使轮垦农业获得持续性发展并使其具有经济竞争力。尽管试验是在具体的立地条件下进行的,但实验中所用树种在拉丁美洲分布广泛,我们希望这一制度能够应用于生态和社会经济条件都相似的其它地区。 | Florencia Montagnini Robert O.Mendelsohn 刘伟 | 1997 | 人类环境杂志1997，26，2： | 2 |
| 15 | The Course of Posttransplant Hepatitis C Infection: Comparative Impact of Donor and Recipient Source of the Favorable IL28B Genotype and Other Variables显示文摘 | Andres Duarte-Rojo Bart J. Veldt David D. Goldstein Hans L. Tillman Kymberly D. Watt Julie K. Heimbach John G. McHutchison John J. Poterucha Florencia Vargas-Vorackova Michael R. Charlton | 2012 | Transplantation Journal2012，，2： | 2 |
| 16 | Seroepidemiology of Hepatitis B and C Viruses in the General Population of Burkina Faso显示文摘 | Issoufou Tao Tegwindé R. Compaoré Birama Diarra Florencia Djigma Theodora M. Zohoncon Maléki Assih Djeneba Ouermi Virginio Pietra Simplice D. Karou Jacques Simpore Annarosa Floreani | 2014 | Hepatitis Research and Treatment2014，，： | 1 |
| 17 | Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration显示文摘 | Alejandro F. De Nicola Florencia Labombarda Maria Claudia Gonzalez Deniselle Susana L. Gonzalez Laura Garay Maria Meyer Gisella Gargiulo Rachida Guennoun Michael Schumacher | 2009 | Frontiers in Neuroendocrinology2009，，2： | 1 |
| 18 | Lateral periodontal cysts: A retrospective study of 11 cases 显示文摘 | Maria Florencia Formoso Senande Leonardo Berini Aytrs | 2008 | Med Oral Patol Oral Cir Bucal2008，13，5： | 1 |
| 19 | Flow cytometric analysis of T-lymphocytes from nasopharynx-associated lymphoid tissue (NALT) in a model of secondary immunodeficiency in Wistar rats显示文摘 | Gustavo Adolfo Sosa María Florencia Quiroga María Estela Roux | 2008 | Immunobiology2008，，5： | 1 |
| 20 | Cadmium induces different biochemical responses in wild type and catalase-deficient tobacco plants显示文摘 | María Florencia Iannone María Daniela Groppa María Patricia Benavides | 2014 | Environmental and Experimental Botany2014，，： | 1 |
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