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| 1 | Progress in researches about focal adhesion kinase in gastrointestinal tract显示文摘Focal adhesion kinase(FAK)is a 125-kDa non-receptor protein tyrosine.Growth factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein tyrosine kinases,resulting in the phosphorylation of Tyr-576 and Tyr-577 in the FAK activation loop and full catalytic FAK activation.FAK plays a critical role in the biological processes of normal and cancer cells including the gastrointestinal tract.FAK also plays an important role in the restitution,cell survival and apoptosis and carcinogenesis of the gastrointestinal tract.FAK is over-expressed in cancer cells and its over-expression and elevated activities are associated with motility and invasion of cancer cells.FAK has been proposed as a potential target in cancer therapy.Small molecule inhibitors effectively inhibit the kinase activity of FAK and show a potent inhibitory effect for the proliferation and migration of tumor cells,indicating a high potential for application in cancer therapy. | Hui Fang Hao Yoshio Naomoto Xiao-Hong Bao Nobuyuki Watanabe Kazufumi Sakurama Kazuhiro Noma Yasuko Tomono Takuya Fukazawa Yasuhiro Shirakawa Tomoki Yamatsuji Junji Matsuoka Munenori Takaoka | 2009 | World Journal of Gastroenterology2009，15，47： | 8 |
| 2 | Peritoneal bleeding due to percutaneous transhepatic gallbladder drainage:An autopsy report显示文摘A 77-year-old man underwent percutaneous transhepatic gallbladder drainage(PTGBD) for acute cholecystitis as a preoperative procedure;however,he suddenly suffered cardiopulmonary arrest 4 h after the PTGBD and died.There were three centesis scars for the PTGBD,and only one pathway from the most dorsal centesis scar reached the gallbladder.Microscopically,the PTGBD pathway crossed and injured the intrahepatic arterial wall,and hepatic parenchymal bleeding extended along the PTGBD pathway to the inferior surface of the liver.Blood flowed to the peritoneal cavity through a small gap between the liver and gallbladder.Consequently,the PTGBD caused lethal bleeding.When the percutaneous transhepatic cholangio drainage/PTGBD pathway runs close to vessels near the liver surface,it might be necessary to deal with the possibility of rapid and lethal peritoneal bleeding. | Yoko Ihama Maki Fukazawa Kenji Ninomiya Takumi Nagai Chiaki Fuke Tetsuji Miyazaki | 2012 | World Journal of Hepatology2012，4，10： | 7 |
| 3 | Role of nitric oxide in liver transplantation:Should it be routinely used?显示文摘Ischemia-reperfusion injury(IRI) continues to be a major contributor to graft dysfunction, thus supporting the need for therapeutic strategies focused on minimizing organ damage especially with growing numbers of extended criteria grafts being utilized which are more vulnerable to cold and warm ischemia. Nitric oxide(NO·) is highly reactive gaseous molecule found in air and regarded as a pollutant. Not surprising, it is extremely bioactive, and has been demonstrated to play major roles in vascular homeostasis, neurotransmission, and host defense inflammatory reactions. Under conditions of ischemia, NO· has consistently been demonstrated to enhance microcirculatory vasorelaxation and mitigate pro-inflammatory responses, making it an excellent strategy for patients undergoing organ transplantation. Clinical studies designed to test this hypothesis have yielded very promising results that includes reduced hepatocellular injury and enhanced graft recovery without any identifiable complications. By what means NO· facilitates extra-pulmonary actions is up for debate and speculation. The general premise is that they are NO· containing intermediates in the circulation, that ultimately mediate either direct or indirect effects. A plethora of data exists explaining how NO·-containing intermediate molecules form in the plasma as S-nitrosothiols(e.g., S-nitrosoalbumin), whereas other compelling data suggest nitrite to be a protective mediator. In this article, we discuss the use of inhaled NO· as a way to protect the donor liver graft against IRI in patients undergoing liver transplantation. | Kyota Fukazawa John D Lang | 2016 | World Journal of Hepatology2016，8，34： | 4 |
| 4 | Poly (ADP-ribose) polymerase 1 inhabits ATM kinase activity in DNA damage response显示文摘 | Watanabe F Fukazawa H Masutani M | 2004 | Biochem Biophys Res Comun2004，319，2： | 1 |
| 5 | Long - term prognosis of patients with Kawasaki disease:At risk for future atherosclerosis 显示文摘 | Fukazawa R Ogawa S | 2009 | J Nippon Med Sch2009，76，3： | 1 |
| 6 | Mitogen-activated protein/ extrace|lular signal- regulated kinase kinase (MEK) inhibitors restore anoikis sensilivity in human breast cancer cell lines with a constitutive- ly activated extracellular-regulated kinase (ERK) pathway 显示文摘 | Fukazawa H Noguchi K Murakami Y | 2002 | Mol Cancer Ther2002，，5： | 1 |
| 7 | Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice 显示文摘 | Suzuki M Honda K Fukazawa M | 2012 | J Pharmacol Exp Ther2012，341，3： | 1 |
| 8 | Imprinting,expression,and localisation of DLK1 in Wilms tumours显示文摘 | FUKAZAWA R HEATHCOTT RW MORISON IM | | 0，，02： | 1 |
| 9 | Antitumor effect of temsirolimus against oral squamous cellcarcinoma associated with bone destruction显示文摘 | Okui T Shimo T Fukazawa T | | 0，，11： | 1 |
| 10 | Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer显示文摘 | Hui-fang Hao Munenori Takaoka Xiao-hong Bao Zhi-gang Wang Yasuko Tomono Kazufumi Sakurama Toshiaki Ohara Takuya Fukazawa Tomoki Yamatsuji Toshiyoshi Fujiwara Yoshio Naomoto | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 11 | Possible synergic effect of angiotensin-I converting enzyme gene Insertion/Deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease显示文摘 | Fukazawa R Sonobe T Hamamoto K | 2004 | Pediatr Res2004，56，4： | 1 |
| 12 | Activation of ERK cascade promotes accumulation of Vesl-1S/Homer-1 a immunoreactivity at synapses 显示文摘 | Kato A Fukazawa Y Ozawa F l | 2003 | Brain Res Mol Brain Res2003，118，12： | 1 |
| 13 | Estimation of myocardial hemodynamics before and after intervention in children with Kawasaki disease显示文摘 | Ogawa S Ohkubo T Fukazawa R | 2004 | J Am Coll Cardiol2004，43，4： | 1 |
| 14 | Antitumor eff- ect of temsirolimus against oral squamous cell carcinoma associated with bone destruction 显示文摘 | Tatsuo Okui Tsuyoshi Shimo Takuya Fukazawa | 2010 | Mol Cancer2010，9，11： | 1 |
| 15 | Autolysis of squid mantle muscle protein as affected by storage conditions and inhibitors显示文摘 | KONNO K FUKAZAWA C | 1993 | Journal of Food Science1993，58，6： | 1 |
| 16 | Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo显示文摘 | Naito Kurio Tsuyoshi Shimo Takuya Fukazawa Munenori Takaoka Tatsuo Okui Nur Mohammad Monsur Hassan Tatsuki Honami Shinji Hatakeyama Masahiko Ikeda Yoshio Naomoto Akira Sasaki | 2011 | Experimental Cell Research2011，，： | 1 |
| 17 | Association of vitamin Dreceptor gene polymorphism with multiple sclerosis in Japanese显示文摘 | Fukazawa T Yabe I Kikuchi S | 1999 | J Neurol Sci1999，166，1： | 1 |
| 18 | New method for detection of Candaida albicans in human blood by Ploymerase Chian Reaction显示文摘 | Miyakawa Y Mabuchi T Fukazawa Y | 1993 | J Clin Microbiol1993，31，12： | 1 |
| 19 | C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosis显示文摘 | Miyagishi R Niino M Fukazawa T | 2003 | J Neuroimmunol2003，145，12： | 1 |
| 20 | Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence显示文摘 | Fukazawa R Ikegam E Watanabe M | 2007 | Circ J2007，71，5： | 1 |
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