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| 1 | Hepatitis C virus and metabolic disorder interactions towards liver damage and atherosclerosis显示文摘Hepatitis C virus(HCV)is one of the main causes of liver disease worldwide,and alterations of glucose metabolism have reached pandemic proportions in western countries.However,the frequent coexistence between these two conditions is more than simply coincidental,since HCV can induce insulin resistance through several mechanisms.Indeed,the virus interferes with insulin signaling both directly and indirectly,inducing the production of pro-inflammatory cytokines.Furthermore,the entire viral life cycle has strict interconnections with lipid metabolism,and HCV is responsible for a'viral'steatosis which is frequently superimposed to a'metabolic'one.Several evidences suggest that HCV-induced metabolic disorders contribute both to the evolution of liver fibrosis and,likely,to the progression of the other disorders which are typically associated with altered metabolism,in particular atherosclerosis.In the present review,we will examine in depth the links between HCV infection and insulin resistance,liver steatosis and diabetes,and analyze the impact of these interactions on the progression of liver fibrosis and atherosclerosis.Special attention will be focused on the highly debated topic of the relationship between HCV infection and cardiovascular disease.The available clinical literature on this item will be broadly reviewed and all the mechanisms possibly implied will be discussed. | Umberto Vespasiani-Gentilucci Paolo Gallo Antonio De Vincentis Giovanni Galati Antonio Picardi | 2014 | World Journal of Gastroenterology2014，20，11： | 5 |
| 2 | Hepatitis C treatment in the elderly:New possibilities and controversies towards interferon-free regimens显示文摘Due to the progressive aging of the hepatitis C virus(HCV) population which have acquired the infection during its maximum spread after the Second World War, the management of the elderly HCV-infected patient is emerging as a hot topic. Unfortunately, although it is recognized that the progression of HCV-related liver disease gets faster with aging, and that even extrahepatic manifestations of HCV infection are probably worse in the elderly, till now, treatment attempts in this population have been significantly limited by the wellknown contraindications and side effects of interferon(IFN). The arrival of several new anti-HCV drugs, and the possibility to combine them in safe and effective anti-viral regimens, is relighting the hope of a cure for many elderly patients who had been cut out of IFN-based treatments. However, although these new regimens will be certainly more manageable, it should be underscored that IFN-free doesn't mean free from any contraindication or side-effect. Moreover, one issue which promises to become central is that of the possible interactions between antiviral therapy and the multiple drugs frequently assumed by elderly patients because of comorbidities. In this review, we will revise the epidemiology pointing to HCV as an infection of the elderly, the evidences that HCV harms the health of the aged patient more than that of the young one, and the available experiences of HCV treatment in the elderly with the 'old' IFN-based regimens and with the newer drugs. We will conclude that the availability of IFNfree regimens should prompt us to change our mind and consider a significantly larger number of possible candidates among elderly patients, who would take significant advantage from viral eradication. Rather than the anagraphic age, drug-drug interactions and, mainly in case of economic restrictions, an evaluation of life expectancy dependent on liver disease with respect to that dependent on comorbidities, are likely to be the key issues guiding treatment indication in the next future. The sooner we will change our mind with respect to an a priori obstacle for anti-HCV treatment in the elderly, the sooner we will begin to spare many aged HCV patients from avoidable liver-related complications. | Umberto Vespasiani-Gentilucci Giovanni Galati Paolo Gallo Antonio De Vincentis Elisabetta Riva Antonio Picardi | 2015 | World Journal of Gastroenterology2015，21，24： | 4 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | Hepatitis C and double-hit B cell lymphoma successfully treated by antiviral therapy显示文摘B cells lymphoma is one of the most challenging extrahepatic manifestations of hepatitis C virus(HCV). Recently, a new kind of B-cell lymphoma, named doublehit B(DHL), was characterized with an aggressive clinical course whereas a potential association with HCV was not investigated. The new antiviral direct agents(DAAs) against HCV are effective and curative in the majority of HCV infections. We report the first case, to our knowledge, of DHL and HCV-infection successfully treated by new DAAs. According to our experience, a DHL must be suspected in case of HCV-related lymphoma, and an early diagnosis could direct towards a different hematological management because a worse prognosis might be expected. A possible effect of DAAs on DHL regression should be investigated, but eradicating HCV would avoid life-threatening reactivation of viral hepatitis during pharmacological immunosuppression in oncohaematological diseases. | Giovanni Galati Lorenzo Rampa Umberto Vespasiani-Gentilucci Mirella Marino Francesco Pisani Carlo Cota Alessandro Guidi Antonio Picardi | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 5 | Non-cirrhotic portal hypertension with large regenerative nodules: A diagnostic challenge显示文摘Non-cirrhotic portal hypertension is a poorly understood condition characterized by portal hypertension in the absence of conventional hepatic cirrhosis and described in association with blood coagulation disorders, myeloproliferative and immunological diseases and with exposure to toxic drugs. Very recently, precise classification criteria have been proposed in order to define four distinct subcategories. The present case highlights how the clinical presentation, the confounding results from imaging studies, and the difficulties in the histological evaluation often render cases of non-cirrhotic portal hypertension a real diagnostic challenge. It also underscores the classification problems which can be faced once this diagnosis is performed. Indeed, the different subcategories proposed result from the prevalent subtypes in a spectrum of hepatic regenerative responses to a variety of injuries determining microcirculatory dis-turbances. More flexibility in classification should derive from this etiopathogenic background. | Umberto Vespasiani Gentilucci Paolo Gallo Giuseppe Perrone Riccardo Del Vescovo Giovanni Galati Sandro Spataro Chiara Mazzarelli Adriano Pellicelli Antonella Afeltra Antonio Picardi | 2011 | World Journal of Gastroenterology2011，17，20： | 2 |
| 6 | Endoscopic retrograde cholangiography for intrabiliary rupture of hydatid cyst显示文摘 | Gaspare Galati Antonio V. Sterpetti Maria Caputo Marianna Adduci Giorgio Lucandri Stefania Brozzetti Antonio Bolognese Antonino Cavallaro | 2006 | The American Journal of Surgery2006，，2： | 2 |
| 7 | Boceprevir for Chronic HCV Genotype 1 Infection in Patients with Prior Treatment Failure to Peginterferon/Ribavirin, including Prior Null Response显示文摘 | John M. Vierling Mitchell Davis Steven Flamm Stuart C. Gordon Eric Lawitz Eric M. Yoshida Joseph Galati Velimir Luketic Jonathan McCone Ira Jacobson Patrick Marcellin Andrew J. Muir Fred Poordad Lisa D. Pedicone Janice Albrecht Clifford Brass Anita Y.M. H | 2013 | Journal of Hepatology2013，，： | 2 |
| 8 | Transcranial magnetic stimulation highlights the sensorimotor side of empathy for pain 显示文摘 | I Avenanti A Bueti D Galati G | 2005 | Nature Neuroscience2005，8，： | 1 |
| 9 | Dependence of photoemission of amorphous silicon nitride thin films on their composition 显示文摘 | Compagnini G Galati C Miliani C | 2002 | Surface and Coatings Technology2002，，： | 1 |
| 10 | Discontinuous Brillouin Strain Monitoring of Small Concrete Bridges Comparison Between Near-to-surface and Smart FRP Fiber Installation Techniques 显示文摘 | BASTIANINI Filippo RIZZO Andrea GALATI Nestore | 2005 | Proceedings of the SPIE (S0277-786X)2005，5765，： | 1 |
| 11 | Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics显示文摘 | GALATI G TENG S MORIDANI M Y | 2000 | Drug Metab Drug Interact2000，17，： | 1 |
| 12 | Prognostic value of left ventric- ular volume response during dobutamine stress echocardiography 显示文摘 | Coletta C Galati A Ricci R | 1997 | Eur Heart J1997，18，10： | 1 |
| 13 | Peripheral depletion of NK cells and imbalance of the Treg/Thl7 axis in idiopathic pulmonary fibrosis patients显示文摘 | Galati D De Martino M Trotta A | 2014 | Cytokine2014，66，2： | 1 |
| 14 | The serendipity case of the pedunculopontine nucleus low-frequency brain stimulation:chasing a gait response,finding sleep,and cognition improvement显示文摘 | Stefani A Peppe A Galati S | 2013 | Front Neurol2013，4，： | 1 |
| 15 | Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease显示文摘 | Galati JS Holdeman KP Dalrymple GV | 1994 | Am J Gastroenterol1994，89，5： | 1 |
| 16 | Ticagrelor versus prasugrel in acute coi'onary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: a pharmacodynamic study显示文摘 | Alexopoulos D Galati A Xanthopoulou I | 2012 | J Am Coll Cardiol2012，60，3： | 1 |
| 17 | Peroxidative metabolism of apigenin and naringcnin versus luteolin and quereetin: glutathione oxidation and conjugation显示文摘 | GALATI G MORIDANT M Y CHAN T S | 2001 | Free Radical Bio Med2001，30，4： | 1 |
| 18 | Altered patterns of tubulin polymerization in dividing leaf cells of Chlorophyton comosum after a hyperosmotic treatment显示文摘 | Komis G Apostolakos P Galatis B | 2001 | New Phytol2001，149，2： | 1 |
| 19 | Transcranial Magnetic Stimulation Highlights the Sensorimotor Side of Empathy for Pain显示文摘 | Avenanti A Bueti D Galati G Aglioti SM | | 0，，： | 1 |
| 20 | Primary al- dosteronism: emerging trends 显示文摘 | Galati SJ Hopkins SM Cheesman KC | 2013 | Trends Endoerinol Metab2013，24，9： | 1 |
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