|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of potassium in acid secretion显示文摘Potassium (K+) ions are critical for the activation and catalytic cycle of the gastric H+,K+-ATPase, resulting in the secretion of hydrochloric acid into the parietal cell canaliculus. As both symptom, severity and esophageal mucosal damage in gastro-esophageal reflux disease (GERD) are related to the degree of acid exposure, K+ is a logical target for approaches to inhibit acid production.The probable K+ binding site on the gastric H+,K+-ATPase has recently been described and studies are elucidating how K+ activates the enzyme. K+ channels in the apical membrane of the parietal cell are implicated in the recycling of K+ and, to date, three potential K+ channels (KCNQ1, Kir2.1 and Kir4.1) have been identified. The channels represent theoretical sites for agents to control acid secretion but it will be difficult to develop selective blockers. An alternative strategy is to prevent K+ from activating gastric H+,K+-ATPase; the potassiumcompetitive acid blocker (P-CAB) class inhibits acidsecretion by binding at or near the K+ binding site.Ongoing research is further defining the role of K+ in the functioning of the gastric H+,K+-ATPase, as well as determining the clinical utility of agents directed toward this important cation. | John P Geibel | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 2 | Role of calcium and other trace elements in the gastrointestinal physiology显示文摘钙是在海洋、陆上的有机体的一个必要离子,在它在从骨骼的形成和维护到神经元功能的规定的过程起一个关键作用的地方。Ca (2+) 平衡被三个机关系统维持,包括胃肠道,骨头和肾。因为第一在 1993 正在被克隆,察觉到受体的 Ca (2+) 沿着全部胃肠道被表示了,直到现在准确功能仅仅部分被阐明。如果察觉到受体的 Ca (2+) 涉及钙由胃肠道处理,这个日期,它尚待坚定。然而,有很少研究,显示出在冒号在胃的酸分泌物和液体运输上察觉到受体的 Ca (2+) 的生理的效果。另外, polyamines 和氨基酸被显示了激活察觉到受体的 Ca (2+) 并且也充当紧密相联的位的修饰词表明滋养的可获得性到肠的上皮细胞。察觉到受体的结肠的 Ca (2+) 的激活能废除在修改象霍乱一样的能分泌的腹泻建议受体的一个角色的周期的调停核苷酸的液体分泌物。为在细胞外的 Ca (2+) 的许多房间类型变化,集中能从增长交换细胞的行为到终端区别或静止。当癌症主要仍然是在增长,结束和 apoptosis 之间的混乱平衡的疾病,在察觉到受体的 Ca (2+) 的功能的混乱可以贡献肿瘤的疾病的前进。压制提高的细胞外的 Ca (2+) 的效果的生长的损失在冒号癌被表明了,并且在 CaSR 表示的水平与变化被相关。 | P Kirchhoff JP Geibel | 2006 | World Journal of Gastroenterology2006，12，20： | 2 |
| 3 | SVM learning with the Schur-Hadamard inner product for graplas显示文摘 | Jain B J Geibel P Wysotzki F | 2005 | Neuro- computing2005，64，： | 1 |
| 4 | L-type amino acids stimulate gastric acid secretion by activation of the calcium- sensing receptor in parietal cells 显示文摘 | Busque S M Kerstetter J E Geibel J P | 2005 | Am J Physiol Gastrointest Liver Physiol2005，289，4： | 1 |
| 5 | Gastric acid, calcium absorption, and their impact on bone health 显示文摘 | Kopic S Geibel J P | 2013 | Physiol Rev2013，93，1： | 1 |
| 6 | Gi regulation of secretory vesicle swelling examined by atomic force microscopy显示文摘 | Jena B P Schneider S W Geibel J P | 1997 | Proc Natl Acad Sci USA1997，94，13： | 1 |
| 7 | Biological diversity in Malus sieversii populations from central Asia显示文摘 | GEIBEL M DEHMER K J FORSLINE P L | 2000 | Acta Horticulturae2000，538，： | 1 |
| 8 | The European strawberry database and building up a European core collection显示文摘 | GEIBEL M ROUDEILLAC P MASNY A | 2004 | Acta Hort2004，，649： | 1 |
| 9 | Unusual permeability properties of gastric gland cells显示文摘 | WAISBREN S J GEIBEL J P MODLIN I M | 1994 | Nature1994，368，6469： | 1 |
| 10 | The functions and roles of the extra-cellular Ca2+ -Sensing receptor along the gastrointestinal tract显示文摘 | Geibel J P Hebert S C | 2009 | Annu Rev Physiol2009，，71： | 1 |
| 11 | The European strawberry database and building up a European core collection显示文摘 | GEIBEL M ROUDEILLAC P MASNY A | 2004 | Acta Horticulturae2004，649，： | 1 |
| 12 | MALDI-TOF MS Study of Poly(p-phenylene sulfide)显示文摘 | Gies A P Geibel J F Hercules D M | 2009 | Macromolecules2009，43，2： | 1 |
| 13 | The functions and roles of the extracellular Ca2+-sensirtg receptor along the gastrointestinal traet显示文摘 | GEIBEL J P HEBERT S C | 2009 | Annu Rev Physiol2009，71，： | 1 |
| 14 | The functions and roles of the extracellu- lar Ca2 + -sensing receptor along the gastrointestinaltract 显示文摘 | Geibel J P Hebert S C | 2009 | Annu Rev Physiol2009，71，： | 1 |
| 15 | MALDI-TOF MS study of poly(p-phenylene sulfide)显示文摘 | Gies A P Geibel J F Hercules D M | | 0，，： | 1 |
| 16 | New Observations Concerning Magnetism and Superconductivity in Heavy-fermion Metals显示文摘 | GEENWART P GEIBEL C etal | 1996 | Physica1996，2232，： | 1 |
| 17 | MALDI-TOF MS study of poly(p-phenylene sulfide)显示文摘 | Gies A P Geibel J F Hercules D M | 2010 | Macromolecules2010，43，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员