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14篇 您的检索式:作者名="Gratieri"
    题名 作者 年代 出处 被引量
1Not all electronic foramen locators are accurate in teeth with enlarged apical foramina: an in vitro comparison of 5 brands显示文摘Akisue E Gratieri SD Barletta FB 2014J Endod2014,40,1:1
2Iontophoretic transport kinetics of ketorolac in vitro and in vivo:demonstrating local enhanced topical drug delivery to muscle显示文摘Gratieri T Pujol-Bello E Gelfuso G M 2014Eur JPharm Biopharm2014,86,2:1
3A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery显示文摘Taís Gratieri Guilherme Martins Gelfuso Eduardo Melani Rocha Victor Hugo Sarmento Osvaldo de Freitas Renata Fonseca Vianna Lopez 2010European Journal of Pharmaceutics and Biopharmaceutics2010,,2:1
4Enhancing and sustaining the topical ocular delivery of fluconazole using chi- tosan solution and poloxamer/chitosan in situ forming gel显示文摘Gratieri T Gelfuso GM de Freitas O 2011Eur J Pharm Biopharm2011,79,2:1
5Not all electronic foramen loeators are accurate in teeth with enlarged apical fo ramina : an in vitro comparison of 5 brands显示文摘Akisue E Gratieri S D Barletta F B 2014J Endod2014,40,1:1
6A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery显示文摘Gratieri T Gelfuso GM Rocha EM 2010Eur J Pharm Biopharm2010,75,2:1
7A poloxam- er/chitosan in situ forming gel with prolonged retention time for ocular delivery 显示文摘GRATIERI T GELFUSO G M ROCHA E M 2010Eur J Pharm Biopharm2010,75,2:1
8Enhan- cing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel 显示文摘GRATIERI T GELFUSO G M DE FREITAS O 2011Eur J Pharm Biopharm2011,79,2:1
9Enhancing and sustaining the topical ocular delivery of flu conazole using chitosan solution and poloxamer chitosan in situ forming gel显示文摘Tais Gratieri Guilherme Martins Gelfuso Osvaldo de Freitas 2011European Journal of Pharmaceutics and Biop- harmaceutics2011,79,:1
10Enhancing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel 显示文摘GRATIERI T GELFUSO G M DE FREITAS O 2011Eur J Pharm Biopharm2011,79,2:1
11A poloxamer/chitosanin situ forming gel with prolonged retention time for oculardelivery显示文摘Gratieri T Gelfuso GM Rocha EM 2010Eur J Pharm Biopharm2010,75,2:1
12Non-invasive iontophoretic delivery of peptides and proteins across the skin显示文摘Gratieri T Kalaria D Kalia YN 0,,05:1
13Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines显示文摘One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures.This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,tested regarding their morphology and thermal,crystallographic,and spectroscopic profiles.Generally,despite the strong drug-polymer interactions observed,the chemical stability of the model drugs was preserved under such conditions.In fact,in the metoprolol and Soluplus®composition,the drug's solubilization in the polymer produced a delay in the drug decomposition,suggesting a protective effect of the matrix.Paracetamol and polyvinyl alcohol mixture,in turn,showed unmistakable signs of thermal instability and chemical decomposition,in addition to physical changes.In the presented context,establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.Ihatanderson A.Silva Ana Luiza Lima Tais Gratieri Guilherme M.Gelfuso Livia L.Sa-Barreto Marcilio Cunha-Filho 2022Journal of Pharmaceutical Analysis2022,12,3:0
14The influence of porosity on tablet subdivision显示文摘A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical properties.Herein,tablet subdivisions were studied as a functi on of tablet porosity.The tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose monohydrate.Furthermore,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of porosity.Microstructural assays were corre lated to the subdivision performs nee.The increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the subdivision.For all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision occurred.The in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision results.Con trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.Maira T.Teixeira Livia L.Sa-Barreto Izabel C.Silva Tais Gratieri Guilherme M.Gelfuso Ricardo N.Marreto Mariana Landin Marcilio Cunha-Filho 2020Particuology2020,,6:0
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