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| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | 顺义地裂缝成因与顺义-良乡断裂北段第四纪活动性讨论显示文摘本文通过钻孔地层对比方法研究了顺义 -良乡断裂北段的第四纪活动性 ,资料显示该断裂在第四纪期间呈现强弱交替的分期活动特征 ,距今 315万年以来有 3个较强活动期和 3个较弱活动期 ,前三者分别距今 2 6 6~ 315、171~ 2 2 8、73~ 14 7万年 ,后三者距今分别为 2 2 8~ 2 6 6、14 7~ 171、0~ 73万年。中更新世晚期以来断裂活动不明显。超量开采地下水导致地面不均匀沉降是造成顺义地裂缝现今活动的主要原因。 | 张世民 刘旭东 任俊杰 刘光勋 Liu Guangxun | 2005 | 中国地震2005，21，1： | 16 |
| 3 | Celastrol specifically inhibits the activation of NLRP3 inflammasome显示文摘Dear Editor,Inflammasomes are vital components of the innate immune system that survey microbial infections or sterile challenges in the cytosol(de Zoete et al.,2014).A typical inflammasome is composed of a sensor protein such as NOD like receptor(NLR)or AIM2 like receptor(ALR),the | Xuesong Sang Yihui Chen Wei Chen Jing Xie Guangxun Meng Jin Zhong Taisheng Li Ailing Lu | 2018 | Science China(Life Sciences)2018，61，3： | 9 |
| 4 | Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity显示文摘The metabolic intermediate of acetaminophen(APAP)can cause severe hepatocyte necrosis,which triggers aberrant immune activation of liver non-parenchymal cells(NPC).Overzealous hepatic inflammation determines the morbidity and mortality of APAP-induced liver injury(AILI).Interleukin-1 receptor(IL-1R)signaling has been shown to play a critical role in various inflammatory conditions,but its precise role and underlying mechanism in AILI remain debatable.Herein,we show that NLRP3 inflammasome activation of IL-1βis dispensable to AILI,whereas IL-1α,the other ligand of IL-1R1,accounts for hepatic injury by a lethal dose of APAP.Furthermore,Kupffer cells function as a major source of activated IL-1αin the liver,which is activated by damaged hepatocytes through TLR4/MyD88 signaling.Finally,IL-1αis able to chemoattract and activate CD11b^(+)Gr-1^(+) myeloid cells,mostly neutrophils and inflammatory monocytes,to amplify deteriorated inflammation in the lesion.Therefore,this work identifies that MyD88-dependent activation of IL-1αin Kupffer cells plays a central role in the immunopathogenesis of AILI and implicates that IL-1αis a promising therapeutic target for AILI treatment. | Chao Zhang Jin Feng Jun Du Zhiyong Zhuo Shuo Yang Weihong Zhang Weihong Wang Shengyuan Zhang Yoichiro Iwakura Guangxun Meng Yang-Xin Fu Baidong Hou Hong Tang | 2018 | Cellular & Molecular Immunology2018，15，11： | 7 |
| 5 | High-density genetic map construction and identification of loci controlling flower-type traits in Chrysanthemum(Chrysanthemum×morifolium Ramat.)显示文摘Flower type is an important and extremely complicated trait of chrysanthemum.The corolla tube merged degree(CTMD)and the relative number of ray florets(RNRF)are the two key factors affecting chrysanthemum flower type.However,few reports have clarified the inheritance of these two complex traits,which limits directed breeding for flower-type improvement.In this study,305 F1 hybrids were obtained from two parents with obvious differences in CTMD and RNRF performance.Using specific-locus amplified fragment sequencing(SLAF-seq)technology,we constructed a high-density genetic linkage map with an average map distance of 0.76 cM.Three major QTLs controlling CTMD and four major QTLs underlying RNRF were repeatedly detected in the 2 years.Moreover,the synteny between the genetic map and other Compositae species was investigated,and weak collinearity was observed.In QTL regions with a high degree of genomic collinearity,eight annotated genes were probed in the Helianthus annuus L.and Lactuca sativa L.var.ramosa Hort.genomes.Furthermore,20 and 11 unigenes were identified via BLAST searches between the SNP markers of the QTL regions and the C.vestitum and C.lavandulifolium transcriptomes,respectively.These results lay a foundation for molecular marker-assisted breeding and candidate gene exploration in chrysanthemum without a reference assembly. | Xuebin Song Yuhui Xu Kang Gao Guangxun Fan Fan Zhang Chengyan Deng Silan Dai He Huang Huaigen Xin Yingying Li | 2020 | Horticulture Research2020，7，1： | 5 |
| 6 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 7 | Metal-organic framework-derived phosphide nanomaterials for electrochemical applications显示文摘Because of features,such as adjustable structures,high porosity,and high crystallinity,metal-organic frameworks(MOFs)deservedly have received considerable attention.Nevertheless,there is still room for improvements in the electrical conductivity and chemical stability of some MOFs,because of which they cannot be utilized as electrode materials.Fortunately,MOF derivatives have received widespread attention in recent years,especially phosphide materials,which are widely used in practical applications because of their outstanding conductivity,excellent specific surface area,and standout charge mobility.In this review,the latest developments of MOF-derived phosphides in electrocatalysis related to energy,including the excellent performance in terms of electrochemical energy storage and ingenious strategies,and diversified synthetic approaches are emphasized and summarized.Additionally,the arduous task and feasible proposals of MOF-derived phosphides are also discussed. | Xinlan Wang Guangxun Zhang Wei Yin Shasha Zheng Qingquan Kong Jingqi Tian Huan Pang | 2022 | Carbon Energy2022，4，2： | 3 |
| 8 | Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome显示文摘The fungus Trichophyton schoenleinii(T.schoenleinii)is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa.Hu-man innate immune system plays an important role in combating with various pathogens including fungi.The inflammasome is one of the most critical arms of host innate immunity,which is a protein complex controlling maturation of IL-1β.To clarify whether T.schoenleinii is able to activate the infl ammasome,we analyzed human monocytic cell line THP-1 for IL-1βproduction upon infec-tion with T.schoenleinii strain isolated from Tinea favosa patients,and rapid IL-1βsecretion from THP-1 cells was observed.Moreover,applying competitive inhibitors and gene specifi c silencing with shRNA,we found that T.sch-oenleinii induced IL-1βsecretion,ASC pyroptosome for-mation as well as caspase-1 activation were all dependent on NLRP3.Cathepsin B activity,ROS production and K+effl ux were required for the infl ammasome activation by T.schoenleinii.Our data thus reveal that the NLRP3 infl am-masome plays an important role in host defense against T.schoenleinii,and suggest that manipulating NLRP3 signaling can be a novel approach for control of diseases caused by T.schoenleinii infection. | Hua Li Shuxian Wu Liming Mao Guowei Lei Liping Zhang Ailing Lu Liguo An Guiwen Yang Paride Abliz Guangxun Meng | 2013 | Protein & Cell2013，4，7： | 3 |
| 9 | Ciliate Uronema marinum is the causative agent of scuticociliatosis in farm raised turbot Scophthalmus maximus显示文摘To identify the pathogen that causes scuticociliatosis in farmed-raised turbot Scophthalmus maximus , we isolated a ciliate from the brain tissue of an infected turbot and identifi ed it as Uronema marinum based on morphological and molecular evidence. We then infected the turbots in artifi cial laboratory settings with pure cultured U . marinum . The infected turbots showed syndromes similar to those observed in naturally infected ones. Furthermore, microscopic examination and PCR detection confi rmed the presence of the ciliate in the tissues of those laboratory-infected turbots. To our best knowledge, this is the fi rst report of scuticociliatosis caused by U . marinum in farm-raised turbot S . maximus in China. | DU Guangxun QU Lingyun SHANG Kun SUN Chengjun WANG Chen GAO Ping | 2019 | Journal of Oceanology and Limnology2019，37，5： | 2 |
| 10 | Cellular localization of NLRP3 inflammasome显示文摘Infl ammasome is a large protein complex activated upon cellular stress or microbial infection,which triggers maturation of pro-inflammatory cytokines interleukin-1βand interleukin-18 through caspase-1 activation.Nod-like receptor family protein 3(NLRP3)is the most character-ized infl ammasome activated by various stimuli.However,the mechanism of its activation is unclear and its exact cellular localization is still unknown.We examined the potential co-localization of NLRP3 infl ammasome with mi-tochondria and seven other organelles under adenosine triphosphate,nigericin or monosodium urate stimulation in mouse peritoneal macrophages using confocal micros-copy approach.Our results revealed that the activated endogenous apoptosis-associated speck-like protein containing a CARD(ASC)pyroptosome forms in the cyto-plasm and co-localizes with NLRP3 and caspase-1,but not with any of the organelles screened.This study indicates that the ASC pyroptosome universally localizes within the cytoplasm rather than with any specifi c organelles. | Yan Wang Chen Yang Kairui Mao Shuzhen Chen Guangxun Meng Bing Sun | 2013 | Protein & Cell2013，4，6： | 2 |
| 11 | Production and characterization of a complete set of individual chromosome additions from Oryza officinalis to Oryza sativa using RFLP and GISH analyses显示文摘 | Guangxun Tan Huajun Jin Gang Li Ruifeng He Lili Zhu Guangcun He | 2005 | Theoretical and Applied Genetics2005，，8： | 1 |
| 12 | Metal-Organic Framework-Based Sulfur-Loaded Materials显示文摘Lithium-sulfur batteries(LSBs)are considered promising new energy storage systems given their outstanding theoretical energy densities.Nevertheless,issues such as low electrical conductivity and severe volume expansion,along with the formation of polysulfides during cycling,restrict their practical applications.To overcome these issues,it is necessary to find suitable and effective sulfur host materials.Metal-organic frameworks(MOFs),which are porous crystalline materials in the bourgeoning developmental stages,have demonstrated enormous potential in LSBs owing to their high porosity and tunable porous structure.Herein,we provide a comprehensive overview of MOF-based sulfur-loaded materials and discuss the charge/discharge mechanisms,strategies of enhancing battery performance,sulfur loading methods,and applications in LSBs.An outlook on future directions,prospects,and possible obstacles for the development of these materials is also provided. | Meng Du Qing Li Guangxun Zhang Feifei Wang Huan Pang | 2022 | Energy & Environmental Materials2022，5，1： | 1 |
| 13 | Cancer prevention by tocopherols and tea polyphenols显示文摘 | YANG C S LI Guangxun YANG Zhihong | 2013 | Cancer Letters2013，334，1： | 1 |
| 14 | Recent advances in the development of perovskite@metal-organicframeworks composites显示文摘Metal-organic frameworks(MOFs)have received considerable attention because of their advantages of adjustable structure,high porosity,and rich active centers.Meanwhile,perovskite has attracted research interest due to its unique highemission quantum yield and excellent optoelectronic properties.However,the instability of perovskites under certain conditions hinders their more comprehensive development.A novel strategy encapsulates perovskite in the pores of MOFs to protect it from external interference and increase the active centers,thus improving the performance of perovskite@MOF composites.In this review,the latest research progress in the synthesis strategy,function,and application of perovskite@MOF composites is systematically summarized.Additionally,the challenges of further developing perovskite@MOF composites are discussed.Hopefully,this review provides creative inspiration to advance future studies on perovskite@MOF composites in this emerging field. | Qian Li Yanfei Zhang Guangxun Zhang Yixuan Wang Huan Pang | 2023 | National Science Open2023，2，3： | 1 |
| 15 | Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2显示文摘 | Guangxun M Alina G Mario V | 2003 | J Biol Chem2003，278，39： | 1 |
| 16 | Mitochondrial DNA reveals low population differentiation in elongate loach, Lep- tobotia elongata (Bleeker) : implications for conservation 显示文摘 | LIU Guangxun ZHOU Jian ZHOU Dinggang | 2012 | Environ Biol Fish2012，93，1： | 1 |
| 17 | The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice显示文摘 | Guangxun Li Mao-Jung Lee Anna Ba Liu Zhihong Yang Yong Lin Weichung Joe Shih Chung S. Yang | 2011 | Free Radical Biology and Medicine2011，，7： | 1 |
| 18 | Characteristics of catalytic cracking reactions relating to resins contained in Shengli vacuum residue显示文摘 | Xu Chunming Lin Shixiong Wang Guangxun | 1994 | Acta Petrolei Sinica (Petroleum Processing Section)1994，10，2： | 1 |
| 19 | application of polymeric fluorescent whitening agents显示文摘 | Yun Liu Guangxun Guo Jun Zhang | 2001 | Journal of Surfaerants and Detergents2001，4，2： | 1 |
| 20 | cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes显示文摘The innate immune responses,including inflammasome activation,are paramount for host defense against pathogen infection.In contrast to canonical and noncanonical inflammasome activation,in this study,heat-killed gram-negative bacteria(HK bacteria)were identified as single-step stimulators of the NLRP3 inflammasome in human monocytes,and they caused a moderate amount of IL-1βto be released from cells.Time course experiments showed that this alternative inflammasome response was finished within a few hours.Further analysis showed that the intrinsically limited NLRP3 inflammasome activation response was due to the negative regulation of caspase-8 by the short isoform of cFLIP(cFLIPs),which was activated by NF-κB.In contrast,overexpressed cFLIPS,but not overexpressed cFLIPL,inhibited the activation of caspase-8 and the release of IL-1βin response to HK bacteria infection in human monocytes.Furthermore,we demonstrated that TAK1 activity mediated the expression of cFLIPs and was upstream and essential for the caspase-8 cleavage induced by HK bacteria in human monocytes.The functional specificity of cFLIPs and TAK1 revealed unique responses of human monocytes to a noninvasive pathogen,providing novel insights into an alternative regulatory pathway of NLRP3 inflammasome activation. | Yuhui Gao Shi Yu Mengdan Chen Xun Wang Lei Pan Bin Wei Guangxun Meng | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
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