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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Strategic supply chain optimization for the pharmaceutical industries显示文摘 | Lazaros G Papageorgiou Guillermo E Rotstein Nilay Shah | 2001 | Ind Eng Chem Res2001，40，1： | 2 |
| 5 | Cardiac amyloidoma with IgM-κ gammopathy显示文摘 | Kathleen JW Gerald G Guillermo AH | 1994 | Arch Pathol Lab Med1994，118，： | 1 |
| 6 | Giant outbursts of luminous blue variables and the formation of the homunculus nebula around η carinae显示文摘 | Guillermo G | 1999 | The Astrophysical Journal1999，520，7： | 1 |
| 7 | FT-Raman Determination of Mepiquat Chloride in Agrochemical Products显示文摘 | GUILLERMO Q SALVADOR G AGUST1N P | 2004 | Vibrational Spectroscopy2004，36，： | 1 |
| 8 | Nitrogen availability influences the biochemical composition and photosynthesis of tank-cultivated Ulva rigida (Chlorophyta)显示文摘 | Juan Luis Gómez Pinchetti Elena del Campo Fernández Paula Moreno Díez Guillermo García Reina | 1998 | Journal of Applied Phycology1998，，4： | 1 |
| 9 | Coal blend combustion: Link between unbumt carbon in fly ashes and maceral composition显示文摘 | SONIA H ALFREDO G GUILLERMO A XIMENA G CLAUDIA U | 2003 | Fuel Process Technol2003，80，3： | 1 |
| 10 | 4,5- dihydroblumenol A,a new nor-isoprenoid from Perrottetia multiflora 显示文摘 | Gonz61ez A G Guillermo J A Ravelo A G | 2004 | J Nat Prod2004，57，3： | 1 |
| 11 | FT-Raman Determination of Mepiquat Chloride in Agrochemical Products显示文摘 | GUILLERMO Q SALVADOR G PASTOR A | 2004 | Vibrational Spectroscopy2004，36，： | 1 |
| 12 | 4, 5-Dihydroblumenol A, a new nor-isoprenoid from Perrottetia multiflpra 显示文摘 | Gonzalez A G Guillermo J A Ravelo A G | 1994 | J Nat Prod1994，57，3： | 1 |
| 13 | Synthesis of black ceramic pig- ments from secondary raw materials 显示文摘 | Costa G Della V P Ribeiro M J De Oliverira Antonio Pedro Novaes Monros Tomas Guillermo Labrineha Batista Joao Antonio | 2008 | Dyes and Pig- ments2008，，77： | 1 |
| 14 | Antifouling paints based on marine natural products from Colombian Caribbean显示文摘 | Marisol Santos Acevedo Carlos Puentes Katerine Carre?o Javier Gómez León Mirta Stupak Mónica García Miriam Pérez Guillermo Blustein | 2013 | International Biodeterioration & Biodegradation2013，，： | 1 |
| 15 | Temporal dynamics of stem expansion and contraction in savanna trees : withdrawal and recharge of stored water 显示文摘 | Fabian G S Sandra J B Guillermo G | 2008 | Tree Physiology2008，28，3： | 1 |
| 16 | Purification and characterization of urease from Helicobacter pylori显示文摘 | Bruce E D Campbell G P Guillermo I | 1990 | The J of Biological Chemistry1990，265，： | 1 |
| 17 | The bubble size distribution in wheat flour dough 显示文摘 | Guillermo G Bellido Martin G Scanlon | 2006 | Food Research International2006，，39： | 1 |
| 18 | Measurement of dough specific volume in chemically leavened dough systems 显示文摘 | Guillermo G Bellido Martin G Scanlon John H Page | 2009 | Journal of Cereal Science2009，49，： | 1 |
| 19 | Experimental Analysis and Modeling of the Separation of Triacylglycerol and Free Fatty Acid Mixtures Using Molecular Distillation显示文摘 | Guillermo A M Arturo J G Hugo S G | 2011 | Industrial & Engineering Chemistry Research2011，50，11： | 1 |
| 20 | Solvent Effects on the Reduction Potentials of Nitroanilines 显示文摘 | Maria A S Isabel C Guillermo G | 1985 | J Chem Soc Perkin Trans1985，2，11： | 1 |
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