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| 1 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 2 | Phcnotypc-dependent susceptibility of cholinergic ncuroblastoma cells to ncurotoxic inputs显示文摘 | Szutowicz A Biclarczyk H Gul S ct al | 2006 | Met Brain Dis2006，21，23： | 1 |
| 3 | Diagnosis and prognosis in double-out let right ventricle显示文摘 | Gedikbasi A Oztarhan K Gul A | 2008 | Am J Perinatol2008，25，7： | 1 |
| 4 | Management of intradialytie hy- pertension: the ongoing challenge显示文摘 | CHEN J GUL A SAMAK M J | 2006 | Semin Dial2006，19，2： | 1 |
| 5 | expression and regulation of bcl-2, bcl-xl, and bax correlate with p53 statics and sensitivity to apoptosis in childhood acute lymphoblastic leukemia 显示文摘 | Findley H W Gul P Reager A M | 1997 | Blood1997，89，8： | 1 |
| 6 | Effect of compatible osmotica and plant growth regulators in alleviating salinity stress on the seed germination of Allem'olfea occidentalis显示文摘 | Gul B Khan M A | 2008 | Pakistan Journal of Botany2008，40，5： | 1 |
| 7 | Prenatal uhrasonograph- ie features of persistenturogenital sinus with hydrometroeolpos and aseites, 显示文摘 | Gul A Yildirim G Gedikbasi A | 2008 | Archives of Gynecology and Obstetrics2008，278，5： | 1 |
| 8 | Effect of temperature and salinity on the germination of Sarcobatus vermiculatus显示文摘 | KHAN M A GUL B WEBER D J | | 0，，： | 1 |
| 9 | Germination of dimorphic seeds of Suaeda moquinii under high salinity stess显示文摘 | Khan M A Gul B Weber D J | | 0，，02： | 1 |
| 10 | Synthesis,characterization,e- lectrochemistry and spectro-electrochemistry of novel soluble pot phyrazines bearing unsaturated functional groups显示文摘 | TUNCE S KOCA A GUL A | 2012 | Dyes and Pigments2012，92，1： | 1 |
| 11 | The deformation evaluation of kizlac T3A tunnel显示文摘 | Ozbek A Turkmen S Gul M | 2003 | Engineering Geology2003，67，3： | 1 |
| 12 | Management of intradialytic hypertension: The ongoing challenge显示文摘 | Chen J Gul A Sarnak MJ | 2006 | Semin Dial2006，19，2： | 1 |
| 13 | Hippophae rhamnoides L- Chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects 显示文摘 | Guliyev V B Gul M Yildirim A | 2004 | Journal of Chromatography B2004，2，： | 1 |
| 14 | Discretionary-accruals models and audit qualifications显示文摘 | BARTOV E GUL F A TSUI J S L | 2000 | Journal of Accounting and Economics2000，30，3： | 1 |
| 15 | Recovery of Co, Ni, and Cu from the tailings of Divrigi Iron Ore Concentrator 显示文摘 | Sirkeci A A Gul A Bulut G | 2006 | Mineral Processing and Extractive Metallurgy Re- view2006，27，2： | 1 |
| 16 | Do individual auditors affect audit quality? Evidence from archival data 显示文摘 | Gul F A Wu D H Yang Z F | 2013 | The Accounting Review2013，88，6： | 1 |
| 17 | Cost analysis of health- care associated infection in a training hospital显示文摘 | Ozbek G Gul HC Karakas A | 2014 | Int J Infect Dis2014，21，： | 1 |
| 18 | Effect of steel fibers on the mechanical properties of natural lightweight aggregate concrete显示文摘 | DUZGUN OguzAkm GUL R AYDIN A C | 2005 | Materials Letters2005，59，27： | 1 |
| 19 | Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma显示文摘 | KHOR T O GUL Y A ITHNIN H | 2004 | Cancer Lett2004，210，： | 1 |
| 20 | Electrical and mag-netic characterization of nanocrystalline Ni-Zn ferrite syn-thesis by co-precipitation route 显示文摘 | GUL I H’AHMED W MAQS00D A | 2008 | J Mag Mag Mater2008，320，： | 1 |
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