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| 1 | AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma显示文摘BACKGROUND: In liver transplantation or resection for hepatocellular carcinoma (HCC), patient selection depends on morphological features. In patients with HCC, we performed a clinicopathological analysis of risk factors that affected survival after liver transplantation. METHODS: In 389 liver transplantations performed from 2004 to 2010, 102 were for HCC patients. Data were collected retrospectively from the Organ Transplantation Center Database. Variables were as follows: age, gender, preoperative alpha-fetoprotein (AFP) levels, Child-Pugh and MELD scores, prognostic staging criteria (Milan and UCSF), etiology, number of tumors, the largest tumor size, total tumor size, multifocality, intrahepatic portal vein tumor thrombosis, bilobarity, and histological differentiation. RESULTS: One hundred and two patients were evaluated. The 5-year overall survival rate was 56.5%. According to the UCSF criteria, 63% of the patients were within and 37% were beyond UCSF (P=0.03). Ten patients were excluded (one with fibrolamellary HCC and 9 because of early postoperative death without HCC recurrence), and 92 patients were assessed. The mean age of the patients was 56.5±6.9 years. Sixty-two patients underwent living donor liver transplantations. The mean follow-up time was 29.4±22.6 months. Fifteen patients (16.3%) died in the follow-up period due to HCC recurrence. Univariate analysis showed that AFP level, intrahepatic portal vein tumor thrombosis, histologic differentiation and UCSF criteria were significant factors related to survival and tumor recurrence. The 5-year estimated overall survival rate was 62.2% in allpatients. According to the UCSF criteria, and the 5-year overall survival rate was 66.7% within and 52.7% beyond the criteria (P=0.04). Multivariate analysis showed that AFP level and poor differentiation were independent factors. CONCLUSIONS: For proper patient selection in liver trans- plantation for HCC, prognostic criteria related to tumor biology (especially AFP level and histological differentiation) should be considered. Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation. | Onur Yaprak Murat Akyildiz Murat Dayangac Baha Tolga Demirbas Necdet Guler Gulen Bulbul Dogusoy Yildiray Yuzer Yaman Tokat | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 15 |
| 2 | Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer显示文摘AIM: To assess the incidence of MLH1 (the human MutL homologue) and MSH2 (the human MutS homologue) protein expression in Turkish patients with sporadic colorectal cancers and to compare their survival and clinicopathological features. METHODS: We validated the tissue microarray technology in 77 colorectal carcinomas by analyzing the immunohistochemical expression of proteins involved in two main pathways of colorectal carcinogenesis: p53 protein for loss of heterozygosity tumors; MLH1 and MSH2 proteins for microsatellite instability (MSI). RESULTS: Our analysis showed that 29 (39.2%) had loss of MLH1 expression, 5 (6.8%) had loss of MSH2 expression and 2 cases had loss of expression of both proteins. We found that 60% of MSH2-negative tumors were located in the right side of the colon; all MSH2-negative cases were women. In addition, the loss of MSH2 expression was correlated with low p53 expression. Neither MLH1 nor MSH2 expressions were associated with prognosis, although there seemed a tendency of longer survival (71.7 ± 8.65 mo vs 47.08 ± 5.26 mo) for the patients with MLH1-negative versus MLH1-positive carcinomas. There were not significant differences in overall and recurrence-free survival among MLH1/MSH2-positive and -negative cases.CONCLUSION: Our data supports that Turkish patients with MLH1- and MSH2-defective tumors have some distinct features from each other. Although prognostic importance remains controversial, immunohistochemical analysis of mismatch repair genes may be used as a routine histopathological examination of sporadic colorectal carcinomas. | Sibel Erdamar Esra Ucaryilmaz Gokhan Demir Tayfun Karahasanoglu Gulen Dogusoy Ahmet Dirican Suha Goksel | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | ACS Nano:新型纳米颗粒运输系统或能克服CRISPR基因编辑障碍显示文摘近日,一项刊登在国际杂志ACSNano上的研究报告中,来自马萨诸塞大学阿默斯特分校的研究人员通过研究利用纳米颗粒设计出了一种新系统能够帮助CRISPR/Cas9系统跨过细胞膜进入到细胞核中,同时还能够避免被细胞器所捕获。研究者Rubul Mout说道,CRISPR由两种组分组成,包括名为Cas9的剪刀样蛋白和名为sgRNA的RNA分子,sgRNA分子能够引导Cas9进入到靶点位置。 | Rubul Mout† Moumita Ray† Gulen Yesilbag Tonga Yi-Wei Lee Tristan Tay Kanae Sasaki Vincent M. Rotello | 2017 | 现代生物医学进展2017，17，14： | 3 |
| 4 | An assessment of antioxidant status in patients with carbon monoxide poisoning显示文摘BACKGROUND: Carbon monoxide poisoning(COP) is an important cause of mortality and morbidity worldwide. This study was to investigate the levels of serum paraoxonase(PON), arylesterase(ARYL), ceruloplasmin(Cp), and sulfhydryl(-SH) in the treatment of COP, and to further understand the pathophysiology of COP.METHODS: This prospective study comprised 107 individuals with COP(group 1) and 50 healthy volunteers(group 2). Serum, plasma, and erythrocyte samples were taken on admission from all participants with COP. This process was repeated in the 90 th and 180 th minutes of treatment. Samples were taken from the control group only once. The levels of plasma PON, ARYL, Cp activity and-SH were measured in both groups.RESULTS: Age, gender, and carboxyhemoglobin level were not correlated with PON, ARYL, Cp, and-SH levels. PON, ARYL, and-SH levels were signifi cantly decreased in group 1 compared with group 2. Conversely, Cp was signifi cantly elevated in group 1 in contrast to group 2. Although ARYL was lower on admission in patients with COP than that was observed in the 90 th and 180 th minutes(P<0.001), Cp was higher on admission than at the other time points(P<0.001).CONCLUSIONS: Participants with COP had decreased levels of antioxidants(PON, ARLY, and-SH). COP represses the antioxidant system. | Suat Zengin Behcet A Sahin Karta Basri Can Mustafa Orkmez Abdullah Taskin Ugur Lok Bediha Gulen Cuma Yildirim Seyithan Taysi | 2014 | World Journal of Emergency Medicine2014，5，2： | 2 |
| 5 | Corporate Political Contributions and Stock Returns 显示文摘 | Cooper M J H Gulen and A V Ovtchinnikov | 2010 | Journal of Finance2010，，65： | 1 |
| 6 | The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of the immune response显示文摘 | Bulek K Swaidani S Qin J Lu Y. Gulen M.F. Herjan T. Min B. Kastelein R.A. Aronica M. Kosz-Vnenchak M. and Li X | | 0，，182： | 1 |
| 7 | Changing Name with Style: Mutual Fund Name Changes and Their Effects on Fund Flows 显示文摘 | Michael J Cooper Huseyin Gulen P Raghavendra Rau | 2005 | The Journal of Finance2005，，6： | 1 |
| 8 | Effects of heat stress on peroxidase activi- ty and total protein content in strawberry plants 显示文摘 | Gulen H Eris A | 2004 | Plant Science2004，166，3： | 1 |
| 9 | The Serum Endothel?n-1 Level in Steatos?s and NASH, and Its Relat?on w?th Sever?ty of L?ver F?bros?s显示文摘 | Bulent Degertekin Seren Ozenirler Sehri Elbeg Gulen Akyol | 2007 | Digestive Diseases and Sciences2007，，10： | 1 |
| 10 | Changing Names with Style: Mutual Fund Name Changes and Their Effects on Fund Flows 显示文摘 | Cooper Michael J Huseyin Gulen P Raghavendra Rau | 2003 | Journal of Finance2003，，： | 1 |
| 11 | Binary biosorption of iron(Ⅲ)and iron(Ⅲ)-cyanide complexions on rhizopus arrhizus:modeling of synergistic interaction 显示文摘 | AKSU Z GULEN H | 2002 | Proc Biochem2002，38，： | 1 |
| 12 | Efficiency in the crude oil futures market显示文摘 | Gulen S G | 1998 | Journal of Energy Fiance and Development1998，3，1： | 1 |
| 13 | Stock index futures trading and volatility in in- ternational equity markets 显示文摘 | Gulen H Mayhew S | 2000 | Journal of Futures Markets2000，20，： | 1 |
| 14 | The Toll-interleu-kin-1 receptor member SIGIRR regulates colonic epithelialhomeostasis, inflammation, and tumorigenesis显示文摘 | Xiao H Gulen MF Qin J Yao J Bulek K Kish D Altun-tas CZ Wald D Ma C Zhou H Tuohy VK Fairchild RL de la Motte C Cua D Vallance BA Li X | 2007 | Immuni-ty2007，26，4： | 1 |
| 15 | Changing Names with Style:Mutual Fund Name Changes and Their Effects on Fund Flows 显示文摘 | Cooper M J Gulen H Rau P R | 2005 | Journal of Finance2005，60，6： | 1 |
| 16 | Effect of heat stress on peroxidase activity and total protein content in strawberry plants 显示文摘 | Gulen H Eris A | 2004 | Plant Science2004，166，3： | 1 |
| 17 | Peroxidase isozume profiles in compatible and incompatible pear-quince graft combinations显示文摘 | Gulen H Arora R Kuden A | | 0，，02： | 1 |
| 18 | Effect of heat stress on peroxidase activity and total protein content in strawberry plants显示文摘 | Gulen H Eris A | 2004 | Plant Science2004，166，： | 1 |
| 19 | Corporate political contributions and stock returns显示文摘 | COOPER M J GULEN H OVECHINNIKOV A V | 2010 | Journal of Finance2010，65，2： | 1 |
| 20 | Acute mesenteric ischemia: endovascular therapy显示文摘 | Gulen Demirpolat Ismail Oran Sadik Tamsel Mustafa Parildar Ahmet Memis | 2007 | Abdominal Imaging2007，，3： | 1 |
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