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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | 星形胶质细胞介导的免疫反应在癫痫发病中的作用显示文摘星形胶质细胞是中枢神经系统中主要的细胞种类之一,在许多疾病过程中参与调节免疫/炎性反应。在癫痫相关病理损伤过程中可观察到星形胶质细胞的活化增殖,其在癫痫发生过程中的病理生理学作用值得我们进一步研究。在癫痫患者的脑组织中,星形胶质细胞的物理特性发生了明显改变,其中一个重要的变化就是星形胶质细胞炎性反应途径的激活。越来越多的研究表明,促炎分子可以改变胶质细胞-神经元之间的通信,导致痫性发作及痫性发作相关的神经元损伤。离体和在体研究均发现星形胶质细胞是致痫炎性信号的主要来源及作用靶点。因此,理解癫痫大脑组织中的星形胶质细胞炎性反应有助于为星形胶质细胞介导的癫痫的靶向干预策略提供新的思路。本文对星形胶质细胞在癫痫内源性免疫反应中的作用进行综述,讨论并评价耐药癫痫患者的临床研究及临床相关模型实验研究的结果,重点关注炎症反应相关通路(如白介素-1β/Toll样受体4),这些通路有可能是抗痫治疗的潜在靶点及疾病调整治疗的新策略。 | ELEONORA ARONICA TERESA RAVIZZA EMANUELE ZUROLO ANNAMARIA VEZZANI | 2012 | 神经损伤与功能重建2012，7，5： | 2 |
| 3 | Induction of the Wnt inhibitor,Dickkopf-1,is associated with neurodegeneration related to temporal lobe epilepsy显示文摘 | BUSCETI CL BIAGIONI F ARONICA E | 2007 | Epilepsia2007，48，4： | 1 |
| 4 | Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors显示文摘 | Aronica E Gorter JA Jansen GH | 2003 | Neuroscience2003，118，： | 1 |
| 5 | Estimation of flood inundation probabilities using global hazard indexes based on hydrodynamic variables显示文摘 | Aronica G T Candela A Fabio P | 2012 | Physics and Chemistry of the Earth 42-442012，，： | 1 |
| 6 | The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission显示文摘 | Blumcke I Thom M Aronica E | 2011 | Epilepsia2011，52，1： | 1 |
| 7 | Intramuscular Administration of AAV1-Lipoprotein LipaseS447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients显示文摘 | Erik S. Stroes Melchior C. Nierman Janneke J. Meulenberg Remco Franssen Jaap Twisk C Pieter Henny Mario M. Maas Aeilko H. Zwinderman Colin Ross Eleonora Aronica Katherine A. High Marcel M. Levi Michael R. Hayden John J. Kastelein Jan Albert Kuivenhoven | 2008 | Arteriosclerosis Thrombosis and Vascular Biology2008，，12： | 1 |
| 8 | Long-term epilepsy- associated tumors 显示文摘 | Thom M Blurncke I Aronica E | 2012 | Brain Pathol2012，22，3： | 1 |
| 9 | Stimulation of estrogen receptor - mediated transcriptionand alteration in the phosphorylation state of the rat uterine estrogenreceptor by estrogen,cyclic adenosine monophosphate,and insulin -like growth factor -1 显示文摘 | Aronica SM | 1993 | Mol Endocrinol1993，7，6： | 1 |
| 10 | Innate and adaptive immunity during epileptogenesis and spontane- ous seizures:evidence from experimental models and human temporal lobe epilepsy 显示文摘 | Ravizza T Gagliardi B No6 F Boer K Aronica E Vezzani A | 2008 | Neurobiol Dis2008，29，1： | 1 |
| 11 | Macrophage inflammatory pretein-1 alpha en hance growth factor stimulated phosphatidylcholine metabolisms and increase cAMP levels in the human growth factor dependent cell line Mo7e events associated with growth suppression显示文摘 | Mantel C Aronica S Luo Z | 1995 | J Immanol1995，154，5： | 1 |
| 12 | The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of the immune response显示文摘 | Bulek K Swaidani S Qin J Lu Y. Gulen M.F. Herjan T. Min B. Kastelein R.A. Aronica M. Kosz-Vnenchak M. and Li X | | 0，，182： | 1 |
| 13 | Expression pattern of miR -146a, an inflammation-associated microRNA, in experi- mental and human temporal lobe epilepsy显示文摘 | Aronica E Fluiter K Iyer A | 2010 | EurJ Neurosci2010，31，6： | 1 |
| 14 | Electrocorticography discharge patterns in patients with a cavernous hemangioma and pharmacoresistent epilepsy显示文摘 | Ferrier C H Aronica E Leijten F S | 2007 | J Neurosurg2007，107，3： | 1 |
| 15 | RealEaseTMNon-Stick Porcelain Enamel显示文摘 | Charles Baldwin Alain Aronica Brad Devine Graham Rose | 2004 | Ceramic Engineering and Science Proceedings2004，25，5： | 1 |
| 16 | Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy显示文摘 | ARONICA E GORTER JA RAMKEMA M | 2004 | Epilepsia2004，45，： | 1 |
| 17 | Expression and cellular discribution of major vault protein:a putative marker for pharmacosistance in a rat model for temporal lobe epilepsy显示文摘 | Van Vliet EA Aronica E Redeker S | 2004 | Epilepsia2004，45，12： | 1 |
| 18 | Derivation of flood frequency curves in poorly gauged Mediterranean catchments using a simple stochastic hydrological rainfall-runoff model 显示文摘 | Aronica G T Candela A | 2007 | Journal of Hydrology2007，327，： | 1 |
| 19 | Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors显示文摘 | ARONICA E GORTER JA JANSEN GH | 2003 | Neuroscience2003，118，： | 1 |
| 20 | Retroviral mediated gene transfer of Flt3 ligand enhances proliferation and MAP kinase activity of AML5 cells 显示文摘 | Braun SE Aronica SM Ge Y | 1997 | Exp Hematol1997，25，1： | 1 |
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