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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Lens aldose reductase inhibiting potential of some indigenous plants显示文摘 | N Halder S Joshi S.K Gupta | 2003 | Journal of Ethnopharmacology2003，，1： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Cytogenetic effects of cypermethrin and fenvalerate on the root meristem cells of A Ilium cepa显示文摘 | Chauhan L K S Saxena P N Gupta S K | 1999 | Environ Experi Botany1999，42，3： | 1 |
| 5 | Estimation of partial discharge parameters in gis using acoustic emission techniques显示文摘 | Gupta N Ramu T S | 2001 | Journal of Sound and Vibration2001，247，2： | 1 |
| 6 | Momentum transfer in curved pipes ( 2 ) : Non-Newtonian fluids 显示文摘 | Mishra P Gupta S N | 1979 | Ind Eng Chem Process Des1979，18，： | 1 |
| 7 | Crystallization of PP in PP/SEBS Blends and Its Correlation with Tensile Properties 显示文摘 | Gupta A K Purwat S N | 1984 | J Appl Polym Sci1984，29，5： | 1 |
| 8 | Pathogenic mechanisms in en- dometriosis-associated infertility 显示文摘 | Gupta S Goldberg JM Aziz N | 2008 | Fertil Steril2008，90，2： | 1 |
| 9 | Effect of projectile nose shape,impact velocity and target thickness on the de-formation behavior of layered plates显示文摘 | Gupta N K Iqbal M A Sekhon G S | 2008 | Int J Impact Eng2008，35，1： | 1 |
| 10 | A simple method of obtaining equivalent doses for use in HDR brachytherapy显示文摘 | Nag S Gupta N | 2000 | Int J Radiat Oncol Biol Phys2000，46，2： | 1 |
| 11 | Role of early screening for diabetic retinopathy in patients with diabetes mellitus: an overview 显示文摘 | Vashist P Singh S Gupta N | 2011 | Indian J Community Med2011，36，4： | 1 |
| 12 | Comparison of oral naproxen and intrauterine lignocaine instillation for pain relief during hysterosalpingography显示文摘 | Gupta N Ghosh B Mittal S | | 0，，： | 1 |
| 13 | Potentiostatically deposited nano- structured CoNil- layered double hydroxides as electrode materi- als for redox-supercapacitors 显示文摘 | GUPTA V GUPTA S MIURA N | 2008 | Journal of Power Sources2008，175，1： | 1 |
| 14 | Active earth pressure on retaining wall for c-φ soil baekfill under seismic loading condition 显示文摘 | SHUKLA S K GUPTA S K SIVAKUGAN N | 2009 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2009，135，5： | 1 |
| 15 | An analysis of axial crushing of composite tubes显示文摘 | N K Gupta R Velmurugan S K Gupta | 1997 | Journal of Composite Material1997，31，13： | 1 |
| 16 | Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy显示文摘 | GUPTA S PURCELL N H LIN A | 2002 | J Cell Boil2002，159，6： | 1 |
| 17 | Involvement of Fas (APOI/CD95)during photodynamic-therapy-mediated apoptosis in homan epidermoid esxcinonla A431 cells显示文摘 | Ahmad N Gupta S Feyes DK | 2000 | J Invest Dermatol2000，115，6： | 1 |
| 18 | Rechargeable manganese oxide electrodes: Part Ⅱ , physically modified materials 显示文摘 | WROBLOW H S GUPTA N | 1987 | J Electroanal Chem1987，238，： | 1 |
| 19 | Targeting the Hedgehog path- way in cancer 显示文摘 | Gupta S Takebe N Lorusso P | 2010 | Ther Adv Med Oncol2010，2，4： | 1 |
| 20 | Active earth pressure on retaining wall for c-soil backfill under seismic loading condition显示文摘 | SHUKLA S K GUPTA S K SIVAKUGAN N | 2009 | Journal of Geotechnical and Geoenvironmental Engineering2009，135，5： | 1 |
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