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| 1 | Gene and cell therapy based treatment strategies for inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD)are a group of chronic inflammatory disorders most commonly affecting young adults.Currently available therapies can result in induction and maintenance of remission,but are not curative and have sometimes important side effects.Advances in basic research in IBD have provided new therapeutic opportunities to target the inflammatory process involved.Gene and cell therapy approaches are suitable to prevent inflammation in the gastrointestinal tract and show therefore potential in the treatment of IBD.In this review,we present the current progress in the field of both gene and cell therapy and future prospects in the context of IBD.Regarding gene therapy,we focus on viral vectors and their applications in preclinical models.The focus for cell therapy is on regulatory T lymphocytes and mesenchymal stromal cells,their potential for the treatment of IBD and the progress made in both preclinical models and clinical trials. | Sander van der Marel Anna Majowicz Sander van Deventer Harald Petry Daniel W Hommes Valerie Ferreira | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 2 | Conservative management of thoracolumbar and lumbar spine eompression and burst fractures:functional and radiographic outcomes in 136 cases treated by closed reduction and casting显示文摘 | Patrick W Arthur S Harald H | 2009 | Arch Orthop Trauma surg2009，129，： | 1 |
| 3 | Growth mechanism of poly(divinylbenzene) microspheres in precipitation polymerization显示文摘 | Jeffrey S D Li W H Harald D H | 1999 | Macromolecules1999，32，： | 1 |
| 4 | Human capital heterogeneity,collaborative relationships,and publication patterns in a multidisciplinary scientific alliance:a comparative case study of two scientific teams显示文摘 | JOSEPH F P JAMES B W HARALD M F | 2004 | Research Policy2004，，33： | 1 |
| 5 | Development of an InternationalStandard for Shear Testing显示文摘 | CARSON J W HARALD W | 2006 | Powder Technology2006，167，： | 1 |
| 6 | The Fas signaling pathway:more than a paradigm显示文摘 | Harald W | 2002 | Science2002，296，： | 1 |
| 7 | Animal models of type Ⅰallergy using recombinant allergens显示文摘 | UDO H HARALD R URSULA W | 2004 | Methods2004，32，： | 1 |
| 8 | Reduced expression of Ca^(2+)-regulating proteins in the upper gastrointestinal tract of patients with achalasia显示文摘AIM: To compare expression of Ca2+-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS: Sarcoplasmic reticulum Ca2+ ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats, rabbits, and humans. Furthermore, expression profi les of these proteins in biopsies of lower esophageal sphincter and esophagus from patients with achalasia and healthy volunteers were analyzed. RESULTS: SERCA 2a protein expression was much higher in human heart (cardiac ventricle) compared to esophagus. However, SERCA 2b was expressed predominantly in the esophagus. The highest CRT expression was noted in the human esophagus, while PLB, although highly expressed in the heart, was below our detection limit in upper GI tissue. Compared to healthy controls, CSQ and CRT expression in lower esophageal sphincter and distal esophageal body were signif icantly reduced in patients with achalasia (P < 0.05). CONCLUSION: PLB in the human esophagus mightbe of lesser importance for regulation of SERCA than in heart. Lower expression of Ca2+ storage proteins (CSQ and CRT) might contribute to increased lower esophageal sphincter pressure in achalasia, possibly by increasing free intracellular Ca2+. | Harald Fischer Judith Fischer Peter Boknik Ulrich Gergs Wilhelm Schmitz Wolfram Domschke Jan W Konturek Joachim Neumann | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 9 | Capture of endothelial progenitor cells by a bispecific protein/monoclonal anti- body molecule induces reendothelialization of vascular lesions 显示文摘 | Harald F Langer Jtirgen W von der Ruhr Karin Daub | 2010 | JMol Med2010，88，7： | 1 |
| 10 | The Fas signaling pathway: more than a paradigm显示文摘 | | 2002 | Science2002，296，5573： | 1 |
| 11 | Interaction-free measurement显示文摘 | Harald W Thomas H | 1995 | Phys Rev Lett1995，74，24： | 1 |
| 12 | The one-dimensional cuttingstock problem with due dates显示文摘 | HARALD R VOSSEN W M | 2010 | European Journal of Operational Research2010，201，3： | 1 |
| 13 | High tempera- ture smart-cut SO1 pressure sensor显示文摘 | GUO S W HARALD E KIMIKO C | 2009 | Sensors and Actua-tors: A2009，154，2： | 1 |
| 14 | Peak Performance and Higher States of Consciousness: A Study of World - Class Performers 显示文摘 | Harald S H Dennis P H William W G | 1996 | Journal of Manage- rial Psychology1996，11，4： | 1 |
| 15 | Microalbumin measurement alone or calculation of the albumin/creatinine ratio for the screening of hypertension patients显示文摘 | Harald K Christian W | 2002 | Nephrol Dial Transplant2002，17，： | 1 |
| 16 | Comparison of pressure and ultrasound measurements in vortex flow meters 显示文摘 | Volker H Harald W | 2003 | Measurement2003，33，2： | 1 |
| 17 | Model based fault detection of vehicle suspension and hydraulic brake systems显示文摘 | MARCUS B HARALD S THOMAS W | 2002 | Mechatronics2002，12，8： | 1 |
| 18 | Neuronal nitric oxide synthase knockout mice show impaired cognitive performance显示文摘 | Rachel W Harald H Efrem E | 2004 | Nitric Oxide2004，10，3： | 1 |
| 19 | Metabolic and endocrine traits of neonatal calves are influenced by feeding colostrums for different du- rations or only milk re-placer显示文摘 | HARALD M H JUERG W B | 1998 | J Nutr1998，128，3： | 1 |
| 20 | Electronic semiconductor-support interaction-A novel effect in semaconductor photocatalysis显示文摘 | Harald W | 2001 | Angew Chem Int Ed Engl2001，40，20： | 1 |
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