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| 1 | Effect of mucin production on survival in colorectal cancer:A case-control study显示文摘AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). OS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularlywhen mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. | Mirna H Farhat Kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine | 2008 | World Journal of Gastroenterology2008，14，45： | 6 |
| 2 | Paradox of simuhaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease 显示文摘 | HATOUM O A BINION D G GU33'ERMAN D D | 2005 | Eur J Clin Invest2005，35，10： | 1 |
| 3 | Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis显示文摘 | Kabbout M Hatoum A Abou-Lteif G | 2004 | Mol Carcinog2004，40，1： | 1 |
| 4 | Tar-geted metabolomics study of'Braeburn'apples during long-term storage显示文摘 | HATOUM D ANNARATONE C HERTOG M L A T M | 2014 | Postharvest Biology and Technology2014，96，： | 1 |
| 5 | Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis显示文摘 | EL-SABBAN ME KHOURY J | 2001 | Carcinogenesis2001，22，12： | 1 |
| 6 | Emerging role of epoxyeicosatrienoic acids in coronary vascular function显示文摘 | Larsen B T Gutterman D D Hatoum O A | 2006 | Eur J Clin Invest2006，36，5： | 1 |
| 7 | Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis 显示文摘 | Hatoum A El-Sabban ME Khoury J | 2001 | Carcinogenesis2001，22，： | 1 |
| 8 | Treatment of metastatic breast cancer: state-of- the-art, subtypes and perspectives显示文摘 | EL SAGHIR N S TFAYLI A HATOUM H A | 2011 | Crit Rev Oncol Hematol2011，80，3： | 1 |
| 9 | The impact of zoledronic acid treatment on frequency of skeletal complications experienced and on follow up duration post diagnosis of bone metastasis in lung cancer patients显示文摘 | Hatoum HT Lin S Lipton A | 2008 | J Clin Oncol2008，26，15： | 1 |
| 10 | Emerging role of epoxyeicosatrienoic acids in coronary vascular function显示文摘 | Larsen B T Gutterman D D Hatoum O A | 2006 | Eur J Clin Invest2006，36，： | 1 |
| 11 | Overexpression of reti- noic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid - induced growth arrest and apoptosis 显示文摘 | Hatoum A EL Sabban ME Khoury J | 2001 | Carcinogenesis2001，22，12： | 1 |
| 12 | Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with nonmetastatic lymph node-positive breast cancer 显示文摘 | Hatoum H A Jamali F R El-Saghir N S | 2009 | Annals of Surgical Oncology2009，16，12： | 1 |
| 13 | Clusterbasedresource management in OFDMA femtocell net-works with QoS guarantees显示文摘 | HATOUM A LANGAR R AITSAADI N | 2014 | IEEE Transactions on Ve-hicular Technology2014，63，5： | 1 |
| 14 | En- dothelium-derived microparticles induce endothelial dysfunction and acute lung injury显示文摘 | Densmore JC Signorino PR Ou J Hatoum OA et a/ | 2006 | Shoek2006，26，5： | 1 |
| 15 | Overexpression of retinoic acid receptors alpha and gamma into neoplastic epider mal ceils causes retinoic acid induced growth arrest and apop tosis显示文摘 | Hatoum A El- Sabban ME Khoury J | 2001 | Car- cinogenesis2001，22，19： | 1 |
| 16 | Acquired microvascular dysfunction in inflammatory bowel disease: loss of nitric oxide-mediated vasodilation显示文摘 | Ossama A Hatoum David G Binion Mary F Otterson David D Gutterman | 2003 | Gastroenterology2003，，1： | 1 |
| 17 | Assessment of the health - related quality of life impact of Euflexxa ? ( 1% sodium hya- luronate) using the short form (SF) -36 data collected in a random- ized clinical trial显示文摘 | Hatoum H T Rosen J E Fierlinger A L | 2013 | Osteoarthritis and Cartilage2013，21，： | 1 |
| 18 | Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis显示文摘 | Hatoum A El Sabban ME Khoury J | 2001 | Carcinogenesis2001，22，12： | 1 |
| 19 | Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKCa channels:implications for soluble epoxide hydrolase inhibition显示文摘 | LARSEN B T MIURA H HATOUM O A | | 0，，02： | 1 |
| 20 | Persistency on monthly zoledronic acid impacts risk and frequency of skeletal complications and follow-up duration in lung cancer patients显示文摘 | Hatoum HT Lin S J Lipton A | 2009 | J Thorac Oncol2009，4，91： | 1 |
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