|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 3 | GNSS Spoofing Detection Based on Consistency Check of Velocities显示文摘Spoofing attacks for Global navigation satellite system(GNSS) would cause the abnormal changes of receiver measurements. Monitoring the abnormal changes is the main pattern of anti-spoofing techniques.Anomalies of Doppler shifts are important for GNSS spoofing detection. Most researchers focus on the consistency of Doppler such as the consistency of carrier Doppler and code rate. But the method is powerless in some cases.Doppler shift measurement is proportional to change rate of pseudorange, and the relationship would be broken in the case of spoofing attack. As both Doppler measurements and pseudoranges are related to velocity of receiver,two approaches of computing velocity can be used to check the consistency of Doppler shifts and pseudoranges measurements. An efficient spoofing detection method based on the consistency check of velocities is proposed in the paper. Principle of the method is given in detail and its performance evaluations are provided as well. Simulation results demonstrate the effectiveness of the solution. | TAO Huiqi WU Hailing LI Hong LU Mingquan | 2019 | Chinese Journal of Electronics2019，28，2： | 10 |
| 4 | Mycorrhizas Affect Polyphyllin Accumulation of Paris polyphylla var.yunnanensis through Promoting PpSE Expression显示文摘Paris polyphylla var.yunnanensis is a traditional Chinese medicinal plant,in which polyphyllin as the main medicinal component is an important secondary metabolite with bioactivity.Arbuscular mycorrhizal fungi(AMF)have multiple positive effects on plants,while it is not clear whether AMF increase the content of medicinal components in medicinal plants.In this study,a total of nine AMF treatments were laid to analyze the mycorrhizal effect on polyphyllin accumulation and PpHMGR and PpSE expression of P.polyphylla var.yunnanensis.AMF increased the content of polyphyllin in the cultivated variety with low relation to the increase of inoculation intensity.Polyphyllin I,II,and VII were identified and partly improved by AMF inoculation,dependent on AMF treatments and culture environments.Similarly,the PpHMGR and PpSE expression was induced by mycorrhization,dependent on AMF species,whilst the induction was more obvious in PpSE than in PpHMGR after mycorrhization.It concluded that the symbiotic relationship between P.polyphylla var.yunnanensis and AMF increased polyphyllin content level in the plant,which was associated with the up-regulation of PpSE transcripts. | Hailing Li Lingfeng Xu Zhuowei Li Shunxin Zhao Dongqin Guo Lu Rui Nong Zhou | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 2 |
| 5 | Analysis of the electric field and ion current density under ultra high- voltage direct-current transmission lines based on finite element method显示文摘 | Lu Tiebing Feng Hail Zhao Zhibin | 2007 | IEEE Transactions on Magnetics2007，43，4： | 1 |
| 6 | Prognostic values of osteopontin-c, E-cadherin and β-catenin in breast cancer 显示文摘 | Hui Pang Hailing Lu Hongtao Song | 2013 | Cancer Epidemiology2013，37，6： | 1 |
| 7 | Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions显示文摘 | Baowei Zhang Wenhui Peng Hailing Li Yuyan Lu Jianhui Zhuang Ke Wang Yang Su Yawei Xu | 2013 | Clinical Biochemistry2013，，： | 1 |
| 8 | IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated reiection of breast cancers in neu-transgenic mice显示文摘 | Yushe Dang Hailing Lu | 2006 | Journal of Immunology2006，177，1： | 1 |
| 9 | Direct detection of carcinoembry0nic antigen autoantibodies in clinical human serum samples using a surface plasmon resonance sensor 显示文摘 | Ladd Jon Lu Hailing Taylor Allen D | 2009 | Colloids and Surfaces B: Biointerfaces2009，70，： | 1 |
| 10 | Polysaccharide krestin is a novelTLR2 agonist that mediates inhibition of tumor growth via stimulationof CD8 T cells and NK cells显示文摘 | LU Hailing YANG Yi GAD E | 2011 | Clin Cancer Res2011，17，1： | 1 |
| 11 | Nanoporous Au-Sn with solute strain for simultaneously enhanced selectivity and durability during electrochemical CO2 reduction显示文摘Electrochemical carbon dioxide reduction meditated by metallic catalysts suffers from restricted selectivity and competition from hydrogen evolution, which sensitively depends on ambiguous contributions of alloying and strain state in bimetallic catalysts. Herein, nanoporous Au-Sn(NPAS) containing trace tin solute in Au lattices is delicately designed to convince real strain effect, while eliminating other undesirable factors, such as alloying, crystal facets and surface composition. Compared with nanoporous gold(NPG), the NPAS with a solute strain of ~2.2% enables more efficient CO2-to-CO conversion, with an efficiency as high as 92% at-0.85 V versus reversible hydrogen electrode(vs. RHE), and the high activity can retain for more than 8 h. The combination of HRTEM and surface valence band photoemission spectra reveals that the tensile strain on the surface of 3 D nanoporous structure promotes the catalytic activity by shifting up the d-band center and strengthening the adsorption of key intermediate *COOH. A small amount of Sn solute in the nanoporous alloy can prevent ligament coarsening effectively and improve the electrochemical stability. | Xianglong Lu Tianshui Yu Hailing Wang Lihua Qian Ruichun Luo Pan Liu Yao Yu Lin Liu Pengxiang Lei Songliu Yuan | 2020 | Journal of Materials Science & Technology2020，36，8： | 0 |
| 12 | Aberrant microRNA expression in the development of breast carcinoma显示文摘microRNAs,a class of small non-coding regulatory RNAs,are involved in oncogenesis and cancer development.Studies have shown that aberrant miRNA expression occurs in breast cancer and is associated with specific clinicopathological features.Some miRNAs might act as suppressor genes or oncogenes,which can be considered as novel markers for breast cancer diagnosis and as prognostic factors.Here we present a review of recent discoveries on miRNAs involved in breast cancer tumorigenesis,invasion,and metastasis. | WU Qian LI HaiLing LU JiaFeng GE QingYu LU ZuHong | 2010 | Chinese Science Bulletin2010，55，31： | 0 |
| 13 | Clinical Efficacy Analysis of Tiotropium Bromide Combined with Budesonide and Formoterol Inhalation in Treating COPD显示文摘Objective:To analyze the clinical efficacy of tiotropium bromide(TB)combined with budesonide formoterol(BUD/FM)inhalation in treating chronic obstructive pulmonary disease(COPD).Methods:62 COPD patients admitted to the hospital between June 2020 and December 2022 were selected as samples for this study.The patients were divided into a combination group and a conventional group using the random number table method,with 31 cases in each group.The patients in the combination group were treated with TB combined with BUD/FM inhalation,whereas the patients in the conventional group were treated with BUD/FM inhalation only.The treatment efficacy and changes in lung function indicators of both groups were compared.Results:The total efficacy of treatment in the combined group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).Before treatment,there was no difference in pulmonary function indicators between the two groups(P>0.05).After three months of treatment,all lung function indicators of the combined group were higher than those of the conventional group,and the difference was statistically significant(P<0.05).Conclusion:Combining TB with BUD/FM inhalation therapy increases the efficacy of treatment for patients with COPD.Besides,it also improves lung function and leads to a better prognosis. | Hailing Lin Yanjie Lu | 2024 | Journal of Clinical and Nursing Research2024，8，1： | 0 |
| 14 | Self-Supported Nanoporous Gold with Gradient Tin Oxide for Sustainable and Efficient Hydrogen Evolution in Neutral Media显示文摘Hydrogen evolution reaction(HER)in neutral medium suffers from slow kinetics as compared to that in alkaline or acidic conditions,owing to larger Ohmic loss and low proton concentration.Here we report that a self-supported nanoporous Au-SnO_(x)(NP Au-SnO_(x))catalyst with gradient tin oxide surface could significantly enhance HER activity in neutral buffer solution(0.2 M PBS).The NP Au-SnO_(x)catalyst exhibits a low onset overpotential of 38 mV and a small Tafel slope of 79 mV dec^(−1).The current density of 10 mA cm^(−2)is manifested at an overpotential as low as 148 mV,representing the comparable performance of Pt/C catalyst.This high catalytic activity can retain at least 10 hours without any detectable decay.The superior HER activity is proposed to originate from the gradient SnO_(x)structure and metal/oxide interfaces in nanoporous ligaments.Furthermore,the X-ray photoelectron spectroscopy reveals that the gradient oxide in the ligament is remarkably stable during long-term reaction. | Xianglong Lu Tianshui Yu Hailing Wang Ruichun Luo Pan Liu Songliu Yuan Lihua Qian | 2020 | Journal of Renewable Materials2020，8，2： | 0 |
| 15 | Different Laboratory Abnormalities in COVID-19 Patients with Hypertension or Diabetes显示文摘Dear Editor,The pandemic of COVID-19,a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2;previously known as 2019-n Co V),has placed an enormous burden on health authorities in 213 countries and territories.At the time of writing,over 26 million cases have been recorded across the world,with more than 870 k associated deaths(www.worldometers.info/coronavirus/).World Bank warns COVID-19 pandemic risks dramatic rise in poverty,with the majority of economies expecting to suffer from falling levels of GDP in 2020. | Xiaojun Wu Tong Wang Yilu Zhou Xiaofan Liu Hong Zhou Yang Lu Weijun Tan Mingli Yuan Xuhong Ding Jinjing Zou Ruiyun Li Hailing Liu Rob MEwing Yi Hu Hanxiang Nie Yihua Wang | 2020 | Virologica Sinica2020，35，6： | 0 |
| 16 | ADVANCES IN EXPERIMENTAL APPROACHES FOR INVESTIGATING CELL AGGREGATE MECHANICS显示文摘Cells tend to form hierarchy structures in native tissues.Formation of cell aggregates in vitro such as cancer spheroids and embryonic bodies provides a unique means to study the mechanical properties and biological behaviors/functions of their counterparts in vivo.In this paper,we review state-of-the-art experimental approaches to assess the mechanical properties and mechanically-induced responses of cell aggregates in vitro.These approaches are classified into five categories according to loading modality,including micropipette aspiration,centrifugation,compression loading,substrate distention,and fluid shear loading.We discussed the advantages and disadvantages of each approach,and the potential biomedical applications.Understanding of the mechanical behavior of cell aggregates provides insights to physical interactions between cells and integrity of biological functions,which may enable mechanical intervention for diseases such as atheromatosis and cancer. | Wenjun Zhang Shuqi Wang Min Lin Yulong Hail Guiping Zhao Tian Jian Lu Feng Xu | 2012 | Acta Mechanica Solida Sinica2012，25，5： | 0 |
| 17 | A metal ions-mediated natural small molecules carrier-free injectable hydrogel achieving laser-mediated photo-Fenton-like anticancer therapy by synergy apoptosis/cuproptosis/anti-inflammation显示文摘Tumor microenvironment (TME) plays an important role in the tumorigenesis, proliferation, invasion and metastasis. Thereby developing synergistic anticancer strategies with multiple mechanisms are urgent. Copper is widely used in the treatment of tumor chemodynamic therapy (CDT) due to its excellent laser-mediated photo- Fenton-like reaction. Additionally, copper can induce cell death through cuproptosis, which is a new modality different from the known death mechanisms and has great promise in tumor treatment. Herein, we report a natural small molecules carrier-free injectable hydrogel (NCTD Gel) consisted of Cu2+-mediated self-assembled glycyrrhizic acid (GA) and norcantharidin (NCTD), which are mainly governed by coordination and hydrogen bonds. Under 808 nm laser irradiation, NCTD Gel can produce reactive oxygen species (ROS), consume glutathione (GSH) and overcome hypoxia in TME, leading to synergistically regulate TME via apoptosis, cuproptosis and anti-inflammation. In addition, NCTD Gel’s CDT display high selectivity and good biocompatibility as it relies on the weak acidity and H2O2 overexpression of TME. Notably, NCTD Gel’s components are originated from clinical agents and its preparation process is easy, green and economical, without any excipients. This study provides a new carrier-free hydrogel synergistic antitumor strategy, which has a good prospect in industrial production and clinical transformation. | Wenmin Pi Linying Wu Jihui Lu Xiaoyu Lin Xuemei Huang Zhijia Wang Zhihua Yuan Hailing Qiu Jianglan Zhang Haimin Lei Penglong Wang | 2023 | Bioactive Materials2023，，11： | 0 |
| 18 | Advances in the treatment of IgA nephropathy with biological agents显示文摘Immunoglobulin A nephropathy(IgAN)is the most common primary glomerular disease,and the“four-hit”theory represents its currently accepted pathogenic mechanism.Mucosal immunity triggered by infections in the respiratory tract,intestines,or other areas leads to antigen presentation,T cell stimulation,B cell maturation,and the production of IgA-producing plasma cells.The proteins B-lymphocyte stimulator(BLyS)and a proliferation-inducing ligand(APRIL)are involved in this process,and alternative complement and lectin pathway activation are also part of the pathogenic mechanism.Kidney Disease Improving Global Outcomes guidelines indicate that a specific effective treatment for IgAN is lacking,with renin-angiotensin-aldosterone system inhibitors being the primary therapy.Recent research shows that biological agents can significantly reduce proteinuria,stabilize the estimated glomerular filtration rate,and reverse some pathological changes,such as endocapillary proliferation and crescent formation.There are four main categories of biological agents used to treat IgA nephropathy,specifically anti-CD20 monoclonal antibodies,anti-BLyS or APRIL monoclonal antibodies,monoclonal antibodies targeting both BLyS and APRIL(telitacicept and atacicept),and monoclonal antibodies inhibiting complement system activation(narsoplimab and eculizumab).However,further research on the dosages,treatment duration,long-term efficacy,and safety of these biological agents is required. | Yongze Zhuang Hailing Lu Junxia Li | 2024 | Chronic Diseases and Translational Medicine2024，10，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员